{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:58:14Z","timestamp":1789743494281,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004091","name":"Kumamoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.exger.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T01:04:18Z","timestamp":1550365458000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"120","author":[{"given":"Kenyu","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushin","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Takeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-9086","authenticated-orcid":false,"given":"Akitake","family":"Mukasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokei","family":"Kim-Mitsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2019.02.007_bb0005","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1097\/CCM.0b013e3182474bc1","article-title":"Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice","volume":"40","author":"Altay","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exger.2019.02.007_bb0010","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archneurol.2010.38","article-title":"Reduced lean mass in early Alzheimer disease and its association with brain atrophy","volume":"67","author":"Burns","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2019.02.007_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/joim.12287","article-title":"Heart failure and Alzheimer's disease","volume":"277","author":"Cermakova","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.exger.2019.02.007_bb0020","article-title":"Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism","volume":"1","author":"Deleon-Pennell","year":"2013","journal-title":"Phys. Rep."},{"key":"10.1016\/j.exger.2019.02.007_bb0025","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.2337\/dc08-0026","article-title":"Periodontal disease and incident type 2 diabetes: results from the first national health and nutrition examination survey and its epidemiologic follow-up study","volume":"31","author":"Demmer","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2019.02.007_bb0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012","volume":"86","author":"Eke","year":"2015","journal-title":"J. Periodontol."},{"key":"10.1016\/j.exger.2019.02.007_bb0035","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/cvr\/cvn286","article-title":"Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice","volume":"81","author":"Gitlin","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.exger.2019.02.007_bb0040","doi-asserted-by":"crossref","first-page":"G434","DOI":"10.1152\/ajpgi.00562.2004","article-title":"Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation","volume":"289","author":"Goralski","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.exger.2019.02.007_bb0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/STROKEAHA.110.597344","article-title":"Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats","volume":"42","author":"Hasegawa","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2019.02.007_bb0050","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fnins.2014.00347","article-title":"An evaluation of progressive amyloidogenic and pro-inflammatory change in the primary visual cortex and retina in Alzheimer's disease (AD)","volume":"8","author":"Hill","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exger.2019.02.007_bb0055","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s11606-008-0787-6","article-title":"Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis","volume":"23","author":"Humphrey","year":"2008","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.exger.2019.02.007_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151081","article-title":"Periodontitis and cognitive decline in Alzheimer's disease","volume":"11","author":"Ide","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2019.02.007_bb0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41514-017-0015-x","article-title":"Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice","volume":"3","author":"Ishida","year":"2017","journal-title":"NPJ Aging Mech Dis"},{"key":"10.1016\/j.exger.2019.02.007_bb0070","first-page":"142","article-title":"Body mass index in mild cognitive impairment according to age, sex, cognitive intervention, and hypertension and risk of progression to Alzheimer's disease","volume":"9","author":"Joo","year":"2018","journal-title":"Front. Psychol."},{"key":"10.1016\/j.exger.2019.02.007_bb0075","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1902\/jop.2008.070575","article-title":"P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers","volume":"79","author":"Liu","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.exger.2019.02.007_bb0080","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.4049\/jimmunol.167.9.5278","article-title":"Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli","volume":"167","author":"Martin","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.exger.2019.02.007_bb0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0765.1983.tb00333.x","article-title":"Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis","volume":"18","author":"Nair","year":"1983","journal-title":"J. Periodontal Res."},{"issue":"40","key":"10.1016\/j.exger.2019.02.007_bb0090","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2019.02.007_bb0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2012.10.017","article-title":"PPARgamma activation prevents impairments in spatial memory and neurogenesis following transient illness","volume":"29","author":"Ormerod","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2019.02.007_bb0100","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-121918","article-title":"Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue","volume":"36","author":"Poole","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2019.02.007_bb0105","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archinte.166.9.1003","article-title":"Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study","volume":"166","author":"Qiu","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.exger.2019.02.007_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/137357","article-title":"Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer's disease","volume":"2015","author":"Singhrao","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.exger.2019.02.007_bb0115","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.ajpath.2011.02.012","article-title":"Inflammation induced by infection potentiates tau pathological features in transgenic mice","volume":"178","author":"Sy","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exger.2019.02.007_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004897","article-title":"Detrimental effects of centrally administered angiotensin II are enhanced in a mouse model of Alzheimer disease independently of blood pressure","volume":"6","author":"Takane","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.exger.2019.02.007_bb0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-051X.2009.01417.x","article-title":"Periodontitis and risk for atherosclerosis: an update on intervention trials","volume":"36 Suppl 10","author":"Tonetti","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.exger.2019.02.007_bb0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-150642","article-title":"Intracerebroventricular infusion of angiotensin-(1-7) ameliorates cognitive impairment and memory dysfunction in a mouse model of Alzheimer's disease","volume":"53","author":"Uekawa","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2019.02.007_bb0135","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1460-9568.2006.04722.x","article-title":"NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production","volume":"23","author":"Valerio","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exger.2019.02.007_bb0140","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fphar.2016.00384","article-title":"Lentiviral-mediated overexpression of the 18\u202fkDa translocator protein (TSPO) in the hippocampal dentate gyrus ameliorates LPS-induced cognitive impairment in mice","volume":"7","author":"Wang","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2019.02.007_bb0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrneurol.2017.147","article-title":"A systemic view of Alzheimer disease - insights from amyloid-beta metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.exger.2019.02.007_bb0150","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1056\/NEJM200104123441501","article-title":"A reevaluation of the duration of survival after the onset of dementia","volume":"344","author":"Wolfson","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2019.02.007_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/471342","article-title":"Lessons from microglia aging for the link between inflammatory bone disorders and Alzheimer's disease","volume":"2015","author":"Wu","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.exger.2019.02.007_bb0160","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbi.2017.06.002","article-title":"Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice","volume":"65","author":"Wu","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2019.02.007_bb0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer's disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exger.2019.02.007_bb0170","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12974-015-0238-3","article-title":"Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice","volume":"12","author":"Zhang","year":"2015","journal-title":"J. Neuroinflammation"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556518305709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556518305709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:32:52Z","timestamp":1759977172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556518305709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":34,"alternative-id":["S0531556518305709"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2019.02.007","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}