{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:21:37Z","timestamp":1769754097525,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.exger.2005.05.004","type":"journal-article","created":{"date-parts":[[2005,7,19]],"date-time":"2005-07-19T14:28:06Z","timestamp":1121783286000},"page":"599-604","source":"Crossref","is-referenced-by-count":40,"title":["Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors"],"prefix":"10.1016","volume":"40","author":[{"given":"M.","family":"Barbieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Papa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Acampora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Marchegiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Paolisso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2005.05.004_bib32","doi-asserted-by":"crossref","unstructured":"Alberti, K.G.M.M., Zimmet, P.Z., for the WHO Consultation, 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional Report of a WHO Consultation. Diabetic Medicine 15, 539\u2013553.","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"10.1016\/j.exger.2005.05.004_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/79839","article-title":"The common PPAR Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes","volume":"26","author":"Altshuler","year":"2000","journal-title":"Nat. Genet."},{"issue":"Suppl 4","key":"10.1016\/j.exger.2005.05.004_bib2","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1038\/sj.ijo.0801507","article-title":"Hunting for human obesity genes? Look in the adipose tissue!","volume":"24","author":"Arner","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"Suppl 1","key":"10.1016\/j.exger.2005.05.004_bib3","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1017\/S0007114500000891","article-title":"Obesity\u2014a genetic disease of adipose tissue?","volume":"83","author":"Arner","year":"2000","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.exger.2005.05.004_bib31","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/jc.87.5.2084","article-title":"Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro","volume":"87","author":"Bastard","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2005.05.004_bib25","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.2337\/diabetes.47.11.1806","article-title":"Association of the Pro \/Ala variant in the peroxisome proliferator activated receptor \u03b32 gene with obesity in two Caucasian population","volume":"47","author":"Beamer","year":"1998","journal-title":"Diabetes"},{"issue":"2\u20135","key":"10.1016\/j.exger.2005.05.004_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0960-0760(03)00214-0","article-title":"Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation","volume":"85","author":"Blanquart","year":"2003","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2005.05.004_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/diacare.23.1.57","article-title":"Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity","volume":"23","author":"Bonora","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2005.05.004_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ijo.0801191","article-title":"The Pro115Gln and Pro12Ala PPAR gene mutations in obesity and type 2 diabetes","volume":"24","author":"Clement","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"1","key":"10.1016\/j.exger.2005.05.004_bib42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: the link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.exger.2005.05.004_bib14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/3099","article-title":"A Pro12Ala substitution in PPARG2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity","volume":"20","author":"Deeb","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2005.05.004_bib20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/sj.ijo.0801214","article-title":"Variation in the gene for human peroxisome proliferator activated receptor (PPAR) does not play a major role in the development of morbid obesity","volume":"24","author":"Evans","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"3","key":"10.1016\/j.exger.2005.05.004_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2337\/diabetes.49.3.517","article-title":"Interleukin-6 gene polymorphism and insulin sensitivity","volume":"49","author":"Fernandez-Real","year":"2000","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.exger.2005.05.004_bib29","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.exger.2005.05.004_bib5","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1210\/jc.2003-030435","article-title":"The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation","volume":"88","author":"Gurnell","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2005.05.004_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1210\/jc.86.2.536","article-title":"Effect of the peroxisome proliferator-activated receptor-2 Pro12Ala variant on obesity, glucose homeostasis, and blood pressure in members of familial Type 2 diabetic kindreds","volume":"86","author":"Hasstedt","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.exger.2005.05.004_bib40","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2337\/diacare.24.4.672","article-title":"Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity","volume":"24","author":"Hsueh","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2005.05.004_bib43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/35154","article-title":"PPAR\u2014agonists inhibit production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exger.2005.05.004_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","article-title":"Roles of PPARs in health and diseases","volume":"405","author":"Kersten","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.exger.2005.05.004_bib17","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s001250051225","article-title":"The PPAR2 amino acid polymorphism Pro12Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects","volume":"42","author":"Koch","year":"1999","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.exger.2005.05.004_bib26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2337\/diabetes.52.2.558","article-title":"The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity","volume":"52","author":"Kubaszek","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.exger.2005.05.004_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1749-6632.1996.tb18619.x","article-title":"PPAR tissue distribution and interactions with other hormone-signaling pathways","volume":"804","author":"Lemberger","year":"1996","journal-title":"Ann. NY Acad. Sci."},{"issue":"4","key":"10.1016\/j.exger.2005.05.004_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/1566524033479735","article-title":"Molecular and genetic mechanisms of obesity: implications for future management","volume":"3","author":"Liu","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.exger.2005.05.004_bib24","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.2337\/diabetes.48.7.1466","article-title":"Pro12Ala substitution in the peroxisome proliferator-activated receptor \u03b3 2 is not associated with type 2 diabetes","volume":"48","author":"Mancini","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.exger.2005.05.004_bib37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.exger.2005.05.004_bib39","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1172\/JCI1748","article-title":"Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model","volume":"101","author":"Mehrabian","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2005.05.004_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.ijo.0801112","article-title":"Impact of the peroxisome proliferator activated receptor 2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus","volume":"24","author":"Meirhaeghe","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"4","key":"10.1016\/j.exger.2005.05.004_bib28","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1210\/jc.2003-031101","article-title":"Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes","volume":"89","author":"Mohlig","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl 3","key":"10.1016\/j.exger.2005.05.004_bib10","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1038\/sj.ijo.0802494","article-title":"Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation","volume":"3","author":"Moller","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"2\u20133","key":"10.1016\/j.exger.2005.05.004_bib36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1744-313X.1998.tb01147.x","article-title":"A novel NlaIII polymorphism in the human IL-6 promoter","volume":"25","author":"Olomolaiye","year":"1998","journal-title":"Eur. J. Immunogenet."},{"key":"10.1016\/j.exger.2005.05.004_bib33","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/ajcn\/62.4.746","article-title":"Body composition, body fat distribution and resting metabolic rate in healthy centenarians","volume":"62","author":"Paolisso","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exger.2005.05.004_bib1","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1111\/j.1753-4887.1999.tb01785.x","article-title":"Genotype environment interaction in human obesity","volume":"57","author":"Perusse","year":"1999","journal-title":"Nutr. Rev."},{"issue":"4A","key":"10.1016\/j.exger.2005.05.004_bib12","doi-asserted-by":"crossref","first-page":"34J","DOI":"10.1016\/S0002-9149(03)00614-3","article-title":"The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis","volume":"92","author":"Plutzky","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.exger.2005.05.004_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor (PPARG) is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.exger.2005.05.004_bib15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJM199810013391403","article-title":"Obesity associated with a mutation in a genetic regulator of adipocyte differentiation","volume":"339","author":"Ristow","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.exger.2005.05.004_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/dmrr.371","article-title":"The Pro12Ala PPARG2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men","volume":"19","author":"Rosmond","year":"2003","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.exger.2005.05.004_bib34","series-title":"Molecular Cloning: A Laboratory Manual","year":"1989"},{"key":"10.1016\/j.exger.2005.05.004_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.47.4.507","article-title":"PPARG: adipogenic regulator and thiazolidinedione receptor","volume":"47","author":"Spiegelman","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.exger.2005.05.004_bib18","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1210\/jc.84.10.3708","article-title":"Two polymorphisms in the peroxisome proliferator-activated receptor- gene are associated with severe overweight among obese women","volume":"84","author":"Valve","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.exger.2005.05.004_bib30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/oby.2001.54","article-title":"Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion","volume":"9","author":"Vozarova","year":"2001","journal-title":"Obes. Res."},{"issue":"12","key":"10.1016\/j.exger.2005.05.004_bib41","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.exger.2005.05.004_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/bbrc.1997.7798","article-title":"Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation","volume":"241","author":"Yen","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"29","key":"10.1016\/j.exger.2005.05.004_bib8","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.0403652101","article-title":"Selective disruption of PPARG 2 impairs the development of adipose tissue and insulin sensitivity","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556505000926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556505000926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T08:19:54Z","timestamp":1586333994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556505000926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0531556505000926"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2005.05.004","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}