{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:20:49Z","timestamp":1783761649494,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King&apos;s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009362","name":"South London and Maudsley NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.exger.2020.111223","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T15:44:16Z","timestamp":1610552656000},"page":"111223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Motor signs in Alzheimer's disease and vascular dementia: Detection through natural language processing, co-morbid features and relationship to adverse outcomes"],"prefix":"10.1016","volume":"146","author":[{"given":"Ahmed M.","family":"Al-Harrasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehtesham","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsamakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judista","family":"Lasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romayne","family":"Gadelrab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Soysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiptsios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2020.111223_bb0005","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(05)78999-6","article-title":"Neuroleptic sensitivity in dementia with Lewy bodies and Alzheimer's disease","volume":"351","author":"Ballard","year":"1998","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.exger.2020.111223_bb0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.exger.2020.111223_bb0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1056\/NEJM199601113340202","article-title":"Prevalence of parkinsonian signs and associated mortality in a community population of older people","volume":"334","author":"Bennett","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2020.111223_bb0025","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1192\/bjp.174.5.424","article-title":"Health of the nation outcome scales for elderly people (HoNOS 65+)","volume":"174","author":"Burns","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.exger.2020.111223_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-017-0254-x","article-title":"The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the joint program for neurodegenerative diseases working group","volume":"9","author":"Costa","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.exger.2020.111223_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002854","article-title":"Getting more out of biomedical documents with GATE\u2019s full lifecycle open source text analytics","volume":"9","author":"Cunningham","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.exger.2020.111223_bb0040","first-page":"1","article-title":"Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies","author":"Donaghy","year":"2018","journal-title":"Psychol. Med."},{"key":"10.1016\/j.exger.2020.111223_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-017-0841-2","article-title":"Big data and data repurposing - using existing data to answer new questions in vascular dementia research","volume":"17","author":"Doubal","year":"2017","journal-title":"BMC Neurol."},{"key":"10.1016\/j.exger.2020.111223_bb0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00002093-199601020-00008","article-title":"Extrapyramidal motor signs in clinically diagnosed Alzheimer disease","volume":"10","author":"Ellis","year":"1996","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.exger.2020.111223_bb0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.exger.2020.111223_bb0060","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.exger.2020.111223_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187121","article-title":"ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records","volume":"12","author":"Iqbal","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2020.111223_bb0070","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000492860","article-title":"Hasselbalch, S.G. Quantitative measurements of motor function in Alzheimer\u2019s disease, frontotemporal dementia, and dementia with Lewy bodies: a proof-of-concept study","volume":"46","author":"Jeppesen Kragh","year":"2018","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.exger.2020.111223_bb0075","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1177\/0269881118796809","article-title":"Predicting parkinsonism side-effects of antipsychotic polypharmacy prescribed in secondary mental healthcare","volume":"32","author":"Kadra","year":"2018","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.exger.2020.111223_bb0080","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3233\/JAD-171128","article-title":"The impact of hospitalization on readmission, institutionalization, and mortality of people with dementia: a systematic review and meta-analysis","volume":"64","author":"Lehmann","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2020.111223_bb0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0404.1995.tb00426.x","article-title":"Long-term survival and predictors of mortality in Alzheimer\u2019s disease and multi-infarct dementia","volume":"91","author":"Molsa","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.exger.2020.111223_bb0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1474-4422(17)30074-1","article-title":"The prognosis of dementia with Lewy bodies","volume":"16","author":"Mueller","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2020.111223_bb0100","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.exger.2018.02.011","article-title":"Polypharmacy in people with dementia: associations with adverse health outcomes","volume":"106","author":"Mueller","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2020.111223_bb0105","article-title":"Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes","author":"Mueller","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.exger.2020.111223_bb0110","unstructured":"NHS Digital. Hospital Episode Statistics (HES)."},{"key":"10.1016\/j.exger.2020.111223_bb0115","series-title":"The English Indices of Deprivation 2007","author":"Noble","year":"2007"},{"key":"10.1016\/j.exger.2020.111223_bb0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3389\/fphar.2019.01045","article-title":"Antipsychotic treatment of behavioral and psychological symptoms of dementia (BPSD): management of extrapyramidal side effects","volume":"10","author":"Ohno","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2020.111223_bb0125","series-title":"Flexible Multiple Imputation by Chained Equations of the AVO-95 Survey: TNO Prevention and Health Leiden","author":"Oudshoorn","year":"1999"},{"key":"10.1016\/j.exger.2020.111223_bb0130","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-008721","article-title":"Cohort profile of the South London and Maudsley NHS Foundation Trust biomedical research Centre (SLaM BRC) case register: current status and recent enhancement of an electronic mental health record-derived data resource","volume":"6","author":"Perera","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.exger.2020.111223_bb0135","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1001\/archneur.1991.00530230055021","article-title":"Interrater reliability of extrapyramidal signs in a group assessed for dementia","volume":"48","author":"Richards","year":"1991","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.exger.2020.111223_bb0140","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0145","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"2004"},{"key":"10.1016\/j.exger.2020.111223_bb0150","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jalz.2018.06.3054","article-title":"High prevalence of parkinsonism in patients with MCI or mild Alzheimer\u2019s disease","volume":"14","author":"Sasaki","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.exger.2020.111223_bb0155","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1212\/01.WNL.0000138440.39918.0C","article-title":"Motor signs during the course of Alzheimer disease","volume":"63","author":"Scarmeas","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0160","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1212\/01.WNL.0000162054.15428.E9","article-title":"Motor signs predict poor outcomes in Alzheimer disease","volume":"64","author":"Scarmeas","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0165","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/STROKEAHA.107.493353","article-title":"Neurological signs in relation to type of cerebrovascular disease in vascular dementia","volume":"39","author":"Staekenborg","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2020.111223_bb0170","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1212\/WNL.44.12.2300","article-title":"Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission, and death in Alzheimer\u2019s disease: prospective analyses from the predictors study","volume":"44","author":"Stern","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0175","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/wps.20567","article-title":"Management of common adverse effects of antipsychotic medications","volume":"17","author":"Stroup","year":"2018","journal-title":"World Psychiatry"},{"key":"10.1016\/j.exger.2020.111223_bb0180","series-title":"The Maudsley Prescribing Guidelines in Psychiatry","author":"Taylor","year":"2018"},{"key":"10.1016\/j.exger.2020.111223_bb0185","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/gps.4948","article-title":"Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: the DIAMOND Lewy study","volume":"33","author":"Thomas","year":"2018","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.exger.2020.111223_bb0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1192\/bjp.2019.195","article-title":"The individual course of neuropsychiatric symptoms in people with Alzheimer\u2019s and Lewy body dementia: 12-year longitudinal cohort study","volume":"216","author":"Vik-Mo","year":"2020","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.exger.2020.111223_bb0195","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/brain\/awz050","article-title":"Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease","volume":"142","author":"Voglein","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.exger.2020.111223_bb0200","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1212\/WNL.58.12.1815","article-title":"Progression of gait disorder and rigidity and risk of death in older persons","volume":"58","author":"Wilson","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2020.111223_bb0205","series-title":"International Statistical Classifications of Diseases and Related Health Problems. 10th Revision Vol 2 Instruction Manual","author":"World Health Organisation","year":"2010"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520305714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556520305714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:20:40Z","timestamp":1759980040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556520305714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":40,"alternative-id":["S0531556520305714"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2020.111223","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor signs in Alzheimer's disease and vascular dementia: Detection through natural language processing, co-morbid features and relationship to adverse outcomes","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2020.111223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111223"}}