{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:06:25Z","timestamp":1784297185710,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/6\/1\/OPH\/2020-NCD-II"],"award-info":[{"award-number":["5\/4\/6\/1\/OPH\/2020-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.exer.2026.111121","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:24:52Z","timestamp":1781159092000},"page":"111121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["To delineate the role of Zinc Alpha 2 Glycoprotein in the pathophysiology of diabetic retinopathy using in vitro models of retinal endothelial cells and pericytes"],"prefix":"10.1016","volume":"270","author":[{"given":"Ramya Benita","family":"Babu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathik","family":"Shajahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharathidevi Subramaniam","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.111121_bib1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1194\/jlr.M082180","article-title":"ZAG alleviates HFD-induced insulin resistance accompanied with decreased lipid depot in skeletal muscle in mice","volume":"59","author":"Gao","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2026.111121_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2020.00591","article-title":"Endothelial dysfunction in diabetic retinopathy","volume":"11","author":"Gui","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exer.2026.111121_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154742","article-title":"Adipokine zinc-\u03b12-glycoprotein alleviates lipopolysaccharide-induced inflammatory responses through the \u03b23-AR\/PKA\/CREB pathway","volume":"123","author":"Guo","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2026.111121_bib4","doi-asserted-by":"crossref","first-page":"E1055","DOI":"10.1152\/ajpendo.00075.2019","article-title":"Role of adipokine zinc-\u03b12-glycoprotein in coronary heart disease","volume":"317","author":"Huang","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.exer.2026.111121_bib5","first-page":"1","article-title":"Association of inflammation-related markers and diabetic retinopathy severity in the aqueous humor, but not serum of type 2 diabetic patients","volume":"18","author":"Id","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2026.111121_bib6","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2174\/0113816128302667240422110226","article-title":"The regulation of selenoproteins in diabetes: a new way to treat diabetes","volume":"30","author":"Liang","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.exer.2026.111121_bib7","article-title":"Zinc-\u03b12-glycoprotein is associated with obesity in Chinese people and HFD-induced obese mice","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.exer.2026.111121_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12974-018-1132-6","article-title":"Overexpression of zinc- \u03b1 2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol- kindled rats","volume":"15","author":"Liu","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2026.111121_bib9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.bbalip.2010.04.012","article-title":"beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK","volume":"1801","author":"Mottillo","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2026.111121_bib10","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.3390\/ijms26125438","article-title":"Acute downregulation of zinc \u03b12-Glycoprotein: evidence from human and HepG2 cell studies","volume":"26","author":"Navarro-Masip","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111121_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128899","article-title":"Unveiling the therapeutic potential of a mutated paraoxonase 2 in diabetic retinopathy: defying glycation, mitigating oxidative stress, ER stress and inflammation","volume":"258","author":"Ravi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.exer.2026.111121_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117397","article-title":"Effect of advanced glycation end product on paraoxonase 2 expression: its impact on endoplasmic reticulum stress and inflammation in HUVECs","volume":"246","author":"Ravi","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.exer.2026.111121_bib13","article-title":"FBXW7 hypermethylation in a carboxymethyl lysine- driven retinal co-culture model: an epigenetic biomarker with translational potential for diabetic retinopathy","volume":"199","author":"Sathik","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.exer.2026.111121_bib14","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.36011","article-title":"Zinc alpha 2 glycoprotein as an early biomarker of diabetic nephropathy in type 2 diabetes mellitus patients","author":"Sonkar","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.exer.2026.111121_bib15","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.111121_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s10792-025-03482-w","article-title":"A case\u2013control prospective study to unravel zinc alpha 2 glycoprotein role in the pathophysiology of diabetic retinopathy","volume":"45","author":"Umapathy","year":"2025","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2026.111121_bib17","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s41467-025-56675-3","article-title":"PPAR\u03b1-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma","volume":"16","author":"Van den Bossche","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111121_bib18","article-title":"Zinc Alpha-2-Glycoprotein (ZAG\/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis","author":"Verma","year":"2024","journal-title":"bioRxiv Prepr. Serv. Biol."},{"key":"10.1016\/j.exer.2026.111121_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.exer.2018.05.004","article-title":"Free amino acids hydroxyproline, lysine, and glycine promote differentiation of retinal pericytes to adipocytes: a protective role against proliferative diabetic retinopathy","volume":"173","author":"Vidhya","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111121_bib20","article-title":"Diabetic retinopathy: pathophysiology and treatments","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111121_bib21","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jdiacomp.2016.08.005","article-title":"Pericytes in diabetes-associated vascular disease","volume":"30","author":"Warmke","year":"2016","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.exer.2026.111121_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-024-05183-x","article-title":"AZGP1 deficiency promotes angiogenesis in prostate cancer","volume":"22","author":"Wen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.exer.2026.111121_bib23","article-title":"Synergistic effect of VEGF and SDF-1\u03b1 in endothelial progenitor cells and vascular smooth muscle cells","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2026.111121_bib24","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/dc12-0940","article-title":"Zinc-\u03b12-glycoprotein is associated with insulin resistance in humans and is regulated by hyperglycemia, hyperinsulinemia, or liraglutide administration: cross-sectional and interventional studies in normal subjects, insulin-resistant subjects, and subject","volume":"36","author":"Yang","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exer.2026.111121_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1167\/iovs.66.4.83","article-title":"AZGP1 Attenuates subretinal Fibrosis and inhibits epithelial-mesenchymal transition by blocking the PI3K\/AKT signaling pathway","volume":"66","author":"Yang","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111121_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104736","article-title":"Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids","volume":"55","author":"Zhang","year":"2025","journal-title":"Photodiagnosis Photodyn. Ther."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:36:32Z","timestamp":1784295392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526002770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"alternative-id":["S0014483526002770"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111121","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"To delineate the role of Zinc Alpha 2 Glycoprotein in the pathophysiology of diabetic retinopathy using in vitro models of retinal endothelial cells and pericytes","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111121"}}