{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:27:05Z","timestamp":1793600825778,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.exer.2026.110944","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:07:39Z","timestamp":1771978059000},"page":"110944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sigma-2 receptor modulators alter low-density lipoprotein receptor-mediated lipid uptake in retinal pigment epithelial cells"],"prefix":"10.1016","volume":"267","author":[{"given":"Britney N.","family":"Lizama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Reaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Look","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony O.","family":"Caggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-1853","authenticated-orcid":false,"given":"Mary E.","family":"Hamby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.110944_bib1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/ng.938","article-title":"Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population","volume":"43","author":"Arakawa","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cmet.2009.05.009","article-title":"Identification of cholesterol-regulating genes by targeted RNAi screening","volume":"10","author":"Bartz","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.exer.2026.110944_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mvr.2009.02.005","article-title":"Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency","volume":"78","author":"Chen","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.exer.2026.110944_bib4","series-title":"Cognition Therapeutics Reports Topline Results Showing Oral Zervimesine (CT1812) Reduced Lesion Growth in Phase 2 Study in Geographic Atrophy","year":"2025"},{"key":"10.1016\/j.exer.2026.110944_bib5","doi-asserted-by":"crossref","first-page":"AMD160","DOI":"10.1167\/iovs.18-24882","article-title":"Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies","volume":"59","author":"Curcio","year":"2018","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib6","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1136\/bjophthalmol-2011-300344","article-title":"The oil spill in ageing Bruch membrane","volume":"95","author":"Curcio","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2026.110944_bib7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.oret.2024.04.023","article-title":"Vision loss reduction with avacincaptad pegol for geographic atrophy","volume":"8","author":"Danzig","year":"2024","journal-title":"Ophthalmol. Retin."},{"key":"10.1016\/j.exer.2026.110944_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.110143","article-title":"Neuroprotective effect of Sigma-2 modulator CT2074 in a mouse model of ocular hypertension","volume":"249","author":"Donkor","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.110944_bib9","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1093\/hmg\/ddw204","article-title":"Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells","volume":"25","author":"Ebrahimi-Fakhari","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1167\/iovs.05-0719","article-title":"Cigarette smoke\u2013related oxidants and the development of Sub-RPE deposits in an experimental animal model of dry AMD","volume":"47","author":"Espinosa-Heidmann","year":"2006","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-Related macular degeneration","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.exer.2026.110944_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ng.2578","article-title":"Seven new loci associated with age-related macular degeneration","volume":"45","author":"Fritsche","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","article-title":"Age-Related macular degeneration: genetics and biology coming together","volume":"15","author":"Fritsche","year":"2014","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib15","first-page":"19","article-title":"Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis","volume":"85","author":"Go","year":"2012","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.exer.2026.110944_bib16","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1167\/iovs.04-0074","article-title":"RPE cells internalize low-density lipoprotein (LDL) and oxidized LDL (oxLDL) in large quantities in vitro and in vivo","volume":"45","author":"Gordiyenko","year":"2004","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exer.2018.10.009","article-title":"Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide","volume":"179","author":"Hazim","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.110944_bib18","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/ng.2740","article-title":"A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration","volume":"45","author":"Helgason","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.exer.2026.110944_bib20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1167\/iovs.15-18316","article-title":"The Association between subretinal drusenoid deposits in older adults in normal macular health and incident age-related macular degeneration","volume":"57","author":"Huisingh","year":"2016","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.826379","article-title":"Low-Density lipoprotein internalization, degradation and receptor recycling along membrane contact sites","volume":"10","author":"Islam","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2026.110944_bib22","article-title":"Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits","volume":"9","author":"Izzo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2026.110944_bib23","article-title":"Alzheimer's therapeutics targeting amyloid beta 1\u201342 oligomers II: Sigma-2\/PGRMC1 receptors mediate abeta 42 oligomer binding and synaptotoxicity","volume":"9","author":"Izzo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2026.110944_bib24","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/alz.12302","article-title":"Preclinical and clinical biomarker studies of CT1812: a novel approach to Alzheimer's disease modification","volume":"17","author":"Izzo","year":"2021","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.exer.2026.110944_bib25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.110944_bib26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ajo.2025.04.022","article-title":"Ocular adverse events associated with Pegcetacoplan and avacincaptad pegol for geographic atrophy: a population-based pharmacovigilance Study","volume":"276","author":"Kailani","year":"2025","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2026.110944_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abh2169","article-title":"A single\u2013cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exer.2026.110944_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mnfr.201800951","article-title":"Oxidative stress and dysfunctional intracellular traffic linked to an unhealthy diet results in impaired cargo transport in the Retinal Pigment Epithelium (RPE)","volume":"63","author":"Keeling","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.exer.2026.110944_bib29","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.3390\/ijms21186647","article-title":"An In-Vitro cell model of intracellular protein aggregation provides insights into RPE stress associated with retinopathy","volume":"21","author":"Keeling","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/cells7020016","article-title":"Impaired cargo clearance in the Retinal Pigment Epithelium (RPE) underlies irreversible blinding diseases","volume":"7","author":"Keeling","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.exer.2026.110944_bib66","doi-asserted-by":"crossref","first-page":"101037","DOI":"10.1016\/j.preteyeres.2021.101037","article-title":"Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life","volume":"89","author":"Lewandowski","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2026.110944_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.110944_bib32","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2217\/imt-2022-0078","article-title":"Pegcetacoplan treatment for geographic atrophy due to age-related macular Degeneration: a Plain Language Summary of the FILLY Study","volume":"14","author":"Liao","year":"2022","journal-title":"Immunotherapy"},{"key":"10.1016\/j.exer.2026.110944_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076251","article-title":"Sigma-2 Receptors\u2014From basic biology to therapeutic target: a focus on age-related degenerative diseases","author":"Lizama","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib34","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1038\/s41598-025-87921-9","article-title":"Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD)","volume":"15","author":"Lizama","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.110944_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106575","article-title":"An interim exploratory proteomics biomarker analysis of a phase 2 clinical trial to assess the impact of CT1812 in Alzheimer's disease","volume":"199","author":"Lizama","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2026.110944_bib36","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1002\/alz.14152","article-title":"CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease","volume":"20","author":"Lizama","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.exer.2026.110944_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12177","article-title":"Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection","volume":"4","author":"Lu","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.exer.2026.110944_bib38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13195-025-01784-w","article-title":"A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (A\u03b2)-mediated retinal pathology from age-related changes","volume":"17","author":"Lynn","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.exer.2026.110944_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13287-020-1568-3","article-title":"Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting","volume":"11","author":"Michelet","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.exer.2026.110944_bib40","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1097\/MS9.0000000000001466","article-title":"Advancements in the treatment of geographic atrophy: focus on pegcetacoplan in age-related macular degeneration","volume":"85","author":"Nadeem","year":"2023","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.exer.2026.110944_bib41","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1073\/pnas.0912019107","article-title":"Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)","volume":"107","author":"Neale","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preteyeres.2014.03.002","article-title":"Cholesterol in the retina: the best is yet to come","volume":"41","author":"Pikuleva","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2026.110944_bib43","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41588-019-0351-9","article-title":"Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration","volume":"51","author":"Ratnapriya","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib44","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ng.976","article-title":"A rare penetrant mutation in CFH confers high risk of age-related macular degeneration","volume":"43","author":"Raychaudhuri","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib45","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s12035-020-01988-1","article-title":"The Sigma-2 Receptor\/TMEM97, PGRMC1, and LDL receptor complex are responsible for the cellular uptake of A\u03b242 and its protein aggregates","volume":"57","author":"Riad","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2026.110944_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35430-3","article-title":"Sigma-2 Receptor\/TMEM97 and PGRMC-1 increase the rate of internalization of LDL by LDL receptor through the Formation of a ternary complex","volume":"8","author":"Riad","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.110944_bib47","first-page":"715","article-title":"Accumulation of lipid particles in the rupture membrane of LDL receptor-deficient mice as a model for age-related macular degeneration","volume":"101","author":"Rudolf","year":"2004","journal-title":"Ophthalmol. Times"},{"key":"10.1016\/j.exer.2026.110944_bib48","first-page":"60","article-title":"Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells","volume":"23","author":"Samuel","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2026.110944_bib49","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110078","article-title":"TMEM97 ablation aggravates oxidant-induced retinal degeneration","volume":"86","author":"Shen","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exer.2026.110944_bib51","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900540","article-title":"BRD2 regulation of sigma-2 receptor upon cholesterol deprivation","volume":"4","author":"Shen","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.exer.2026.110944_bib52","article-title":"Cholesterol biosynthesis and homeostasis in regulation of the cell cycle","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2026.110944_bib53","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.3390\/jcm13144227","article-title":"Summary of the therapeutic options for patients with dry and neovascular AMD","volume":"13","author":"\u015apiewak","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exer.2026.110944_bib54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/cells12010043","article-title":"Oxidative stress and lipid accumulation augments cell death in LDLR-Deficient RPE cells and Ldlr\u2212\/\u2212 mice","volume":"12","author":"Sreekumar","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exer.2026.110944_bib55","first-page":"1306","article-title":"Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"issue":"347","key":"10.1016\/j.exer.2026.110944_bib56","article-title":"Tissue-based map of the human proteome","volume":"80","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.exer.2026.110944_bib57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13195-024-01382-2","article-title":"A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease","volume":"16","author":"van Dyck","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.exer.2026.110944_bib58","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.ophtha.2016.08.047","article-title":"Optical coherence Tomography Reflective Drusen substructures predict progression to geographic atrophy in age-related macular degeneration","volume":"123","author":"Veerappan","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.110944_bib59","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.14283\/jpad.2024.154","article-title":"A pilot electroencephalography Study of the effect of CT1812 treatment on synaptic activity in patients with mild to moderate alzheimer's disease","volume":"11","author":"Vijverberg","year":"2024","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.exer.2026.110944_bib60","article-title":"Randomized, double-blind study of zervimesine in mild to moderate Alzheimer\u2019s disease","author":"Vijverberg","year":"2025","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.exer.2026.110944_bib61","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.3390\/ijms24043417","article-title":"Development of a CRISPRi human retinal pigmented epithelium model for functional Study of age-related macular degeneration genes","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.110944_bib62","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1471-4159.2008.05211.x","article-title":"Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells","volume":"105","author":"Yamada","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2026.110944_bib63","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/hmg\/ddy002","article-title":"Genome-wide analysis of disease progression in age-related macular degeneration","volume":"27","author":"Yan","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2026.110944_bib64","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10753-013-9769-x","article-title":"Difference in LDL receptor feedback regulation in macrophages and vascular smooth muscle cells: foam cell transformation under inflammatory stress","volume":"37","author":"Ye","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.exer.2026.110944_bib65","article-title":"Spatial distribution of the pathways of cholesterol homeostasis in Human retina","volume":"7","author":"Zheng","year":"2012","journal-title":"PLoS One"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:34:28Z","timestamp":1793597668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"alternative-id":["S0014483526001004"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.110944","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.08.22.670986","asserted-by":"object"}]},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sigma-2 receptor modulators alter low-density lipoprotein receptor-mediated lipid uptake in retinal pigment epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.110944","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110944"}}