{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:58:39Z","timestamp":1790031519803,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.exger.2013.12.017","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T10:30:54Z","timestamp":1389436254000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-9806","authenticated-orcid":false,"given":"Arto P.","family":"Koistinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa P.","family":"Halmesm\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarkko T.","family":"Iivarinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari P.A.","family":"Arokoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.J.","family":"Brama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka S.","family":"Jurvelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki J.","family":"Helminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2013.12.017_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/S0029665108005971","article-title":"Exercise for optimising peak bone mass in women","volume":"67","author":"Bailey","year":"2008","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.exger.2013.12.017_bb0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0531-5565(99)00016-9","article-title":"Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly","volume":"34","author":"Bailey","year":"1999","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2013.12.017_bb0015","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/jbmr.5650080806","article-title":"Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats","volume":"8","author":"Barengolts","year":"1993","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.exger.2013.12.017_bb0020","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1007\/BF01673401","article-title":"Age-related changes in female femoral neck geometry: implications for bone strength","volume":"53","author":"Beck","year":"1993","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0025","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1097\/00005768-200212000-00015","article-title":"Age does not influence the bone response to treadmill exercise in female rats","volume":"34","author":"Bennell","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.exger.2013.12.017_bb0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0031-9384(74)90207-8","article-title":"Absence of weight regulation in exercising hamsters","volume":"12","author":"Borer","year":"1974","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.exger.2013.12.017_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0031-9384(77)90089-0","article-title":"Exercise-induced growth in golden hamsters: effects of age, weight, and activity level","volume":"18","author":"Borer","year":"1977","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.exger.2013.12.017_bb0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/jn\/109.2.222","article-title":"The effect of exercise and dietary protein levels on somatic growth, body composition, and serum lipid levels in adult hamsters","volume":"109","author":"Borer","year":"1979","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2013.12.017_bb0045","doi-asserted-by":"crossref","first-page":"031102","DOI":"10.1117\/1.1922927","article-title":"Infrared analysis of bone in health and disease","volume":"10","author":"Boskey","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.exger.2013.12.017_bb0050","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bone.2008.05.004","article-title":"Three-dimensional microstructure of the bone in a hamster model of senile osteoporosis","volume":"43","author":"Chen","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02553293","article-title":"Mechanical properties of collagen from decalcified rat femur in relation to age and in vitro maturation","volume":"39","author":"Danielsen","year":"1986","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0060","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bone.2005.07.022","article-title":"Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element","volume":"37","author":"De Souza","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0065","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bone.2005.02.013","article-title":"Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia","volume":"36","author":"Fritton","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0070","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1359\/jbmr.2003.18.11.1964","article-title":"Rapid loss of bone mineral density of the femoral neck after cessation of ice hockey training: a 6-year longitudinal study in males","volume":"18","author":"Gustavsson","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s001980050004","article-title":"Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography","volume":"11","author":"Hasegawa","year":"2000","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00421-011-2008-y","article-title":"Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study","volume":"112","author":"Hind","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.exger.2013.12.017_bb0085","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bone.2008.07.254","article-title":"Changes in subchondral bone mineral density and collagen matrix organization in growing horses","volume":"43","author":"Holopainen","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1620\/tjem.185.15","article-title":"Effects of exercise at different ages on bone density and mechanical properties of femoral bone of aged mice","volume":"185","author":"Hoshi","year":"1998","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.exger.2013.12.017_bb0095","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.exger.2009.08.005","article-title":"Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix","volume":"44","author":"Isaksson","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2013.12.017_bb0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00223-009-9273-3","article-title":"Physical exercise improves properties of bone and its collagen network in growing and maturing mice","volume":"85","author":"Isaksson","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0105","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/jor.21186","article-title":"Collagen and mineral deposition in rabbit cortical bone during maturation and growth: effects on tissue properties","volume":"28","author":"Isaksson","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S8756-3282(98)00189-6","article-title":"Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat","volume":"24","author":"Iwamoto","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S8756-3282(98)00076-3","article-title":"Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia","volume":"23","author":"Jamsa","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0120","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1359\/jbmr.2003.18.7.1292","article-title":"Femoral neck response to exercise and subsequent deconditioning in young and adult rats","volume":"18","author":"Jarvinen","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0125","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S8756-3282(03)00212-6","article-title":"Effects of endurance exercise on three-dimensional trabecular bone microarchitecture in young growing rats","volume":"33","author":"Joo","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1469-7580.2010.01270.x","article-title":"Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters","volume":"217","author":"Julkunen","year":"2010","journal-title":"J. Anat."},{"key":"10.1016\/j.exger.2013.12.017_bb0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7326\/0003-4819-123-1-199507010-00003","article-title":"Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players","volume":"123","author":"Kannus","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.exger.2013.12.017_bb0140","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0140-6736(00)82020-6","article-title":"Exercise during growth and bone mineral density and fractures in old age","volume":"355","author":"Karlsson","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2013.12.017_bb0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/00016470510030274","article-title":"Maternity and bone mineral density","volume":"76","author":"Karlsson","year":"2005","journal-title":"Acta Orthop."},{"key":"10.1016\/j.exger.2013.12.017_bb0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s002230010060","article-title":"Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL\/6J mice but not in C3H\/Hej mice","volume":"66","author":"Kodama","year":"2000","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0155","first-page":"172","article-title":"Training a large number of laboratory mice using running wheels and analyzing running behavior by use of a computer-assisted system","volume":"47","author":"Lapvetelainen","year":"1997","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.exger.2013.12.017_bb0160","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/bjsm.36.4.250","article-title":"Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic review","volume":"36","author":"MacKelvie","year":"2002","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.exger.2013.12.017_bb0165","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bone.2006.06.008","article-title":"Bone tissue compositional differences in women with and without osteoporotic fracture","volume":"39","author":"McCreadie","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0170","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/geronj\/41.4.445","article-title":"Age-related differences in the bone mineralization pattern of rats following exercise","volume":"41","author":"McDonald","year":"1986","journal-title":"J. Gerontol."},{"key":"10.1016\/j.exger.2013.12.017_bb0175","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00198-004-1749-4","article-title":"Bone gained from physical activity and lost through detraining: a longitudinal study in young males","volume":"16","author":"Nordstrom","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jmor.10587","article-title":"Bone modeling response to voluntary exercise in the hindlimb of mice","volume":"269","author":"Plochocki","year":"2008","journal-title":"J. Morphol."},{"key":"10.1016\/j.exger.2013.12.017_bb0185","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1359\/jbmr.1999.14.3.321","article-title":"Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training?","volume":"14","author":"Puustjarvi","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0190","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1152\/jappl.1990.68.1.130","article-title":"Bone mechanical properties after exercise training in young and old rats","volume":"68","author":"Raab","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.exger.2013.12.017_bb0195","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/jbmr.5650060712","article-title":"A histomorphometric study of cortical bone activity during increased weight-bearing exercise","volume":"6","author":"Raab","year":"1991","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0200","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jbiomech.2006.03.002","article-title":"Local variations in the micromechanical properties of mouse femur: the involvement of collagen fiber orientation and mineralization","volume":"40","author":"Ramasamy","year":"2007","journal-title":"J. Biomech."},{"key":"10.1016\/j.exger.2013.12.017_bb0205","first-page":"63","article-title":"Overview of osteoporosis","volume":"154","author":"Riggs","year":"1991","journal-title":"West. J. Med."},{"key":"10.1016\/j.exger.2013.12.017_bb0210","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1359\/jbmr.2002.17.8.1545","article-title":"Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts","volume":"17","author":"Robling","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.exger.2013.12.017_bb0215","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1007\/BF02406128","article-title":"Skeletal strain and the functional significance of bone architecture","volume":"36","author":"Rubin","year":"1984","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0220","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/8756-3282(93)90087-Q","article-title":"Adaptations of immature trabecular bone to moderate exercise: geometrical, biochemical, and biomechanical correlates","volume":"14","author":"Salem","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0225","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jbmr.5650090317","article-title":"Long-term exercise of young and adult female rats: effect on femoral neck biomechanical competence and bone structure","volume":"9","author":"Sogaard","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0230","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00003086-198105000-00007","article-title":"Effects of activity on bone growth and development in the rat","author":"Steinberg","year":"1981","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0235","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jbmr.5650010504","article-title":"The effects of immobilization on bone histomorphometry in rats","volume":"1","author":"Turner","year":"1986","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0240","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","article-title":"Basic biomechanical measurements of bone: a tutorial","volume":"14","author":"Turner","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.exger.2013.12.017_bb0245","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/jbmr.5650101016","article-title":"Aging changes mechanical loading thresholds for bone formation in rats","volume":"10","author":"Turner","year":"1995","journal-title":"J. Bone Miner. Res."},{"issue":"49 Suppl.","key":"10.1016\/j.exger.2013.12.017_bb0250","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1007\/BF02555080","article-title":"Pathogenesis of osteoporosis","author":"Vaananen","year":"1991","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0255","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1359\/JBMR.050107","article-title":"Reduced training is associated with increased loss of BMD","volume":"20","author":"Valdimarsson","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0260","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00198-005-2035-9","article-title":"The role of collagen in bone strength","volume":"17","author":"Viguet-Carrin","year":"2006","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.exger.2013.12.017_bb0265","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1359\/JBMR.041222","article-title":"Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance","volume":"20","author":"Warden","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2013.12.017_bb0270","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1359\/jbmr.061107","article-title":"Exercise when young provides lifelong benefits to bone structure and strength","volume":"22","author":"Warden","year":"2007","journal-title":"J. Bone Miner. Res."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556514000035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556514000035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:22:40Z","timestamp":1759976560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556514000035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":54,"alternative-id":["S0531556514000035"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2013.12.017","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2013.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}