{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:44:35Z","timestamp":1789562675906,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.exger.2020.111051","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T10:31:04Z","timestamp":1596969064000},"page":"111051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Blood NAD levels are reduced in very old patients hospitalized for heart failure"],"prefix":"10.1016","volume":"139","author":[{"given":"Marie","family":"Breton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Costemale-Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Lafuente-Lafuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Belmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Mericskay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.exger.2020.111051_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186459","article-title":"An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers","volume":"12","author":"Airhart","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.exger.2020.111051_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"issue":"4","key":"10.1016\/j.exger.2020.111051_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019194","article-title":"Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats","volume":"6","author":"Braidy","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.exger.2020.111051_bb0020","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","article-title":"CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism","volume":"23","author":"Camacho-Pereira","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.exger.2020.111051_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/rej.2018.2077","article-title":"The plasma NAD+ metabolome is dysregulated in \u201cnormal\u201d aging","volume":"22","author":"Clement","year":"2019","journal-title":"Rejuvenation Res."},{"issue":"1","key":"10.1016\/j.exger.2020.111051_bb0030","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1038\/s41598-019-46120-z","article-title":"Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults","volume":"9","author":"Conze","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.exger.2020.111051_bb0035","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/jn\/137.9.2013","article-title":"Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra","volume":"137","author":"Creeke","year":"2007","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.exger.2020.111051_bb0040","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11897-017-0347-7","article-title":"Targeting mitochondrial calcium handling and reactive oxygen species in heart failure","volume":"14","author":"Dietl","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"issue":"21","key":"10.1016\/j.exger.2020.111051_bb0045","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/CIRCULATIONAHA.116.026099","article-title":"Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy","volume":"137","author":"Diguet","year":"2018","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.exger.2020.111051_bb0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqy132","article-title":"A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects","volume":"108","author":"Dollerup","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exger.2020.111051_bb0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00394-019-01919-4","article-title":"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study","volume":"59","author":"Dolopikou","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.exger.2020.111051_bb0060","doi-asserted-by":"crossref","unstructured":"Fukuwatari, T.; Shibata, K. Consideration of diurnal variations in human blood NAD and NADP concentrations. J. Nutr. Sci. Vitaminol. (Tokyo) 2009, 55 (3), 279\u2013281. doi:https:\/\/doi.org\/10.3177\/jnsv.55.279.","DOI":"10.3177\/jnsv.55.279"},{"issue":"1","key":"10.1016\/j.exger.2020.111051_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085335","article-title":"Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid","volume":"9","author":"Guest","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.exger.2020.111051_bb0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.84897","article-title":"Mitochondrial protein hyperacetylation in the failing heart","volume":"1","author":"Horton","year":"2016","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.exger.2020.111051_bb0075","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1172\/JCI120842","article-title":"The role of mitochondria in aging","volume":"128","author":"Jang","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.exger.2020.111051_bb0080","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCRESAHA.118.312498","article-title":"Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases","volume":"123","author":"Kane","year":"2018","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.exger.2020.111051_bb0085","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.116.022495","article-title":"Normalization of NAD+ redox balance as a therapy for heart failure","volume":"134","author":"Lee","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.exger.2020.111051_bb0090","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1038\/s41598-019-39419-4","article-title":"Targeting NAD+ metabolism as interventions for mitochondrial disease","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2020.111051_bb0095","doi-asserted-by":"crossref","unstructured":"Di Lisa, F.; Menab\u00f2, R.; Canton, M.; Barile, M.; Bernardi, P. Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J. Biol. Chem.. 2001, 276 (4), 2571\u20132575. doi: doi:https:\/\/doi.org\/10.1074\/jbc.M006825200.","DOI":"10.1074\/jbc.M006825200"},{"issue":"3","key":"10.1016\/j.exger.2020.111051_bb0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.108.175919","article-title":"Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching","volume":"103","author":"Liu","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2020.111051_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jchromb.2015.12.040","article-title":"Surrogate analyte approach for quantitation of endogenous NAD(+) in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry","volume":"1011","author":"Liu","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci."},{"issue":"7","key":"10.1016\/j.exger.2020.111051_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042357","article-title":"Age-associated changes in oxidative stress and NAD+ metabolism in human tissue","volume":"7","author":"Massudi","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.exger.2020.111051_bb0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.acvd.2015.10.004","article-title":"Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: pathophysiological implications and therapeutic potential","volume":"109","author":"Mericskay","year":"2016","journal-title":"Arch. Cardiovasc. Dis."},{"issue":"5927","key":"10.1016\/j.exger.2020.111051_bb0120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1171641","article-title":"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis","volume":"324","author":"Ramsey","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.exger.2020.111051_bb0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.exger.2016.05.004","article-title":"From concept to clinical practice","volume":"87","author":"Sieber","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111051_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.exger.2020.111051_bb0135","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1093\/hmg\/ddy278","article-title":"Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A\/C gene mutation","volume":"27","author":"Vignier","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"21","key":"10.1016\/j.exger.2020.111051_bb0140","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1161\/CIRCULATIONAHA.117.032626","article-title":"Raising NAD in heart failure: time to translate?","volume":"137","author":"Walker","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2020.111051_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.05.006","article-title":"NAD metabolism: implications in aging and longevity","volume":"47","author":"Yaku","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"9","key":"10.1016\/j.exger.2020.111051_bb0150","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.exger.2020.111051_bb0155","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences","volume":"112","author":"Zhu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520303995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520303995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:06:33Z","timestamp":1759979193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556520303995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":31,"alternative-id":["S0531556520303995"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2020.111051","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood NAD levels are reduced in very old patients hospitalized for heart failure","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2020.111051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111051"}}