{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:38:36Z","timestamp":1782412716174,"version":"3.54.5"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.exger.2019.110675","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T11:18:13Z","timestamp":1563794293000},"page":"110675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice"],"prefix":"10.1016","volume":"125","author":[{"given":"Mi-Jung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraiya","family":"Haroon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wanagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karessa","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Caicedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Linser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Tanokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Prolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vermulst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0005","first-page":"449","article-title":"Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study","volume":"18","author":"Bai","year":"1997","journal-title":"Am. J. Otol."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0010","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1074\/jbc.275.5.3343","article-title":"Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart","volume":"275","author":"Barazzoni","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2015.04.005","article-title":"Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging","volume":"21","author":"Baris","year":"2015","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2019.110675_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2350-12-8","article-title":"The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.exger.2019.110675_bb0030","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.heares.2012.11.016","article-title":"Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus","volume":"295","author":"Chen","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2019.110675_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2014.08.004","article-title":"Prolonged noise exposure-induced auditory threshold shifts in rats","volume":"317","author":"Chen","year":"2014","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2019.110675_bb0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.dnarep.2014.03.010","article-title":"Mitochondrial genome maintenance in health and disease","volume":"19","author":"Copeland","year":"2014","journal-title":"DNA Repair (Amst)"},{"issue":"11","key":"10.1016\/j.exger.2019.110675_bb0045","first-page":"510","volume":"13","author":"Ding","year":"1999","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"issue":"11","key":"10.1016\/j.exger.2019.110675_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079817","article-title":"Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures","volume":"8","author":"Ding","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0055","doi-asserted-by":"crossref","first-page":"730","DOI":"10.18632\/aging.100927","article-title":"N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in gamma-glutamyl transferase 1 deficient mice","volume":"8","author":"Ding","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0060","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1121\/1.423293","article-title":"Are inner or outer hair cells the source of summating potentials recorded from the round window?","volume":"104","author":"Durrant","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0065","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1073\/pnas.0605208103","article-title":"Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons","volume":"104","author":"Ekstrand","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2019.110675_bb0070","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2147\/TCRM.S117491","article-title":"The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis","volume":"12","author":"Falah","year":"2016","journal-title":"Ther. Clin. Risk Manag."},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110675_bb0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-5955(97)00077-4","article-title":"Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations","volume":"110","author":"Fischel-Ghodsian","year":"1997","journal-title":"Hear. Res."},{"issue":"11","key":"10.1016\/j.exger.2019.110675_bb0080","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.mad.2005.06.008","article-title":"Lack of age-related increase of mitochondrial DNA amount in brain, skeletal muscle and human heart","volume":"126","author":"Frahm","year":"2005","journal-title":"Mech. Ageing Dev."},{"issue":"9","key":"10.1016\/j.exger.2019.110675_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004620","article-title":"Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing","volume":"10","author":"Greaves","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exger.2019.110675_bb0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mcn.2012.07.004","article-title":"Mouse models of age-related mitochondrial neurosensory hearing loss","volume":"55","author":"Han","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.exger.2019.110675_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180817","article-title":"GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: possible role of the thioredoxin system as a functional backup for GSR","volume":"12","author":"Han","year":"2017","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.exger.2019.110675_bb0100","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/gerona\/glx058","article-title":"Digital PCR quantitation of muscle mitochondrial DNA: age, fiber type, and mutation-induced changes","volume":"72","author":"Herbst","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2019.110675_bb0115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2016.10.021","article-title":"Plastic changes along auditory pathway during salicylate-induced ototoxicity: hyperactivity and CF shifts","volume":"347","author":"Jiang","year":"2017","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2006.02.021","article-title":"Strain background effects and genetic modifiers of hearing in mice","volume":"1091","author":"Johnson","year":"2006","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110675_bb0125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.heares.2011.11.007","article-title":"Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice","volume":"283","author":"Kane","year":"2012","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmet.2016.09.017","article-title":"Mammalian mitochondria and aging: an update","volume":"25","author":"Kauppila","year":"2017","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1399-0004.2007.00800.x","article-title":"Mitochondrial deafness","volume":"71","author":"Kokotas","year":"2007","journal-title":"Clin. Genet."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0140","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.exger.2019.110675_bb0145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng.f.94","article-title":"What causes mitochondrial DNA deletions in human cells?","volume":"40","author":"Krishnan","year":"2008","journal-title":"Nat. Genet."},{"issue":"5733","key":"10.1016\/j.exger.2019.110675_bb0150","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1182\/blood-2014-07-586396","article-title":"Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice","volume":"125","author":"Li-Harms","year":"2015","journal-title":"Blood"},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110675_bb0160","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mrfmmm.2007.12.007","article-title":"Detection of mitochondrial DNA deletions in the cochlea and its structural elements from archival human temporal bone tissue","volume":"640","author":"Markaryan","year":"2008","journal-title":"Mutat. Res."},{"issue":"6","key":"10.1016\/j.exger.2019.110675_bb0165","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/lary.20218","article-title":"Quantification of the mitochondrial DNA common deletion in presbycusis","volume":"119","author":"Markaryan","year":"2009","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.exger.2019.110675_bb0170","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3109\/00016480903397702","article-title":"Major arc mitochondrial DNA deletions in cytochrome c oxidase-deficient human cochlear spiral ganglion cells","volume":"130","author":"Markaryan","year":"2010","journal-title":"Acta Otolaryngol."},{"issue":"1\u20133","key":"10.1016\/j.exger.2019.110675_bb0175","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbagen.2005.03.001","article-title":"Quantitative change in mitochondrial DNA content in various mouse tissues during aging","volume":"1723","author":"Masuyama","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.exger.2019.110675_bb0180","first-page":"F1751","article-title":"Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells","volume":"292","author":"McKiernan","year":"2007","journal-title":"Am. J. Phys. Renal Phys."},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110675_bb0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2004.08.011","article-title":"A physiological place-frequency map of the cochlea in the CBA\/J mouse","volume":"202","author":"Muller","year":"2005","journal-title":"Hear. Res."},{"issue":"8","key":"10.1016\/j.exger.2019.110675_bb0190","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.tcb.2018.03.006","article-title":"Regulation and roles of autophagy at synapses","volume":"28","author":"Nikoletopoulou","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"18","key":"10.1016\/j.exger.2019.110675_bb0195","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/j.yexcr.2007.05.029","article-title":"Somatic mtDNA mutations cause progressive hearing loss in the mouse","volume":"313","author":"Niu","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0920","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10162-010-0228-1","article-title":"Divergent aging characteristics in CBA\/J and CBA\/CaJ mouse cochleae.","volume":"11","author":"Ohlemiller","year":"2010","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.exger.2019.110675_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/srep15037","article-title":"A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis","volume":"5","author":"Rocha","year":"2015","journal-title":"Sci. Rep."},{"issue":"7467","key":"10.1016\/j.exger.2019.110675_bb0210","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature12474","article-title":"Germline mitochondrial DNA mutations aggravate ageing and can impair brain development","volume":"501","author":"Ross","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exger.2019.110675_bb0215","first-page":"621","article-title":"Inner hair cell loss disrupts hearing and cochlear function leading to sensory deprivation and enhanced central auditory gain","volume":"10","author":"Salvi","year":"2016","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.21217","article-title":"Prevalence of mitochondrial DNA disease in adults","volume":"63","author":"Schaefer","year":"2008","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.exger.2019.110675_bb0225","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.neuron.2011.06.003","article-title":"Mitochondria: the next (neurode)generation","volume":"70","author":"Schon","year":"2011","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.exger.2019.110675_bb0230","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrg3275","article-title":"Human mitochondrial DNA: roles of inherited and somatic mutations","volume":"13","author":"Schon","year":"2012","journal-title":"Nat. Rev. Genet."},{"issue":"6","key":"10.1016\/j.exger.2019.110675_bb0235","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00005537-199606000-00021","article-title":"Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool","volume":"106","author":"Seidman","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.exger.2019.110675_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2015.04.007","article-title":"Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats","volume":"327","author":"Sheppard","year":"2015","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2019.110675_bb0245","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2017.07.005","article-title":"Prolonged low-level noise-induced plasticity in the peripheral and central auditory system of rats","volume":"359","author":"Sheppard","year":"2017","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.exger.2019.110675_bb0250","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0925-4439(92)90059-V","article-title":"Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR","volume":"1180","author":"Simonetti","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.exger.2019.110675_bb0255","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neurobiolaging.2007.01.014","article-title":"The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma","volume":"29","author":"Someya","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.exger.2019.110675_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171159","article-title":"Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice","volume":"12","author":"Someya","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.exger.2019.110675_bb0265","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1121\/1.418315","article-title":"Quantitative measures of hair cell loss in CBA and C57BL\/6 mice throughout their life spans","volume":"101","author":"Spongr","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"issue":"5","key":"10.1016\/j.exger.2019.110675_bb0270","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1606","article-title":"Mitochondrial DNA mutations in human disease","volume":"6","author":"Taylor","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0275","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ng1988","article-title":"Mitochondrial point mutations do not limit the natural lifespan of mice","volume":"39","author":"Vermulst","year":"2007","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.exger.2019.110675_bb0280","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng.95","article-title":"DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice","volume":"40","author":"Vermulst","year":"2008","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.exger.2019.110675_bb0285","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1096\/fj.00-0320com","article-title":"Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia","volume":"15","author":"Wanagat","year":"2001","journal-title":"FASEB J."},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110675_bb0290","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-5955(97)00020-8","article-title":"Effects of selective inner hair cell loss on auditory nerve fiber threshold, tuning and spontaneous and driven discharge rate","volume":"107","author":"Wang","year":"1997","journal-title":"Hear. Res."},{"issue":"23","key":"10.1016\/j.exger.2019.110675_bb0295","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1523\/JNEUROSCI.0519-17.2017","article-title":"G6pd deficiency does not affect the cytosolic glutathione or thioredoxin antioxidant defense in mouse cochlea","volume":"37","author":"White","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0300","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1038\/s41598-018-23436-w","article-title":"Loss of IDH2 accelerates age-related hearing loss in male mice","volume":"8","author":"White","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.exger.2019.110675_bb0305","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/sj.cr.7310124","article-title":"Mitochondrial rRNA and tRNA and hearing function","volume":"17","author":"Xing","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.exger.2019.110675_bb0310","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss: epidemiology and mechanistic pathways","volume":"303","author":"Yamasoba","year":"2013","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.exger.2019.110675_bb0315","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.nbd.2007.06.006","article-title":"The role of mitochondrial DNA large deletion for the development of presbycusis in Fischer 344 rats","volume":"27","author":"Yin","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.exger.2019.110675_bb0320","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2006.01.107","article-title":"Auditory brainstem responses in 10 inbred strains of mice","volume":"1091","author":"Zhou","year":"2006","journal-title":"Brain Res."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651930035X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155651930035X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:38:34Z","timestamp":1759977514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155651930035X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":63,"alternative-id":["S053155651930035X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2019.110675","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2019.110675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110675"}}