{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:29:19Z","timestamp":1793946559915,"version":"4.8.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004286","name":"Santen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.exer.2026.111255","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:49:51Z","timestamp":1790610591000},"page":"111255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Changes in molecular signature on the ocular surface in response to optimising therapy in aqueous-deficient dry eye disease"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-7973","authenticated-orcid":false,"given":"Emily","family":"Greenan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh M.C.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Madden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Siby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eibhlin","family":"Conneally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Annett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Castellanos-Uribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean T.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacintha","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipto","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"N\u00ed Gabhann-Dromgoole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2026.111255_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1261\/rna.2183803","article-title":"A uniform system for microRNA annotation","volume":"9","author":"Ambros","year":"2003","journal-title":"Rna"},{"key":"10.1016\/j.exer.2026.111255_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2022.101705","article-title":"Diurnal variation on tear stability and correlation with tear cytokine concentration","volume":"45","author":"Arroyo","year":"2022","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.exer.2026.111255_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.exer.2012.11.017","article-title":"Effect of TGF-\u03b2 on ocular surface epithelial cells","volume":"107","author":"Benito","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111255_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105048","article-title":"Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy","volume":"144","author":"Brennan","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2026.111255_bib5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.bbmt.2012.01.020","article-title":"Roles of transforming growth Factor-\u03b2 in graft-versus-host and graft-versus-tumor effects","volume":"18","author":"Carli","year":"2012","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.exer.2026.111255_bib6","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2026.111255_bib7","first-page":"293","article-title":"Cadherin-11 and its role in tissue fibrosis","volume":"212","author":"Chavula","year":"2023","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.exer.2026.111255_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cellsig.2017.12.004","article-title":"TGF-\u03b21 up-regulates cadherin-11 expression through snail: a potential mechanism for human trophoblast cell differentiation","volume":"43","author":"Cheng","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exer.2026.111255_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.exer.2026.111255_bib10","series-title":"TFOS DEWS II Definition and Classification Report","author":"Craig","year":"2017"},{"key":"10.1016\/j.exer.2026.111255_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150154","article-title":"Urinary exosomal miRNA signature in type II diabetic nephropathy patients","volume":"11","author":"Deli\u0107","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2026.111255_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jtos.2021.07.010","article-title":"Optimising the method for isolating ocular surface microRNA using impression cytology","volume":"22","author":"Greenan","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111255_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216658120","article-title":"MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control","volume":"120","author":"Heiland","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2026.111255_bib14","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2026.111255_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.bjc.6603023","article-title":"MicroRNAs in cell proliferation, cell death, and tumorigenesis","volume":"94","author":"Hwang","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.exer.2026.111255_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.exer.2026.111255_bib17","first-page":"4800","article-title":"The value of MiR-146a and MiR-4484 expressions in the diagnosis of anti-SSA antibody positive Sjogren syndrome and the correlations with prognosis","volume":"22","author":"Jiang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111255_bib19","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1158\/0008-5472.CAN-16-0714","article-title":"Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells","volume":"76","author":"Kanlikilicer","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2026.111255_bib20","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","article-title":"DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA-gene interactions","volume":"46","author":"Karagkouni","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2026.111255_bib21","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1167\/iovs.19-27062","article-title":"Comparison of MicroRNA expression in tears of normal subjects and sj\u00f6gren syndrome patients","volume":"60","author":"Kim","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib22","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/ki.2013.272","article-title":"The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-\u03b2\/Smad3-Azin1 pathway","volume":"84","author":"Li","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.exer.2026.111255_bib23","article-title":"MicroRNAs in diabetic kidney disease","volume":"2014","author":"Li","year":"2014","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.exer.2026.111255_bib24","unstructured":"Meso Scale Discovery, Proinflammatory Panel 1 (Human) Kits. Meso Scale Discovery, Rockville, MD."},{"key":"10.1016\/j.exer.2026.111255_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1542-0124(12)70289-6","article-title":"Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease","volume":"7","author":"Nguyen","year":"2009","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111255_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116114","article-title":"Cascade of inflammatory, fibrotic processes, and stress-induced senescence in chronic GVHD-Related dry eye disease","volume":"22","author":"Ogawa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108294","article-title":"Inflammatory basis for dry eye disease flares","volume":"201","author":"Perez","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111255_bib28","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease: what we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2026.111255_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","article-title":"Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca","volume":"19","author":"Pflugfelder","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2026.111255_bib30","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1214\/16-AOAS920","article-title":"Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression","volume":"10","author":"Phipson","year":"2016","journal-title":"Ann. Appl. Stat."},{"key":"10.1016\/j.exer.2026.111255_bib31","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/s41598-020-64422-5","article-title":"miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome","volume":"10","author":"Pilson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111255_bib32","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/s41598-020-64422-5","article-title":"miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome","volume":"10","author":"Pilson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111255_bib33","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1080\/02713683.2022.2110597","article-title":"Tear film miRNAs and their association with human dry eye disease","volume":"47","author":"Pucker","year":"2022","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2026.111255_bib34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/1471-2164-10-493","article-title":"Quality control in microarray assessment of gene expression in human airway epithelium","volume":"10","author":"Raman","year":"2009","journal-title":"BMC Genom."},{"key":"10.1016\/j.exer.2026.111255_bib35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.18240\/ijo.2022.05.20","article-title":"Inflammation and dry eye disease-where are we?","volume":"15","author":"Rao","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2026.111255_bib36","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jtos.2017.05.007","article-title":"Review: MicroRNAS in ocular surface and dry eye diseases","volume":"15","author":"Rassi","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2026.111255_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093111","article-title":"Dry eye disease and tear cytokine Levels-A meta-analysis","volume":"21","author":"Roda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50695-y","article-title":"A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients","volume":"9","author":"Rusek","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111255_bib39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/labinvest.3700375","article-title":"TGFbeta pathobiology in the eye","volume":"86","author":"Saika","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2026.111255_bib40","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.gt.3301320","article-title":"Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis","volume":"7","author":"Sakamoto","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2026.111255_bib41","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022236","article-title":"Regulation of the immune response by TGF-\u03b2: from conception to autoimmunity and infection","volume":"9","author":"Sanjabi","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2026.111255_bib42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1096\/fj.11-186098","article-title":"Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-\u03b2 production and epithelial to mesenchymal transition","volume":"26","author":"Schneider","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2026.111255_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2199-7-3","article-title":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements","volume":"7","author":"Schroeder","year":"2006","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.exer.2026.111255_bib44","first-page":"2283","article-title":"Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease","volume":"42","author":"Solomon","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.847168","article-title":"MicroRNA profiling of the tears of children with vernal keratoconjunctivitis","volume":"13","author":"Syed","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.exer.2026.111255_bib46","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1038\/srep05089","article-title":"Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system","volume":"4","author":"Tanaka","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2026.111255_bib47","series-title":"R: a Language and Environment for Statistical Computing","author":"Team","year":"2022"},{"key":"10.1016\/j.exer.2026.111255_bib48","series-title":"Flashtag\u2122 Biotin HSR RNA Labeling Kit for Genechip\u2122 Mirna Arrays User Guide","year":"2016"},{"key":"10.1016\/j.exer.2026.111255_bib49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1472-6750-7-57","article-title":"Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA","volume":"7","author":"Thompson","year":"2007","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.exer.2026.111255_bib50","doi-asserted-by":"crossref","first-page":"D360","DOI":"10.1093\/nar\/gkx1144","article-title":"mirDIP 4.1-integrative database of human microRNA target predictions","volume":"46","author":"Tokar","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2026.111255_bib51","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1874312901206010130","article-title":"Role of MicroRNAs in fibrosis","volume":"6","author":"Vettori","year":"2012","journal-title":"Open Rheumatol. J."},{"key":"10.1016\/j.exer.2026.111255_bib52","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/0004563220961746","article-title":"Discovery of microRNA expression profiles involved in regulating TGF-\u03b22 expression in the tears of dry eye patients","volume":"57","author":"Wang","year":"2020","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.exer.2026.111255_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106440","article-title":"MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice","volume":"83","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exer.2026.111255_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v040.i01","article-title":"The split-apply-combine strategy for data analysis","volume":"40","author":"Wickham","year":"2011","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.exer.2026.111255_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108089","article-title":"Corneal wound healing","volume":"197","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2026.111255_bib56","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.exer.2026.111255_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.699722","article-title":"Sclerosing sialadenitis is associated with salivary Gland hypofunction and a unique gene expression profile in Sj\u00f6gren's Syndrome","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2026.111255_bib58","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.exer.2026.111255_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239138","article-title":"TGF-\u03b2 pathway in salivary Gland fibrosis","volume":"21","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2026.111255_bib60","doi-asserted-by":"crossref","DOI":"10.1177\/10760296221093595","article-title":"The extensive regulation of MicroRNA in immune thrombocytopenia","volume":"28","author":"Zhao","year":"2022","journal-title":"Clin. Appl. Thromb. Hemost."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526004112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483526004112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:50:28Z","timestamp":1793944228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483526004112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":60,"alternative-id":["S0014483526004112"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2026.111255","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in molecular signature on the ocular surface in response to optimising therapy in aqueous-deficient dry eye disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2026.111255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111255"}}