{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:03:43Z","timestamp":1790813023890,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.exger.2016.11.012","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T09:46:27Z","timestamp":1480585587000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"PA","title":["Chronic kidney disease accelerates cognitive impairment in a mouse model of Alzheimer's disease, through angiotensin II"],"prefix":"10.1016","volume":"87","author":[{"given":"Takashi","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-7009","authenticated-orcid":false,"given":"Ken","family":"Uekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokei","family":"Kim-Mitsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2016.11.012_bb0005","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2016.11.012_bb0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1681\/ASN.2012050536","article-title":"Cognitive disorders and dementia in CKD: the neglected kidney-brain axis","volume":"24","author":"Bugnicourt","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.exger.2016.11.012_bb0015","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/HJH.0000000000000086","article-title":"Angiotension receptor blockers reduce the risk of dementia","volume":"32","author":"Chiu","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.exger.2016.11.012_bb0020","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1159\/000338135","article-title":"Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis","volume":"35","author":"Etgen","year":"2012","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.exger.2016.11.012_bb0025","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2016.11.012_bb0030","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archneurol.2012.1010","article-title":"Impact of angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series","volume":"69","author":"Hajjar","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2016.11.012_bb0035","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archinternmed.2011.1391","article-title":"Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial","volume":"172","author":"Hajjar","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.exger.2016.11.012_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.exger.2016.11.012_bb0045","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2016.11.012_bb0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.exger.2016.11.012_bb0055","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2369-14-116","article-title":"A novel model of adenine-induced tubulointerstitial nephropathy in mice","volume":"14","author":"Jia","year":"2013","journal-title":"BMC Nephrol."},{"issue":"Suppl. 2","key":"10.1016\/j.exger.2016.11.012_bb0060","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.3233\/JAD-2012-111376","article-title":"The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?","volume":"30","author":"Kehoe","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2016.11.012_bb0065","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/01.STR.0000163084.16505.e3","article-title":"Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats","volume":"36","author":"Kim-Mitsuyama","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2016.11.012_bb0070","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1111\/j.1532-5415.2004.52508.x","article-title":"Cognitive impairment in chronic kidney disease","volume":"52","author":"Kurella","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.exger.2016.11.012_bb0075","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1681\/ASN.2005010005","article-title":"Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study","volume":"16","author":"Kurella","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.exger.2016.11.012_bb0080","doi-asserted-by":"crossref","first-page":"b5465","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.exger.2016.11.012_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003154","article-title":"High-fat-diet intake enhances cerebral amyloid angiopathy and cognitive impairment in a mouse model of Alzheimer's disease, independently of metabolic disorders","volume":"5","author":"Lin","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.exger.2016.11.012_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/BCI.S13025","article-title":"Molecular differences and similarities between Alzheimer's disease and the 5XFAD transgenic mouse model of amyloidosis","volume":"6","author":"Maarouf","year":"2013","journal-title":"Biochem. Insights"},{"key":"10.1016\/j.exger.2016.11.012_bb0095","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"Mancia","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.exger.2016.11.012_bb0100","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2016.11.012_bb0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0022-3565(25)07684-0","article-title":"Adenine intoxication in relation to in vivo formation and deposition of 2.8-dioxyadenine in renal tubules","volume":"104","author":"Philips","year":"1952","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.exger.2016.11.012_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jns.2009.02.321","article-title":"Blood-brain barrier alterations in ageing and dementia","volume":"283","author":"Popescu","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.exger.2016.11.012_bb0115","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1159\/000299794","article-title":"Vascular calcification in animal models of CKD: a review","volume":"31","author":"Shobeiri","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.exger.2016.11.012_bb0120","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","article-title":"Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?","volume":"34","author":"Wardlaw","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2016.11.012_bb0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12035-014-8720-y","article-title":"Cognitive reserve and Alzheimer's disease","volume":"51","author":"Xu","year":"2015","journal-title":"Mol. Neurobiol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556516303187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556516303187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T23:46:32Z","timestamp":1749771992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556516303187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":25,"alternative-id":["S0531556516303187"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2016.11.012","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic kidney disease accelerates cognitive impairment in a mouse model of Alzheimer's disease, through angiotensin II","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2016.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}