{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:06:31Z","timestamp":1784297191450,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["H2025206588"],"award-info":[{"award-number":["H2025206588"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.exer.2026.111109","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:23:43Z","timestamp":1780719823000},"page":"111109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["miR-20a-5p alleviates diabetic retinopathy by targeting TXNIP to inhibit NLRP3 inflammasome-dependent pyroptosis"],"prefix":"10.1016","volume":"270","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.exer.2026.111109_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11203269","article-title":"Key Genes associated with pyroptosis in gout and construction of a miRNA-mRNA regulatory network","volume":"11","author":"Bai","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.exer.2026.111109_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100141","article-title":"Brief guide to RT-qPCR","volume":"47","author":"Bong","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.exer.2026.111109_bib3","article-title":"Pyroptosis: a new frontier in cancer","volume":"121","author":"Fang","year":"2020","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"6","key":"10.1016\/j.exer.2026.111109_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.9.6.16","article-title":"microRNA expression profile in the vitreous of proliferative diabetic retinopathy patients and differences from patients treated with Anti-VEGF therapy","volume":"9","author":"Friedrich","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"2","key":"10.1016\/j.exer.2026.111109_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7861\/clinmed.2021-0792","article-title":"Diabetic retinopathy for the non-ophthalmologist","volume":"22","author":"Fung","year":"2022","journal-title":"Clin. Med."},{"key":"10.1016\/j.exer.2026.111109_bib6","first-page":"274","article-title":"Streptozotocin as a tool for induction of rat models of diabetes: a practical guide","volume":"22","author":"Ghasemi","year":"2023","journal-title":"EXCLI J."},{"issue":"9","key":"10.1016\/j.exer.2026.111109_bib7","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.exer.2026.111109_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.109656","article-title":"ResViT FusionNet Model: an explainable AI-driven approach for automated grading of diabetic retinopathy in retinal images","volume":"186","author":"Ikram","year":"2025","journal-title":"Comput. Biol. Med."},{"issue":"5","key":"10.1016\/j.exer.2026.111109_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303094","article-title":"A novel fusion of genetic grey wolf optimization and kernel extreme learning machines for precise diabetic eye disease classification","volume":"19","author":"Khan","year":"2024","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.exer.2026.111109_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jb\/mvab047","article-title":"MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK\/NF-\u03baB signalling pathway","volume":"170","author":"Liu","year":"2021","journal-title":"J. Biochem."},{"key":"10.1016\/j.exer.2026.111109_bib11","article-title":"Cordycepin attenuates NLRP3\/Caspase-1\/GSDMD-mediated LPS-induced macrophage pyroptosis","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2026.111109_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.108123","article-title":"Aortic valve neocuspidization and bioprosthetic valves: evaluating turbulence haemodynamics","volume":"171","author":"Manchester","year":"2024","journal-title":"Comput. Biol. Med."},{"issue":"6","key":"10.1016\/j.exer.2026.111109_bib13","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1109\/JSAC.2024.3389123","article-title":"Self-Optimizing near and far-field MIMO transmit waveforms","volume":"42","author":"Naderi","year":"2024","journal-title":"IEEE J. Sel. Area. Commun."},{"issue":"3","key":"10.1016\/j.exer.2026.111109_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s40291-018-0325-0","article-title":"Decreased expression of circulating miR-20a-5p in South African women with gestational diabetes mellitus","volume":"22","author":"Pheiffer","year":"2018","journal-title":"Mol. Diagn. Ther."},{"issue":"3","key":"10.1016\/j.exer.2026.111109_bib15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12020-019-02017-5","article-title":"Activation of retinal M\u00fcller cells in response to glucose variability","volume":"65","author":"Picconi","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.exer.2026.111109_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-026-02513-7","article-title":"Effects of new P2X7R antagonists on retinal inflammatory degenerative conditions","author":"Platania","year":"2026","journal-title":"Inflammation"},{"issue":"13","key":"10.1016\/j.exer.2026.111109_bib16","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/bph.14665","article-title":"Retinal and circulating miRNA expression patterns in diabetic retinopathy: an in silico and in vivo approach","volume":"176","author":"Platania","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"14","key":"10.1016\/j.exer.2026.111109_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202409362","article-title":"Inhibition of Caspase-1 suppresses GSDMD-mediated peritoneal mesothelial cell pyroptosis and inflammation in peritoneal fibrosis","volume":"21","author":"Shi","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.exer.2026.111109_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114473","article-title":"Circulating miRNAs in diabetic retinopathy patients: prognostic markers or pharmacological targets?","volume":"186","author":"Trotta","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2026.111109_bib20","article-title":"Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy","volume":"83","author":"Victoria","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2026.111109_bib21","article-title":"Lysosome-Targeted biosensor for the super-resolution imaging of lysosome-mitochondrion interaction","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.exer.2026.111109_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70351","article-title":"Glycolysis-Histone lactylation crosstalk drives TXNIP-NLRP3-Mediated PANoptosome assembly and PANoptosis activation underlying diabetic retinopathy pathogenesis","volume":"6","author":"Xi","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.exer.2026.111109_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.112012","article-title":"DNMT1 regulates miR-20a\/TXNIP-mediated pyroptosis of retinal pigment epithelial cells through DNA methylation","volume":"577","author":"Xi","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.exer.2026.111109_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.exer.2026.111109_bib25","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.2147\/DMSO.S338097","article-title":"Effect of LncPVT1\/miR-20a-5p on lipid metabolism and insulin resistance in NAFLD","volume":"14","author":"Zhang","year":"2021","journal-title":"Diabetes, Metab. Syndrome Obes. Targets Ther."},{"key":"10.1016\/j.exer.2026.111109_bib26","article-title":"The mechanisms of NLRP3 inflammasome\/pyroptosis activation and their role in diabetic retinopathy","volume":"14","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.exer.2026.111109_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/genes10050377","article-title":"Retinal miRNA functions in health and disease","volume":"10","author":"Zuzic","year":"2019","journal-title":"Genes"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:36:16Z","timestamp":1784295376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526002654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S0014483526002654"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111109","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-20a-5p alleviates diabetic retinopathy by targeting TXNIP to inhibit NLRP3 inflammasome-dependent pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111109"}}