{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:20:15Z","timestamp":1783153215702,"version":"3.54.6"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202103188"],"award-info":[{"award-number":["tsqn202103188"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870632"],"award-info":[{"award-number":["81870632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800800"],"award-info":[{"award-number":["81800800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.exer.2026.111062","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:33:48Z","timestamp":1778654028000},"page":"111062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clioquinol alleviates Aspergillus fumigatus keratitis through antifungal and anti-inflammatory effects associated with metal chelation and Nrf2\/HO-1 signaling"],"prefix":"10.1016","volume":"269","author":[{"given":"Zhipeng","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-072X","authenticated-orcid":false,"given":"Guiqiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib1","first-page":"39","article-title":"Repression of the acid ZrfA\/ZrfB zinc-uptake system of Aspergillus fumigatus mediated by PacC under neutral, zinc-limiting conditions","volume":"12","author":"Amich","year":"2009","journal-title":"Int. Microbiol."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12281-013-0150-1","article-title":"Current thoughts in fungal keratitis: diagnosis and treatment","volume":"7","author":"Ansari","year":"2013","journal-title":"Curr. Fungal. Infect. Rep."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10123-019-00081-5","article-title":"New insights into copper homeostasis in filamentous fungi","volume":"23","author":"Antsotegi-Uskola","year":"2020","journal-title":"Int. Microbiol."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-5949.2010.00231.x","article-title":"Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders","volume":"18","author":"Bareggi","year":"2012","journal-title":"CNS Neurosci. Ther."},{"issue":"2","key":"10.1016\/j.exer.2026.111062_bib5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.biotechadv.2017.12.012","article-title":"Nrf2 as regulator of innate immunity: a molecular Swiss army knife","volume":"36","author":"Battino","year":"2018","journal-title":"Biotechnol. Adv."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib6","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib8","first-page":"775","article-title":"Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis","volume":"39","author":"Cai","year":"2023","journal-title":"Pakistan J. Med. Sci."},{"key":"10.1016\/j.exer.2026.111062_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.fgb.2017.08.003","article-title":"Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus","volume":"107","author":"Cai","year":"2017","journal-title":"Fungal Genet. Biol."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101069","article-title":"New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3","volume":"15","author":"Chen","year":"2025","journal-title":"J. Pharm. Anal."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1095\/biolreprod.115.136580","article-title":"Toll-like receptors 4 and 5 cooperatively initiate the innate immune responses to uropathogenic Escherichia coli infection in mouse epididymal epithelial cells","volume":"94","author":"Cheng","year":"2016","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.exer.2026.111062_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02594-23","article-title":"Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole","volume":"12","author":"Corrales","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.det.2009.05.003","article-title":"Unusual patterns in contact dermatitis: medicaments","volume":"27","author":"Davis","year":"2009","journal-title":"Dermatol. Clin."},{"issue":"10","key":"10.1016\/j.exer.2026.111062_bib13","article-title":"In vitro evaluation of the efficacy of 8-hydroxyquinoline derivatives for the control of Phaeomoniella chlamydospora, the causative agent of Petri disease in grapevines","volume":"134","author":"de Souza","year":"2023","journal-title":"J. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.exer.2026.111062_bib14","first-page":"295","article-title":"Percutaneous absorption of clioquinol (Vioform)","volume":"159","author":"Degen","year":"1979","journal-title":"Dermatologica"},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01951-21","article-title":"Selective metal chelation by a thiosemicarbazone derivative interferes with mitochondrial respiration and ribosome biogenesis in Candida albicans","volume":"10","author":"Duan","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.exer.2026.111062_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120881","article-title":"Roles of pattern recognition receptors in response to fungal keratitis","volume":"307","author":"Fang","year":"2022","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.exer.2026.111062_bib17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.biocel.2007.11.003","article-title":"Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity","volume":"40","author":"Filiz","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exer.2026.111062_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114202","article-title":"Hydroxytyrosol downregulates inflammatory responses via Nrf2\/HO-1 axis during fungal keratitis and exerts antifungal effects","volume":"149","author":"Gu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib19","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1080\/10717544.2021.1965675","article-title":"Nanocubosomal based gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment","volume":"28","author":"Hosny","year":"2021","journal-title":"Drug Deliv."},{"issue":"26","key":"10.1016\/j.exer.2026.111062_bib20","first-page":"1265","article-title":"Topical antimicrobial therapy: the efficacy of clioquinol- and tribromphenolbismuth- zinc oxide preparations","volume":"100","author":"Kaiser","year":"1982","journal-title":"Fortschr. Med."},{"issue":"9","key":"10.1016\/j.exer.2026.111062_bib21","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/myc.13619","article-title":"Exploring the intersection of Aspergillus fumigatus biofilms, infections, immune response and antifungal resistance","volume":"66","author":"Kashyap","year":"2023","journal-title":"Mycoses"},{"issue":"4","key":"10.1016\/j.exer.2026.111062_bib22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3233\/JAD-2010-100024","article-title":"The metal chelating and chaperoning effects of clioquinol: insights from yeast studies","volume":"21","author":"Li","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exer.2026.111062_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114286","article-title":"Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR\/HIF-1\u03b1 pathway","volume":"150","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"23","key":"10.1016\/j.exer.2026.111062_bib23","doi-asserted-by":"crossref","first-page":"16364","DOI":"10.1021\/acs.jmedchem.3c01771","article-title":"Discovery of novel 8-Hydroxyquinoline derivatives with potent in vitro and in vivo antifungal activity","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.exer.2026.111062_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110323","article-title":"Rutin resists Aspergillus fumigatus keratitis by activating Nrf2\/HO-1 pathway, inhibiting Dectin-1\/p-Syk pathway and affecting fungal structures","volume":"254","author":"Li","year":"2025","journal-title":"Exp. Eye Res."},{"issue":"16","key":"10.1016\/j.exer.2026.111062_bib26","article-title":"Nrf2 and its signaling pathways in sepsis and its complications: a comprehensive review of research progress","volume":"104","author":"Liu","year":"2025","journal-title":"Medicine (Baltim.)"},{"issue":"12","key":"10.1016\/j.exer.2026.111062_bib27","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/myc.12822","article-title":"Fungal keratitis: an overview of clinical and laboratory aspects","volume":"61","author":"Mahmoudi","year":"2018","journal-title":"Mycoses"},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.freeradbiomed.2009.04.033","article-title":"Nrf2 is a critical modulator of the innate immune response in a model of uveitis","volume":"47","author":"Nagai","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.exer.2026.111062_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-4362.1977.tb04317.x","article-title":"The halogenated 8-hydroxyquinolines","volume":"16","author":"Neldner","year":"1977","journal-title":"Int. J. Dermatol."},{"issue":"11","key":"10.1016\/j.exer.2026.111062_bib30","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1111\/1751-7915.14346","article-title":"Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi","volume":"16","author":"Pijuan","year":"2023","journal-title":"Microb. Biotechnol."},{"issue":"11","key":"10.1016\/j.exer.2026.111062_bib31","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1099\/jmm.0.000850","article-title":"Clioquinol is a promising preventive morphological switching compound in the treatment of Candida infections linked to the use of intrauterine devices","volume":"67","author":"Pippi","year":"2018","journal-title":"J. Med. Microbiol."},{"issue":"4","key":"10.1016\/j.exer.2026.111062_bib32","first-page":"281","article-title":"Differential expression of genes involved in iron metabolism in Aspergillus fumigatus","volume":"9","author":"Power","year":"2006","journal-title":"Int. Microbiol."},{"key":"10.1016\/j.exer.2026.111062_bib33","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2147\/DDDT.S49763","article-title":"8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications","volume":"7","author":"Prachayasittikul","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00378-23","article-title":"SARS-CoV-2 inhibits NRF2-Mediated antioxidant responses in airway epithelial cells and in the lung of a murine model of infection","volume":"11","author":"Qu","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"3","key":"10.1016\/j.exer.2026.111062_bib35","article-title":"Fungal-metal interactions: a review of toxicity and homeostasis","volume":"7","author":"Robinson","year":"2021","journal-title":"J. Fungi. (Basel)"},{"issue":"2","key":"10.1016\/j.exer.2026.111062_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14020210","article-title":"Effects of sulforaphane treatment on skeletal muscle from exhaustive exercise-induced inflammation and oxidative stress through the Nrf2\/HO-1 signaling pathway","volume":"14","author":"Ruhee","year":"2025","journal-title":"Antioxidants"},{"issue":"18","key":"10.1016\/j.exer.2026.111062_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25184321","article-title":"Recent advances in the synthesis and biological activity of 8-Hydroxyquinolines","volume":"25","author":"Saadeh","year":"2020","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.exer.2026.111062_bib38","article-title":"Elucidating the role of Nrf2 signaling pathway in mycoplasma infections","volume":"30","author":"Saha","year":"2025","journal-title":"Front. Biosci. (Landmark Ed.)"},{"issue":"39","key":"10.1016\/j.exer.2026.111062_bib39","doi-asserted-by":"crossref","first-page":"37561","DOI":"10.1074\/jbc.M306137200","article-title":"The antifungal drug amphotericin B promotes inflammatory cytokine release by a toll-like receptor- and CD14-dependent mechanism","volume":"278","author":"Sau","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2026.111062_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1424219","article-title":"Protective effect of andrographolide against ulcerative colitis by activating Nrf2\/HO-1 mediated antioxidant response","volume":"15","author":"Shu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2026.111062_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fcimb.2013.00065","article-title":"Fungal zinc metabolism and its connections to virulence","volume":"3","author":"Staats","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exer.2026.111062_bib42","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2389","article-title":"Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose","volume":"4","author":"Suwanjang","year":"2016","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.exer.2026.111062_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01211-25","article-title":"Iron acquisition strategies in pathogenic fungi","volume":"16","author":"Takemura","year":"2025","journal-title":"mBio"},{"issue":"10","key":"10.1016\/j.exer.2026.111062_bib44","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/acsinfecdis.4c00123","article-title":"Licochalcone A ameliorates Aspergillus fumigatus Keratitis by reducing fungal load and activating the Nrf2\/HO-1 signaling pathway","volume":"10","author":"Tian","year":"2024","journal-title":"ACS Infect. Dis."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0773.1984.tb01963.x","article-title":"Effect of 5-chloro-7-iodo-8-hydroxy-quinoline (clioquinol) on the uptake and distribution of nickel, zinc and mercury in mice","volume":"55","author":"Tj\u00e4lve","year":"1984","journal-title":"Acta Pharmacol. Toxicol."},{"issue":"17","key":"10.1016\/j.exer.2026.111062_bib46","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"8","key":"10.1016\/j.exer.2026.111062_bib47","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1111\/1462-2920.14618","volume":"21","author":"Vicentefranqueira","year":"2019","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.exer.2026.111062_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.143355","article-title":"Econazolium-gallate-econazole: the first econazole salt cocrystal registers dual optimizations in both physicochemical properties and antifungal efficacy","volume":"1347","author":"Wang","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"21","key":"10.1016\/j.exer.2026.111062_bib48","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1021\/acs.jmedchem.5b01222","article-title":"Design, synthesis, and evaluation of orally available clioquinol-moracin M hybrids as multitarget-directed ligands for cognitive improvement in a rat model of neurodegeneration in alzheimer's disease","volume":"58","author":"Wang","year":"2015","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.exer.2026.111062_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011478","article-title":"The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans","volume":"19","author":"Wildeman","year":"2023","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1167\/iovs.02-0446","article-title":"Experimental keratomycosis in a mouse model","volume":"44","author":"Wu","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12866-020-01850-3","article-title":"The effects of clioquinol in morphogenesis, cell membrane and ion homeostasis in Candida albicans","volume":"20","author":"You","year":"2020","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.exer.2026.111062_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174955","article-title":"Eugenol protects against Aspergillus fumigatus keratitis by inhibiting inflammatory response and reducing fungal load","volume":"924","author":"Yu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2026.111062_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103206","article-title":"Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects","volume":"73","author":"Yu","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.exer.2026.111062_bib55","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13019-024-02530-3","article-title":"Nrf2\/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis","volume":"19","author":"Zhang","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"issue":"12","key":"10.1016\/j.exer.2026.111062_bib56","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1097\/ICO.0000000000001756","article-title":"Fenretinide inhibits neutrophil recruitment and IL-1\u03b2 production in Keratitis","volume":"37","author":"Zhao","year":"2018","journal-title":"Cornea"},{"issue":"138","key":"10.1016\/j.exer.2026.111062_bib57","first-page":"1303","article-title":"Expression and potential role of major inflammatory cytokines in experimental keratomycosis","volume":"15","author":"Zhong","year":"2009","journal-title":"Mol. Vis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:03:27Z","timestamp":1783152207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526002186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":57,"alternative-id":["S0014483526002186"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111062","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clioquinol alleviates Aspergillus fumigatus keratitis through antifungal and anti-inflammatory effects associated with metal chelation and Nrf2\/HO-1 signaling","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111062"}}