{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:51:05Z","timestamp":1791363065593,"version":"4.3.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171030"],"award-info":[{"award-number":["82171030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870678"],"award-info":[{"award-number":["81870678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ50537"],"award-info":[{"award-number":["2025JJ50537"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6586"],"award-info":[{"award-number":["2024JJ6586"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ5845"],"award-info":[{"award-number":["2020JJ5845"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30925"],"award-info":[{"award-number":["2021JJ30925"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.exer.2026.111234","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:41:01Z","timestamp":1788565261000},"page":"111234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Single-cell RNA-seq analysis revealed that BHLHE40 and its binding protein THBS1 are involved in diabetic corneal epitheliopathy"],"prefix":"10.1016","volume":"272","author":[{"given":"Shirui","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6367-9119","authenticated-orcid":false,"given":"Baihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.111234_bib1","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1038\/s41433-023-02539-3","article-title":"Single-cell transcriptomics of the ocular anterior segment: a comprehensive review","volume":"37","author":"Ahsanuddin","year":"2023","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2026.111234_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.stem.2021.04.003","article-title":"Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing","volume":"28","author":"Altshuler","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2026.111234_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01015-w","article-title":"Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stroma","volume":"11","author":"Catala","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111234_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.redox.2018.10.009","article-title":"Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells","volume":"20","author":"Chang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2026.111234_bib5","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.ophtha.2009.01.002","article-title":"In vivo confocal microscopic findings of corneal wound healing after corneal epithelial debridement in diabetic vitrectomy","volume":"116","author":"Chen","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.111234_bib6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jtos.2021.03.010","article-title":"A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells","volume":"21","author":"Collin","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111234_bib7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.it.2020.09.002","article-title":"Transcription factor Bhlhe40 in immunity and autoimmunity","volume":"41","author":"Cook","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.exer.2026.111234_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-026-00687-w","article-title":"Type 2 diabetes mellitus","volume":"12","author":"Davies","year":"2026","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.exer.2026.111234_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jtos.2020.09.006","article-title":"Ocular surface diabetic disease: a neurogenic condition?","volume":"19","author":"Di Zazzo","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111234_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","article-title":"Mitochondrial metabolic reprogramming in diabetic kidney disease","volume":"15","author":"Fan","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2026.111234_bib11","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1038\/s41467-024-47867-4","article-title":"Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease","volume":"15","author":"Flones","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111234_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jtos.2019.06.001","article-title":"Thrombospondin-1 in ocular surface health and disease","volume":"17","author":"Foulsham","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111234_bib13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-025-03451-6","article-title":"Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism","volume":"23","author":"Gao","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.exer.2026.111234_bib14","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.exer.2026.111234_bib15","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.4049\/jimmunol.2200819","article-title":"BHLHE40 regulates Myeloid cell polarization through IL-10-Dependent and -Independent mechanisms","volume":"212","author":"Hendrix","year":"2024","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2026.111234_bib16","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.2147\/DMSO.S424847","article-title":"MicroRNA-221-3p targets THBS1 to promote wound healing in diabetes","volume":"16","author":"Hu","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.exer.2026.111234_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.trsl.2015.11.002","article-title":"High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation","volume":"169","author":"Lan","year":"2016","journal-title":"Transl. Res."},{"issue":"Pt 19","key":"10.1016\/j.exer.2026.111234_bib18","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","article-title":"Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation","volume":"111","author":"Lehrer","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2026.111234_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtos.2020.12.004","article-title":"Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea","volume":"20","author":"Li","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111234_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.62.9.36","article-title":"Single-cell transcriptomics identifies a unique entity and signature markers of transit-amplifying cells in human corneal limbus","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib21","article-title":"Chirality regulates stem cell fate and promotes corneal epithelial regeneration via manipulating notch pathway","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.exer.2026.111234_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154402","article-title":"Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice","volume":"114","author":"Li","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.exer.2026.111234_bib23","article-title":"Energy-sensing molecule RORgamma regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging","volume":"17","author":"Liang","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111234_bib24","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41467-025-67635-2","article-title":"Restoration of PKM1 improves functional maturation of human stem-cell derived-beta cell by regulating PEP metabolism","volume":"17","author":"Lin","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111234_bib25","article-title":"Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis","volume":"120","author":"Lin","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2026.111234_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jtos.2025.02.010","article-title":"Decoding the corneal immune microenvironment in healthy and diabetic mice during corneal wound healing","volume":"37","author":"Lin","year":"2025","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111234_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2337\/db25-0590","article-title":"Diabetic corneal neuropathy precedes and is associated with diabetic retinopathy","volume":"75","author":"Liu","year":"2026","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2026.111234_bib28","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00417-010-1396-8","article-title":"In vivo confocal microscopy of corneal small fiber damage in diabetes mellitus","volume":"248","author":"Messmer","year":"2010","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2026.111234_bib29","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1167\/iovs.15-16711","article-title":"In vivo confocal microscopy of corneal nerves: an ocular biomarker for peripheral and cardiac autonomic neuropathy in type 1 diabetes mellitus","volume":"56","author":"Misra","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib30","article-title":"Impact of the national steps challenge physical activity programme on obesity and type 2 diabetes prevalence in Singapore to 2050: simulation-based forecasting analysis","volume":"68","author":"Normatov","year":"2026","journal-title":"Lancet Reg. Health West. Pac."},{"key":"10.1016\/j.exer.2026.111234_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/iovs.61.10.27","article-title":"Epithelial cell migration and proliferation patterns during initial wound closure in normal mice and an experimental model of limbal stem cell deficiency","volume":"61","author":"Puri","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032841","article-title":"Epigenetic regulation of corneal epithelial differentiation by TET2","volume":"24","author":"Sasamoto","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib33","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s00125-023-05960-1","article-title":"Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells","volume":"66","author":"Shah","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.exer.2026.111234_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101417","article-title":"The ocular surface in type 2 diabetes: pathophysiology and impact of anti-diabetic drugs","volume":"110","author":"Singh","year":"2026","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2026.111234_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2026.115595","article-title":"Metal-phenolic nanoparticles with ROS\/pH dual-responsiveness for liver fibrosis therapy via synergistic microenvironment remodeling and metabolic reprogramming","volume":"263","author":"Su","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.exer.2026.111234_bib36","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/s41423-025-01356-w","article-title":"IL-18 drives the Bhlhe40-mediated pathogenic Th17 cell response and exacerbates autoimmune disease progression","volume":"22","author":"Tang","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.exer.2026.111234_bib37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1167\/iovs.05-1182","article-title":"Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth","volume":"47","author":"Tanifuji-Terai","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202256227","article-title":"Hypoxia causes pancreatic beta-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40","volume":"24","author":"Tsuyama","year":"2023","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.exer.2026.111234_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00795-025-00451-1","article-title":"THBS1 inhibition alleviates inflammatory response by inhibiting TGF-beta and NLRP3 inflammasome in experimental murine dry eye","volume":"59","author":"Tu","year":"2025","journal-title":"Med. Mol. Morphol."},{"key":"10.1016\/j.exer.2026.111234_bib40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.7150\/ijbs.63219","article-title":"The advanced glycation end-products (AGEs)\/ROS\/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration","volume":"18","author":"Wan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2026.111234_bib41","first-page":"957","volume":"8","author":"Wang","year":"2025"},{"key":"10.1016\/j.exer.2026.111234_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/scd.2020.0196","article-title":"The effect of SPARC on the proliferation and migration of limbal epithelial stem cells during the corneal epithelial wound healing","volume":"30","author":"Wang","year":"2021","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.exer.2026.111234_bib43","article-title":"Metabolic reprogramming: a novel therapeutic target in diabetic kidney disease","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2026.111234_bib44","article-title":"GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exer.2026.111234_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14268","article-title":"The circadian rhythm: a key variable in aging?","volume":"23","author":"Winterhalter","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.exer.2026.111234_bib46","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2337\/db08-0997","article-title":"High glucose suppresses epidermal growth factor receptor\/phosphatidylinositol 3-kinase\/Akt signaling pathway and attenuates corneal epithelial wound healing","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2026.111234_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101286","article-title":"Exploring single-cell RNA sequencing as a decision-making tool in the clinical management of Fuchs' endothelial corneal dystrophy","volume":"102","author":"Yang","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2026.111234_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101039","article-title":"The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas","volume":"89","author":"Yu","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2026.111234_bib49","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100944R","article-title":"BHLHE40 promotes macrophage pro-inflammatory gene expression and functions","volume":"35","author":"Zafar","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2026.111234_bib50","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1038\/s41467-025-62890-9","article-title":"Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2026.111234_bib51","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12964-025-02365-y","article-title":"The mechanobiology of extracellular matrix: a focus on thrombospondins","volume":"23","author":"Zhao","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.exer.2026.111234_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1079541","article-title":"Mechanistic investigations of diabetic ocular surface diseases","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exer.2026.111234_bib53","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.2337\/db13-1819","article-title":"Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes","volume":"63","author":"Ziegler","year":"2014","journal-title":"Diabetes"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526003908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:06:17Z","timestamp":1791360377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526003908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":53,"alternative-id":["S0014483526003908"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111234","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell RNA-seq analysis revealed that BHLHE40 and its binding protein THBS1 are involved in diabetic corneal epitheliopathy","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111234"}}