{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:00:17Z","timestamp":1780966817588,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.exer.2026.111047","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T23:04:45Z","timestamp":1778367885000},"page":"111047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea"],"prefix":"10.1016","volume":"269","author":[{"given":"Annette Y.","family":"Kaminaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Bossardi-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro P.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Wladis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2026.111047_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbamcr.2006.08.040","article-title":"p120-ctn: a nexus for contextual signaling via rho GTPases","volume":"1773","author":"Anastasiadis","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.exer.2026.111047_bib2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/tra.12448","article-title":"Cadherin tales: regulation of cadherin function by endocytic membrane trafficking","volume":"17","author":"Cadwell","year":"2016","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.exer.2026.111047_bib3","doi-asserted-by":"crossref","first-page":"8737","DOI":"10.1038\/s41467-024-52946-7","article-title":"Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/1346-8138.14792","article-title":"Claudin reduction may relate to an impaired skin barrier in rosacea","volume":"46","author":"Deng","year":"2019","journal-title":"J Dermatol."},{"issue":"1","key":"10.1016\/j.exer.2026.111047_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jaad.2017.08.037","article-title":"Standard classification and pathophysiology of rosacea: the 2017 update by the national rosacea society expert committee","volume":"78","author":"Gallo","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.exer.2026.111047_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1615\/CritRevImmunol.v32.i2.20","article-title":"p120-Catenin: a novel regulator of innate immunity and inflammation","volume":"32","author":"Hu","year":"2012","journal-title":"Crit. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.exer.2026.111047_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241299","article-title":"Loss of p120ctn causes EGFR-targeted therapy resistance and failure","volume":"15","author":"Landmesser","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib8","first-page":"4204","article-title":"P120 catenin attenuates lipopolysaccharide-induced blood-brain barrier dysfunction and inflammatory responses in human brain microvascular endothelial cells","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"10","key":"10.1016\/j.exer.2026.111047_bib9","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.jid.2020.02.025","article-title":"Rosacea is characterized by a profoundly diminished skin barrier","volume":"140","author":"Medgyesi","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.exer.2026.111047_bib10","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1074\/jbc.M109.043760","article-title":"Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells","volume":"285","author":"Ooshio","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.exer.2026.111047_bib11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.11.043","article-title":"p120-catenin mediates inflammatory responses in the skin","volume":"124","author":"Perez-Moreno","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1101\/gad.11.4.463","article-title":"Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins","volume":"11","author":"Perona","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2026.111047_bib13","first-page":"323","article-title":"Cutaneous and ocular rosacea: common and specific physiopathogenic mechanisms and study models","volume":"27","author":"Rodrigues-Braz","year":"2021","journal-title":"Mol. Vis."},{"issue":"7","key":"10.1016\/j.exer.2026.111047_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800227","article-title":"Cell adhesion structures in epithelial cells are formed in dynamic and cooperative ways","volume":"41","author":"Shigetomi","year":"2019","journal-title":"Bioessays"},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ccr.2011.02.007","article-title":"Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene","volume":"19","author":"Stairs","year":"2011","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.exer.2026.111047_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/ceo.13900","article-title":"Ocular manifestations of rosacea: a clinical review","volume":"49","author":"Tavassoli","year":"2021","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2026.111047_bib17","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20140021","article-title":"Rho protein GTPases and their interactions with NFkappaB: crossroads of inflammation and matrix biology","volume":"34","author":"Tong","year":"2014","journal-title":"Biosci. Rep."},{"issue":"2","key":"10.1016\/j.exer.2026.111047_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2018.09.008","article-title":"The claudins: from tight junctions to biological systems","volume":"44","author":"Tsukita","year":"2019","journal-title":"Trends Biochem. Sci."},{"issue":"5","key":"10.1016\/j.exer.2026.111047_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1590\/S0004-27492012000500016","article-title":"Ocular rosacea--a review","volume":"75","author":"Vieira","year":"2012","journal-title":"Arq. Bras. Oftalmol."},{"issue":"2","key":"10.1016\/j.exer.2026.111047_bib20","doi-asserted-by":"crossref","first-page":"L197","DOI":"10.1152\/ajplung.00048.2011","article-title":"Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin","volume":"301","author":"Wang","year":"2011","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"5","key":"10.1016\/j.exer.2026.111047_bib21","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.1001252","article-title":"Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin","volume":"186","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.exer.2026.111047_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/01676830.2021.1905668","article-title":"Myeloid differentiation factor 88 expression in eyelid specimens of rosacea","volume":"41","author":"Wladis","year":"2022","journal-title":"Orbit"},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib24","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/IOP.0b013e318293764c","article-title":"Toll-like receptors and vascular markers in ocular rosacea","volume":"29","author":"Wladis","year":"2013","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.exer.2026.111047_bib25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/IOP.0b013e31824dd9d4","article-title":"Molecular biologic assessment of cutaneous specimens of ocular rosacea","volume":"28","author":"Wladis","year":"2012","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"10.1016\/j.exer.2026.111047_bib26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ajo.2019.01.018","article-title":"Nuclear factor Kappa-B is enriched in eyelid specimens of rosacea: implications for pathogenesis and therapy","volume":"201","author":"Wladis","year":"2019","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2026.111047_bib27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1167\/iovs.16-20275","article-title":"Activation of p38 and erk mitogen-activated protein kinases signaling in ocular rosacea","volume":"58","author":"Wladis","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2026.111047_bib22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.survophthal.2017.07.005","article-title":"Treatment of ocular rosacea","volume":"63","author":"Wladis","year":"2018","journal-title":"Surv. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2026.111047_bib28","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J. Invest. Dermatol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:32:13Z","timestamp":1780965133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526002034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":28,"alternative-id":["S0014483526002034"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111047","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111047"}}