{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:47Z","timestamp":1791230927750,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.exger.2019.110680","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T19:43:09Z","timestamp":1564774989000},"page":"110680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Involvement of hemoglobins in the pathophysiology of Alzheimer's disease"],"prefix":"10.1016","volume":"126","author":[{"given":"Meric A.","family":"Altinoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Guloksuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainald","family":"Schmidt-Kastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Kenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahri","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.F.","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.exger.2019.110680_bb0005","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1248\/bpb.27.765","article-title":"Alzheimer's, angiotensin IV and an aminopeptidase","volume":"27","author":"Albiston","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.exger.2019.110680_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijdevneu.2017.06.007","article-title":"Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects","volume":"61","author":"Altinoz","year":"2017","journal-title":"Int. J. Dev. Neurosci."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0035-1566120","article-title":"Hemoglobins, hemorphins, and 11p15.5 chromosomal region in cancer biology and immunity with special emphasis for brain tumors","volume":"77","author":"Altinoz","year":"2016","journal-title":"J. Neurol. Surg. A Cent. Eur. Neurosurg."},{"issue":"5","key":"10.1016\/j.exger.2019.110680_bb0020","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s11011-016-9845-7","article-title":"Hemoglobins as new players in multiple sclerosis: metabolic and immune aspects","volume":"31","author":"Altinoz","year":"2016","journal-title":"Metab. Brain Dis."},{"issue":"2","key":"10.1016\/j.exger.2019.110680_bb0025","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neurobiolaging.2005.02.007","article-title":"Anaemia increases the risk of dementia in cognitively intact elderly","volume":"27","author":"Atti","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2019.110680_bb0030","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00018-014-1570-y","article-title":"Hemoglobin as a source of iron overload in multiple sclerosis: does multiple sclerosis share risk factors with vascular disorders?","volume":"71","author":"Bamm","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1047-2797(97)00015-X","article-title":"Risk of Alzheimer's disease among elderly patients with anemia: population-based investigations in Olmsted County, Minnesota","volume":"7","author":"Beard","year":"1997","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0950-3536(98)80070-X","article-title":"Alpha-thalassaemia","volume":"11","author":"Bernini","year":"1998","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1016\/j.exger.2019.110680_bb0050","doi-asserted-by":"crossref","first-page":"15454","DOI":"10.1073\/pnas.0813216106","article-title":"Unexpected expression of alpha and beta-globin in mesencephalic dopaminergic neurons and glial cells","volume":"106","author":"Biagioli","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.exger.2019.110680_bb0055","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1523\/JNEUROSCI.23-09-03807.2003","article-title":"Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment","volume":"23","author":"Blalock","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-015-0711-6","article-title":"Neuronal hemoglobin expression and its relevance to multiple sclerosis neuropathology","volume":"59","author":"Brown","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exger.2019.110680_bb0065","doi-asserted-by":"crossref","first-page":"b158","DOI":"10.1136\/bmj.b158","article-title":"Alzheimer's disease","volume":"338","author":"Burns","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.exger.2019.110680_bb0070","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ajpath.2010.12.006","article-title":"Blood-brain barrier disruption and oxidative stress in Guinea pig after systemic exposure to modified cell-free hemoglobin","volume":"178","author":"Butt","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exger.2019.110680_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101187","article-title":"Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of A\u03b2 peptide","volume":"24","author":"Castillo","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0080","doi-asserted-by":"crossref","first-page":"23","DOI":"10.17219\/acem\/61044","article-title":"Neuroprotective effects of erythropoietin on Alzheimer's dementia model in rats","volume":"26","author":"Cevik","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"issue":"8","key":"10.1016\/j.exger.2019.110680_bb0085","doi-asserted-by":"crossref","first-page":"e1203","DOI":"10.1038\/tp.2017.154","article-title":"RNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia","volume":"7","author":"Chang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110680_bb0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-328X(00)00157-1","article-title":"Production and processing of erythropoietin receptor transcripts in brain","volume":"81","author":"Chin","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033120","article-title":"Interactions between amyloid-\u03b2 and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease","volume":"7","author":"Chuang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0100","doi-asserted-by":"crossref","first-page":"e2538","DOI":"10.1038\/cddis.2016.458","article-title":"Neuronal hemoglobin affects dopaminergic cells' response to stress","volume":"8","author":"Codrich","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exger.2019.110680_bb0105","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ejhg.2010.90","article-title":"Carrier screening for beta-thalassaemia: a review of international practice","volume":"18","author":"Cousens","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.exger.2019.110680_bb0110","series-title":"No362. World Health Organization. Archived from the Original on 18 March 2015","author":"Dementia Fact Sheet","year":"2016"},{"issue":"11","key":"10.1016\/j.exger.2019.110680_bb0120","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/mp.2013.178","article-title":"An anemia of Alzheimer's disease","volume":"19","author":"Faux","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0125","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3233\/JAD-2010-101485","article-title":"Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies","volume":"23","author":"Ferrer","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2019.110680_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2019.01.009","article-title":"Chronic treatment with five vascular risk factors causes cerebral amyloid angiopathy but no Alzheimer pathology in C57BL6 mice","author":"Foidl","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.exger.2019.110680_bb0135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archneur.58.2.186","article-title":"Synucleinopathies: clinical and pathological implications","volume":"58","author":"Galvin","year":"2001","journal-title":"Arch. Neurol."},{"issue":"Database issue","key":"10.1016\/j.exger.2019.110680_bb0140","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gkt911","article-title":"Updates of the HbVar database of human hemoglobin variants and thalassemia mutations","volume":"42","author":"Giardine","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.exger.2019.110680_bb0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/jbiol92","article-title":"Globin genes on the move","volume":"7","author":"Hardison","year":"2008","journal-title":"J. Biol."},{"key":"10.1016\/j.exger.2019.110680_bb0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.neuroscience.2018.08.001","article-title":"CEPO-Fc (an EPO derivative) protects hippocampus against A\u03b2-induced memory deterioration: a behavioral and molecular study in a rat model of A\u03b2 toxicity","volume":"388","author":"Hooshmandi","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.exger.2019.110680_bb0165","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.exger.2010.11.032","article-title":"Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?","volume":"46","author":"Humpel","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2019.110680_bb0175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2015.05.031","article-title":"Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid \u03b242 in mice","volume":"1618","author":"Li","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2019.110680_bb0185","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2147\/NDT.S200264","article-title":"Identification of key genes, pathways, and miRNA\/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis","volume":"15","author":"Ma","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0925-4439(02)00213-2","article-title":"Characterization of hydrogen peroxide removal reaction by hemoglobin in the presence of reduced pyridine nucleotides","volume":"1637","author":"Masuoka","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0195","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-017-0470-4","article-title":"Transmission of \u03b1-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?","volume":"5","author":"Matsumoto","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"issue":"2","key":"10.1016\/j.exger.2019.110680_bb0200","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10048-014-0430-0","article-title":"Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy","volume":"16","author":"Mills","year":"2015","journal-title":"Neurogenetics"},{"key":"10.1016\/j.exger.2019.110680_bb0205","author":"Modell"},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0210","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/ajh.20798","article-title":"Cognitive dysfunction in beta-thalassemia minor","volume":"82","author":"Nevruz","year":"2007","journal-title":"Am. J. Hematol."},{"issue":"7","key":"10.1016\/j.exger.2019.110680_bb0215","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/jnr.21275","article-title":"An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach","volume":"85","author":"Newman","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exger.2019.110680_bb0220","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00277-007-0302-x","article-title":"Discrimination indices as screening tests for beta-thalassemic trait","volume":"86","author":"Ntaios","year":"2007","journal-title":"Ann. Hematol."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2013.07.008","article-title":"Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice","volume":"35","author":"Orre","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"1\u20132","key":"10.1016\/j.exger.2019.110680_bb0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0167-4838(00)00057-1","article-title":"Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation","volume":"1479","author":"Oyama","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.exger.2019.110680_bb0235","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00019442-200409000-00011","article-title":"Hemoglobin levels and Alzheimer disease: an epidemiologic study in India","volume":"12","author":"Pandav","year":"2004","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0240","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S1041610215000733","article-title":"Decreased hemoglobin levels, cerebral small-vessel disease, and cortical atrophy: among cognitively normal elderly women and men","volume":"28","author":"Park","year":"2016","journal-title":"Int. Psychogeriatr."},{"issue":"2","key":"10.1016\/j.exger.2019.110680_bb0245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neurobiolaging.2006.10.017","article-title":"Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease","volume":"29","author":"Perry","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"18","key":"10.1016\/j.exger.2019.110680_bb0250","article-title":"Haemoglobin, anaemia, dementia and cognitive decline in the elderly, a systematic review","volume":"8","author":"Peters","year":"2008","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.exger.2019.110680_bb0255","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/cne.22062","article-title":"Neurons express hemoglobin alpha- and beta-chains in rat and human brains","volume":"515","author":"Richter","year":"2009","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.exger.2019.110680_bb0260","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0268-960X(94)90109-0","article-title":"Fetal hemoglobin levels in adults","volume":"8","author":"Rochette","year":"1994","journal-title":"Blood Rev."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0265","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3233\/JAD-160500","article-title":"An intranasal formulation of erythropoietin (neuro-EPO) prevents memory deficits and amyloid toxicity in the APPSwe transgenic mouse model of Alzheimer's disease","volume":"55","author":"Rodr\u00edguez Cruz","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"29","key":"10.1016\/j.exger.2019.110680_bb0270","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1074\/jbc.RA117.001050","article-title":"Heme and hemoglobin suppress amyloid \u03b2-mediated inflammatory activation of mouse astrocytes","volume":"293","author":"Sankar","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0280","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/jcbfm.2008.152","article-title":"Expression of hemoglobin in rodent neurons","volume":"29","author":"Schelshorn","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"10.1016\/j.exger.2019.110680_bb0285","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/1615-9861(200111)1:12<1519::AID-PROT1519>3.0.CO;2-L","article-title":"Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process","volume":"1","author":"Schonberger","year":"2001","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0290","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000170905","article-title":"Relation of hemoglobin to level of cognitive function in older persons","volume":"32","author":"Shah","year":"2009","journal-title":"Neuroepidemiology"},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0295","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1212\/WNL.0b013e318225aaa9","article-title":"Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis","volume":"77","author":"Shah","year":"2011","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0300","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3233\/JAD-2012-120952","article-title":"Association of lower hemoglobin level and neuropathology in community-dwelling older persons","volume":"32","author":"Shah","year":"2012","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0305","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mito.2013.12.001","article-title":"A mitochondrial location for haemoglobins\u2014dynamic distribution in ageing and Parkinson's disease","volume":"14","author":"Shephard","year":"2014","journal-title":"Mitochondrion"},{"issue":"10","key":"10.1016\/j.exger.2019.110680_bb0310","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1007\/s12035-018-0971-6","article-title":"Erythropoietin upregulates brain hemoglobin expression and supports neuronal mitochondrial activity","volume":"55","author":"Singhal","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.exger.2019.110680_bb0315","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1523\/JNEUROSCI.14-04-02225.1994","article-title":"Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum","volume":"14","author":"Slemmon","year":"1994","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exger.2019.110680_bb0320","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ijc.26450","article-title":"Hemorphin as a prognostic biomarker and potential drug for breast cancer?","volume":"131","author":"Song","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"7\u20138","key":"10.1016\/j.exger.2019.110680_bb0325","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/prca.201400178","article-title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF","volume":"9","author":"Spellman","year":"2015","journal-title":"Proteomics Clin. Appl."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0330","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.mehy.2008.04.007","article-title":"What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages","volume":"71","author":"Stone","year":"2008","journal-title":"Med. Hypotheses"},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0335","first-page":"365","article-title":"Erythropoietin protects erythrocytes against oxidative stress-induced eryptosis in vitro","volume":"64","author":"Sun","year":"2018","journal-title":"Clin. Lab."},{"issue":"6","key":"10.1016\/j.exger.2019.110680_bb0340","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41390-018-0054-4","article-title":"Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs","volume":"84","author":"Teramo","year":"2018","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.exger.2019.110680_bb0350","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5045\/kjh.2011.46.1.41","article-title":"Role of iron deficiency anemia in the propagation of beta thalassemia gene","volume":"46","author":"Usman","year":"2011","journal-title":"Korean J. Hepatol."},{"key":"10.1016\/j.exger.2019.110680_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00008","article-title":"Hemoglobin mRNA changes in the frontal cortex of patients with neurodegenerative diseases","volume":"12","author":"Vanni","year":"2018","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2019.110680_bb0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-018-0556-z","article-title":"Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease","volume":"10","author":"Winchester","year":"2018","journal-title":"Genome Med."},{"issue":"3","key":"10.1016\/j.exger.2019.110680_bb0365","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nbd.2004.08.014","article-title":"Hemoglobin promotes Abeta oligomer formation and localizes in neurons and amyloid deposits","volume":"17","author":"Wu","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.exger.2019.110680_bb0370","first-page":"118","article-title":"Proteomic analysis of cerebral synaptosomes isolated from rat model of alzheimer's disease","volume":"49","author":"Yang","year":"2011","journal-title":"Indian J. Exp. Biol."},{"issue":"7","key":"10.1016\/j.exger.2019.110680_bb0375","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.18632\/oncotarget.7046","article-title":"Neuronal hemoglobin in mitochondria is reduced by forming a complex with \u03b1-synuclein in aging monkey brains","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"issue":"33","key":"10.1016\/j.exger.2019.110680_bb0380","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1039\/C3CP52354C","article-title":"Heme prevents amyloid beta peptide aggregation through hydrophobic interaction based on molecular dynamics simulation","volume":"15","author":"Zhao","year":"2013","journal-title":"Phys. Chem. Chem. Phys."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556519303110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556519303110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:34:28Z","timestamp":1759977268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556519303110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":68,"alternative-id":["S0531556519303110"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2019.110680","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of hemoglobins in the pathophysiology of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2019.110680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110680"}}