{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:36:02Z","timestamp":1791225362634,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.exger.2011.02.006","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T07:00:32Z","timestamp":1299567632000},"page":"533-541","source":"Crossref","is-referenced-by-count":58,"title":["Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice"],"prefix":"10.1016","volume":"46","author":[{"given":"Qinying","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2011.02.006_bb0005","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.mad.2009.09.001","article-title":"Autophagy upregulation and loss of NF-kB in oxidative stress-related immunodeficient SAMP8 mice","volume":"130","author":"Caballero","year":"2009","journal-title":"Mech. Aging. Dev."},{"key":"10.1016\/j.exger.2011.02.006_bb0010","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.mad.2005.07.008","article-title":"Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)","volume":"126","author":"Canudas","year":"2005","journal-title":"Mech. Aging. Dev."},{"key":"10.1016\/j.exger.2011.02.006_bb0015","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/sj.cdd.4401692","article-title":"Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting","volume":"12","author":"Ciechanover","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exger.2011.02.006_bb0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.exger.2009.03.006","article-title":"Age-related changes of cell death pathways in rat extraocular muscle","volume":"44","author":"Colleen","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2011.02.006_bb0025","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3233\/JAD-2010-1321","article-title":"Early amyloid accumulation in the hippocampus of SAMP8 mice","volume":"19","author":"Del Valle","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2011.02.006_bb0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/auto.2156","article-title":"Neurodegeneration induces upregulation of Beclin 1","volume":"2","author":"Erlich","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2011.02.006_bb0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.mam.2006.08.001","article-title":"Autophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically","volume":"27","author":"Ettore","year":"2006","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.exger.2011.02.006_bb0040","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mad.2009.01.007","article-title":"Age-related modifications of egr1 expression and ubiquitin\u2013proteasome components in pet dog hippocampus","volume":"130","author":"Ghi","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2011.02.006_bb0045","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exger.2011.02.006_bb0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0047-6374(84)90168-4","article-title":"Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM)","volume":"26","author":"Hosokawa","year":"1984","journal-title":"Mech. Aging. Dev."},{"key":"10.1016\/j.exger.2011.02.006_bb0055","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1101\/gad.1600707","article-title":"Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila","volume":"21","author":"Juh\u00e1sz","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.exger.2011.02.006_bb0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0531-5565(96)00063-0","article-title":"Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory","volume":"32","author":"Kawamata","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2011.02.006_bb0065","doi-asserted-by":"crossref","first-page":"20567","DOI":"10.1073\/pnas.0810611105","article-title":"Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes","volume":"105","author":"Kim","year":"2008","journal-title":"Prog. Nat. Sci."},{"key":"10.1016\/j.exger.2011.02.006_bb0070","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exger.2011.02.006_bb0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ncb0910-836","article-title":"Selective autophagy: ubiquitin-mediated recognition and beyond","volume":"12","author":"Kraft","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exger.2011.02.006_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.exger.2011.02.006_bb0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exger.2011.02.006_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0076-6879(05)99007-1","article-title":"Application of ubiquitin immunohistochemistry to the diagnosis of disease","volume":"399","author":"Lowe","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exger.2011.02.006_bb0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000109761","article-title":"The role of autophagy in age-related neurodegeneration","volume":"16","author":"McCray","year":"2008","journal-title":"Neurosignals"},{"key":"10.1016\/j.exger.2011.02.006_bb0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0531-5565(96)00061-7","article-title":"Characteristics of age-related behavioural changes in senescence-accelerated mouse SAMP8 and SAMP10","volume":"32","author":"Miyamoto","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2011.02.006_bb0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jnen\/64.2.113","article-title":"Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study","volume":"64","author":"Nixon","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.exger.2011.02.006_bb0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0197-4580(99)00006-8","article-title":"Age-related defects in lifespan and learning ability in SAMP8 mice","volume":"20","author":"Nomura","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2011.02.006_bb0115","first-page":"2190","article-title":"The autophagy-related protein shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice","volume":"118","author":"Pickford","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2011.02.006_bb0120","first-page":"84","article-title":"In search of an \u201cautophagomometer\u201d","volume":"1","author":"Rubinsztein","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2011.02.006_bb0125","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1074\/jbc.M600364200","article-title":"Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1","volume":"281","author":"Shibata","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2011.02.006_bb0130","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.exger.2011.02.006_bb0135","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/auto.5269","article-title":"Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila","volume":"4","author":"Simonsen","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2011.02.006_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60607-8","article-title":"Alzheimer disease","volume":"42","author":"Smith","year":"1998","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.exger.2011.02.006_bb0145","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1523\/JNEUROSCI.4390-09.2009","article-title":"Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases","volume":"29","author":"Spencer","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2011.02.006_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0167-4943(94)90039-6","article-title":"A novel murine model of aging, senescence-accelerated mouse (SAM)","volume":"19","author":"Takeda","year":"1994","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.exger.2011.02.006_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0531-5565(96)00068-X","article-title":"Pathobiology of the senescence-accelerated mouse (SAM)","volume":"32","author":"Takeda","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2011.02.006_bb0160","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/auto.1.2.1697","article-title":"Lysosomal turnover, but not a cellular level of endogenous LC3 is a marker for autophagy","volume":"1","author":"Tanida","year":"2005","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2011.02.006_bb0165","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s11064-009-9923-x","article-title":"Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence","volume":"34","author":"Tomobe","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exger.2011.02.006_bb0170","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neulet.2009.03.030","article-title":"Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice","volume":"454","author":"Wang","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exger.2011.02.006_bb0175","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(02)00861-9","article-title":"A novel protein complex linking the 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice","volume":"35","author":"Yue","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2011.02.006_bb0180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0736-5748(90)90032-W","article-title":"Age-related changes in uptake and release on L-[3H] noradrenaline in brain slices of senescence accelerated mouse","volume":"8","author":"Zhao","year":"1990","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.exger.2011.02.006_bb0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0736-5748(92)90040-7","article-title":"Age-related changes in NMDA-induced [3H]acetylcholine release from brain slices of senescence accelerated mouse","volume":"10","author":"Zhao","year":"1992","journal-title":"Int. J. Dev. Neurosci."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556511000568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556511000568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T04:23:47Z","timestamp":1560054227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556511000568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0531556511000568"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2011.02.006","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}