{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:43:22Z","timestamp":1792039402034,"version":"4.4.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH Office of Research Infrastructure Programs","award":["(P40OD010440)"],"award-info":[{"award-number":["(P40OD010440)"]}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"crossref","award":["MFAG11509"],"award-info":[{"award-number":["MFAG11509"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heinrich Heine University","award":["SFF701301988"],"award-info":[{"award-number":["SFF701301988"]}]},{"name":"Heinrich Heine University","award":["Forschungskommission 43\/2013"],"award-info":[{"award-number":["Forschungskommission 43\/2013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.exger.2014.03.026","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T05:46:19Z","timestamp":1396590379000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis"],"prefix":"10.1016","volume":"56","author":[{"given":"Silvia","family":"Maglioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Runci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjumara","family":"Shaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-4321","authenticated-orcid":false,"given":"Natascia","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0235","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0896-6273(03)00816-X","article-title":"Regulation of C. elegans longevity by specific gustatory and olfactory neurons","volume":"41","author":"Alcedo","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2014.03.026_bb0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fgene.2013.00071","article-title":"Neuronal inputs and outputs of aging and longevity","volume":"4","author":"Alcedo","year":"2013","journal-title":"Front. Genet."},{"issue":"6763","key":"10.1016\/j.exger.2014.03.026_bb0230","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/45544","article-title":"Regulation of lifespan by sensory perception in Caenorhabditis elegans","volume":"402","author":"Apfeld","year":"1999","journal-title":"Nature"},{"issue":"5554","key":"10.1016\/j.exger.2014.03.026_bb0130","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.1065768","article-title":"Regulation of life-span by germ-line stem cells in Caenorhabditis elegans","volume":"295","author":"Arantes-Oliveira","year":"2002","journal-title":"Science"},{"issue":"18","key":"10.1016\/j.exger.2014.03.026_bb0315","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1097\/00001756-200512190-00005","article-title":"Selective sensitivity of Caenorhabditis elegans neurons to RNA interference","volume":"16","author":"Asikainen","year":"2005","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0340","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0896-6273(91)90276-6","article-title":"Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans","volume":"7","author":"Bargmann","year":"1991","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0335","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0290","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cm.970200108","article-title":"Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans","volume":"20","author":"Barstead","year":"1991","journal-title":"Cell Motil. Cytoskeleton"},{"issue":"12","key":"10.1016\/j.exger.2014.03.026_bb0155","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1096\/fj.10-162941","article-title":"Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism","volume":"24","author":"Butler","year":"2010","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0050","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nn.2291","article-title":"Oxidation of a potassium channel causes progressive sensory function loss during aging","volume":"12","author":"Cai","year":"2009","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arr.2007.07.001","article-title":"Converging concepts: adaptive response, preconditioning, and the Yerkes\u2013Dodson Law are manifestations of hormesis","volume":"7","author":"Calabrese","year":"2008","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exger.2012.02.004","article-title":"Hormesis: toxicological foundations and role in aging research","volume":"48","author":"Calabrese","year":"2013","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0200","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/0960327112455069","article-title":"Hormesis: its impact on medicine and health","volume":"32","author":"Calabrese","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0385","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","article-title":"Protective role of autophagy in neonatal hypoxia\u2013ischemia induced brain injury","volume":"32","author":"Carloni","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0355","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1474-9726.2007.00305.x","article-title":"Longevity determined by developmental arrest genes in Caenorhabditis elegans","volume":"6","author":"Chen","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2014.03.026_bb0420","first-page":"1","article-title":"The measurement and analysis of age-related changes in Caenorhabditis elegans","author":"Collins","year":"2008","journal-title":"WormBook"},{"issue":"19","key":"10.1016\/j.exger.2014.03.026_bb0120","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2009.08.016","article-title":"Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain","volume":"19","author":"Copeland","year":"2009","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-4933-10-15","article-title":"Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: mitochondria as a \u201cchi\u201d","volume":"10","author":"Cornelius","year":"2013","journal-title":"Immun. Ageing"},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0190","doi-asserted-by":"crossref","first-page":"B109","DOI":"10.1093\/gerona\/57.3.B109","article-title":"Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity","volume":"57","author":"Cypser","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"22","key":"10.1016\/j.exger.2014.03.026_bb0350","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.cub.2007.10.017","article-title":"Hypoxic preconditioning requires the apoptosis protein CED-4 in C. elegans","volume":"17","author":"Dasgupta","year":"2007","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0125","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/hmg\/ddl477","article-title":"Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice","volume":"16","author":"Dell'agnello","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0265","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2010.12.016","article-title":"The cell-non-autonomous nature of electron transport chain-mediated longevity","volume":"144","author":"Durieux","year":"2011","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0300","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/genetics\/80.2.297","article-title":"Chemotaxis-defective mutants of the nematode Caenorhabditis elegans","volume":"80","author":"Dusenbery","year":"1975","journal-title":"Genetics"},{"issue":"5707","key":"10.1016\/j.exger.2014.03.026_bb0240","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.1105299","article-title":"Anticonvulsant medications extend worm life-span","volume":"307","author":"Evason","year":"2005","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0330","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1534-5807(01)00071-5","article-title":"Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans","volume":"1","author":"Feng","year":"2001","journal-title":"Dev. Cell"},{"issue":"12","key":"10.1016\/j.exger.2014.03.026_bb0045","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/gerona\/59.12.1251","article-title":"Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty","volume":"59","author":"Glenn","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6909","key":"10.1016\/j.exger.2014.03.026_bb0040","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature01135","article-title":"Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans","volume":"419","author":"Herndon","year":"2002","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.exger.2014.03.026_bb0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0531-5565(78)90027-X","article-title":"Age dependent changes in the behavior of Caenorhabditis elegans on attraction to Escherichia coli","volume":"13","author":"Hosono","year":"1978","journal-title":"Exp. Gerontol."},{"issue":"34","key":"10.1016\/j.exger.2014.03.026_bb0025","first-page":"re4","article-title":"Subfield history: Caenorhabditis elegans as a system for analysis of the genetics of aging","author":"Johnson","year":"2002","journal-title":"Sci. Aging Knowledge Environ."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0275","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome-wide RNAi screening in Caenorhabditis elegans","volume":"30","author":"Kamath","year":"2003","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0320","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2000-2-1-research0002","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"Kamath","year":"2001","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0065","doi-asserted-by":"crossref","first-page":"e1000372","DOI":"10.1371\/journal.pbio.1000372","article-title":"Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age","volume":"8","author":"Kauffman","year":"2010","journal-title":"PLoS Biol."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0310","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0896-6273(00)80202-0","article-title":"Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans","volume":"17","author":"Komatsu","year":"1996","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1159\/000211949","article-title":"Frailty syndrome: a transitional state in a dynamic process","volume":"55","author":"Lang","year":"2009","journal-title":"Gerontology"},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0250","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ydbio.2006.11.028","article-title":"Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans","volume":"303","author":"Lans","year":"2007","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1056","article-title":"A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity","volume":"33","author":"Lee","year":"2003","journal-title":"Nat. Genet."},{"issue":"5619","key":"10.1016\/j.exger.2014.03.026_bb0145","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1083614","article-title":"DAF-16 target genes that control C. elegans life-span and metabolism","volume":"300","author":"Lee","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.exger.2014.03.026_bb0225","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-cellbio-092910-154240","article-title":"Sensory perception and aging in model systems: from the outside in","volume":"27","author":"Linford","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0085","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cmet.2013.08.007","article-title":"Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans","volume":"18","author":"Liu","year":"2013","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0255","doi-asserted-by":"crossref","first-page":"e1000376","DOI":"10.1371\/journal.pbio.1000376","article-title":"A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan","volume":"8","author":"Maier","year":"2010","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.arr.2007.07.003","article-title":"Hormesis: a promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders","volume":"7","author":"Marini","year":"2008","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"10.1016\/j.exger.2014.03.026_bb0325","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jez.545","article-title":"Retention time of attenuated response to diacetyl after pre-exposure to diacetyl in Caenorhabditis elegans","volume":"311","author":"Matsuura","year":"2009","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"issue":"6","key":"10.1016\/j.exger.2014.03.026_bb0210","doi-asserted-by":"crossref","first-page":"997","DOI":"10.4161\/auto.20748","article-title":"Hormesis: protecting neurons against cellular stress in Parkinson disease","volume":"8","author":"Matus","year":"2012","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kft102","article-title":"Mitochondria as a target of environmental toxicants","volume":"134","author":"Meyer","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"47","key":"10.1016\/j.exger.2014.03.026_bb0060","doi-asserted-by":"crossref","first-page":"10894","DOI":"10.1523\/JNEUROSCI.3600-04.2005","article-title":"Aging-dependent and -independent modulation of associative learning behavior by insulin\/insulin-like growth factor-1 signal in Caenorhabditis elegans","volume":"25","author":"Murakami","year":"2005","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00007611-199903000-00002","article-title":"Aging and sensory senescence","volume":"92","author":"Nusbaum","year":"1999","journal-title":"South. Med. J."},{"issue":"7470","key":"10.1016\/j.exger.2014.03.026_bb0395","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature12639","article-title":"Functional interaction between autophagy and ciliogenesis","volume":"502","author":"Pampliega","year":"2013","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.exger.2014.03.026_bb0075","doi-asserted-by":"crossref","first-page":"9274","DOI":"10.1073\/pnas.1011711108","article-title":"Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons","volume":"108","author":"Pan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0305","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0012-1606(86)90314-3","article-title":"Mutant sensory cilia in the nematode Caenorhabditis elegans","volume":"117","author":"Perkins","year":"1986","journal-title":"Dev. Biol."},{"issue":"7169","key":"10.1016\/j.exger.2014.03.026_bb0245","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature05991","article-title":"An antidepressant that extends lifespan in adult Caenorhabditis elegans","volume":"450","author":"Petrascheck","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0185","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10522-011-9334-7","article-title":"Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans","volume":"12","author":"Pietsch","year":"2011","journal-title":"Biogerontology"},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0415","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0168-9525(99)01695-9","article-title":"Chemosensation: molecular mechanisms in worms and mammals","volume":"15","author":"Prasad","year":"1999","journal-title":"Trends Genet."},{"issue":"11","key":"10.1016\/j.exger.2014.03.026_bb0140","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.exger.2005.06.015","article-title":"Metabolism in the Caenorhabditis elegans Mit mutants","volume":"40","author":"Rea","year":"2005","journal-title":"Exp. Gerontol."},{"issue":"10","key":"10.1016\/j.exger.2014.03.026_bb0115","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1371\/journal.pbio.0050259","article-title":"Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans","volume":"5","author":"Rea","year":"2007","journal-title":"PLoS Biol."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/156720511795745401","article-title":"Mitochondria as a therapeutic target for aging and neurodegenerative diseases","volume":"8","author":"Reddy","year":"2011","journal-title":"Curr. Alzheimer Res."},{"issue":"6","key":"10.1016\/j.exger.2014.03.026_bb0165","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)","volume":"45","author":"Ristow","year":"2010","journal-title":"Exp. Gerontol."},{"issue":"8","key":"10.1016\/j.exger.2014.03.026_bb0380","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.4161\/auto.6994","article-title":"Autophagy protects against hypoxic injury in C. elegans","volume":"4","author":"Samokhvalov","year":"2008","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0365","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.exger.2012.12.002","article-title":"Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans","volume":"48","author":"Schiavi","year":"2013","journal-title":"Exp. Gerontol."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0180","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/acel.12076","article-title":"Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension","volume":"12","author":"Schmeisser","year":"2013","journal-title":"Aging Cell"},{"issue":"Suppl. 1","key":"10.1016\/j.exger.2014.03.026_bb0020","doi-asserted-by":"crossref","first-page":"i76","DOI":"10.1093\/geronb\/gbp048","article-title":"Assessment of sensory function in the National Social Life, Health, and Aging Project","volume":"64","author":"Schumm","year":"2009","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"issue":"6","key":"10.1016\/j.exger.2014.03.026_bb0370","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(94)90028-0","article-title":"The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily","volume":"79","author":"Sengupta","year":"1994","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0345","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1602\/neurorx.1.1.26","article-title":"Hypoxic preconditioning protects against ischemic brain injury","volume":"1","author":"Sharp","year":"2004","journal-title":"NeuroRx"},{"issue":"1","key":"10.1016\/j.exger.2014.03.026_bb0285","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/genetics\/139.1.171","article-title":"Mutations affecting the chemosensory neurons of Caenorhabditis elegans","volume":"139","author":"Starich","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.exger.2014.03.026_bb0425","first-page":"1","article-title":"Maintenance of C. elegans","author":"Stiernagle","year":"2006","journal-title":"WormBook"},{"issue":"7470","key":"10.1016\/j.exger.2014.03.026_bb0400","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature12606","article-title":"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites","volume":"502","author":"Tang","year":"2013","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.exger.2014.03.026_bb0080","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1523\/JNEUROSCI.6606-10.2011","article-title":"Spontaneous age-related neurite branching in Caenorhabditis elegans","volume":"31","author":"Tank","year":"2011","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0170","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.mehy.2005.09.009","volume":"66","author":"Tapia","year":"2006","journal-title":"Med. Hypotheses"},{"issue":"7","key":"10.1016\/j.exger.2014.03.026_bb0030","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00391-013-0533-5","article-title":"Healthy aging: what can we learn from Caenorhabditis elegans?","volume":"46","author":"Torgovnick","year":"2013","journal-title":"Z. Gerontol. Geriatr."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0390","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4161\/auto.5618","article-title":"Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans","volume":"4","author":"Toth","year":"2008","journal-title":"Autophagy"},{"issue":"26","key":"10.1016\/j.exger.2014.03.026_bb0070","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1523\/JNEUROSCI.1494-11.2012","article-title":"Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system","volume":"32","author":"Toth","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2014.03.026_bb0100","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fgene.2012.00244","article-title":"Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration","volume":"3","author":"Troulinaki","year":"2012","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0110","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/biot.200600248","article-title":"Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction","volume":"2","author":"Ventura","year":"2007","journal-title":"Biotechnol. J."},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1474-9726.2005.00149.x","article-title":"Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans","volume":"4","author":"Ventura","year":"2005","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.exger.2014.03.026_bb0160","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.exger.2006.06.060","article-title":"Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases","volume":"41","author":"Ventura","year":"2006","journal-title":"Exp. Gerontol."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0280","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1474-9726.2009.00482.x","article-title":"p53\/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress","volume":"8","author":"Ventura","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2014.03.026_bb0360","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu. Rev. Genet."},{"issue":"6","key":"10.1016\/j.exger.2014.03.026_bb0260","doi-asserted-by":"crossref","first-page":"e1001084","DOI":"10.1371\/journal.pbio.1001084","article-title":"The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans","volume":"9","author":"Walter","year":"2011","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0295","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.70.3.817","article-title":"Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants","volume":"70","author":"Ward","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2014.03.026_bb0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.pathmechdis.2.010506.092044","article-title":"The aging brain","volume":"3","author":"Yankner","year":"2008","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.exger.2014.03.026_bb0105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/ars.2012.4774","article-title":"Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration","volume":"20","author":"Yin","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.exger.2014.03.026_bb0035","doi-asserted-by":"crossref","first-page":"e1002082","DOI":"10.1371\/journal.pgen.1002082","article-title":"A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans","volume":"7","author":"Youngman","year":"2011","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.exger.2014.03.026_bb0375","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1073\/pnas.1018695108","article-title":"mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.exger.2014.03.026_bb0405","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/iub.1126","article-title":"Mitochondrial involvement in neurodegenerative diseases","volume":"65","author":"Zsurka","year":"2013","journal-title":"IUBMB Life"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651400117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651400117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:25:16Z","timestamp":1648754716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155651400117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":83,"alternative-id":["S053155651400117X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2014.03.026","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2014.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}