{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:59:07Z","timestamp":1774868347786,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.exger.2017.12.010","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T23:09:04Z","timestamp":1513292944000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["VEGF attenuates 2-VO induced cognitive impairment and neuronal injury associated with the activation of PI3K\/Akt and Notch1 pathway"],"prefix":"10.1016","volume":"102","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuening","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2017.12.010_bb0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuron.2011.01.004","article-title":"Activity-induced notch signaling in neurons requires Arc\/Arg3.1 and is essential for synaptic plasticity in hippocampal networks","volume":"69","author":"Alberi","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2017.12.010_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.arr.2013.03.004","article-title":"Notch signaling in the brain: in good and bad times","volume":"12","author":"Alberi","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2017.12.010_bb0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejphar.2007.05.048","article-title":"Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion","volume":"571","author":"Annahazi","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exger.2017.12.010_bb0020","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2017.12.010_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071440","article-title":"17beta-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells","volume":"8","author":"Caliceti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2017.12.010_bb0030","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.exger.2017.12.010_bb0035","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng1395","article-title":"VEGF links hippocampal activity with neurogenesis, learning and memory","volume":"36","author":"Cao","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2017.12.010_bb0040","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2017.12.010_bb0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2045-824X-3-2","article-title":"Notch modulates VEGF action in endothelial cells by inducing matrix metalloprotease activity","volume":"3","author":"Funahashi","year":"2011","journal-title":"Vasc. Cell"},{"key":"10.1016\/j.exger.2017.12.010_bb0050","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrg3272","article-title":"The notch signalling system: recent insights into the complexity of a conserved pathway","volume":"13","author":"Guruharsha","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.exger.2017.12.010_bb0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2013.05.036","article-title":"Signaling through the vascular endothelial growth factor receptor VEGFR-2 protects hippocampal neurons from mitochondrial dysfunction and oxidative stress","volume":"63","author":"Hao","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2017.12.010_bb0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2010.03.038","article-title":"Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus","volume":"636","author":"Ji","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exger.2017.12.010_bb0065","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1073\/pnas.97.18.10242","article-title":"Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia","volume":"97","author":"Jin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2017.12.010_bb0070","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0306-4522(00)00331-6","article-title":"Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3\u2032-kinase\/Akt signaling by global cerebral ischemia in the rat","volume":"100","author":"Jin","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.exger.2017.12.010_bb0075","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0306-4522(01)00154-3","article-title":"Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor","volume":"108","author":"Jin","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.exger.2017.12.010_bb0080","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1096\/fj.05-4829fje","article-title":"The phosphatidylinositol-3 kinase\/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia","volume":"20","author":"Kilic","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2017.12.010_bb0085","doi-asserted-by":"crossref","first-page":"12439","DOI":"10.1523\/JNEUROSCI.0434-06.2006","article-title":"Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1\/2 and Akt pathways","volume":"26","author":"Kilic","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2017.12.010_bb0090","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrneurol.2016.88","article-title":"Vascular endothelial growth factor: a neurovascular target in neurological diseases","volume":"12","author":"Lange","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.exger.2017.12.010_bb0095","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exger.2017.12.010_bb0100","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1007\/s12035-015-9324-x","article-title":"Hydrogen sulfide prevents synaptic plasticity from VD-induced damage via Akt\/GSK-3beta pathway and notch signaling pathway in rats","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exger.2017.12.010_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081220","article-title":"Norisoboldine suppresses VEGF-induced endothelial cell migration via the cAMP-PKA-NF-kappaB\/Notch1 pathway","volume":"8","author":"Lu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2017.12.010_bb0110","article-title":"The role of oxidative damage in the pathogenesis and progression of Alzheimer's disease and vascular dementia","volume":"6","author":"Luca","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2017.12.010_bb0115","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/cdd.2015.23","article-title":"Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry","volume":"22","author":"Marathe","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exger.2017.12.010_bb0120","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exger.2017.12.010_bb0125","doi-asserted-by":"crossref","first-page":"31277","DOI":"10.1074\/jbc.M300763200","article-title":"Regulation of hypoxia-inducible factor-1 alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase\/Akt\/glycogen synthase kinase 3 beta pathway in HepG2 cells","volume":"278","author":"Mottet","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2017.12.010_bb0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.exger.2017.12.010_bb0135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbr.2013.02.036","article-title":"VEGF reverts the cognitive impairment induced by a focal traumatic brain injury during the development of rats raised under environmental enrichment","volume":"246","author":"Ortuzar","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.exger.2017.12.010_bb0140","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.neuron.2011.07.013","article-title":"The neurovascular link in health and disease: molecular mechanisms and therapeutic implications","volume":"71","author":"Quaegebeur","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2017.12.010_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nlm.2013.03.001","article-title":"Disrupting Jagged1-notch signaling impairs spatial memory formation in adult mice","volume":"103","author":"Sargin","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.exger.2017.12.010_bb0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1582-4934.2005.tb00337.x","article-title":"The activation of Akt\/PKB signaling pathway and cell survival","volume":"9","author":"Song","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.exger.2017.12.010_bb0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI20682","article-title":"VEGF: a critical player in neurodegeneration","volume":"113","author":"Storkebaum","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2017.12.010_bb0160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nn1360","article-title":"Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS","volume":"8","author":"Storkebaum","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exger.2017.12.010_bb0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0925-4773(02)00043-6","article-title":"Notch1 and its ligands Delta-like and jagged are expressed and active in distinct cell populations in the postnatal mouse brain","volume":"114","author":"Stump","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.exger.2017.12.010_bb0170","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Sun","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2017.12.010_bb0175","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1095\/biolreprod.113.114876","article-title":"Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the cross talk between Notch1 and PI3K\/Akt signaling","volume":"90","author":"Wang","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.exger.2017.12.010_bb0180","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coph.2007.10.013","article-title":"VEGF as a potential target for therapeutic intervention in depression","volume":"8","author":"Warner-Schmidt","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.exger.2017.12.010_bb0185","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12017-013-8284-4","article-title":"VEGF ameliorates cognitive impairment in in vivo and in vitro ischemia via improving neuronal viability and function","volume":"16","author":"Yang","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.exger.2017.12.010_bb0190","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/hipo.22544","article-title":"Paradoxical effects of VEGF on synaptic activity partially involved in notch1 signaling in the mouse hippocampus","volume":"26","author":"Yang","year":"2016","journal-title":"Hippocampus"},{"key":"10.1016\/j.exger.2017.12.010_bb0195","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000088637","article-title":"Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential","volume":"14","author":"Zachary","year":"2005","journal-title":"Neurosignals"},{"key":"10.1016\/j.exger.2017.12.010_bb0200","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/FBP.0b013e32834afef9","article-title":"Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation","volume":"22","author":"Zhang","year":"2011","journal-title":"Behav. Pharmacol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556517306228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556517306228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T07:36:52Z","timestamp":1535182612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556517306228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":40,"alternative-id":["S0531556517306228"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2017.12.010","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEGF attenuates 2-VO induced cognitive impairment and neuronal injury associated with the activation of PI3K\/Akt and Notch1 pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2017.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}