{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:14:15Z","timestamp":1778354055807,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.exger.2012.02.006","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T20:31:51Z","timestamp":1329942711000},"page":"329-336","source":"Crossref","is-referenced-by-count":11,"title":["Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush"],"prefix":"10.1016","volume":"47","author":[{"given":"Qiuju","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanxing","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwok Yeung","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn S.E.","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai-Man","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwok-Fai","family":"So","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wutian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-xiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2012.02.006_bb0005","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(88)90143-2","article-title":"The jun proto-oncogene is positively autoregulated by its product, Jun\/AP-1","volume":"55","author":"Angel","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.exger.2012.02.006_bb0010","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1523\/JNEUROSCI.0372-10.2010","article-title":"Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration","volume":"30","author":"Barnat","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0015","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbi.2010.07.249","article-title":"Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration","volume":"24","author":"Barrette","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2012.02.006_bb0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/exnr.1997.6665","article-title":"c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy","volume":"148","author":"Broude","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0304-3940(85)90459-8","article-title":"Dorsal root innervation of spinal cord neurons after dorsal root implantation into the spinal cord of adult rats","volume":"55","author":"Carlstedt","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exger.2012.02.006_bb0030","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jnr.1041","article-title":"c-Jun regulation in rat neonatal motoneurons postaxotomy","volume":"63","author":"Casanovas","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0035","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3171\/2009.8.JNS09850","article-title":"Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury","volume":"112","author":"Cheng","year":"2010","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.exger.2012.02.006_bb0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/02844319509034329","article-title":"Electrophysiological, morphological, and morphometric effects of aging on nerve regeneration in rats","volume":"29","author":"Choi","year":"1995","journal-title":"Scand. J. Plast. Reconstr. Surg. Hand Surg."},{"key":"10.1016\/j.exger.2012.02.006_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1096-9861(19960617)370:1<97::AID-CNE9>3.0.CO;2-G","article-title":"Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: the influence of a peripheral nerve graft","volume":"370","author":"Chong","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.neuro.13.1.43","article-title":"Peripheral nerve regeneration","volume":"13","author":"Fawcett","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0055","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00438-001-0592-y","article-title":"A genetic analysis of the cytological region 46C-F containing the Drosophila melanogaster homolog of the jun proto-oncogene","volume":"266","author":"Goldstein","year":"2001","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.exger.2012.02.006_bb0060","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1523\/JNEUROSCI.4564-03.2004","article-title":"Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"24","author":"Hayley","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0166-2236(96)01000-4","article-title":"The c-Jun transcription factor\u2014bipotential mediator of neuronal death, survival and regeneration","volume":"20","author":"Herdegen","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(92)90772-2","article-title":"Age-related differences in proliferative responses of Schwann cells during Wallerian degeneration","volume":"573","author":"Komiyama","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0075","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1073\/pnas.2336254100","article-title":"A critical role of neural-specific JNK3 for ischemic apoptosis","volume":"100","author":"Kuan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2012.02.006_bb0080","first-page":"807","article-title":"Effect of age on the number and size of myelinated nervous fibers. A qualitative and quantitative study in the rat","volume":"117","author":"Lapierre","year":"1991","journal-title":"Chirurgie"},{"key":"10.1016\/j.exger.2012.02.006_bb0085","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.92.21.9771","article-title":"Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor","volume":"92","author":"Li","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2012.02.006_bb0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.mcn.2004.07.001","article-title":"Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons","volume":"27","author":"Lindwall","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0095","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/01.wnr.0000183324.75499.fc","article-title":"The role of p-c-Jun in survival and outgrowth of developing sensory neurons","volume":"16","author":"Lindwall","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.exger.2012.02.006_bb0100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neures.2009.06.003","article-title":"Synergistic effect of GDNF and NGF on axonal branching and elongation in vitro","volume":"65","author":"Madduri","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0105","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.biomaterials.2009.11.073","article-title":"Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration","volume":"31","author":"Madduri","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.exger.2012.02.006_bb0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.expneurol.2008.10.012","article-title":"Deafferentation and axotomy each cause neurturin-independent upregulation of c-Jun in rodent pelvic ganglia","volume":"215","author":"Nangle","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(88)90973-0","article-title":"Effect of age and maturation on sudomotor nerve regeneration in mice","volume":"447","author":"Navarro","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0120","first-page":"1","article-title":"Recovery of sensibility and sudomotor activity in the hand after nerve suture","volume":"300","author":"Onne","year":"1962","journal-title":"Acta Chir. Scand. Suppl."},{"key":"10.1016\/j.exger.2012.02.006_bb0125","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00355-6","article-title":"JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis","volume":"38","author":"Putcha","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2012.02.006_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2004.06.005","article-title":"The AP-1 transcription factor c-Jun is required for efficient axonal regeneration","volume":"43","author":"Raivich","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2012.02.006_bb0135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2202-9-88","article-title":"Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair","volume":"9","author":"Saito","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0301-0082(98)00033-1","article-title":"Experimental strategies to promote axonal regeneration after traumatic central nervous system injury","volume":"56","author":"Stichel","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.exger.2012.02.006_bb0145","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1523\/JNEUROSCI.4970-04.2005","article-title":"Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascade","volume":"25","author":"Sun","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2012.02.006_bb0150","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.903080205","article-title":"Myelinated fiber regeneration after crush injury is retarded in sciatic nerves of aging mice","volume":"308","author":"Tanaka","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-4886(92)90022-I","article-title":"Myelinated fiber regeneration after sciatic nerve crush: morphometric observations in young adult and aging mice and the effects of macrophage suppression and conditioning lesions","volume":"118","author":"Tanaka","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0006-8993(95)00762-F","article-title":"The effect of aging on efferent nerve fibers regeneration in mice","volume":"696","author":"Verdu","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1529-8027.2000.00026.x","article-title":"Influence of aging on peripheral nerve function and regeneration","volume":"5","author":"Verdu","year":"2000","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.exger.2012.02.006_bb0170","first-page":"648","article-title":"Degeneration and regeneration of the peripheral nervous system with aging","volume":"23","author":"Verdu","year":"1995","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0175","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jns.2009.06.034","article-title":"JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease","volume":"285","author":"Wang","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.exger.2012.02.006_bb0180","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/exnr.1996.0153","article-title":"Potential roles of gene expression change in adult rat spinal motoneurons following axonal injury: a comparison among c-Jun, off-affinity nerve growth factor receptor (LNGFR), and nitric oxide synthase (NOS)","volume":"141","author":"Wu","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0185","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/jnen\/60.10.972","article-title":"Altered immediate early gene expression in injured diabetic nerve: implications in regeneration","volume":"60","author":"Xu","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.exger.2012.02.006_bb0190","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.wnr.0000214390.35480.1a","article-title":"Age-related reexpression of p75 in axotomized motoneurons","volume":"17","author":"Yuan","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.exger.2012.02.006_bb0195","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2010.01.038","article-title":"Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury","volume":"1320","author":"Yuan","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2007.04.084","article-title":"A subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats","volume":"1159","author":"Yuan","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2012.02.006_bb0205","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000320571","article-title":"Differential patterns of local gene regulation in crush lesions of the rat optic and sciatic nerve: relevance to posttraumatic regeneration","volume":"26","author":"Zickler","year":"2010","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651200037X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651200037X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T23:26:29Z","timestamp":1543188389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155651200037X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S053155651200037X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2012.02.006","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}