{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:01Z","timestamp":1790909641458,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.exger.2006.05.016","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T08:18:54Z","timestamp":1152778734000},"page":"129-138","source":"Crossref","is-referenced-by-count":156,"title":["Early detection of Alzheimer\u2019s disease using neuroimaging"],"prefix":"10.1016","volume":"42","author":[{"given":"Lisa","family":"Mosconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslaw","family":"Brys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Glodzik-Sobanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"De Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Rusinek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony J.","family":"de Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2006.05.016_bib1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/archneur.62.11.1728","article-title":"Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease","volume":"62","author":"Anchisi","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00001756-200103260-00045","article-title":"Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment","volume":"12","author":"Arnaiz","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.exger.2006.05.016_bib3","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.42.9.1681","article-title":"Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer\u2019s disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0140-6736(85)90965-1","article-title":"A new definition of Alzheimer\u2019s disease: a hippocampal dementia","volume":"1","author":"Ball","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2006.05.016_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-3956(98)90048-6","article-title":"Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimer\u2019s disease","volume":"33","author":"Berent","year":"1999","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.exger.2006.05.016_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0140-6736(05)74869-8","article-title":"MRI of entorhinal cortex in mild Alzheimer\u2019s disease","volume":"353","author":"Bobinski","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2006.05.016_bib7","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0306-4522(99)00476-5","article-title":"The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer\u2019s disease","volume":"95","author":"Bobinski","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.exger.2006.05.016_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exger.2006.05.016_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s004010050508","article-title":"Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis","volume":"92","author":"Braak","year":"1996","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exger.2006.05.016_bib10","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","article-title":"Projections of Alzheimer\u2019s disease in the United States and the public health impact of delaying disease onset","volume":"88","author":"Brookmeyer","year":"1998","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.exger.2006.05.016_bib11","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/01.WNL.0000055847.17752.E6","article-title":"Mild cognitive impairment: can FDG-PET predict who is to rapidly convert to Alzheimer\u2019s disease?","volume":"60","author":"Chetelat","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib12","series-title":"Language, Memory and Aging","first-page":"171","article-title":"Age differences in memory for texts: production deficiency or processing limitations?","author":"Cohen","year":"1990"},{"key":"10.1016\/j.exger.2006.05.016_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0197-4580(99)00107-4","article-title":"Atrophy of the medial occipito-temporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer\u2019s disease","volume":"21","author":"Convit","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2006.05.016_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0140-6736(95)90265-1","article-title":"Hippocampal volume losses in minimally impaired elderly","volume":"345","author":"Convit","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2006.05.016_bib15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 Allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.exger.2006.05.016_bib16","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.191044198","article-title":"Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose\/positron-emission tomography (FDG\/PET)","volume":"98","author":"de Leon","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2006.05.016_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(96)00213-8","article-title":"Frequency of hippocampal formation atrophy in normal aging and Alzheimer\u2019s disease","volume":"18","author":"de Leon","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2006.05.016_bib18","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.82.10.3251","article-title":"Cortisol reduces hippocampal glucose metabolism in normal elderly but not in Alzheimer\u2019s disease","volume":"82","author":"de Leon","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2006.05.016_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0197-4580(01)00230-5","article-title":"Hippocampal formation glucose metabolism and volume losses in MCI and AD","volume":"22","author":"De Santi","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2006.05.016_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0197-4580(97)00114-0","article-title":"Alzheimer\u2019s disease: in vivo detection of differential vulnerability of brain regions","volume":"18","author":"de Toledo-Morrell","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2006.05.016_bib21","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer\u2019s disease","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archpsyc.63.1.57","article-title":"Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people","volume":"63","author":"den Heijer","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.exger.2006.05.016_bib23","first-page":"1625","article-title":"Prediction of individual outcome in MCI by means of genetic assessment and 18F-FDG PET","volume":"46","author":"Drzezga","year":"2005","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.exger.2006.05.016_bib24","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-003-1194-1","article-title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer\u2019s disease: a PET follow-up study","volume":"30","author":"Drzezga","year":"2003","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.exger.2006.05.016_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(01)05408-3","article-title":"Imaging of onset and progression of Alzheimer\u2019s disease with voxel-compression mapping of serial magnetic resonance images","volume":"358","author":"Fox","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2006.05.016_bib26","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(99)00496-1","article-title":"Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer\u2019s disease","volume":"353","author":"Fox","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2006.05.016_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1995","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.exger.2006.05.016_bib28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/BF00294172","article-title":"Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population","volume":"87","author":"Giannakopoulos","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exger.2006.05.016_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer\u2019s disease","volume":"41","author":"Gomez-Isla","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1159\/000017196","article-title":"Impairment of neocortical metabolism predicts progression in Alzheimer\u2019s disease","volume":"10","author":"Herholz","year":"1999","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.exger.2006.05.016_bib31","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1212\/WNL.50.6.1585","article-title":"Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer\u2019s disease","volume":"50","author":"Ibanez","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib32","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1212\/WNL.55.4.484","article-title":"Rates of hippocampal atrophy correlate with change in clinical status in aging and AD","volume":"55","author":"Jack","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1212\/WNL.42.1.183","article-title":"MR-based hippocampal volummetry in the diagnosis of Alzheimer\u2019s disease","volume":"42","author":"Jack","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib34","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.52.7.1397","article-title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","volume":"52","author":"Jack","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1212\/01.WNL.0000110315.26026.EF","article-title":"Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD","volume":"62","author":"Jack","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0197-4580(98)00007-4","article-title":"Volumes of the entorhinal and perirhinal cortices in Alzheimer\u2019s disease","volume":"19","author":"Juottonen","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2006.05.016_bib37","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1212\/WNL.48.5.1297","article-title":"Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia","volume":"48","author":"Kaye","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)11270-7","article-title":"Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer\u2019s Disease","volume":"186","author":"Kennedy","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exger.2006.05.016_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/brain\/118.1.185","article-title":"Chromosome 14 linked familial Alzheimer\u2019s disease. A clinico-pathological study of a single pedigree","volume":"118","author":"Kennedy","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.exger.2006.05.016_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1212\/WNL.41.1.51","article-title":"Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer\u2019s disease","volume":"41","author":"Kesslak","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib41","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1212\/WNL.58.8.1188","article-title":"MRI measures of entorhinal cortex vs hippocampus in preclinical AD","volume":"58","author":"Killiany","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib42","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/archneur.1993.00540090052010","article-title":"Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer\u2019s disease","volume":"50","author":"Killiany","year":"1993","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1212\/01.WNL.0000133114.92694.93","article-title":"Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment","volume":"63","author":"Korf","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib44","series-title":"Positron Emission Tomography & Autoradiography: Principles & Applications for the Brain & Heart","first-page":"493","article-title":"Positron emission tomography studies of the brain","author":"Mazziotta","year":"1986"},{"key":"10.1016\/j.exger.2006.05.016_bib45","first-page":"23","article-title":"Lack of prognostic significance of SPECT abnormalities in non-demented elderly subjects with memory loss","volume":"26","author":"McKelvey","year":"1999","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.exger.2006.05.016_bib46","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health & Human Services Task Force on Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib47","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00004728-199007000-00011","article-title":"Correction of PET data for partial volume effects in human cerebral cortex by MR imaging","volume":"14","author":"Meltzer","year":"1990","journal-title":"J. Comp. Assist. Tomogr."},{"key":"10.1016\/j.exger.2006.05.016_bib48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(00)81109-5","article-title":"Neuroplasticity failure in Alzheimer\u2019s disease: bridging the gap between plaques and tangles","volume":"24","author":"Mesulam","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2006.05.016_bib49","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s007020050097","article-title":"Normal and pathological aging \u2013 findings of positron-emission-tomography","volume":"105","author":"Mielke","year":"1998","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.exger.2006.05.016_bib50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer\u2019s disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1212\/WNL.46.3.707","article-title":"Cerebral amyloid deposition and diffuse plaques in \u201cnormal\u201d aging: evidence for presymptomatic and very mild Alzheiemer\u2019s disease","volume":"46","author":"Morris","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib52","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1126\/science.278.5337.412","article-title":"Life and death of neurons in the aging brain","volume":"278","author":"Morrison","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exger.2006.05.016_bib53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00259-005-1956-z","article-title":"Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer\u2019s disease using FDG-PET","volume":"33","author":"Mosconi","year":"2006","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.exger.2006.05.016_bib54","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1212\/01.WNL.0000147469.18313.3B","article-title":"MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET","volume":"63","author":"Mosconi","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib55","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/01.WNL.0000086816.30011.75","article-title":"Brain metabolic differences between sporadic and familial Alzheimer\u2019s disease","volume":"61","author":"Mosconi","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib56","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1212\/01.WNL.0000163856.13524.08","article-title":"Reduced hippocampal metabolism in mild cognitive impairment and Alzheimer\u2019s disease: automated FDG-PET image analysis","volume":"64","author":"Mosconi","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ana.10669","article-title":"Limbic hypometabolism in Alzheimer\u2019s disease and mild cognitive impairment","volume":"54","author":"Nestor","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/WNL.51.1.136","article-title":"Altered glucose metabolism in the hippocampal head in memory impairment","volume":"51","author":"Ouchi","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib59","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment","volume":"58","author":"Petersen","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib60","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib61","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","article-title":"Practice parameter: early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"56","author":"Petersen","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib62","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1212\/WNL.42.4.765","article-title":"Blinded clinical evaluation of positron emission tomography for diagnosis of probable Alzheimer\u2019s disease","volume":"42","author":"Powers","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib64","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1212\/WNL.39.11.1537","article-title":"Memory and regional cerebral blood flow in mildly symptomatic Alzheimer\u2019s disease","volume":"39","author":"Reed","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2006.05.016_bib65","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1073\/pnas.061509598","article-title":"Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer\u2019s disease","volume":"98","author":"Reiman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2006.05.016_bib66","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","article-title":"Preclinical evidence of Alzheimer\u2019s disease in persons homozygous for the E4 allele for apolipoprotein E","volume":"334","author":"Reiman","year":"1996","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.exger.2006.05.016_bib67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer\u2019s dementia","volume":"101","author":"Reiman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2006.05.016_bib68","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ana.410440226","article-title":"Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer\u2019s disease","volume":"44","author":"Reiman","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib69","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1148\/radiol.2293021299","article-title":"Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging","volume":"229","author":"Rusinek","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.exger.2006.05.016_bib70","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1073\/pnas.052587399","article-title":"Mapping the evolution of regional atrophy in Alzheimer\u2019s disease: unbiased analysis of fluid-registered serial MRI","volume":"99","author":"Scahill","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2006.05.016_bib71","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1474-4422(03)00502-7","article-title":"Treatment of Alzheimer\u2019s disease: current status and new perspectives","volume":"2","author":"Scarpini","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib72","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.exger.2006.05.016_bib73","first-page":"253","article-title":"Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits","volume":"43","author":"Silverman","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.exger.2006.05.016_bib74","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/jama.286.17.2120","article-title":"Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome","volume":"286","author":"Silverman","year":"2001","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.exger.2006.05.016_bib75","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.090106797","article-title":"Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer\u2019s disease","volume":"97","author":"Small","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2006.05.016_bib76","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.273.12.942","article-title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.exger.2006.05.016_bib77","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S1041610294001596","article-title":"Age-associated memory loss: initial neuropsychological and cerebral metabolic findings of a longitudinal study","volume":"6","author":"Small","year":"1994","journal-title":"Int. Psychogeriat."},{"key":"10.1016\/j.exger.2006.05.016_bib78","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(01)00476-7","article-title":"New frontiers in Alzheimer\u2019s disease genetics","volume":"32","author":"Tanzi","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2006.05.016_bib79","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib80","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003","article-title":"Dynamics of gray matter loss in Alzheimer\u2019s disease","volume":"23","author":"Thompson","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2006.05.016_bib81","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/ana.410170309","article-title":"Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer\u2019s disease and senile dementia of Alzheimer type","volume":"17","author":"Ulrich","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exger.2006.05.016_bib82","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/jnnp.57.8.1015","article-title":"Visual rating of hippocampal atrophy: correlation with volumetry","volume":"57","author":"Vermersch","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.exger.2006.05.016_bib83","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s004150050387","article-title":"Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment","volume":"246","author":"Visser","year":"1999","journal-title":"J. Neurol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556506001355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556506001355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T20:48:04Z","timestamp":1555706884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556506001355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":83,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0531556506001355"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2006.05.016","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}