{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:41:16Z","timestamp":1759981276891,"version":"build-2065373602"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.exger.2020.111093","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:48:04Z","timestamp":1600346884000},"page":"111093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["An acute estrogen receptor agonist enhances protective effects of cardioplegia in hearts from aging male and female mice"],"prefix":"10.1016","volume":"141","author":[{"given":"Anjali","family":"Ghimire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Howlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2020.111093_bb0005","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/ATVBAHA.116.307301","article-title":"Sex hormones and sex chromosomes cause sex differences in the development of cardiovascular diseases","volume":"37","author":"Arnold","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0010","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.3390\/ijms21124314","article-title":"The role of estrogen receptors in cardiovascular disease","volume":"21","author":"Aryan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2020.111093_bb0015","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1010-7940(01)01168-X","article-title":"Myocardial injury in hypertrophic hearts of patients undergoing aortic valve surgery using cold or warm blood cardioplegia","volume":"21","author":"Ascione","year":"2002","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0020","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1440-1681.2011.05567.x","article-title":"Cardiac ischaemic stress: cardiomyocyte Ca2+, sex and sex steroids","volume":"38","author":"Bell","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.exger.2020.111093_bb0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jsbmb.2013.05.015","article-title":"Sex and sex hormones in cardiac stress\u2014mechanistic insights","volume":"137","author":"Bell","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0030","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/0267659114524977","article-title":"Understanding innovations in the evolving practice of blood and crystalloid cardioplegia","volume":"29","author":"Bhakri","year":"2014","journal-title":"Perfusion"},{"key":"10.1016\/j.exger.2020.111093_bb0035","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/CIRCRESAHA.116.307509","article-title":"The importance of biological sex and estrogen in rodent models of cardiovascular health and disease","volume":"118","author":"Blenck","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2020.111093_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exger.2018.02.003","article-title":"Buckberg\u2019s blood cardioplegia for protection of adult and senile myocardium in a rat in vitro model of acute myocardial infarction","volume":"104","author":"Boening","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111093_bb0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nchembio775","article-title":"Virtual and biomolecular screening converge on a selective agonist for GPR30","volume":"2","author":"Bologa","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.exger.2015.04.012","article-title":"Differences in ischemic damage between young and old hearts\u2014effects of blood cardioplegia","volume":"67","author":"B\u00f6ning","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111093_bb0055","doi-asserted-by":"crossref","first-page":"H16","DOI":"10.1152\/ajpheart.00588.2009","article-title":"A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury","volume":"298","author":"Bopassa","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.exger.2020.111093_bb0060","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-5223(95)70388-8","article-title":"Blood cardioplegia in the senescent heart","volume":"109","author":"Caldarone","year":"1995","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0065","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s10753-019-01158-z","article-title":"Isofraxidin alleviates myocardial infarction through nlrp3 inflammasome inhibition","volume":"43","author":"Chen","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2020.111093_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101490","article-title":"Uncovering sex-specific mechanisms of action of testosterone and redox balance","volume":"31","author":"Cruz-Topete","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/JME-16-0117","article-title":"GPER modulates tone and coronary vascular reactivity in male and female rats","volume":"59","author":"Debortoli","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.exger.2020.111093_bb0080","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1006\/jmcc.1996.0093","article-title":"Protection from myocardial reperfusion injury by acute administration of 17 beta-estradiol","volume":"28","author":"Delyani","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.exger.2020.111093_bb0085","doi-asserted-by":"crossref","first-page":"H1806","DOI":"10.1152\/ajpheart.00283.2009","article-title":"Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats","volume":"297","author":"Deschamps","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.exger.2020.111093_bb0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tcm.2010.05.001","article-title":"Estrogen receptor activation and cardioprotection in ischemia reperfusion injury","volume":"20","author":"Deschamps","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.exger.2020.111093_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1749-8090-9-11","article-title":"The Na+\/Ca2+ exchange inhibitor SEA0400 limits intracellular Ca2+ accumulation and improves recovery of ventricular function when added to cardioplegia","volume":"9","author":"Egar","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0100","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1111\/bph.14033","article-title":"Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia\/reperfusion injury by reducing mitochondrial dysfunction and mitophagy","volume":"174","author":"Feng","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exger.2020.111093_bb0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.exger.2020.111093_bb0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2017.05.006","article-title":"Role of GPER in estrogen-dependent nitric oxide formation and vasodilation","volume":"176","author":"Fredette","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.apcsb.2019.01.001","article-title":"Estrogen receptor signaling mechanisms","volume":"116","author":"Fuentes","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13293-019-0256-4","article-title":"Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice","volume":"10","author":"Ghimire","year":"2019","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.exger.2020.111093_bb0125","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1213\/ANE.0000000000001560","article-title":"Frailty, aging, and cardiovascular surgery","volume":"124","author":"Graham","year":"2017","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.exger.2020.111093_bb0130","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3389\/fendo.2019.00919","article-title":"Female heart health: is GPER the missing link?","volume":"10","author":"Groban","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.exger.2020.111093_bb0135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0002-8703(96)90419-6","article-title":"Beta-estradiol, but not alpha estradiol, reduced myocardial necrosis in rabbits after ischemia and reperfusion","volume":"132","author":"Hale","year":"1996","journal-title":"Am. Heart J."},{"issue":"47\u201352","key":"10.1016\/j.exger.2020.111093_bb0140","first-page":"1997","article-title":"Estradiol, administered acutely, protects ischemic myocardium in both female and male rabbits","volume":"2","author":"Hale","year":"1997","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.exger.2020.111093_bb0145","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000271","article-title":"Testosterone and the cardiovascular system: a comprehensive review of the basic science literature","volume":"2","author":"Herring","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.exger.2020.111093_bb0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13293-019-0219-9","article-title":"Estrogen receptor profiles across tissues from male and female Rattus norvegicus","volume":"10","author":"Hutson","year":"2019","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.exger.2020.111093_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013260","article-title":"Sex differences in long-term survival after major cardiac surgery: a population-based cohort study","volume":"8","author":"Johnston","year":"2019","journal-title":"J. Am. Heart Assoc."},{"year":"2020","series-title":"Retrograde cardioplegia, in: StatPearls [Internet]","author":"Kamassai","key":"10.1016\/j.exger.2020.111093_bb0160"},{"key":"10.1016\/j.exger.2020.111093_bb0165","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/1440-1681.12668","article-title":"Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies","volume":"43","author":"Kane","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.exger.2020.111093_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exger.2020.111093_bb0175","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1051\/ject\/201446317","article-title":"Use of del Nido Cardioplegia for adult cardiac surgery at the Cleveland Clinic: perfusion implications","volume":"46","author":"Kim","year":"2014","journal-title":"J Extra Corpor Technol"},{"key":"10.1016\/j.exger.2020.111093_bb0180","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2015.12.005","article-title":"Testosterone and cardiovascular disease","volume":"67","author":"Kloner","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.exger.2020.111093_bb0185","first-page":"1143","article-title":"Preservation solutions for cardiac and pulmonary donor grafts: a review of the current literature","volume":"6","author":"Latchana","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.exger.2020.111093_bb0190","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/MAT.0b013e318188b86c","article-title":"The myocardial protection of HTK cardioplegic solution on the long-term ischemic period in pediatric heart surgery","volume":"54","author":"Liu","year":"2008","journal-title":"ASAIO J."},{"key":"10.1016\/j.exger.2020.111093_bb0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000204096","article-title":"Expression, distribution and regulation of sex steroid hormone receptors in mouse heart","volume":"23","author":"Lizotte","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exger.2020.111093_bb0200","first-page":"1017","article-title":"The role of estrogen and estrogen receptors on cardiomyocytes: an overview","volume":"32","author":"Luo","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.exger.2020.111093_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/apha.12978","article-title":"Molecular pathways of oestrogen receptors and \u03b2-adrenergic receptors in cardiac cells: recognition of their similarities, interactions and therapeutic value","volume":"222","author":"Machuki","year":"2018","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.exger.2020.111093_bb0210","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/HYPERTENSIONAHA.115.06967","article-title":"Report of the National Heart, Lung, and Blood Institute Working Group on sex differences research in cardiovascular disease: scientific questions and challenges","volume":"67","author":"Maric-Bilkan","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.exger.2020.111093_bb0215","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1161\/CIRCRESAHA.115.305376","article-title":"The expanding complexity of estrogen receptor signaling in the cardiovascular system","volume":"118","author":"Menazza","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2020.111093_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1096\/fj.201600781r","article-title":"Considering sex as a biological variable in preclinical research","volume":"31","author":"Miller","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2020.111093_bb0225","first-page":"e38","article-title":"American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Heart disease and stroke statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2020.111093_bb0230","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exger.2016.04.019","article-title":"Cardiac surgery as a stressor and the response of the vulnerable older adult","volume":"87","author":"Neupane","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111093_bb0235","doi-asserted-by":"crossref","first-page":"736298","DOI":"10.1155\/2014\/736298","article-title":"The evolution of cardiovascular surgery in elderly patient: a review of current options and outcomes","volume":"2014","author":"Nicolini","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.exger.2020.111093_bb0240","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jtcvs.2010.06.004","article-title":"Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia","volume":"141","author":"O\u2019Blenes","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00021.2015","article-title":"Mechanistic pathways of sex differences in cardiovascular disease","volume":"97","author":"Regitz-Zagrosek","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2020.111093_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038425","article-title":"Age and ovariectomy abolish beneficial effects of female sex on rat ventricular myocytes exposed to simulated ischemia and reperfusion","volume":"7","author":"Ross","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2020.111093_bb0255","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.atherosclerosis.2018.05.005","article-title":"Myeloid peroxisome proliferator-activated receptor gamma deficiency aggravates myocardial infarction in mice","volume":"274","author":"Shen","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.exger.2020.111093_bb0260","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/jocs.12360","article-title":"Myocardial protection using del Nido cardioplegia solution in adult reoperative aortic valve surgery","volume":"29","author":"Sorabella","year":"2014","journal-title":"J. Card. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0265","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.athoracsur.2015.12.058","article-title":"Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting: initial experience with 100 consecutive patients","volume":"101","author":"Timek","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.exger.2020.111093_bb0270","first-page":"609","article-title":"Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia\/reperfusion injury via eNOS-dependent mechanism","volume":"113","author":"Valle Raleigh","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.exger.2020.111093_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146429","article-title":"Protective effect of creatine elevation against ischaemia reperfusion injury is retained in the presence of co-morbidities and during cardioplegia","volume":"11","author":"Whittington","year":"2016","journal-title":"PLoS One"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520304411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520304411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:05:16Z","timestamp":1759979116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556520304411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":55,"alternative-id":["S0531556520304411"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2020.111093","relation":{},"ISSN":["0531-5565"],"issn-type":[{"type":"print","value":"0531-5565"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An acute estrogen receptor agonist enhances protective effects of cardioplegia in hearts from aging male and female mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2020.111093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111093"}}