{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:49:12Z","timestamp":1790509752435,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\u2013NIA","award":["R01AG039659"],"award-info":[{"award-number":["R01AG039659"]}]},{"name":"UF Clinical and Translational Science Institute","award":["UL1TR000064"],"award-info":[{"award-number":["UL1TR000064"]}]},{"name":"NIH\u2013NIA","award":["K01AG048259"],"award-info":[{"award-number":["K01AG048259"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.exger.2015.09.017","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:17:41Z","timestamp":1444943861000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Age differences in cytokine expression under conditions of health using experimental pain models"],"prefix":"10.1016","volume":"72","author":[{"given":"Yenisel","family":"Cruz-Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Sorenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tighe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Wallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph L.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.exger.2015.09.017_bb0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneuroim.2010.08.013","article-title":"The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines","volume":"229","author":"Austin","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.exger.2015.09.017_bb0015","first-page":"e27638","article-title":"IL-4, JAK-STAT signaling, and pain","volume":"2","author":"Busch-Dienstfertig","year":"2013","journal-title":"JAKSTAT"},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gde.2010.10.005","article-title":"Cellular senescence: putting the paradoxes in perspective","volume":"21","author":"Campisi","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.exger.2015.09.017_bb0025","first-page":"803","article-title":"Neuropathic pain and cytokines: current perspectives","volume":"6","author":"Clark","year":"2013","journal-title":"J. Pain Res."},{"key":"10.1016\/j.exger.2015.09.017_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.bjp.0702266","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4","volume":"126","author":"Cunha","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/NNR.0000000000000013","article-title":"The association of pain with protein inflammatory biomarkers: a review of the literature","volume":"63","author":"DeVon","year":"2014","journal-title":"Nurs. Res."},{"issue":"2","key":"10.1016\/j.exger.2015.09.017_bb9000","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0034-7094(11)70029-0","article-title":"Cytokines and pain","volume":"61","author":"de Oliveira","year":"2011","journal-title":"Rev. Bras. Anestesiol."},{"issue":"3","key":"10.1016\/j.exger.2015.09.017_bb0040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.03.002","article-title":"Incidence rates and treatment of neuropathic pain conditions in the general population","volume":"137","author":"Dieleman","year":"2008","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.exger.2015.09.017_bb0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000087104","article-title":"Cytokine dysregulation, inflammation and well-being","volume":"12","author":"Elenkov","year":"2005","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.exger.2015.09.017_bb0050","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.exger.2015.09.017_bb0060","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbi.2011.04.003","article-title":"Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain","volume":"25","author":"Grace","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2015.09.017_bb0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02289823","article-title":"On methods in the analysis of profile data","volume":"24","author":"Greenhouse","year":"1959","journal-title":"Psychometrika"},{"issue":"3","key":"10.1016\/j.exger.2015.09.017_bb0070","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jbspin.2011.10.008","article-title":"Pain and immunity","volume":"79","author":"Guillot","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"2","key":"10.1016\/j.exger.2015.09.017_bb0075","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.expneurol.2011.10.010","article-title":"Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats","volume":"234","author":"Gwak","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2015.09.017_bb0080","doi-asserted-by":"crossref","first-page":"329792","DOI":"10.1155\/2015\/329792","article-title":"Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization","volume":"2015","author":"Imamura","year":"2015","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.exger.2015.09.017_bb0085","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1B, interleukin-6, and tumor necrosis factor-\u03b1 in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2015.09.017_bb0090","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2015.09.017_bb0095","doi-asserted-by":"crossref","first-page":"e44232","DOI":"10.1371\/journal.pone.0044232","article-title":"Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients","volume":"7","author":"Kwok","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2015.09.017_bb0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.exger.2015.09.017_bb0105","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/gerona\/61.6.575","article-title":"Interleukin-6 in aging and chronic disease: a magnificent pathway","volume":"61","author":"Maggio","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"7","key":"10.1016\/j.exger.2015.09.017_bb0110","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.exger.2015.09.017_bb0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1214\/aoms\/1177731915","article-title":"Significance test for sphericity of n-variate normal population","volume":"11","author":"Mauchly","year":"1940","journal-title":"Ann. Math. Stat."},{"key":"10.1016\/j.exger.2015.09.017_bb0120","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.expneurol.2004.11.001","article-title":"Immune and glial cell factors as pain mediators and modulators","volume":"192","author":"McMahon","year":"2005","journal-title":"Exp. Neurol."},{"issue":"2 Pt 1","key":"10.1016\/j.exger.2015.09.017_bb0125","first-page":"753","article-title":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome","volume":"167","author":"Miller","year":"2002","journal-title":"J. Urol."},{"key":"10.1016\/j.exger.2015.09.017_bb0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.exger.2015.09.017_bb0135","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1568-1637(03)00030-8","article-title":"Immunoproteasomes and immunosenescence","volume":"2","author":"Mishto","year":"2003","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.exger.2015.09.017_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1037\/a0035794","article-title":"Overview of persistent pain in older adults","volume":"69","author":"Molton","year":"2014","journal-title":"Am. Psychol."},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000049690","article-title":"Increased monocyte activation in elderly patients after surgical stress","volume":"33","author":"Ono","year":"2001","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.exger.2015.09.017_bb0150","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0160","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/edrv.23.1.0456","article-title":"Changes in proinflammatory cytokine activity after menopause","volume":"23","author":"Pfeilschifter","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.exger.2015.09.017_bb0165","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/157488711796575577","article-title":"Neuroinflammation and ageing: current theories and an overview of the data","volume":"6","author":"Pizza","year":"2011","journal-title":"Rev. Recent Clin. Trials"},{"issue":"11","key":"10.1016\/j.exger.2015.09.017_bb0170","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/nm.2234","article-title":"Interactions between the immune and nervous systems in pain","volume":"16","author":"Ren","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2015.09.017_bb0175","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/01.HYP.33.2.708","article-title":"Alpha1-adrenergic receptor subtypes in human peripheral blood lymphocytes","volume":"33","author":"Ricci","year":"1999","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.exger.2015.09.017_bb0180","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpain.2013.10.015","article-title":"Age and race effects on pain sensitivity and modulation among middle-aged and older adults","volume":"15","author":"Riley","year":"2014","journal-title":"J. Pain"},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0185","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pain.2010.04.020","article-title":"Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults","volume":"150","author":"Riley","year":"2010","journal-title":"Pain"},{"issue":"2\u20133","key":"10.1016\/j.exger.2015.09.017_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0047-6374(97)00153-X","article-title":"Altered cytokine production in the elderly","volume":"102","author":"Rink","year":"1998","journal-title":"Mech. Ageing Dev."},{"issue":"1\u20132","key":"10.1016\/j.exger.2015.09.017_bb0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-5728(02)00062-0","article-title":"Pfeilschifter et al., 2002) age and sex steroid-related changes in glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress","volume":"126","author":"Rohleder","year":"2002","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.exger.2015.09.017_bb0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.arr.2010.11.002","article-title":"Inflammatory markers in population studies of aging","volume":"10","author":"Singh","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2015.09.017_bb0210","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2003.12.007","article-title":"Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia","volume":"361","author":"Sommer","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exger.2015.09.017_bb0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/ard.2004.027045","article-title":"Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain","volume":"64","author":"St\u00fcrmer","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.exger.2015.09.017_bb0220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000210032","article-title":"Cellular senescence and inflammation: a noteworthy link","volume":"28","author":"Tsirpanlis","year":"2009","journal-title":"Blood Purif."},{"key":"10.1016\/j.exger.2015.09.017_bb0225","doi-asserted-by":"crossref","first-page":"e28205","DOI":"10.1371\/journal.pone.0028205","article-title":"IL-4 deficiency is associated with mechanical hypersensitivity in mice","volume":"6","author":"Uceyler","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2015.09.017_bb0230","doi-asserted-by":"crossref","first-page":"e31167","DOI":"10.1371\/journal.pone.0031167","article-title":"Morphine suppresses IFN signaling pathway and enhances AIDS virus infection","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.exger.2015.09.017_bb0235","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2796.2004.01443.x","article-title":"Immune regulation of central nervous system functions: from sickness responses to pathological pain","volume":"257","author":"Watkins","year":"2005","journal-title":"J. Intern. Med."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556515300607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556515300607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T15:50:33Z","timestamp":1537285833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556515300607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":44,"alternative-id":["S0531556515300607"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2015.09.017","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age differences in cytokine expression under conditions of health using experimental pain models","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2015.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}