{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:26:22Z","timestamp":1788207982557,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401250"],"award-info":[{"award-number":["82401250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011488","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["2026-PWDL-05"],"award-info":[{"award-number":["2026-PWDL-05"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFA1105502"],"award-info":[{"award-number":["2022YFA1105502"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762077"],"award-info":[{"award-number":["2024M762077"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1438200"],"award-info":[{"award-number":["23ZR1438200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exer.2026.111164","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:32:43Z","timestamp":1783751563000},"page":"111164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Proteomic profiling of human corneal stroma reveals molecular signatures associated with myopia progression"],"prefix":"10.1016","volume":"271","author":[{"given":"Yahan","family":"Ju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/ph17030307","article-title":"The role of Chitinase-3-like Protein-1 (YKL40) in the therapy of cancer and other chronic-inflammation-related diseases","volume":"17","author":"Chang","year":"2024","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.exer.2026.111164_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav4116","article-title":"Targeting RalGAP\u03b11 in skeletal muscle to simultaneously improve postprandial glucose and lipid control","volume":"5","author":"Chen","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exer.2026.111164_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1406748","article-title":"Proteomic analysis reveals key differences in pro-stromal corneal tissue between highly myopic males and females","volume":"11","author":"Cui","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.exer.2026.111164_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1406748","article-title":"Proteomic analysis reveals key differences in pro-stromal corneal tissue between highly myopic males and females","volume":"11","author":"Cui","year":"2024","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2023.101820","article-title":"Proteomic profiling of human corneal stroma from long-term contact lens wearers reveals activation of inflammatory responses","volume":"46","author":"Deng","year":"2023","journal-title":"Contact Lens Anterior Eye"},{"issue":"31","key":"10.1016\/j.exer.2026.111164_bib6","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2217795120","article-title":"Redefining the human corneal immune compartment using dynamic intravital imaging","volume":"120","author":"Downie","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10090","key":"10.1016\/j.exer.2026.111164_bib7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(17)31614-8","article-title":"Retinal detachment in severe myopia","volume":"390","author":"Dragoumis","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2026.111164_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/ebm.2025.10866","article-title":"Integrated tear proteomics define the molecular blueprint of corneal epithelial repair","volume":"250","author":"Feret","year":"2026","journal-title":"Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add6495","article-title":"ArpC5 isoforms regulate Arp2\/3 complex-dependent protrusion through differential Ena\/VASP positioning","volume":"9","author":"F\u00e4\u00dfler","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s44321-025-00341-0","article-title":"Corneal biomechanical cues mediated by PAI-2: the origin of PM2.5-induced corneal disease","volume":"18","author":"Hao","year":"2026","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12967-024-05048-3","article-title":"Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate","volume":"22","author":"He","year":"2024","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.exer.2026.111164_bib12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib13","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1038\/s41467-022-33605-1","article-title":"Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes","volume":"13","author":"Ikeda","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111164_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101156","article-title":"Myopia: histology, clinical features, and potential implications for the etiology of axial elongation","volume":"96","author":"Jonas","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib15","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1038\/s41598-021-84904-4","article-title":"Corneal proteome and differentially expressed corneal proteins in highly myopic chicks using a label-free SWATH-MS quantification approach","volume":"11","author":"Kang","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.exer.2026.111164_bib16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.exer.2004.07.008","article-title":"Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathology","volume":"79","author":"Klenkler","year":"2004","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2026.111164_bib17","first-page":"Cd014758","article-title":"Interventions for myopia control in children: a living systematic review and network meta-analysis","volume":"2","author":"Lawrenson","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12864-025-11422-2","article-title":"Transcriptomic and proteomic analyses of sclera in lens-induced myopic Guinea pigs","volume":"26","author":"Li","year":"2025","journal-title":"BMC Genom."},{"key":"10.1016\/j.exer.2026.111164_bib19","article-title":"Integrative pan-cancer analysis confirmed that FCGR3A is a candidate biomarker associated with tumor immunity","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.exer.2026.111164_bib18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.trecan.2022.02.010","article-title":"FTO in cancer: functions, molecular mechanisms, and therapeutic implications","volume":"8","author":"Li","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.exer.2026.111164_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fimmu.2016.00036","article-title":"Early components of the complement classical activation pathway in human systemic autoimmune diseases","volume":"7","author":"Lintner","year":"2016","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.exer.2026.111164_bib22","article-title":"Extracellular matrix stiffness modulates myopia scleral remodeling through Integrin\/F-Actin\/YAP axis","volume":"66","author":"Liu","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1350-9462(02)00063-0","article-title":"Role of the sclera in the development and pathological complications of myopia","volume":"22","author":"McBrien","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2026.111164_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12551-009-0011-x","article-title":"Corneal collagen-its role in maintaining corneal shape and transparency","volume":"1","author":"Meek","year":"2009","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.exer.2026.111164_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101090","article-title":"Corneal stromal repair and regeneration","volume":"91","author":"Mohan","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"9827","key":"10.1016\/j.exer.2026.111164_bib26","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2026.111164_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.preteyeres.2017.10.005","article-title":"Diagnosis and treatment guideline for myopic choroidal neovascularization due to pathologic myopia","volume":"63","author":"Ohno-Matsui","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2026.111164_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.exer.2005.08.009","article-title":"The sclera and myopia","volume":"82","author":"Rada","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111164_bib29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.preteyeres.2018.10.005","article-title":"Myopic maculopathy: current status and proposal for a new classification and grading system (ATN)","volume":"69","author":"Ruiz-Medrano","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-24993-7","article-title":"TPM2 regulates contractility and biomechanical properties in trabecular meshwork cells","volume":"15","author":"Shen","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111164_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fendo.2020.00024","article-title":"The IGF\/Insulin-IGFBP axis in corneal development, wound healing, and disease","volume":"11","author":"Stuard","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ng.2554","article-title":"Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia","volume":"45","author":"Verhoeven","year":"2013","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.exer.2026.111164_bib33","article-title":"Interventions to slow progression of myopia in children","volume":"1","author":"Walline","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.exer.2026.111164_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109619","article-title":"Effects of blue light exposure on ocular parameters and choroidal blood perfusion in Guinea pig","volume":"235","author":"Wang","year":"2023","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2026.111164_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ophtha.2024.11.016","article-title":"Evidence-based guidelines for keratorefractive lenticule extraction surgery","volume":"132","author":"Wang","year":"2025","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.exer.2026.111164_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/biology13030144","article-title":"The role of Insulin-like Growth Factor (IGF) system in the corneal epithelium homeostasis-from limbal epithelial stem cells to therapeutic applications","volume":"13","author":"Woronkowicz","year":"2024","journal-title":"Biology"},{"issue":"30","key":"10.1016\/j.exer.2026.111164_bib37","doi-asserted-by":"crossref","first-page":"E7091","DOI":"10.1073\/pnas.1721443115","article-title":"Scleral hypoxia is a target for myopia control","volume":"115","author":"Wu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2026.111164_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1015128","article-title":"Complement C1s as a diagnostic marker and therapeutic target: progress and propective","volume":"13","author":"Ye","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2026.111164_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109726","article-title":"Exploration of the pathophysiology of high myopia via proteomic profiling of human corneal stromal lenticules","volume":"238","author":"Yu","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111164_bib40","first-page":"494","article-title":"Comparative proteome analysis of form-deprivation myopia in sclera with iTRAQ-based quantitative proteomics","volume":"27","author":"Yuan","year":"2021","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2026.111164_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1187400","article-title":"Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy","volume":"17","author":"Zeng","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exer.2026.111164_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1187400","article-title":"Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy","volume":"17","author":"Zeng","year":"2023","journal-title":"Front. Cell. Neurosci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:05:08Z","timestamp":1788206708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526003209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S0014483526003209"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111164","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic profiling of human corneal stroma reveals molecular signatures associated with myopia progression","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111164"}}