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Psychopharmacol."},{"key":"10.1016\/j.exger.2005.08.009_bib92","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0748730404269890","article-title":"Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats","volume":"20","author":"Hirai","year":"2005","journal-title":"J. Biol. Rhythms."},{"key":"10.1016\/j.exger.2005.08.009_bib93","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0021-9258(19)42976-1","article-title":"In vitro and in vivo formation of two new metabolites of melatonin","volume":"249","author":"Hirata","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2005.08.009_bib94","doi-asserted-by":"crossref","first-page":"11764","DOI":"10.1016\/S0021-9258(18)60877-4","article-title":"Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity, Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity","volume":"262","author":"Ho","year":"1987","journal-title":"J. Biol. 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Acad Sci. USA"},{"key":"10.1016\/j.exger.2005.08.009_bib107","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2310\/6650.2001.34088","article-title":"Circadian phase resetting in older people by ocular bright light exposure","volume":"49","author":"Klerman","year":"2001","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.exger.2005.08.009_bib108","first-page":"243","article-title":"Circadian rhythm of melatonin in postmenopausal asthmatic women with hormone replacement therapy","volume":"23","author":"Kos-Kudla","year":"2002","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.exger.2005.08.009_bib109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-244X-4-8","article-title":"Ethnicity, sleep, mood, and illumination in postmenopausal women","volume":"4","author":"Kripke","year":"2004","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.exger.2005.08.009_bib110","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1388-2457(00)00542-3","article-title":"Age-dependent changes in sleep EEG topography","volume":"112","author":"Landolt","year":"2001","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.exger.2005.08.009_bib111","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0013-4694(86)90123-9","article-title":"Ultrashort sleep-waking schedule. III. \u2019Gates\u2019 and \u2019forbidden zones\u2019 for sleep","volume":"63","author":"Lavie","year":"1986","journal-title":"Electroencephalogr. Clin. 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Sleep Res."},{"key":"10.1016\/j.exger.2005.08.009_bib115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.amjmed.2003.07.017","article-title":"Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy","volume":"116","author":"Leger","year":"2004","journal-title":"Am. J. Med."},{"key":"10.1016\/j.exger.2005.08.009_bib116","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.lfs.2004.03.003","article-title":"Melatonin and mitochondrial function","volume":"75","author":"Leon","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2005.08.009_bib117","first-page":"590","article-title":"Melatonin","volume":"19","author":"Lerner","year":"1960","journal-title":"Fed. Proc."},{"key":"10.1016\/j.exger.2005.08.009_bib118","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1021\/ja01543a060","article-title":"Isolation of melatonin, a pineal factor.that lightens melanocytes","volume":"80","author":"Lerner","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.exger.2005.08.009_bib119","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/ja01531a060","article-title":"Structure of melatonin","volume":"81","author":"Lerner","year":"1959","journal-title":"J. Am. Chem. 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Ter."},{"key":"10.1016\/j.exger.2005.08.009_bib138","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1053\/smrv.2000.0127","article-title":"Treatment of sleep disturbance in Alzheimer's disease","volume":"4","author":"McCurry","year":"2000","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.exger.2005.08.009_bib139","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-079X.1989.tb00412.x","article-title":"Human melatonin suppression by light is intensity dependent","volume":"6","author":"McIntyre","year":"1989","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.exger.2005.08.009_bib140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/archpsyc.1985.01790260019002","article-title":"Insomnia and its treatment, Prevalence and correlates","volume":"42","author":"Mellinger","year":"1985","journal-title":"Arch. Gen. 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Physiol."},{"key":"10.1016\/j.exger.2005.08.009_bib163","unstructured":"Rechtschaffen, A., Kales, A., 1968. A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages of Human Subjects, US Department of Health, Education, and Welfare Public Health Service- NIH\/NIND, Bethesda, MD."},{"key":"10.1016\/j.exger.2005.08.009_bib164","first-page":"410","article-title":"Sleep in old age: focus on gender differences","volume":"13","author":"Rediehs","year":"1990","journal-title":"Sleep"},{"key":"10.1016\/j.exger.2005.08.009_bib165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1521-690X(03)00016-2","article-title":"Melatonin: clinical relevance","volume":"17","author":"Reiter","year":"2003","journal-title":"Best. Pract. Res. Clin. Endocrinol. 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Pineal. Res."},{"key":"10.1016\/j.exger.2005.08.009_bib222","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1210\/jc.2003-030833","article-title":"Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages","volume":"88","author":"Wu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2005.08.009_bib223","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0140-6736(95)92509-0","article-title":"Improvement of sleep quality by melatonin","volume":"346","author":"Wurtman","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2005.08.009_bib224","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1532-5415.2003.51356.x","article-title":"Age-related changes of circadian rhythms and sleep-wake cycles","volume":"51","author":"Yoon","year":"2003","journal-title":"J. Am. Geriatr. 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