{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:18:23Z","timestamp":1793204303104,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.exer.2026.110849","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:59:39Z","timestamp":1767916779000},"page":"110849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["miR-29b-3p promotes the recovery of alkali-burned cornea by targeting Ddx3x"],"prefix":"10.1016","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-1532","authenticated-orcid":false,"given":"Juan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-4222","authenticated-orcid":false,"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.110849_bib1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41433-019-0456-5","article-title":"An update on chemical eye burns","volume":"33","author":"Bizrah","year":"2019","journal-title":"Eye"},{"key":"10.1016\/j.exer.2026.110849_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12958-019-0506-7","article-title":"Downregulation of miR-322 promotes apoptosis of GC-2 cell by targeting Ddx3x","volume":"17","author":"Che","year":"2019","journal-title":"Reprod. Biol. Endocrinol. : RB&E"},{"key":"10.1016\/j.exer.2026.110849_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2023.02.074","article-title":"The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis","volume":"655","author":"Chi","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2026.110849_bib4","article-title":"Amniotic membrane transplantation for acute ocular burns","author":"Clare","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.exer.2026.110849_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073597","article-title":"MicroRNAs expression in response to rhNGF in epithelial corneal cells: focus on neurotrophin signaling pathway","volume":"23","author":"Compagnoni","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.110849_bib6","doi-asserted-by":"crossref","first-page":"C367","DOI":"10.1152\/ajpcell.00051.2022","article-title":"The microRNA-29 family: role in metabolism and metabolic disease","volume":"323","author":"Dalgaard","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2026.110849_bib7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tig.2022.02.006","article-title":"Emerging concepts of miRNA therapeutics: from cells to clinic","volume":"38","author":"Diener","year":"2022","journal-title":"Trends Genet. : TIG (Trends Genet.)"},{"key":"10.1016\/j.exer.2026.110849_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41419-024-07076-9","article-title":"The cytoplasmic-nuclear transport of DDX3X promotes immune-mediated liver injury in mice regulated by endoplasmic reticulum stress","volume":"15","author":"Fan","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2026.110849_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12672-025-01959-9","article-title":"Pingxiao pian attenuate invasiveness and proliferation of lung adenocarcinoma through regulating miR-29b-3p\/TGF-\u03b21\/Smad\/EMT pathway","volume":"16","author":"Feng","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.exer.2026.110849_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/jop.2023.0130","article-title":"Elevated KDM4D expression in pterygium: impact and potential inhibition by Lycium barbarum polysaccharide","volume":"40","author":"Gao","year":"2024","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2026.110849_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jtos.2024.09.007","article-title":"Recent advances in NLRP3 inflammasome in corneal diseases: preclinical insights and therapeutic implications","volume":"34","author":"Ge","year":"2024","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.110849_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/iovs.65.13.9","article-title":"Silencing METTL3 increases HSP70 expression and alleviates fibrosis in keratocytes","volume":"65","author":"Jing","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.110849_bib13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuron.2020.01.042","article-title":"Pathogenic DDX3X mutations impair RNA metabolism and neurogenesis during fetal cortical development","volume":"106","author":"Lennox","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2026.110849_bib14","article-title":"Circulating small extracellular vesicles involved in systemic regulation respond to RGC degeneration in glaucoma","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.exer.2026.110849_bib15","article-title":"Circulating small extracellular vesicles involved in systemic regulation respond to RGC degeneration in glaucoma","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.exer.2026.110849_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118017","article-title":"MSC-derived exosomal miR-34a\/c-5p and miR-29b-3p improve intestinal barrier function by targeting the Snail\/Claudins signaling pathway","volume":"257","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.exer.2026.110849_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109716","article-title":"miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A","volume":"74","author":"Li","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exer.2026.110849_bib18","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4934","article-title":"Silencing microRNA-29b-3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway","volume":"47","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exer.2026.110849_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.65.6.16","article-title":"Mesenchymal stem cell-derived exosomes as drug carriers for delivering miRNA-29b to ameliorate inflammation in corneal injury via activating autophagy","volume":"65","author":"Liu","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.110849_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115127","article-title":"miR-135a-5p alleviates cerebral ischemia-reperfusion injury by inhibiting pyroptosis mediated through the DDX3X\/NLRP3 pathway","volume":"385","author":"Liu","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2026.110849_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41419-023-05913-x","article-title":"Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress","volume":"14","author":"Luo","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2026.110849_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2026.110849_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12943-021-01325-7","article-title":"DDX3X: structure, physiologic functions and cancer","volume":"20","author":"Mo","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.exer.2026.110849_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijcard.2019.04.006","article-title":"Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p","volume":"292","author":"Ni","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.exer.2026.110849_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fphar.2016.00226","article-title":"Ophthalmic combination of SurR9-C84A and Trichostatin-A targeting molecular pathogenesis of alkali burn","volume":"7","author":"Roy","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2026.110849_bib26","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-019-1551-2","article-title":"DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome","volume":"573","author":"Samir","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exer.2026.110849_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.survophthal.2017.09.005","article-title":"Treatment of acute ocular chemical burns","volume":"63","author":"Sharma","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2026.110849_bib28","doi-asserted-by":"crossref","first-page":"D304","DOI":"10.1093\/nar\/gkad1071","article-title":"TarBase-v9.0 extends experimentally supported miRNA-gene interactions to cell-types and virally encoded miRNAs","volume":"52","author":"Skoufos","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2026.110849_bib29","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.2147\/OPTH.S235873","article-title":"Management strategies of ocular chemical burns: current perspectives","volume":"14","author":"Soleimani","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2026.110849_bib30","first-page":"2450","article-title":"Bone marrow mesenchymal stem cells-derived exosomal MiR-29b-3p regulates aging-associated insulin resistance","volume":"13","author":"Su","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.exer.2026.110849_bib31","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1002\/jcp.29706","article-title":"Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis","volume":"235","author":"Wan","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2026.110849_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.894","article-title":"TLR4 aggravates microglial pyroptosis by promoting DDX3X-mediated NLRP3 inflammasome activation via JAK2\/STAT1 pathway after spinal cord injury","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.exer.2026.110849_bib33","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.18632\/aging.102672","article-title":"MiR-29b-3p promotes particulate matter-induced inflammatory responses by regulating the C1QTNF6\/AMPK pathway","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.exer.2026.110849_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108089","article-title":"Corneal wound healing","volume":"197","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.110849_bib35","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201227","article-title":"miR-29b-3p inhibits post-infarct cardiac fibrosis by targeting FOS","volume":"40","author":"Xue","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2026.110849_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16061131","article-title":"DDX3X and stress granules: emerging players in cancer and drug resistance","volume":"16","author":"Zhang","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.exer.2026.110849_bib37","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212241","article-title":"XSSJS inhibits hepatic fibrosis by promoting the miR-29b-3p\/VEGFA axis in vitro and in vivo","volume":"42","author":"Zhang","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2026.110849_bib38","article-title":"Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526000059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526000059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:40:13Z","timestamp":1781685613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":38,"alternative-id":["S0014483526000059"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.110849","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-29b-3p promotes the recovery of alkali-burned cornea by targeting Ddx3x","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.110849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110849"}}