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Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.110851_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2005.03.012","article-title":"Src kinase regulation by phosphorylation and dephosphorylation","volume":"331","author":"Roskoski","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2026.110851_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108547","article-title":"Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: challenges and research opportunities","volume":"251","author":"Rungratanawanich","year":"2023","journal-title":"Pharmacol. 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Macromol."},{"key":"10.1016\/j.exer.2026.110851_bib197","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.4161\/cc.7.12.6156","article-title":"Cytoplasmic sumoylation by PIAS-type Siz1-SUMO ligase","volume":"7","author":"Takahashi","year":"2008","journal-title":"Cell cycle (Georgetown, Tex.)"},{"key":"10.1016\/j.exer.2026.110851_bib198","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/BST20190390","article-title":"The role of SUMOylation during development","volume":"48","author":"Talamillo","year":"2020","journal-title":"Biochem. Soc. 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Genom."},{"key":"10.1016\/j.exer.2026.110851_bib202","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.molcel.2005.02.004","article-title":"E1 on the move","volume":"17","author":"VanDemark","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2026.110851_bib203","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10792-015-0128-9","article-title":"Patterns of uveitis at the apex institute for eye care in India: results from a prospectively enrolled patient data base (2011-2013)","volume":"36","author":"Venkatesh","year":"2016","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2026.110851_bib204","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-981-15-0602-4_12","article-title":"Protein modification and autophagy activation","volume":"1206","author":"Wang","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2026.110851_bib205","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.sbi.2008.09.004","article-title":"Structure and chemistry of the p300\/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function","volume":"18","author":"Wang","year":"2008","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.exer.2026.110851_bib206","article-title":"Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.exer.2026.110851_bib207","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.7150\/ijbs.75434","article-title":"Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2026.110851_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102297","article-title":"Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1\/M2 phenotypic polarization","volume":"52","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2026.110851_bib209","series-title":"Progranulin Suppressed Autoimmune Uveitis and Autoimmune Neuroinflammation by Inhibiting Th1\/Th17 Cells and Promoting Treg Cells and M2 Macrophages. 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