{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:48:07Z","timestamp":1785912487859,"version":"3.56.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,19]],"date-time":"2027-06-19T00:00:00Z","timestamp":1813363200000},"content-version":"am","delay-in-days":291,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY024906"],"award-info":[{"award-number":["R01 EY024906"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.exer.2026.111127","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:31:08Z","timestamp":1781677868000},"page":"111127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Electron transport chain activity balances cell cycle progression and differentiation of retinal progenitor cells"],"prefix":"10.1016","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4181-9382","authenticated-orcid":false,"given":"Elda M.","family":"Rueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Wasel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlina M.","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Barrasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"Poch\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.exer.2026.111127_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molcel.2008.10.021","article-title":"Respiratory active mitochondrial supercomplexes","volume":"32","author":"Acin-Perez","year":"2008","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.exer.2026.111127_bib1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.bbabio.2013.12.009","article-title":"The function of the respiratory supercomplexes: the plasticity model","volume":"1837","author":"Acin-Perez","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.exer.2026.111127_bib3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ncb2531","article-title":"Metabolic differentiation in the embryonic retina","volume":"14","author":"Agathocleous","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1097-0177(199603)205:3<293::AID-AJA9>3.0.CO;2-D","article-title":"Quantitative analysis of proliferation and cell cycle length during development of the rat retina","volume":"205","author":"Alexiades","year":"1996","journal-title":"Dev. Dyn."},{"issue":"6","key":"10.1016\/j.exer.2026.111127_bib5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1242\/dev.124.6.1119","article-title":"Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny","volume":"124","author":"Alexiades","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.exer.2026.111127_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2007.05.021","article-title":"Nuclear migration during retinal development","volume":"1192","author":"Baye","year":"2008","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib7","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cne.901560107","article-title":"Synaptogenesis in the photoreceptor terminal of the mouse retina","volume":"156","author":"Blanks","year":"1974","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2026.111127_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4614-3209-8_2","article-title":"Programmed cell death during retinal development of the mouse eye","volume":"801","author":"Braunger","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"9","key":"10.1016\/j.exer.2026.111127_bib10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(95)93933-O","article-title":"Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model","volume":"18","author":"Caviness","year":"1995","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1073\/pnas.93.2.589","article-title":"Cell fate determination in the vertebrate retina","volume":"93","author":"Cepko","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2026.111127_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91141","article-title":"Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-krebs-cycle","volume":"12","author":"Chen","year":"2024","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41467-021-27759-7","article-title":"Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy","volume":"13","author":"Chern","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111127_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25946","article-title":"Glycolytic reliance promotes anabolism in photoreceptors","volume":"6","author":"Chinchore","year":"2017","journal-title":"eLife"},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tig.2021.09.009","article-title":"Histone lactylation: epigenetic mark of glycolytic switch","volume":"38","author":"Dai","year":"2022","journal-title":"Trends Genet."},{"issue":"12","key":"10.1016\/j.exer.2026.111127_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202200128","volume":"44","author":"Darekar","year":"2022","journal-title":"Bioessays"},{"issue":"5","key":"10.1016\/j.exer.2026.111127_bib17","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/dvdy.23782","article-title":"Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina","volume":"241","author":"Das","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.exer.2026.111127_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31437","article-title":"The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch","volume":"6","author":"Daum","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.exer.2026.111127_bib19","article-title":"Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using blue native gel electrophoresis","volume":"19","author":"D\u00edaz","year":"2009","journal-title":"Curr. Protoc. Hum. Genet. Chapter"},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41556-021-00837-0","article-title":"Metabolic determination of cell fate through selective inheritance of mitochondria","volume":"24","author":"Dohla","year":"2022","journal-title":"Nat. Cell Biol."},{"issue":"21","key":"10.1016\/j.exer.2026.111127_bib21","doi-asserted-by":"crossref","first-page":"13314","DOI":"10.1021\/acs.analchem.9b02410","article-title":"Deciphering metabolic heterogeneity by single-cell analysis","volume":"91","author":"Evers","year":"2019","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cne.901870207","article-title":"Development of synaptic arrays in the inner plexiform layer of neonatal mouse retina","volume":"187","author":"Fisher","year":"1979","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1071\/RD14383","article-title":"Metabolic determinants of embryonic development and stem cell fate","volume":"27","author":"Folmes","year":"2014","journal-title":"Reprod. Fertil. Dev."},{"issue":"10","key":"10.1016\/j.exer.2026.111127_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis","volume":"6","author":"Gotz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib26","article-title":"Mitochondrial metabolism as a regulator of keratinocyte differentiation","volume":"3","author":"Hamanaka","year":"2013","journal-title":"Cell. Logist."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib27","first-page":"689","article-title":"Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells","volume":"20","author":"Han","year":"2008","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/cne.901790204","article-title":"Early development of amacrine cells in the mouse retina: an electron microscopic, serial section analysis","volume":"179","author":"Hinds","year":"1978","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/cne.901870303","article-title":"Differentiation of photoreceptors and horizontal cells in the embryonic mouse retina: an electron microscopic, serial section analysis","volume":"187","author":"Hinds","year":"1979","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902130102","article-title":"Development of retinal amacrine cells in the mouse embryo: evidence for two modes of formation","volume":"213","author":"Hinds","year":"1983","journal-title":"J. Comp. Neurol."},{"issue":"48","key":"10.1016\/j.exer.2026.111127_bib31","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"Irizarry-Caro","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.exer.2026.111127_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/hmg\/ddae029","article-title":"m6A RNA methylation regulates mitochondrial function","volume":"33","author":"Kahl","year":"2024","journal-title":"Hum. Mol. Genet."},{"issue":"14","key":"10.1016\/j.exer.2026.111127_bib33","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.devcel.2022.06.008","article-title":"A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase","volume":"57","author":"Kirova","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.exer.2026.111127_bib34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ng0398-231","article-title":"Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice","volume":"18","author":"Larsson","year":"1998","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.exer.2026.111127_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112596","article-title":"Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/gene.20097","article-title":"Rhodopsin-iCre transgenic mouse line for Cre-mediated rod-specific gene targeting","volume":"41","author":"Li","year":"2005","journal-title":"genesis"},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2019.12.004","article-title":"Histone lactylation: a new role for glucose metabolism","volume":"45","author":"Liberti","year":"2020","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13168","article-title":"Insights into roles of METTL14 in tumors","volume":"55","author":"Liu","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.exer.2026.111127_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.semcdb.2017.07.021","article-title":"Respiratory chain supercomplexes: structures, function and biogenesis","volume":"76","author":"Lobo-Jarne","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molcel.2014.10.027","article-title":"Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation","volume":"57","author":"Lunt","year":"2015","journal-title":"Mol. Cell"},{"issue":"7824","key":"10.1016\/j.exer.2026.111127_bib42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41586-020-2475-6","article-title":"Mitochondrial ubiquinol oxidation is necessary for tumour growth","volume":"585","author":"Martinez-Reyes","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41467-023-44121-1","article-title":"Histone lactylation couples cellular metabolism with developmental gene regulatory networks","volume":"15","author":"Merkuri","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib44","article-title":"Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina","volume":"3","author":"Miles","year":"2016","journal-title":"Neurogenesis (Austin)"},{"issue":"9","key":"10.1016\/j.exer.2026.111127_bib45","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"issue":"11","key":"10.1016\/j.exer.2026.111127_bib46","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nsmb.2159","article-title":"The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA","volume":"18","author":"Ngo","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib47","first-page":"250","article-title":"An electron microscopic study of synapse formation, receptor outer segment development, and other aspects of developing mouse retina","volume":"7","author":"Olney","year":"1968","journal-title":"Investig. Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2026.111127_bib48","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.celrep.2018.04.111","article-title":"Aerobic glycolysis is essential for normal rod function and controls secondary cone death in Retinitis pigmentosa","volume":"23","author":"Petit","year":"2018","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.exer.2026.111127_bib49","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/acs.jproteome.4c00646","article-title":"Recent developments in single-cell metabolomics by mass spectrometry horizontal line A perspective","volume":"24","author":"Petrova","year":"2025","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.exer.2026.111127_bib51","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.celrep.2016.01.039","article-title":"RONIN is an essential transcriptional regulator of genes required for mitochondrial function in the developing retina","volume":"14","author":"Poch\u00e9","year":"2016","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.exer.2026.111127_bib50","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.celrep.2016.01.039","article-title":"RONIN is an essential transcriptional regulator of genes required for mitochondrial function in the developing retina","volume":"14","author":"Poche","year":"2016","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib52","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ydbio.2004.03.039","article-title":"Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter","volume":"271","author":"Rowan","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2026.111127_bib53","first-page":"847","article-title":"The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and \u223cP transferring kinases","volume":"22","author":"Rueda","year":"2016","journal-title":"Mol. Vis."},{"issue":"7","key":"10.1016\/j.exer.2026.111127_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2026.111127_bib55","series-title":"Retinal Development","author":"Sernagor","year":"2006"},{"key":"10.1016\/j.exer.2026.111127_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.07.090","article-title":"Early born lineage of retinal neurons express class III \u03b2-tubulin isotype","volume":"1176","author":"Sharma","year":"2007","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.exer.2026.111127_bib57","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.exer.2026.111127_bib58","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib59","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib60","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.cell.2015.07.017","article-title":"Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells","volume":"162","author":"Sullivan","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib61","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1038\/s41467-023-39672-2","article-title":"Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis","volume":"14","author":"Takata","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-97985-2","article-title":"Asymmetric cell division of ALDH1-positive cancer stem cells generates glycolytic metabolically diverse cell populations","volume":"15","author":"Tamori","year":"2025","journal-title":"Sci. Rep."},{"issue":"6282","key":"10.1016\/j.exer.2026.111127_bib63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.aad4017","article-title":"Complementation of mitochondrial electron transport chain by manipulation of the NAD+\/NADH ratio","volume":"352","author":"Titov","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-023-00602-x","article-title":"Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation","volume":"18","author":"Todorova","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2026.111127_bib65","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fcell.2020.00087","article-title":"Energy metabolism regulates stem cell pluripotency","volume":"8","author":"Tsogtbaatar","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12299","article-title":"The regulation and function of lactate dehydrogenase A: therapeutic potential in brain tumor","volume":"26","author":"Valvona","year":"2016","journal-title":"Brain Pathol."},{"issue":"5930","key":"10.1016\/j.exer.2026.111127_bib67","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.exer.2026.111127_bib68","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"issue":"7599","key":"10.1016\/j.exer.2026.111127_bib69","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature17442","article-title":"Metabolic maintenance of cell asymmetry following division in activated T lymphocytes","volume":"532","author":"Verbist","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.exer.2026.111127_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-201X.1997.00131.x","article-title":"Glucose metabolism in pig outer retina in light and darkness","volume":"160","author":"Wang","year":"1997","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.exer.2026.111127_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02242","article-title":"Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis","volume":"3","author":"Wheaton","year":"2014","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.exer.2026.111127_bib72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cne.902290307","article-title":"Cell death during differentiation of the retina in the mouse","volume":"229","author":"Young","year":"1984","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib73","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ar.1092120215","article-title":"Cell differentiation in the retina of the mouse","volume":"212","author":"Young","year":"1985","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib74","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ar.1092120215","article-title":"Cell differentiation in the retina of the mouse","volume":"212","author":"Young","year":"1985","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.exer.2026.111127_bib75","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-3806(85)90211-1","article-title":"Cell proliferation during postnatal development of the retina in the mouse","volume":"353","author":"Young","year":"1985","journal-title":"Brain Res."},{"issue":"7779","key":"10.1016\/j.exer.2026.111127_bib76","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exer.2026.111127_bib77","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1038\/ncomms4295","article-title":"Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat. Commun."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526002836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:07:37Z","timestamp":1785910057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526002836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":77,"alternative-id":["S0014483526002836"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111127","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electron transport chain activity balances cell cycle progression and differentiation of retinal progenitor cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111127"}}