{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:55Z","timestamp":1788871195673,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Servier Deutschland GmbH, Munich"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.exger.2014.09.002","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T21:23:27Z","timestamp":1409693007000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Ivabradine in combination with beta-blocker reduces symptoms and improves quality of life in elderly patients with stable angina pectoris: Age-related results from the ADDITIONS study"],"prefix":"10.1016","volume":"59","author":[{"given":"Ursula","family":"M\u00fcller-Werdan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"St\u00f6ckl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Ebelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Nuding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"H\u00f6pfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Werdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.exger.2014.09.002_bb9000","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10557-011-6327-3","article-title":"Efficacy of ivabradine in combination with beta-blocker versus uptitration of beta-blocker in patients with stable angina","volume":"25","author":"Amosova","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"9744","key":"10.1016\/j.exger.2014.09.002_bb0005","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(10)61259-7","article-title":"Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial","volume":"376","author":"B\u00f6hm","year":"2010","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.exger.2014.09.002_bb0010","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.0000048143.25023.87","article-title":"Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina. A randomized, double-blind, multicentered, placebo-controlled trial","volume":"107","author":"Borer","year":"2003","journal-title":"Circulation"},{"issue":"1014","key":"10.1016\/j.exger.2014.09.002_bb0015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/pgmj.2009.084384","article-title":"Inadequate control of heart rate in patients with stable angina: results from the European heart survey","volume":"86","author":"Daly","year":"2010","journal-title":"Postgrad. Med. J."},{"issue":"9","key":"10.1016\/j.exger.2014.09.002_bb0020","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00392-008-0680-7","article-title":"Heart failure, aging and beta-blockers: the need of more data on tolerability and efficacy","volume":"97","author":"Damman","year":"2008","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.exger.2014.09.002_bb0025","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/jech.2005.044255","article-title":"Influence of socioeconomic status on clinical outcomes and quality of life after percutaneous coronary intervention","volume":"60","author":"Denvir","year":"2006","journal-title":"J. Epidemiol. Community Health"},{"issue":"7","key":"10.1016\/j.exger.2014.09.002_bb0040","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1185\/030079905X50543","article-title":"Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents","volume":"21","author":"Di Francesco","year":"2005","journal-title":"Curr. Med. Res. Opin."},{"issue":"16","key":"10.1016\/j.exger.2014.09.002_bb0035","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2165\/00003495-200464160-00003","article-title":"Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease","volume":"64","author":"Di Francesco","year":"2004","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.exger.2014.09.002_bb0030","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/eurheartj\/ehi190","article-title":"Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease","volume":"26","author":"Diaz","year":"2005","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.exger.2014.09.002_bb0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1365-2125.2006.02769.x","article-title":"Effectiveness of beta-blocker therapy in daily practice patients with advanced chronic heart failure; is there an effect-modification by age?","volume":"63","author":"Dobre","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"11","key":"10.1016\/j.exger.2014.09.002_bb0050","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005650-199711000-00002","article-title":"Modeling valuations for EuroQol health states","volume":"35","author":"Dolan","year":"1997","journal-title":"Med. Care"},{"key":"10.1016\/j.exger.2014.09.002_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7525-8-13","article-title":"A review of health utilities using the EQ-5D in studies of cardiovascular disease","volume":"8","author":"Dyer","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"issue":"19","key":"10.1016\/j.exger.2014.09.002_bb0060","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/eurheartj\/ehr343","article-title":"Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study","volume":"32","author":"Ekman","year":"2011","journal-title":"Eur. Heart J."},{"issue":"24","key":"10.1016\/j.exger.2014.09.002_bb0065","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1016\/j.jacc.2012.07.013","volume":"60","author":"Fihn","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.exger.2014.09.002_bb0070","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1161\/01.CIR.90.5.2333","article-title":"Effects of acute \u03b2-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise","volume":"90","author":"Fleg","year":"1994","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.exger.2014.09.002_bb0075","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jacc.2007.04.079","article-title":"Resting heart rate in cardiovascular disease","volume":"50","author":"Fox","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9641","key":"10.1016\/j.exger.2014.09.002_bb0080","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0140-6736(08)61170-8","article-title":"Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Fox","year":"2008","journal-title":"Lancet"},{"issue":"9641","key":"10.1016\/j.exger.2014.09.002_bb0085","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(08)61171-X","article-title":"Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial","volume":"372","author":"Fox","year":"2008","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.exger.2014.09.002_bb0090","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1093\/eurheartj\/ehp358","article-title":"Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial","volume":"30","author":"Fox","year":"2009","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.exger.2014.09.002_bb0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2165\/00019053-199916020-00003","article-title":"Review of quality-of-life evaluations in patients with angina pectoris","volume":"16","author":"Gandjour","year":"1999","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.exger.2014.09.002_bb0100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1477-7525-8-54","article-title":"Mapping of the EQ-5D index from clinical outcome measures and demographic variables in patients with coronary heart disease","volume":"8","author":"Goldsmith","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"issue":"11","key":"10.1016\/j.exger.2014.09.002_bb0105","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/jama.1992.03490110055029","article-title":"The exclusion of the elderly and women from clinical trials in acute myocardial infarction","volume":"268","author":"Gurwitz","year":"1992","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.exger.2014.09.002_bb0110","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/sj.bjp.0707673","article-title":"Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents","volume":"153","author":"Heusch","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"24","key":"10.1016\/j.exger.2014.09.002_bb0115","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1053\/euhj.1999.1752","article-title":"Coronary angioplasty in octogenarians","volume":"20","author":"K\u00e4hler","year":"1999","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.exger.2014.09.002_bb0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1477-7525-8-143","article-title":"Health status of the advanced elderly in six European countries: results from a representative survey using EQ-5D and SF-12","volume":"8","author":"K\u00f6nig","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"issue":"4","key":"10.1016\/j.exger.2014.09.002_bb0125","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ahj.2009.06.008","article-title":"Treatment of stable angina pectoris by ivabradine in every day practice: the REDUCTION study","volume":"158","author":"K\u00f6ster","year":"2009","journal-title":"Am. Heart J."},{"issue":"10","key":"10.1016\/j.exger.2014.09.002_bb0130","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00392-010-0172-4","article-title":"Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice","volume":"99","author":"K\u00f6ster","year":"2010","journal-title":"Clin. Res. Cardiol."},{"issue":"2","key":"10.1016\/j.exger.2014.09.002_bb0135","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00392-010-0220-0","article-title":"Ivabradine for the treatment of stable angina pectoris in octogenarians","volume":"100","author":"K\u00f6ster","year":"2011","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.exger.2014.09.002_bb0140","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1152\/physrev.1993.73.2.413","article-title":"Cardiovascular regulatory mechanisms in advanced age","volume":"73","author":"Lakatta","year":"1993","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.exger.2014.09.002_bb0145","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/jama.286.6.708","article-title":"Representation of elderly persons and women in published randomized trials of acute coronary syndromes","volume":"286","author":"Lee","year":"2001","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.exger.2014.09.002_bb0150","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10198-005-0309-y","article-title":"Estimating utility data from clinical indicators for patients with stable angina","volume":"6","author":"Longworth","year":"2005","journal-title":"Eur. J. Health Econ."},{"issue":"10","key":"10.1016\/j.exger.2014.09.002_bb0155","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/eurjhf\/hfq154","article-title":"EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot)","volume":"12","author":"Maggioni","year":"2010","journal-title":"Eur. J. Heart Fail."},{"issue":"38","key":"10.1016\/j.exger.2014.09.002_bb0160","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.exger.2014.09.002_bb0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2165\/00003495-200666020-00001","article-title":"Impact of increased heart rate on clinical outcomes in hypertension: implications for antihypertensive drug therapy","volume":"66","author":"Palatini","year":"2006","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.exger.2014.09.002_bb0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0733-8651(05)70054-0","article-title":"Cardiovascular pharmacotherapy of aging","volume":"17","author":"Podrazik","year":"1999","journal-title":"Cardiol. Clin."},{"issue":"1","key":"10.1016\/j.exger.2014.09.002_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/oxfordjournals.eurheartj.a014695","article-title":"Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS)","volume":"17","author":"Rehnqvist","year":"1996","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.exger.2014.09.002_bb0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00392-010-0207-x","article-title":"Heart rate reduction in cardiovascular disease and therapy","volume":"100","author":"Reil","year":"2010","journal-title":"Clin. Res. Cardiol."},{"issue":"9 Suppl. A","key":"10.1016\/j.exger.2014.09.002_bb0185","first-page":"1007","article-title":"Low incidence of significant bradycardia during therapy with an I(f) current inhibitor ivabradine: heart rate reduction depends on baseline heart rate","volume":"49","author":"Savelieva","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.exger.2014.09.002_bb0190","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00392-006-0393-8","article-title":"Present treatment of acute myocardial infarction in patients over 75years","volume":"95","author":"Schuler","year":"2006","journal-title":"Clin. Res. Cardiol."},{"issue":"5","key":"10.1016\/j.exger.2014.09.002_bb0195","doi-asserted-by":"crossref","first-page":"e36284","DOI":"10.1371\/journal.pone.0036284","article-title":"Heart rate and use of beta-blockers in stable outpatients with coronary artery disease","volume":"7","author":"Steg","year":"2012","journal-title":"PLoS One"},{"issue":"9744","key":"10.1016\/j.exger.2014.09.002_bb0200","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2014.09.002_bb0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/bmb\/ldp016","article-title":"Heart rate as a treatable cardiovascular risk factor","volume":"90","author":"Tardif","year":"2009","journal-title":"Br. Med. Bull."},{"issue":"23","key":"10.1016\/j.exger.2014.09.002_bb0210","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/eurheartj\/ehi586","article-title":"Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina","volume":"26","author":"Tardif","year":"2005","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.exger.2014.09.002_bb0215","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/eurheartj\/ehn571","article-title":"Efficacy of the If current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4month, randomized, placebo-controlled trial","volume":"30","author":"Tardif","year":"2009","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.exger.2014.09.002_bb0220","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/eurjhf\/hft102","article-title":"Efficacy and safety of ivabradine in chronic heart failure across the age spectrum: insights from the SHIFT study","volume":"15","author":"Tavazzi","year":"2013","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.exger.2014.09.002_bb0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000219938","article-title":"Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris","volume":"114","author":"Tendera","year":"2009","journal-title":"Cardiology"},{"issue":"5","key":"10.1016\/j.exger.2014.09.002_bb0230","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00392-011-0402-4","article-title":"Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study","volume":"101","author":"Werdan","year":"2012","journal-title":"Clin. Res. Cardiol."},{"issue":"Abstr. Suppl.","key":"10.1016\/j.exger.2014.09.002_bb0235","first-page":"175","article-title":"Long-term therapy with ivabradine in combination with beta-blockers in patients with stable angina pectoris and effect of beta-blocker background dose: results from the 1-year follow-up of the ADDITIONS study","volume":"34","author":"Werdan","year":"2013","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.exger.2014.09.002_bb0240","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.amjmed.2004.02.044","article-title":"Suboptimal pharmacotherapeutic management of chronic stable angina in the primary care setting","volume":"117","author":"Wiest","year":"2004","journal-title":"Am. J. Med."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556514002526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556514002526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T20:38:57Z","timestamp":1598215137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556514002526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":49,"alternative-id":["S0531556514002526"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2014.09.002","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ivabradine in combination with beta-blocker reduces symptoms and improves quality of life in elderly patients with stable angina pectoris: Age-related results from the ADDITIONS study","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2014.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}