{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:51:14Z","timestamp":1791363074802,"version":"4.3.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["ZXCVBNM00001334"],"award-info":[{"award-number":["ZXCVBNM00001334"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.exer.2026.111202","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:52:50Z","timestamp":1786463570000},"page":"111202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clodronate liposome effectively mitigates chemically-induced retinal pigment epithelium toxicity"],"prefix":"10.1016","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7870-1597","authenticated-orcid":false,"given":"Zixiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.111202_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.exer.2013.12.019","article-title":"N -methyl- N -nitrosourea-induced retinal degeneration in mice","volume":"121","author":"Chen","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111202_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1130735","article-title":"Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1(I249\/M280)-expressing retina","volume":"14","author":"Church","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12974-022-02659-9","article-title":"Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina","volume":"19","author":"Church","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-025-03529-w","article-title":"Macrophage expression of P2X7 controls autoimmune uveitis","volume":"22","author":"D\u00e9chelle-Marquet","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2026.111202_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1703382","article-title":"Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity","volume":"16","author":"Fan","year":"2025","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.exer.2026.111202_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1167\/iovs.66.12.56","article-title":"Evaluating the optic nerve crush model to understand the function of microglia in glaucoma neuroprotection","volume":"66","author":"Gu","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.exer.2026.111202_bib7","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.7150\/thno.99484","article-title":"Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy","volume":"14","author":"Guo","year":"2024","journal-title":"Theranostics"},{"issue":"22","key":"10.1016\/j.exer.2026.111202_bib8","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.3390\/ijms21228603","article-title":"Underestimated peripheral effects following pharmacological and conditional genetic microglial depletion","volume":"21","author":"Han","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.exer.2026.111202_bib9","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1007\/s12035-019-1502-9","article-title":"Microglial depletion with clodronate liposomes increases proinflammatory cytokine levels, induces astrocyte activation, and damages blood vessel integrity","volume":"56","author":"Han","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib10","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1167\/iovs.11-8395","article-title":"In vivo assessment of thickness and reflectivity in a rat outer retinal degeneration model with ultrahigh resolution optical coherence tomography","volume":"53","author":"Hariri","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00795-020-00246-6","article-title":"Ultrastructural changes in the choriocapillaris of N-methyl-N-nitrosourea-induced retinal degeneration in C57BL\/6 mice","volume":"53","author":"Hayakawa","year":"2020","journal-title":"Med. Mol. Morphol."},{"key":"10.1016\/j.exer.2026.111202_bib12","doi-asserted-by":"crossref","first-page":"26734","DOI":"10.1073\/pnas.1915571116","article-title":"Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing","volume":"116","author":"Heng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"25","key":"10.1016\/j.exer.2026.111202_bib13","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1523\/JNEUROSCI.0584-17.2017","article-title":"Microglia are irrelevant for neuronal degeneration and axon regeneration after acute injury","volume":"37","author":"Hilla","year":"2017","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s40135-021-00277-x","article-title":"Update on retinal drug toxicities","volume":"9","author":"Hsu","year":"2021","journal-title":"Curr. Ophthalmol. Rep."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2337\/db21-0551","article-title":"Single-cell transcriptomics reveals novel role of microglia in fibrovascular membrane of proliferative diabetic retinopathy","volume":"71","author":"Hu","year":"2022","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.exer.2026.111202_bib16","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1007\/s12035-016-9960-9","article-title":"Friend or foe? Resident microglia vs bone marrow-derived microglia and their roles in the retinal degeneration","volume":"54","author":"Jin","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2026.111202_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101349","article-title":"Microglial regulation of the retinal vasculature in health and during the pathology associated with diabetes","volume":"106","author":"Jobling","year":"2025","journal-title":"Prog. Retin. Eye Res."},{"issue":"7","key":"10.1016\/j.exer.2026.111202_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.17221\/122\/2024-VETMED","article-title":"Exploring minocycline's effect on retinal degeneration following N-methyl-N-nitrosourea exposure in rats","volume":"70","author":"Karabulut","year":"2025","journal-title":"Vet. Med. (Praha)"},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12979-023-00358-4","article-title":"Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health","volume":"20","author":"Karg","year":"2023","journal-title":"Immun. Ageing"},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/jamaophthalmol.2024.0118","article-title":"Phase 2 trial evaluating minocycline for geographic atrophy in age-related macular degeneration: a nonrandomized controlled trial","volume":"142","author":"Keenan","year":"2024","journal-title":"JAMA Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2026.111202_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23062918","article-title":"Sodium-iodate injection can replicate retinal degenerative disease stages in pigmented mice and rats: non-invasive Follow-Up using OCT and ERG","volume":"23","author":"Koster","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111202_bib22","article-title":"Microglia depletion\/repopulation does not affect light-induced retinal degeneration in mice","volume":"14","author":"Laudenberg","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020660118","article-title":"Reply to green and hume: nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622","volume":"118","author":"Lei","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2026.111202_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114229","article-title":"Alkaline phosphatase-responsive hydrogel for efficient management of autoimmune intraocular inflammation","volume":"387","author":"Li","year":"2025","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib25","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1038\/s41598-017-08702-7","article-title":"Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury","volume":"7","author":"Ma","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.exer.2026.111202_bib26","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/glia.23007","article-title":"Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor","volume":"64","author":"Moller","year":"2016","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.exer.2026.111202_bib27","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1167\/iovs.17-23532","article-title":"Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation","volume":"59","author":"Moriguchi","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2026.111202_bib28","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1755-3768.1977.tb05681.x","article-title":"Changes in ultrastructure and function of the sheep pigment epithelium and retina induced by sodium iodate. I. The ultrastructure of the normal pigment epithelium of the sheep","volume":"55","author":"Nilsson","year":"1977","journal-title":"Acta Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2026.111202_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13092049","article-title":"Enhanced M2 polarization of retinal microglia in streptozotocin-induced diabetic mice upon autoimmune stimulation","volume":"13","author":"Nishio","year":"2025","journal-title":"Biomedicines"},{"issue":"6 2","key":"10.1016\/j.exer.2026.111202_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0002-9394(53)90159-7","article-title":"Experimentally induced toxic effects on structure and function of visual cells and pigment epithelium","volume":"36","author":"Noell","year":"1953","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib31","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/s41598-020-58424-6","article-title":"Phosphatidylserine recognition and Rac1 activation are required for muller glia proliferation, gliosis and phagocytosis after retinal injury","volume":"10","author":"Nomura-Komoike","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111202_bib32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ajo.2018.04.015","article-title":"Progressive chronic retinal axonal loss following acute methanol-Induced optic neuropathy: four-year prospective cohort study","volume":"191","author":"Nurieva","year":"2018","journal-title":"Am. J. Ophthalmol."},{"issue":"27","key":"10.1016\/j.exer.2026.111202_bib33","doi-asserted-by":"crossref","first-page":"E6264","DOI":"10.1073\/pnas.1719601115","article-title":"Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment","volume":"115","author":"Okunuki","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.exer.2026.111202_bib34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4049\/jimmunol.1800982","article-title":"Microglia regulate neuroglia remodeling in various ocular and retinal injuries","volume":"202","author":"Paschalis","year":"2019","journal-title":"J. Immunol."},{"issue":"24","key":"10.1016\/j.exer.2026.111202_bib35","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2026.111202_bib36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nbt.1612","article-title":"V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets","volume":"28","author":"Peng","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.exer.2026.111202_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad038","article-title":"The function of lactate dehydrogenase A in retinal neurons: implications to retinal degenerative diseases","volume":"2","author":"Rajala","year":"2023","journal-title":"PNAS Nexus"},{"issue":"2","key":"10.1016\/j.exer.2026.111202_bib38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/1566524017666170331162048","article-title":"What can pharmacological models of retinal degeneration tell us?","volume":"17","author":"Reisenhofer","year":"2017","journal-title":"Curr. Mol. Med."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12974-023-02983-8","article-title":"Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina","volume":"21","author":"Rodriguez","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.exer.2026.111202_bib40","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2353\/ajpath.2008.080024","article-title":"Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration","volume":"172","author":"Sasahara","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2026.111202_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12974-015-0431-4","article-title":"Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration","volume":"12","author":"Scholz","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.67.1.32","article-title":"Retinal amyloid clearance enhanced by 40-Hz light flicker via MHC-II+ microglia regulation in mice","volume":"67","author":"Sheng","year":"2026","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2026.111202_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70565","article-title":"Repopulating microglia suppress peripheral immune cell infiltration to promote poststroke recovery","volume":"31","author":"Shi","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.exer.2026.111202_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112703","article-title":"Minocycline prevents photoreceptor degeneration in retinitis pigmentosa through modulating mitochondrial homeostasis","volume":"139","author":"Shi","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exer.2026.111202_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1366841","article-title":"Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice","volume":"15","author":"Song","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib46","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40478-019-0702-x","article-title":"Microglia are not required for prion-induced retinal photoreceptor degeneration","volume":"7","author":"Striebel","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.exer.2026.111202_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577244","article-title":"Depletion of microglia and macrophages with clodronate liposomes attenuates zymosan-induced Fos expression and hypothermia in the adult mouse","volume":"344","author":"Takagi","year":"2020","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-025-03393-8","article-title":"Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model","volume":"22","author":"Tang","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.exer.2026.111202_bib49","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1167\/iovs.16-19305","article-title":"Topographic quantification of the transcorneal electrical stimulation (TES)-induced protective effects on N-Methyl-N-Nitrosourea-Treated retinas","volume":"57","author":"Tao","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2026.111202_bib50","first-page":"933","article-title":"Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials","volume":"25","author":"Tsubura","year":"2010","journal-title":"Histol. Histopathol."},{"issue":"10","key":"10.1016\/j.exer.2026.111202_bib51","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00125-020-05218-0","article-title":"Single-cell transcriptome analysis of the akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy","volume":"63","author":"Van Hove","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.exer.2026.111202_bib52","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-3-031-72230-1_50","article-title":"Drug-induced retinal toxicity","volume":"1467","author":"Vyas","year":"2025","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.exer.2026.111202_bib53","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1167\/iovs.13-13075","article-title":"Direct effect of sodium iodate on neurosensory retina","volume":"55","author":"Wang","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111202_bib54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbi.2019.10.016","article-title":"Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice","volume":"83","author":"Wang","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"20","key":"10.1016\/j.exer.2026.111202_bib55","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.1073\/pnas.1901787116","article-title":"Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa","volume":"116","author":"Wang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.exer.2026.111202_bib56","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105123","article-title":"Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling","volume":"40","author":"Wieghofer","year":"2021","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.exer.2026.111202_bib57","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.66.2.2","article-title":"Lamp2 deficiency enhances susceptibility to oxidative stress-induced RPE degeneration","volume":"66","author":"Wu","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"6756","key":"10.1016\/j.exer.2026.111202_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr1015","article-title":"Microglia replacement halts the progression of microgliopathy in mice and humans","volume":"389","author":"Wu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.exer.2026.111202_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111339","article-title":"Celastrol ameliorates experimental autoimmune uveitis through STAT3 targeting and gut microenvironment reprofiling","volume":"127","author":"Xiang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exer.2026.111202_bib60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nbd.2018.05.016","article-title":"Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury","volume":"117","author":"Xu","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2026.111202_bib61","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55564","article-title":"CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization","volume":"9","author":"Yang","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.exer.2026.111202_bib62","first-page":"2919","article-title":"N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene","volume":"15","author":"Yoshizawa","year":"2009","journal-title":"Mol. Vis."},{"issue":"1","key":"10.1016\/j.exer.2026.111202_bib63","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111202_bib64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-3-030-27378-1_30","article-title":"Identification of a unique subretinal microglia type in retinal degeneration using single cell RNA-Seq","volume":"1185","author":"Yu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2026.111202_bib65","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3389\/fnins.2018.00890","article-title":"Muller cell regulated microglial activation and migration in rats with N-Methyl-N-Nitrosourea-Induced retinal degeneration","volume":"12","author":"Zhang","year":"2018","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.exer.2026.111202_bib66","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.15252\/emmm.201505298","article-title":"Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration","volume":"7","author":"Zhao","year":"2015","journal-title":"EMBO Mol. Med."},{"issue":"8","key":"10.1016\/j.exer.2026.111202_bib67","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41419-024-07002-z","article-title":"TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPAR\u03b3 and CD36","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:07:42Z","timestamp":1791360462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526003581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":67,"alternative-id":["S0014483526003581"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111202","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clodronate liposome effectively mitigates chemically-induced retinal pigment epithelium toxicity","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111202"}}