{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:05:01Z","timestamp":1792281901340,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004825","name":"Nordea-fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.exger.2019.03.007","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T14:08:45Z","timestamp":1553177325000},"page":"19-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation"],"prefix":"10.1016","volume":"121","author":[{"given":"A.K.","family":"Ziegler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schjerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1249\/MSS.0b013e3181915670","article-title":"Progression models in resistance training for healthy adults","volume":"41","author":"&NA","year":"2009","journal-title":"Med Sci Sport Exerc [Internet]"},{"issue":"11","key":"10.1016\/j.exger.2019.03.007_bb0010","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.4049\/jimmunol.143.11.3517","article-title":"IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice","volume":"143","author":"Aderka","year":"1989","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0015","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/1097-4598(200007)23:7<1095::AID-MUS13>3.0.CO;2-O","article-title":"Myosin heavy chain IIX overshoot in human skeletal muscle","volume":"23","author":"Andersen","year":"2000","journal-title":"Muscle Nerve"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"Arnold","year":"2007","journal-title":"J Exp Med [Internet]"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0025","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1474-9726.2012.00849.x","article-title":"The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection","volume":"11","author":"Bartlett","year":"2012","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.exger.2019.03.007_bb0030","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nm.4363","article-title":"Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice","volume":"23","author":"Benoit","year":"2017","journal-title":"Nat Med [Internet]"},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/00365517509095787","article-title":"Percutaneous needle biopsy of skeletal muscle in physiological and clinical research","volume":"35","author":"Bergstrom","year":"1975","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0040","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.4049\/jimmunol.1600476","article-title":"IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity","volume":"198","author":"Braune","year":"2017","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.exger.2019.03.007_bb0045","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1177\/18.9.670","article-title":"THREE &quot;MYOSIN ADENOSINE TRIPHOSPHATASE&quot; SYSTEMS: THE NATURE OF THEIR pH LABILITY AND SULFHYDRYL DEPENDENCE","volume":"18","author":"BROOKE","year":"1970","journal-title":"J Histochem Cytochem [Internet]"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0050","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1096\/fj.14-263699","article-title":"The search for exercise factors in humans","volume":"29","author":"Catoire","year":"2015","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.exger.2019.03.007_bb0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jocd.2015.02.001","article-title":"Quantification of visceral fat using dual-energy X-ray absorptiometry and its reliability according to the amount of visceral fat in Korean adults","volume":"18","author":"Choi","year":"2015","journal-title":"J Clin Densitom [Internet]"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0060","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1139\/h11-077","article-title":"Endurance and resistance training lowers C-reactive protein in young, healthy females","volume":"36","author":"Daray","year":"2011","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.exger.2019.03.007_bb0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbi.2014.01.006","article-title":"Effect of exercise training on skeletal muscle cytokine expression in the elderly","volume":"39","author":"Della Gatta","year":"2014","journal-title":"Brain Behav Immun [Internet]"},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0070","doi-asserted-by":"crossref","first-page":"e012951","DOI":"10.1136\/bmjopen-2016-012951","article-title":"Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)","volume":"6","author":"Eriksen","year":"2016","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.exger.2019.03.007_bb0075","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/bjsports-2016-095999","article-title":"Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials","volume":"51","author":"Fedewa","year":"2017","journal-title":"Br. J. Sports Med."},{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1\u03b1 and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev [Internet]"},{"issue":"4","key":"10.1016\/j.exger.2019.03.007_bb0085","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2337\/db06-1656","article-title":"Visceral fat Adipokine secretion is associated with systemic inflammation in obese humans","volume":"56","author":"Fontana","year":"2007","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm850","article-title":"Direct brain infusion of glial cell line\u2013derived neurotrophic factor in Parkinson disease","volume":"9","author":"Gill","year":"2003","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.exger.2019.03.007_bb0095","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat Rev Immunol [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0100","doi-asserted-by":"crossref","unstructured":"GREIWE JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. [Internet]. 2001 Feb 1 [cited 2017 Jun 29];15(2):475\u201382. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11156963","DOI":"10.1096\/fj.00-0274com"},{"issue":"2","key":"10.1016\/j.exger.2019.03.007_bb0105","doi-asserted-by":"crossref","first-page":"e00235","DOI":"10.1002\/phy2.235","article-title":"GDNF content and NMJ morphology are altered in recruited muscles following high-speed and resistance wheel training","volume":"2","author":"Gyorkos","year":"2014","journal-title":"Physiol Rep"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0110","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0002-9343(99)00066-2","article-title":"Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly","volume":"106","author":"Harris","year":"1999","journal-title":"Am. J. Med."},{"issue":"5091","key":"10.1016\/j.exger.2019.03.007_bb0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exger.2019.03.007_bb0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1467-789X.2011.00931.x","article-title":"A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat","volume":"13","author":"Ismail","year":"2012","journal-title":"Obes. Rev."},{"issue":"4","key":"10.1016\/j.exger.2019.03.007_bb0125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00421-009-1139-x","article-title":"Cytokine and hormone responses to resistance training","volume":"107","author":"Izquierdo","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0130","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/sms.12794","article-title":"Composition and adaptation of human myotendinous junction and neighboring muscle fibers to heavy resistance training","volume":"27","author":"Jakobsen","year":"2017","journal-title":"Scand. J. Med. Sci. Sports"},{"issue":"8","key":"10.1016\/j.exger.2019.03.007_bb0135","doi-asserted-by":"crossref","first-page":"e8791","DOI":"10.15252\/emmm.201708791","article-title":"FGF21 gene therapy as treatment for obesity and insulin resistance","volume":"10","author":"Jimenez","year":"2018","journal-title":"EMBO Mol Med [Internet]"},{"issue":"6","key":"10.1016\/j.exger.2019.03.007_bb0140","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/oby.2011.393","article-title":"Dual-energy X-ray absorptiometry for quantification of visceral fat","volume":"20","author":"Kaul","year":"2012","journal-title":"Obesity (Silver Spring) [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0145","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice","volume":"16","author":"Kawanishi","year":"2010","journal-title":"Exerc. Immunol. Rev."},{"issue":"2","key":"10.1016\/j.exger.2019.03.007_bb0150","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/japplphysiol.00006.2008","article-title":"Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons","volume":"105","author":"Lambert","year":"2008","journal-title":"J Appl Physiol [Internet]"},{"issue":"6","key":"10.1016\/j.exger.2019.03.007_bb0155","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1096\/fj.10-176487","article-title":"Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle","volume":"25","author":"Mackey","year":"2011","journal-title":"FASEB J."},{"issue":"22","key":"10.1016\/j.exger.2019.03.007_bb0160","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1113\/jphysiol.2011.217885","article-title":"Strength training increases the size of the satellite cell pool in type I and II fibres of chronically painful trapezius muscle in females","volume":"589","author":"Mackey","year":"2011","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0165","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ni.2865","article-title":"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin","volume":"15","author":"Mauer","year":"2014","journal-title":"Nat Immunol [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuroscience.2010.11.016","article-title":"Glial cell line-derived neurotrophic factor protein content in rat skeletal muscle is altered by increased physical activity in vivo and in vitro","volume":"174","author":"McCullough","year":"2011","journal-title":"Neuroscience [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0175","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neuroscience.2013.02.063","article-title":"Short-term exercise increases GDNF protein levels in the spinal cord of young and old rats","volume":"240","author":"McCullough","year":"2013","journal-title":"Neuroscience"},{"issue":"11\u221212","key":"10.1016\/j.exger.2019.03.007_bb0180","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.mad.2013.11.004","article-title":"Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size","volume":"134","author":"Mikkelsen","year":"2013","journal-title":"Mech Ageing Dev [Internet]"},{"issue":"15","key":"10.1016\/j.exger.2019.03.007_bb0185","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122737","article-title":"Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans","volume":"3","author":"Morville","year":"2018","journal-title":"JCI insight"},{"issue":"11","key":"10.1016\/j.exger.2019.03.007_bb0190","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/j.1532-5415.2008.01994.x","article-title":"Exercise training and plasma C-reactive protein and Interleukin-6 in elderly people","volume":"56","author":"Nicklas","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0195","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1002\/oby.20402","article-title":"Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats","volume":"21","author":"Oliveira","year":"2013","journal-title":"Obesity [Internet]"},{"issue":"6","key":"10.1016\/j.exger.2019.03.007_bb0200","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/sj.ijo.0803534","article-title":"Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women","volume":"31","author":"Olson","year":"2007","journal-title":"Int. J. Obes."},{"issue":"Pt 1","key":"10.1016\/j.exger.2019.03.007_bb0205","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1469-7793.1999.287ad.x","article-title":"Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans","volume":"515","author":"Ostrowski","year":"1999","journal-title":"J Physiol [Internet]"},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0210","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/sj.ijo.0801982","article-title":"Are dual-energy X-ray absorptiometry regional estimates associated with visceral adipose tissue mass?","volume":"26","author":"Park","year":"2002","journal-title":"Int J Obes [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0215","first-page":"72","article-title":"Systemic inflammatory responses to maximal versus submaximal lengthening contractions of the elbow flexors","volume":"12","author":"Peake","year":"2006","journal-title":"Exerc Immunol Rev [Internet]"},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0220","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1007\/s00421-011-1942-z","article-title":"Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: an 18-month randomized controlled trial","volume":"111","author":"Peake","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0225","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1113\/JP271691","article-title":"\u201cAdipaging\u201d: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue","volume":"594","author":"P\u00e9rez","year":"2016","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.exger.2019.03.007_bb0230","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1519\/JSC.0b013e3181cc2212","article-title":"Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity","volume":"24","author":"Phillips","year":"2010","journal-title":"J Strength Cond Res [Internet]"},{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0235","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.exger.2005.12.007","article-title":"Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise","volume":"41","author":"Przybyla","year":"2006","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.exger.2019.03.007_bb0240","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s004180050101","article-title":"Visualisation of capillaries in human skeletal muscle","volume":"107","author":"Qu","year":"1997","journal-title":"Histochem. Cell Biol."},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0245","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s12603-015-0548-2","article-title":"C-reactive protein and resistance exercise in community dwelling old adults","volume":"19","author":"Ramel","year":"2015","journal-title":"J. Nutr. Health Aging"},{"issue":"11","key":"10.1016\/j.exger.2019.03.007_bb0250","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/cns.12312","article-title":"Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells","volume":"20","author":"Revilla","year":"2014","journal-title":"CNS Neurosci Ther [Internet]"},{"issue":"11","key":"10.1016\/j.exger.2019.03.007_bb0255","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1152\/japplphysiol.00412.2012","article-title":"Increased ceramide content and NF?B signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males","volume":"113","author":"Rivas","year":"2012","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0260","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol [Internet]"},{"key":"10.1016\/j.exger.2019.03.007_bb0265","doi-asserted-by":"crossref","unstructured":"Saclier M, Yacoub-Youssef H, Mackey AL, Arnold L, Ardjoune H, Magnan M, et al. Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration. Stem Cells [Internet]. 2013;31(2):384\u201396. Available from: http:\/\/doi.wiley.com\/10.1002\/stem.1288","DOI":"10.1002\/stem.1288"},{"key":"10.1016\/j.exger.2019.03.007_bb0270","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.exger.2018.07.021","article-title":"Effect of resistance training on inflammatory markers of older adults: a meta-analysis","volume":"111","author":"Sardeli","year":"2018","journal-title":"Exp Gerontol [Internet]"},{"issue":"1","key":"10.1016\/j.exger.2019.03.007_bb0275","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood.V75.1.40.40","article-title":"Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF","volume":"75","author":"Schindler","year":"1990","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0280","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00011-008-7243-2","article-title":"Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm- aging, from robustness to frailty","volume":"57","author":"Sergio","year":"2008","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.exger.2019.03.007_bb0285","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-0838.2011.01373.x","article-title":"Inflammation and oxidative stress are lower in physically fit and active adults","volume":"23","author":"Shanely","year":"2013","journal-title":"Scand J Med Sci Sports [Internet]"},{"issue":"4","key":"10.1016\/j.exger.2019.03.007_bb0290","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1515\/cclm-2017-0648","article-title":"Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays","volume":"56","author":"Shen","year":"2018","journal-title":"Clin Chem Lab Med [Internet]"},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.03.007_bb0295","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s004210050652","article-title":"Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise","volume":"82","author":"Smith","year":"2000","journal-title":"Eur. J. Appl. Physiol."},{"issue":"8","key":"10.1016\/j.exger.2019.03.007_bb0300","first-page":"884","article-title":"Exercise and IL-6 infusion inhibit endotoxin-induced TNF-&alpha; production in humans","volume":"17","author":"Starkie","year":"2003","journal-title":"FASEB J [Internet]"},{"issue":"8","key":"10.1016\/j.exger.2019.03.007_bb0305","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1152\/japplphysiol.00066.2015","article-title":"Influence of combined resistance training and healthy diet on muscle mass in healthy elderly women: a randomized controlled trial","volume":"119","author":"Strandberg","year":"2015","journal-title":"J Appl Physiol [Internet]"},{"issue":"7","key":"10.1016\/j.exger.2019.03.007_bb0310","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/oby.2012.24","article-title":"Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects","volume":"20","author":"Tam","year":"2012","journal-title":"Obesity [Internet]"},{"issue":"12","key":"10.1016\/j.exger.2019.03.007_bb0315","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12828","article-title":"Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation","volume":"4","author":"Tanimura","year":"2016","journal-title":"Physiol Rep"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0320","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/hc0502.103331","article-title":"Weight loss reduces C-reactive protein levels in obese postmenopausal women","volume":"105","author":"Tchernof","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0325","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mus.21875","article-title":"Impact of resistance exercise training on interleukin-6 and JAK\/STAT in young men","volume":"43","author":"Trenerry","year":"2011","journal-title":"Muscle Nerve"},{"issue":"3","key":"10.1016\/j.exger.2019.03.007_bb0330","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mus.21875","article-title":"Impact of resistance exercise training on interleukin-6 and JAK\/STAT in young men","volume":"43","author":"Trenerry","year":"2011","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.exger.2019.03.007_bb0335","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2016.01.008","article-title":"Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)","volume":"277","author":"Van Dyke","year":"2016","journal-title":"Exp Neurol [Internet]"},{"issue":"4","key":"10.1016\/j.exger.2019.03.007_bb0340","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbi.2009.01.011","article-title":"Reduction in trunk fat predicts cardiovascular exercise training-related reductions in C-reactive protein","volume":"23","author":"Vieira","year":"2009","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0345","doi-asserted-by":"crossref","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the health ABC study","volume":"57","author":"Visser","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci [Internet]"},{"issue":"5","key":"10.1016\/j.exger.2019.03.007_bb0350","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1007\/s11357-014-9718-0","article-title":"The influence of systemic inflammation on skeletal muscle in physically active elderly women","volume":"36","author":"W\u00e5hlin-Larsson","year":"2014","journal-title":"Age (Omaha)"},{"key":"10.1016\/j.exger.2019.03.007_bb0355","doi-asserted-by":"crossref","unstructured":"Wanderley FAC, Moreira A, Sokhatska O, Palmares C, Moreira P, Sandercock G, et al. Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults. Exp. Gerontol. [Internet]. 2013;48(3):326\u201333. Available from: http:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.exger.2013.01.002.","DOI":"10.1016\/j.exger.2013.01.002"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556518305746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556518305746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:33:23Z","timestamp":1759977203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556518305746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":71,"alternative-id":["S0531556518305746"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2019.03.007","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2019.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}