{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:50:59Z","timestamp":1786989059496,"version":"build-2736575974"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.exger.2020.111163","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T16:13:53Z","timestamp":1605888833000},"page":"111163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy"],"prefix":"10.1016","volume":"143","author":[{"given":"Francesco","family":"Dernie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Adeyoju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2020.111163_bb0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1160\/TH07-07-0468","article-title":"Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis","volume":"99","author":"Adomaityte","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.exger.2020.111163_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1089\/1549168041552964","article-title":"Aging theories of primary osteoarthritis: from epidemiology to molecular biology","volume":"7","author":"Aigner","year":"2004","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.exger.2020.111163_bb0015","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.joca.2016.11.007","article-title":"Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-\u03b2 signaling in chondrocytes","volume":"25","author":"Akagi","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.joca.2013.11.004","article-title":"Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis","volume":"22","author":"Akasaki","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0025","article-title":"A synchronized circadian clock enhances early chondrogenesis","author":"Alagha","year":"2020","journal-title":"Cartilage"},{"key":"10.1016\/j.exger.2020.111163_bb0030","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/ard.2005.051292","article-title":"Diurnal variation in serum levels of cartilage oligomeric matrix protein in patients with knee osteoarthritis or rheumatoid arthritis","volume":"65","author":"Andersson","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0035","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1440-1681.12055","article-title":"Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis","volume":"40","author":"Ando","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.exger.2020.111163_bb0040","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2008.06.050","article-title":"SIRT1 regulates circadian clock gene expression through PER2 deacetylation","volume":"134","author":"Asher","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exger.2020.111163_bb0045","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1126\/science.289.5488.2344","article-title":"Resetting of circadian time in peripheral tissues by glucocorticoid signaling","volume":"289","author":"Balsalobre","year":"2000","journal-title":"Science (80-.)."},{"key":"10.1016\/j.exger.2020.111163_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2020.04.004","article-title":"Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis","author":"Bekki","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0055","first-page":"364","article-title":"Rhythmic variations in pain perception in osteoarthritis of the knee","volume":"17","author":"Bellamy","year":"1990","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.exger.2020.111163_bb0060","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/ard.61.12.1075","article-title":"Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis","volume":"61","author":"Bellamy","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1043-6618(02)00089-0","article-title":"Protective effect of melatonin in carrageenan-induced acute local inflammation","volume":"46","author":"Bilici","year":"2002","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0070","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.joca.2016.02.004","article-title":"Exercise-driven metabolic pathways in healthy cartilage","volume":"24","author":"Blazek","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4161\/auto.3708","article-title":"HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway","volume":"3","author":"Bohensky","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2020.111163_bb0080","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/07420528.2013.836534","article-title":"Long-term consistency of diurnal-type preferences among men","volume":"31","author":"Broms","year":"2014","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.exger.2020.111163_bb0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000320673","article-title":"Systemic and cellular reflections on ageing and the circadian oscillator \u2013 a mini-review","volume":"57","author":"Brown","year":"2011","journal-title":"Gerontology"},{"key":"10.1016\/j.exger.2020.111163_bb0090","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 Deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science (80-.)"},{"key":"10.1016\/j.exger.2020.111163_bb0095","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1046\/j.1460-9568.1999.00575.x","article-title":"Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway","volume":"11","author":"Buijs","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exger.2020.111163_bb0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0140-6736(08)60132-4","article-title":"Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial","volume":"371","author":"Buttgereit","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2020.111163_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/35036078","article-title":"Multilevel regulation of the circadian clock","volume":"1","author":"Cermakian","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2020.111163_bb0110","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.exger.2020.111163_bb0115","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1152\/japplphysiol.00871.2017","article-title":"Parathyroid hormone-(1\u201334) ameliorated knee osteoarthritis in rats via autophagy","volume":"124","author":"Chen","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.exger.2020.111163_bb0120","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jbiomech.2012.09.013","article-title":"Diurnal variations in articular cartilage thickness and strain in the human knee","volume":"46","author":"Coleman","year":"2013","journal-title":"J. Biomech."},{"key":"10.1016\/j.exger.2020.111163_bb0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jbspin.2018.09.003","article-title":"Circadian rhythms and rheumatoid arthritis","volume":"86","author":"Cutolo","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.exger.2020.111163_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2018.02.048","article-title":"Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain","volume":"655","author":"Das","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.exger.2020.111163_bb0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/embo-reports\/kve007","article-title":"The orphan nuclear receptor ROR\u03b1 is a negative regulator of the inflammatory response","volume":"2","author":"Delerive","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.exger.2020.111163_bb0140","doi-asserted-by":"crossref","first-page":"12147","DOI":"10.1073\/pnas.1904226116","article-title":"SR9009 has REV-ERB \u2013 independent effects on cell proliferation and metabolism","volume":"116","author":"Dierickx","year":"2019","journal-title":"PNAS"},{"key":"10.1016\/j.exger.2020.111163_bb0145","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1172\/JCI82755","article-title":"The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity","volume":"126","author":"Dudek","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2020.111163_bb0150","first-page":"0","article-title":"Genome-wide occupancy profiling reveals critical roles of FOXO1 in regulating extracellular matrix and circadian rhythm genes in human chondrocytes","author":"Duffy","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.exger.2020.111163_bb0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tem.2019.04.003","article-title":"Clocking in, working out: circadian regulation of exercise physiology","volume":"30","author":"Duglan","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.exger.2020.111163_bb0160","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.0469-12.2012","article-title":"Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock","volume":"32","author":"Farajnia","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2020.111163_bb0165","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1359\/jbmr.080209","article-title":"ALK1 opposes ALK5\/Smad3 signaling and expression of extracellular matrix components in human chondrocytes","volume":"23","author":"Finnson","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0170","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.joca.2018.07.012","article-title":"Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis","volume":"26","author":"Fisch","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0175","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1136\/bjsports-2015-095424","article-title":"Exercise for osteoarthritis of the knee: a Cochrane systematic review","volume":"49","author":"Fransen","year":"2015","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.exger.2020.111163_bb0180","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/JOE-19-0022","article-title":"Circadian production of melatonin in cartilage modifies rhythmic gene expression","volume":"241","author":"Fu","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.exger.2020.111163_bb0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/jor.21284","article-title":"Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions","volume":"29","author":"Fujita","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0190","first-page":"281","article-title":"The parathyroid hormone circadian rhythm is truly endogenous\u2014a general clinical research center study","volume":"82","author":"Fuleihan","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2020.111163_bb0195","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jbspin.2013.01.001","article-title":"Sirt1-deficient mice exhibit an altered cartilage phenotype","volume":"80","author":"Gabay","year":"2013","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.exger.2020.111163_bb0200","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrendo.2014.78","article-title":"Circadian clock control of endocrine factors","volume":"10","author":"Gamble","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.exger.2020.111163_bb0205","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"GBD","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2020.111163_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/biology6010010","article-title":"Circadian rhythms and hormonal homeostasis: pathophysiological implications","volume":"6","author":"Gnocchi","year":"2017","journal-title":"Biology"},{"key":"10.1016\/j.exger.2020.111163_bb0215","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/art.38035","article-title":"The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis","volume":"65","author":"Gossan","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2020.111163_bb0220","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10522-014-9522-3","article-title":"Ageing and osteoarthritis: a circadian rhythm connection","volume":"16","author":"Gossan","year":"2015","journal-title":"Biogerontology"},{"key":"10.1016\/j.exger.2020.111163_bb0225","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.joca.2015.02.020","article-title":"Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFkB-dependent pathway","volume":"23","author":"Guo","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0230","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar3852","article-title":"Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1b\/TNF","volume":"14","author":"Haas","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2020.111163_bb0235","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/JOE-07-0378","article-title":"Circadian clocks: regulators of endocrine and metabolic rhythms","volume":"195","author":"Hastings","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.exger.2020.111163_bb0240","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.joca.2010.08.002","article-title":"The multidimensionality of sleep quality and its relationship to fatigue in older adults with painful osteoarthritis","volume":"18","author":"Hawker","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0245","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/sleep\/5.3.277","article-title":"All-night sleep polygraphic recordings of healthy aged persons: REM and slow-wave sleep","volume":"5","author":"Hayashi","year":"1982","journal-title":"Sleep"},{"key":"10.1016\/j.exger.2020.111163_bb0250","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cmet.2016.03.007","article-title":"The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome","volume":"23","author":"He","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2020.111163_bb0255","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gene.2018.06.002","article-title":"RNA sequencing reveals target genes of temporomandibular joint osteoarthritis in rats after the treatment of low-intensity pulsed ultrasound","volume":"672","author":"He","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.exger.2020.111163_bb0260","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1073\/pnas.76.2.999","article-title":"The pineal gland: a pacemaker within the circadian system of the house sparrow","volume":"76","author":"Headrick Zimmerman","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2020.111163_bb0265","doi-asserted-by":"crossref","first-page":"23632","DOI":"10.1074\/jbc.M512362200","article-title":"Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes","volume":"281","author":"Hinoi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2020.111163_bb0270","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nature06394","article-title":"CLOCK-mediated acetylation of BMAL1 controls circadian function","volume":"450","author":"Hirayama","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exger.2020.111163_bb0275","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.1223710","article-title":"Identification of small molecule activators of cryptochrome","volume":"337","author":"Hirota","year":"2012","journal-title":"Science (80-.)"},{"key":"10.1016\/j.exger.2020.111163_bb0280","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/jb\/mvt068","article-title":"Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions","volume":"154","author":"Honda","year":"2013","journal-title":"J. Biochem."},{"key":"10.1016\/j.exger.2020.111163_bb0285","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jpi.12143","article-title":"Salutary effects of melatonin combined with treadmill exercise on cartilage damage","volume":"57","author":"Hong","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exger.2020.111163_bb0290","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3390\/jcm8111855","article-title":"Conditional controlled light\/dark cycle influences exercise-induced benefits in a rat model with osteoarthritis: in vitro and in vivo study","volume":"8","author":"Hong","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exger.2020.111163_bb0295","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1267\/ahc.15025","article-title":"Robust circadian rhythm and parathyroid hormone-induced resetting during hypertrophic differentiation in ATDC5 chondroprogenitor cells","volume":"48","author":"Hosokawa","year":"2015","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.exger.2020.111163_bb0300","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3390\/jcm8091415","article-title":"Physiological and pathological role of circadian hormones in osteoarthritis: dose-dependent or time-dependent?","volume":"8","author":"Hossain","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exger.2020.111163_bb0305","doi-asserted-by":"crossref","first-page":"10448","DOI":"10.1038\/ncomms10448","article-title":"GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person","volume":"7","author":"Hu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2020.111163_bb0310","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.odw.2012.09.001","article-title":"Diurnal rhythms in the incorporation and secretion of 3H-proline and 3H-galactose by cartilage cells and osteoblasts in various bone-forming sites in growing rats","volume":"72","author":"Igarashi","year":"2013","journal-title":"Orthod. Waves"},{"key":"10.1016\/j.exger.2020.111163_bb0315","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1111\/bph.13898","article-title":"Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes","volume":"175","author":"Jahanban-Esfahlan","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exger.2020.111163_bb0320","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.stem.2013.09.004","article-title":"Human epidermal stem cell function is regulated by circadian oscillations","volume":"13","author":"Janich","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exger.2020.111163_bb0325","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/annrheumdis-2017-212863","article-title":"Single-cell RNA-seq analysis reveals the progression of human osteoarthritis","volume":"78","author":"Ji","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/srep35453","article-title":"Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial","volume":"6","author":"Jia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2020.111163_bb0335","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41467-018-08259-7","article-title":"Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms","volume":"10","author":"Jones","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2020.111163_bb0340","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1172\/JCI107010","article-title":"Circadian rhythm in serum parathyroid hormone concentration in human subjects: correlation with serum calcium, phosphate, albumin and growth hormone levels","volume":"51","author":"Jubiz","year":"1972","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2020.111163_bb0345","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s10067-018-4040-3","article-title":"The association between osteoarthritis and sleep duration in Koreans: a nationwide cross-sectional observational study","volume":"37","author":"Jung","year":"2018","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.exger.2020.111163_bb0350","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.joca.2018.06.015","article-title":"Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes","volume":"26","author":"Kalev-Zylinska","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0355","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1523\/JNEUROSCI.16-17-05555.1996","article-title":"A diurnal rhythm of stimulatory input to the hypothalamo-pituitary- adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist","volume":"16","author":"Kalsbeek","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2020.111163_bb0360","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5578\/tt.57403","article-title":"Obstructive sleep apnea is a risk factor for osteoarthritis. Tuberk","volume":"66","author":"Kanbay","year":"2018","journal-title":"Toraks"},{"key":"10.1016\/j.exger.2020.111163_bb0365","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/s10165-006-0469-3","article-title":"Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage","volume":"16","author":"Kanbe","year":"2006","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.exger.2020.111163_bb0370","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/jcp.24946","article-title":"Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint","volume":"230","author":"Kc","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exger.2020.111163_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16896","article-title":"Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet","volume":"5","author":"Kc","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2020.111163_bb0380","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/PHM.0000000000000179","article-title":"Ultrasonographic assessment of diurnal variation in the femoral condylar cartilage thickness in healthy young adults","volume":"94","author":"Kilic","year":"2015","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.exger.2020.111163_bb0385","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1002\/art.21977","article-title":"Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis","volume":"54","author":"Kong","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2020.111163_bb0390","doi-asserted-by":"crossref","first-page":"8776","DOI":"10.1073\/pnas.1704955114","article-title":"Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity","volume":"114","author":"Kriebs","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2020.111163_bb0395","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/oem.2009.054445","article-title":"Retrospective cohort study of the risk of obesity among shift workers: findings from the industry-based shift workers\u2019 health study, Japan","volume":"68","author":"Kubo","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.exger.2020.111163_bb0400","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0163-7258(91)90088-4","article-title":"Biological rhythms in the absorption, distribution, metabolism and excretion of drugs","volume":"52","author":"Labrecque","year":"1991","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exger.2020.111163_bb0405","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/1756-185X.12563","article-title":"Endogenous parathyroid hormone and knee osteoarthritis: a cross-sectional study","volume":"19","author":"Lee","year":"2016","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0410","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.smim.2016.10.001","article-title":"The modern interleukin-1 superfamily: divergent roles in obesity","volume":"28","author":"Lee","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.exger.2020.111163_bb0415","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/clpt.1985.15","article-title":"Timing optimizes sustained-release indomethacin treatment of osteoarthritis","volume":"37","author":"Levi","year":"1985","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.exger.2020.111163_bb0420","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-079X.2012.00991.x","article-title":"Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway","volume":"53","author":"Lim","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exger.2020.111163_bb0425","first-page":"1","article-title":"Nobiletin inhibits IL-1\u03b2-induced inflammation in chondrocytes via suppression of NF-\u03baB signaling and attenuates osteoarthritis in mice","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2020.111163_bb0430","first-page":"74","article-title":"The effect of immobility and microgravity on cartilage metabolism","author":"Liphardt","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0435","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature05767","article-title":"Transcriptional coactivator PGC-1\u03b1 integrates the mammalian clock and energy metabolism","volume":"447","author":"Liu","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exger.2020.111163_bb0440","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2015.09.007","article-title":"Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: association with upregulated expression of the circardian gene NPAS2","volume":"141","author":"Liu","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2020.111163_bb0445","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1080\/15384101.2019.1620572","article-title":"Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1\u03b1-VEGF signaling pathway","volume":"18","author":"Ma","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exger.2020.111163_bb0450","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1089\/jmf.2017.4176","article-title":"Resveratrol supplementation reduces pain and inflammation in knee osteoarthritis patients treated with meloxicam: a randomized plcebo-controlled study","volume":"21","author":"Marouf","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.exger.2020.111163_bb0455","first-page":"1","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.exger.2020.111163_bb0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000017464","article-title":"Sleep quality and nocturnal pain in patients with hip osteoarthritis","volume":"98","author":"Martinez","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exger.2020.111163_bb0465","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jor.22268","article-title":"The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1\u03b2 in human chondrocytes","volume":"31","author":"Matsushita","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0470","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1126\/scitranslmed.aan0746","article-title":"FoxO transcription factors influence cartilage maturation, homeostasis and osteoarthritis pathogenesis by modulating autophagy and proteoglycan 4","volume":"10","author":"Matsuzaki","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2020.111163_bb0475","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1007\/s00198-012-1955-4","article-title":"Effects of morning vs. evening teriparatide injection on bone mineral density and bone turnover markers in postmenopausal osteoporosis","volume":"23","author":"Michalska","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.exger.2020.111163_bb0480","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0531-5565(93)90002-U","article-title":"Inducing jet lag in older people: adjusting to a 6-hour phase advance in routine","volume":"28","author":"Monk","year":"1993","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111163_bb0485","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/jor.23840","article-title":"Subchondral bone fragility with meniscal tear accelerates and parathyroid hormone decelerates articular cartilage degeneration in rat osteoarthritis model","author":"Morita","year":"2018","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0490","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","article-title":"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control","volume":"134","author":"Nakahata","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exger.2020.111163_bb0495","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1523\/ENEURO.0064-15.2015","article-title":"Age-related changes in the circadian system unmasked by constant conditions","volume":"2","author":"Nakamura","year":"2015","journal-title":"eNeuro"},{"key":"10.1016\/j.exger.2020.111163_bb0500","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017652","article-title":"Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): protocol for a multicentre randomised double-blind placebo-controlled trial","volume":"7","author":"Nguyen","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.exger.2020.111163_bb0505","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078306","article-title":"Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates","volume":"8","author":"Okubo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2020.111163_bb0510","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/17453674.2015.1029393","article-title":"Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur","volume":"86","author":"Okubo","year":"2015","journal-title":"Acta Orthop."},{"key":"10.1016\/j.exger.2020.111163_bb0515","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3899\/jrheum.140382","article-title":"The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive","volume":"42","author":"Orlowsky","year":"2015","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.exger.2020.111163_bb0520","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0024-3205(00)00955-3","article-title":"Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2","volume":"68","author":"Osseni","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2020.111163_bb0525","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cmet.2006.07.002","article-title":"The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock","volume":"4","author":"Oster","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2020.111163_bb0530","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.exger.2020.111163_bb0535","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","article-title":"Melatonin: Nature\u2019s most versatile biological signal?","volume":"273","author":"Pandi-Perumal","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.exger.2020.111163_bb0540","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2020.111163_bb0545","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-079X.2008.00646.x","article-title":"Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes","volume":"46","author":"Pei","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exger.2020.111163_bb0550","series-title":"Experimental Gerontology","first-page":"1739","article-title":"Age impairments in sleep, metabolic and immune functions","volume":"vol. 39","author":"Prinz","year":"2004"},{"key":"10.1016\/j.exger.2020.111163_bb0555","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.joca.2008.04.023","article-title":"NMDA receptor expression and activity in osteoarthritic human articular chondrocytes","volume":"16","author":"Ramage","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0560","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1171641","article-title":"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis","volume":"324","author":"Ramsey","year":"2009","journal-title":"Science (80-.)"},{"key":"10.1016\/j.exger.2020.111163_bb0565","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.fob.2015.08.012","article-title":"Microgravity influences circadian clock oscillation in human keratinocytes","volume":"5","author":"Ranieri","year":"2015","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.exger.2020.111163_bb0570","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exger.2020.111163_bb0575","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.joca.2019.11.010","article-title":"Osteoarthritis year in review 2019: genetics, genomics and epigenetics","volume":"28","author":"Reynard","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0580","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1\u03b1 and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exger.2020.111163_bb0585","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ceb.2008.02.005","article-title":"FoxO transcription factors in the maintenance of cellular homeostasis during aging","volume":"20","author":"Salih","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.exger.2020.111163_bb0590","first-page":"273","article-title":"NMDA receptor expression and roles in human articular chondrocyte mechanotransduction","volume":"41","author":"Salter","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.exger.2020.111163_bb0595","first-page":"3","article-title":"Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis","author":"Sampson","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2020.111163_bb0600","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2478\/s11658-014-0220-6","article-title":"The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes","volume":"19","author":"Sanz-Ramos","year":"2014","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.exger.2020.111163_bb0605","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s40265-016-0646-4","article-title":"Chronotherapy: intuitive, sound, founded\u2026but not broadly applied","volume":"76","author":"Selfridge","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.exger.2020.111163_bb0610","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/195082a0","article-title":"Diurnal periodicity in epiphyseal growth cartilage","volume":"195","author":"Simmons","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.exger.2020.111163_bb0615","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.1245710","article-title":"A mechanosensory pathway to the Drosophila circadian clock","volume":"343","author":"Simoni","year":"2014","journal-title":"Science (80-.)"},{"key":"10.1016\/j.exger.2020.111163_bb0620","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000333456","article-title":"Nocturnal changes in knee cartilage thickness in young healthy adults","volume":"196","author":"Sitoci","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.exger.2020.111163_bb0625","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3109\/07420528.2016.1158183","article-title":"The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis","volume":"33","author":"Snelling","year":"2016","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.exger.2020.111163_bb0630","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/07420528.2015.1041597","article-title":"Irregular 24-hour activity rhythms and the metabolic syndrome in older adults","volume":"32","author":"Sohail","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.exger.2020.111163_bb0635","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature11030","article-title":"Regulation of circadian behavior and metabolism by synthetic REV-ERB agonists","volume":"485","author":"Solt","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exger.2020.111163_bb0640","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/annrheumdis-2017-212603","article-title":"Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage","volume":"77","author":"Soul","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2020.111163_bb0645","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/rheumatology\/keh121","article-title":"Celecoxib 200 mg q.d. is efficacious in the management of osteoarthritis of the knee or hip regardless of the time of dosing","volume":"43","author":"Stengaard-Pedersen","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.exger.2020.111163_bb0650","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jor.1100080117","article-title":"Is longitudinal bone growth influenced by diurnal variation in the mitotic activity of chondrocytes of the growth plate?","volume":"8","author":"Stevenson","year":"1990","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0655","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/s41588-018-0247-0","article-title":"Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis","volume":"50","author":"Styrkarsdottir","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2020.111163_bb0660","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41588-018-0327-1","article-title":"Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data","volume":"51","author":"Tachmazidou","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2020.111163_bb0665","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12891-018-1993-y","article-title":"Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis","volume":"19","author":"Taylor","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.exger.2020.111163_bb0670","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/art.37867","article-title":"Hypoxia promotes the production and inhibits the destruction of human articular cartilage","volume":"65","author":"Thoms","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2020.111163_bb0675","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrrheum.2016.219","article-title":"The changing role of TGF\u03b2 in healthy, ageing and osteoarthritic joints","volume":"13","author":"Van Der Kraan","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.exger.2020.111163_bb0680","first-page":"97","article-title":"Circadian temperature rhythms in young adult and aged men. Neurobiol","volume":"7","author":"Vitiello","year":"1986","journal-title":"Aging"},{"key":"10.1016\/j.exger.2020.111163_bb0685","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2184.1972.tb00378.x","article-title":"Cell kinetics of growth cartilage in the rat tibia I. Measurements in young male rats","volume":"5","author":"Walker","year":"1972","journal-title":"Cell Prolif."},{"key":"10.1016\/j.exger.2020.111163_bb0690","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/path.2578","article-title":"Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes","volume":"219","author":"Wang","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.exger.2020.111163_bb0695","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1002\/art.38062","article-title":"High body mass index is associated with increased dirunal strains in the articular cartilage of the knee","volume":"65","author":"Widmyer","year":"2013","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.exger.2020.111163_bb0700","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1667\/RR14400.1","article-title":"Spaceflight-relevant challenges of radiation and\/or reduced weight bearing cause arthritic responses in knee articular cartilage","volume":"186","author":"Willey","year":"2016","journal-title":"Radiat. Res."},{"key":"10.1016\/j.exger.2020.111163_bb0705","first-page":"10","article-title":"New insights into the circadian rhythm and its related diseases","author":"Xie","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exger.2020.111163_bb0710","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.joca.2014.07.013","article-title":"Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis","volume":"22","author":"Yan","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0715","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1210\/en.2015-2042","article-title":"Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1","volume":"157","author":"Yang","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.exger.2020.111163_bb0720","first-page":"1","article-title":"Cellular mechano-environment regulates the mammary circadian clock","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2020.111163_bb0725","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1073\/pnas.0308709101","article-title":"PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues","volume":"101","author":"Yoo","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2020.111163_bb0730","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cpr.12727","article-title":"Circadian BMAL1 regulates mandibular condyle development by hedgehog pathway","volume":"53","author":"Yu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.exger.2020.111163_bb0735","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.joca.2019.01.012","article-title":"Clock mutant promotes osteoarthritis by inhibiting the acetylation of NF\u03baB","volume":"27","author":"Yuan","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0740","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.joca.2014.06.028","article-title":"Effectiveness of continuous and pulsed ultrasound for the management of knee osteoarthritis: a systematic review and network meta-analysis","volume":"22","author":"Zeng","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2020.111163_bb0745","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2020.111163_bb0750","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1081\/CBI-120015958","article-title":"Aging and the circadian rhythm of melatonin: a cross-sectional study of Chinese subjects 30\u2013110 yr of age","volume":"19","author":"Zhao","year":"2002","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.exger.2020.111163_bb0755","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5271\/sjweh.3861","article-title":"Shift work and the risk of knee osteoarthritis among Chinese workers: a retrospective cohort study","volume":"46","author":"Zhou","year":"2020","journal-title":"Scand. J. Work Environ. Health"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520305118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520305118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:09:08Z","timestamp":1759979348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556520305118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":151,"alternative-id":["S0531556520305118"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2020.111163","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2020.111163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111163"}}