{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:20:19Z","timestamp":1776190819958,"version":"3.50.1"},"reference-count":83,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.exger.2011.08.001","type":"journal-article","created":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T23:02:16Z","timestamp":1312758136000},"page":"905-914","source":"Crossref","is-referenced-by-count":29,"title":["Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss"],"prefix":"10.1016","volume":"46","author":[{"given":"Srdjan M.","family":"Vlajkovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy X.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Telang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Chi Yan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinthiya","family":"Paramananthasivam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev","family":"Boison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.","family":"Housley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2011.08.001_bb0005","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000059247","article-title":"Effects of aging on C57BL\/6J mice: an electrophysiological and morphological study","volume":"59","author":"Bartolom\u00e9","year":"2002","journal-title":"Adv. Oto-Rhino-Laryngol."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.heares.2008.04.006","article-title":"Age-related hearing loss in the Fischer 344\/NHsd rat substrain","volume":"241","author":"Bielefeld","year":"2008","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.heares.2009.09.001","article-title":"Age-related hearing loss: is it a preventable condition","volume":"264","author":"Bielefeld","year":"2010","journal-title":"Hear. Res."},{"issue":"12","key":"10.1016\/j.exger.2011.08.001_bb0020","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.tips.2006.10.008","article-title":"Adenosine kinase, epilepsy and stroke: mechanisms and therapies","volume":"27","author":"Boison","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.coph.2007.09.002","article-title":"Adenosine as a neuromodulator in neurological diseases","volume":"8","author":"Boison","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.exger.2011.08.001_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11302-005-0649-1","article-title":"Neuroprotection by adenosine in the brain: from A(1) receptor activation to A(2A) receptor blockade","volume":"1","author":"Cunha","year":"2005","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.exger.2011.08.001_bb0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00016480410016586","article-title":"Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis","volume":"124","author":"Dai","year":"2004","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.exger.2011.08.001_bb0040","series-title":"Cellular survival: a play in three Akts","author":"Datta","year":"1999"},{"key":"10.1016\/j.exger.2011.08.001_bb0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/14992020600937402","article-title":"The effect of longitudinal noise exposure on behavioural audiograms and transient-evoked otoacoustic emissions","volume":"46","author":"Duvdevany","year":"2007","journal-title":"Int. J. Audiol."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-5955(93)90207-H","article-title":"Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains","volume":"65","author":"Erway","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2011.08.001_bb0055","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/brain\/awh555","article-title":"Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation","volume":"128","author":"Fedele","year":"2005","journal-title":"Brain"},{"issue":"6809","key":"10.1016\/j.exger.2011.08.001_bb0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.exger.2011.08.001_bb0065","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.AUD.0000079802.82344.B5","article-title":"Mitochondrial deafness","volume":"24","author":"Fischel-Ghodsian","year":"2003","journal-title":"Ear Hear"},{"key":"10.1016\/j.exger.2011.08.001_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-5955(97)00077-4","article-title":"Temporal bone analysis of patients with presbyacusis reveals high frequency of mitochondrial mutations","volume":"110","author":"Fischel-Ghodsian","year":"1997","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0378-5955(97)00103-2","article-title":"Up-regulation of adenosine receptors in the cochlea by cisplatin","volume":"111","author":"Ford","year":"1997","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-5955(03)00212-0","article-title":"The functional age of hearing loss in a mouse model of presbyacusis. II. Neuroanatomical correlates","volume":"183","author":"Francis","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2011.08.001_bb0085","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.exger.2011.08.001_bb0090","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbyacusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0095","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1523\/JNEUROSCI.4781-03.2004","article-title":"Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis","volume":"24","author":"Gouder","year":"2004","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bcp.2003.08.031","article-title":"Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1\/2 via phosphatidylinositol-3\u2032-kinase","volume":"67","author":"Hammarberg","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exger.2011.08.001_bb0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s101620010075","article-title":"Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL\/6J mice","volume":"2","author":"Hequembourg","year":"2001","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.exger.2011.08.001_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00067-4","article-title":"Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA","volume":"179","author":"Hight","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2011.08.001_bb0115","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0378-5955(97)00143-3","article-title":"R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla","volume":"113","author":"Hu","year":"1997","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0378-5955(99)00170-7","article-title":"Age-related changes in the murine cochlear lateral wall","volume":"139","author":"Ichimiya","year":"2000","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0125","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/S0022-3565(24)39018-4","volume":"295","author":"Jarvis","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0130","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0091-3057(02)00840-7","article-title":"Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats","volume":"73","author":"Jarvis","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"10","key":"10.1016\/j.exger.2011.08.001_bb0135","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.neurobiolaging.2006.06.025","article-title":"Oxidative imbalance in the aging inner ear","volume":"28","author":"Jiang","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.exger.2011.08.001_bb0140","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/geno.2002.6858","article-title":"Ahl2, a second locus affecting age-related hearing loss in mice","volume":"80","author":"Johnson","year":"2002","journal-title":"Genomics"},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114","author":"Johnson","year":"1997","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00365-4","article-title":"Age-related hearing loss and the ahl locus in mice","volume":"188","author":"Keithley","year":"2004","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0155","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.heares.2005.06.009","article-title":"Cu\/Zn superoxide dismutase and age-related hearing loss","volume":"209","author":"Keithley","year":"2005","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0160","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/13543784.9.3.551","article-title":"Therapeutic potential of adenosine kinase inhibitors","volume":"9","author":"Kowaluk","year":"2000","journal-title":"Expert Opin. Investig. Drugs."},{"issue":"45","key":"10.1016\/j.exger.2011.08.001_bb0165","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J. Neurosci."},{"issue":"13","key":"10.1016\/j.exger.2011.08.001_bb0170","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/jm000314x","article-title":"Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor","volume":"44","author":"Lee","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.exger.2011.08.001_bb0175","first-page":"571","article-title":"Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice","volume":"118","author":"Li","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.exger.2011.08.001_bb0180","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1474-9728.2002.00014.x","article-title":"The true face of JNK activation in apoptosis","volume":"1","author":"Lin","year":"2002","journal-title":"Aging Cell"},{"issue":"52","key":"10.1016\/j.exger.2011.08.001_bb0185","doi-asserted-by":"crossref","first-page":"18769","DOI":"10.1073\/pnas.0509776102","article-title":"The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations","volume":"102","author":"Loeb","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0190","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0006-291X(03)01125-2","article-title":"Adenosine A2B receptors modulate cAMP levels and induce CREB but not ERK1\/2 and p38 phosphorylation in rat skeletal muscle cells","volume":"307","author":"Lynge","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.exger.2011.08.001_bb0195","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00335-004-2438-5","article-title":"Two quantitative trait loci affecting progressive hearing loss in 101\/H mice","volume":"17","author":"Mashimo","year":"2006","journal-title":"Mamm. Genome."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(99)00018-4","article-title":"Age-related cochlear hair cell loss is enhanced in mice lacking copper\/zinc superoxide dismutase","volume":"20","author":"McFadden","year":"1999","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1568026053386845","article-title":"Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors","volume":"5","author":"McGaraughty","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.exger.2011.08.001_bb0210","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2008.03.031","article-title":"Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone","volume":"1212","author":"Mikuriya","year":"2008","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0215","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbrc.2007.01.115","article-title":"Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss","volume":"355","author":"Morita","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2011.08.001_bb0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.1991.tb19572.x","article-title":"Genetic epidemiology of hearing loss","volume":"630","author":"Morton","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"18","key":"10.1016\/j.exger.2011.08.001_bb0225","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/j.yexcr.2007.05.029","article-title":"Somatic mtDNA mutations cause progressive hearing loss in the mouse","volume":"313","author":"Niu","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0230","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0235","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2006.03.017","article-title":"Contributions of mouse models to understanding of age- and noise-related hearing loss","volume":"1091","author":"Ohlemiller","year":"2006","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0240","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-5955(00)00191-X","article-title":"Vulnerability to noise-induced hearing loss in \u2018middle-aged\u2019 and young adult mice: a dose\u2013response approach in CBA\/J, C57BL, and BALB inbred strains","volume":"149","author":"Ohlemiller","year":"2000","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0245","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"Ohlemiller","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.exger.2011.08.001_bb0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000074184","article-title":"Mutation in mitochondrial DNA as a cause of presbyacusis","volume":"9","author":"Pickles","year":"2004","journal-title":"Audiol. Neuro. Otolaryngol."},{"key":"10.1016\/j.exger.2011.08.001_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.jcbfm.9600334","article-title":"Transgenic overexpression of adenosine kinase aggravates cell death in ischemia","volume":"27","author":"Pignataro","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.jcbfm.9600499","article-title":"Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism","volume":"28","author":"Pignataro","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0265","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0378-5955(03)00211-9","article-title":"The functional age of hearing loss in a mouse model of presbyacusis. I. Behavioral assessments","volume":"183","author":"Prosen","year":"2003","journal-title":"Hear. Res."},{"issue":"5448","key":"10.1016\/j.exger.2011.08.001_bb0270","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1126\/science.286.5448.2358","article-title":"Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons","volume":"286","author":"Riccio","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.exger.2011.08.001_bb0275","series-title":"Sensory Research: Multimodal Perspective","first-page":"91","article-title":"Cochlear potentials in quiet-aged gerbils: does the aging cochlea need a jump start","author":"Schmiedt","year":"1993"},{"key":"10.1016\/j.exger.2011.08.001_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbyacusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"5 Pt 1","key":"10.1016\/j.exger.2011.08.001_bb0285","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00005537-200005000-00003","article-title":"Effects of dietary restriction and antioxidants on presbyacusis","volume":"110","author":"Seidman","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.exger.2011.08.001_bb0290","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/archotol.1997.01900100009001","article-title":"Mitochondrial DNA deletions associated with aging and presbyacusis","volume":"123","author":"Seidman","year":"1999","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"2","key":"10.1016\/j.exger.2011.08.001_bb0295","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0196-0709(00)80003-4","article-title":"Biologic activity of mitochondrial metabolites on aging and age-related hearing loss","volume":"21","author":"Seidman","year":"2000","journal-title":"Am. J. Otol."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0300","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1067\/mhn.2002.127627","article-title":"Influence of lecithin on mitochondrial DNA and age-related hearing loss","volume":"127","author":"Seidman","year":"2002","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear. Res."},{"issue":"10","key":"10.1016\/j.exger.2011.08.001_bb0310","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.neurobiolaging.2006.06.024","article-title":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","volume":"28","author":"Someya","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"46","key":"10.1016\/j.exger.2011.08.001_bb0315","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"Someya","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.exger.2011.08.001_bb0320","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/1874609811003010020","article-title":"Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys","volume":"3","author":"Someya","year":"2010","journal-title":"Curr. Aging Sci."},{"issue":"6","key":"10.1016\/j.exger.2011.08.001_bb0325","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1121\/1.418315","article-title":"Quantitative measures of hair cell loss in CBA\/J and C57BL\/6J mice throughout their life spans","volume":"101","author":"Spongr","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"issue":"6","key":"10.1016\/j.exger.2011.08.001_bb0330","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/00016480152583593","article-title":"Oxidative stress in aging in the C57B16\/J mouse cochlea","volume":"121","author":"Staecker","year":"2001","journal-title":"Acta Otolaryngol."},{"issue":"7","key":"10.1016\/j.exger.2011.08.001_bb0335","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/sj.bjp.0703972","article-title":"The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury","volume":"132","author":"Suzuki","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.exger.2011.08.001_bb0340","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/00206098809081601","article-title":"Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA\/J mouse","volume":"27","author":"Sweet","year":"1988","journal-title":"Audiology"},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0345","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/physrev.00002.2002","article-title":"Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning","volume":"82","author":"Syka","year":"2002","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.exger.2011.08.001_bb0350","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/lary.20244","article-title":"Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344\/NHsd rats","volume":"119","author":"Tanaka","year":"2009","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0355","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1528-1167.2010.02947.x","article-title":"Adenosine kinase as a target for therapeutic antisense strategies in epilepsy","volume":"52","author":"Theofilas","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.exger.2011.08.001_bb0360","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/00005537-199804000-00022","article-title":"Mitochondrial DNA deletion is a predisposing cause for sensorineural hearing loss","volume":"108","author":"Ueda","year":"1998","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.exger.2011.08.001_bb0365","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000106478","article-title":"The complexity of age-related hearing impairment: contributing environmental and genetic factors","volume":"12","author":"Van Eyken","year":"2007","journal-title":"Audiol. Neurootol."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2004.04.016","article-title":"The guide to plotting a cochleogram","volume":"197","author":"Viberg","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2011.08.001_bb0375","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/157015909789152155","article-title":"Adenosine and the auditory system","volume":"7","author":"Vlajkovic","year":"2009","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.exger.2011.08.001_bb0380","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11302-010-9188-5","article-title":"Adenosine amine congener mitigates noise-induced cochlear injury","volume":"6","author":"Vlajkovic","year":"2010","journal-title":"Purinergic Signaling"},{"key":"10.1016\/j.exger.2011.08.001_bb0385","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1002\/jnr.22421","article-title":"The role of adenosine kinase in cochlear development and response to noise","volume":"88","author":"Vlajkovic","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exger.2011.08.001_bb0390","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.bcp.2004.01.010","article-title":"Protection against cisplatin ototoxicity by adenosine agonists","volume":"67","author":"Whitworth","year":"2004","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.exger.2011.08.001_bb0395","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1128\/MCB.16.10.5546","article-title":"Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis","volume":"16","author":"Wilson","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"1\u20132","key":"10.1016\/j.exger.2011.08.001_bb0400","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.heares.2009.12.004","article-title":"A1 adenosine receptor agonists attenuate noise-induced hearing loss","volume":"260","author":"Wong","year":"2010","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.exger.2011.08.001_bb0405","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.nbd.2007.06.006","article-title":"The role of mitochondrial DNA large deletion for the development of presbyacusis in Fischer 344 rats","volume":"27","author":"Yin","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exger.2011.08.001_bb0410","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"Zheng","year":"1999","journal-title":"Hear. Res."},{"issue":"10","key":"10.1016\/j.exger.2011.08.001_bb0415","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.neurobiolaging.2007.12.011","article-title":"A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A\/J mice","volume":"30","author":"Zheng","year":"2009","journal-title":"Neurobiol. Aging"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556511002002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556511002002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T09:17:19Z","timestamp":1741425439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556511002002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":83,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0531556511002002"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2011.08.001","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}