{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:52:02Z","timestamp":1783511522618,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA121298"],"award-info":[{"award-number":["CA121298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.exger.2021.111387","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T01:55:58Z","timestamp":1620006958000},"page":"111387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL\/6 mice via a folate independent mechanism"],"prefix":"10.1016","volume":"150","author":[{"given":"Safa","family":"Beydoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Fardous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Saruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Beydoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan A.","family":"Sorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Aoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Unnikrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Cabelof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Heydari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.exger.2021.111387_bb0005","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/jcp.24351","article-title":"mTOR signaling for biological control and cancer","volume":"228","author":"A","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exger.2021.111387_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2016.01.024","article-title":"Samples and techniques highlighting the links between obesity and microbiota","author":"Angelakis","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.exger.2021.111387_bb0015","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/MCB.00201-08","article-title":"mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice","volume":"28","author":"Antion","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.exger.2021.111387_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/00000658-194404000-00005","article-title":"Clinical and laboratory experiences with succinyl sulfathiazole","author":"Archer","year":"1944","journal-title":"Ann. Surg."},{"key":"10.1016\/j.exger.2021.111387_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2005.02.006","article-title":"Bacterially synthesized folate and supplemental folic acid are absorbed across the large intestine of piglets","author":"Asrar","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.exger.2021.111387_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060042","article-title":"Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy","author":"Bajaj","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111387_bb0035","first-page":"46","article-title":"Succinylsulfathiazole in resection for carcinoma of the colon","volume":"54","author":"Bell","year":"1948","journal-title":"Its. Trans. West. Surg. Assoc."},{"issue":"3","key":"10.1016\/j.exger.2021.111387_bb0040","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/MOG.0000000000000349","article-title":"Intestinal microbiota and NASH","volume":"33","author":"Brandl","year":"2017","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0045","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1113\/JP277336","article-title":"Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice","volume":"597","author":"Brunt","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2021.111387_bb0050","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.70.10.5769-5777.2004","article-title":"Riboflavin production in Lactococcus lactis: potential for in situ production of vitamin-enriched foods","author":"Burgess","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.exger.2021.111387_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/tera.10040","article-title":"Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model","author":"Burgoon","year":"2002","journal-title":"Teratology"},{"key":"10.1016\/j.exger.2021.111387_bb0060","doi-asserted-by":"crossref","first-page":"36504","DOI":"10.1074\/jbc.M405185200","article-title":"Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency","volume":"279","author":"Cabelof","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2021.111387_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.exger.2021.111387_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/nature13264","article-title":"The metabolite \u03b1-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR","author":"Chin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exger.2021.111387_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","author":"Cox","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.exger.2021.111387_bb0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0016-5085(19)36589-8","article-title":"The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine","volume":"16","author":"Dearing","year":"1950","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exger.2021.111387_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2016.06.010","article-title":"Maternal gut and fetal brain connection: increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure","author":"Degroote","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.exger.2021.111387_bb0090","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1074\/jbc.273.24.14845","article-title":"Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation","volume":"273","author":"Dennis","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2021.111387_bb0095","doi-asserted-by":"crossref","DOI":"10.1101\/gad.1617608","article-title":"Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling","author":"Deyoung","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.exger.2021.111387_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/ps\/84.4.634","article-title":"Antibiotic growth promoters in agriculture: history and mode of action","author":"Dibner","year":"2005","journal-title":"Poult. Sci."},{"key":"10.1016\/j.exger.2021.111387_bb0105","first-page":"2018","article-title":"Oxidative stress and the microbiota-gut-brain axis","author":"Dumitrescu","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2021.111387_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2015.06.009","article-title":"2-hydroxyglutarate inhibits ATP synthase and mTOR signaling","author":"Fu","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2021.111387_bb0115","doi-asserted-by":"crossref","DOI":"10.1080\/00365521.1997.11720714","article-title":"Modification of the intestinal microflora using probiotics and prebiotics","author":"Fuller","year":"1997","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"10.1016\/j.exger.2021.111387_bb0120","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/hipo.22327","article-title":"Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits","volume":"24","author":"Gangarossa","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.exger.2021.111387_bb0125","series-title":"Veterinary and Human Toxicology","article-title":"Perturbation of intestinal microflora","author":"Gorbach","year":"1993"},{"key":"10.1016\/j.exger.2021.111387_bb0130","first-page":"284","article-title":"A review of antibiotics, depression, and the gut microbiome","author":"Hao","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.exger.2021.111387_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2004","key":"10.1016\/j.exger.2021.111387_bb0140","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.exger.2021.111387_bb0145","doi-asserted-by":"crossref","DOI":"10.1097\/00008469-199703001-00009","article-title":"Intestinal flora and endogenous vitamin synthesis","author":"Hill","year":"1997","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.exger.2021.111387_bb0150","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/clinchem\/34.11.2357","article-title":"Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates","volume":"34","author":"Horne","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.exger.2021.111387_bb0155","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0160","series-title":"Gut Microbiota and Aging","first-page":"350","author":"Jeffery","year":"2015"},{"key":"10.1016\/j.exger.2021.111387_bb0165","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.040618-0","article-title":"Long-term impacts of antibiotic exposure on the human intestinal microbiota","author":"Jernberg","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.exger.2021.111387_bb0170","first-page":"197","article-title":"The human gut microbiome in health and disease","author":"Jovel","year":"2017","journal-title":"Metagenomics Perspect. Methods, Appl."},{"key":"10.1016\/j.exger.2021.111387_bb0175","article-title":"Chronic repression of mTOR complex 2 induces changes in the gut microbiota of diet-induced obese mice","author":"Jung","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2021.111387_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2021.111387_bb0185","first-page":"5","article-title":"Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells","author":"Kalghatgi","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2021.111387_bb0190","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(04)00115-1","article-title":"Translational control by MAPK signaling in long-term synaptic plasticity and memory","volume":"116","author":"Kelleher","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.exger.2021.111387_bb0195","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/jn\/134.6.1389","article-title":"A large pool of available folate exists in the large intestine of human infants and piglets","volume":"134","author":"Kim","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2021.111387_bb0200","doi-asserted-by":"crossref","DOI":"10.1017\/S095442241700018X","article-title":"Probiotics, prebiotics, synbiotics and insulin sensitivity","author":"Kim","year":"2018","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.exger.2021.111387_bb0205","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809302","article-title":"The role of the microbiome in NAFLD and NASH","author":"Kolodziejczyk","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.exger.2021.111387_bb0210","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.exger.2021.111387_bb0215","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011593","article-title":"mTOR signaling","author":"Laplante","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.exger.2021.111387_bb0220","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1046\/j.1440-1746.2000.02327.x","article-title":"Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status","volume":"15","author":"Le Leu","year":"2000","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exger.2021.111387_bb0225","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2672.2011.05157.x","article-title":"B-group vitamin production by lactic acid bacteria - current knowledge and potential applications","author":"Leblanc","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.exger.2021.111387_bb0230","article-title":"Gut microbiota in Alzheimer\u2019s disease, depression, and type 2 diabetes mellitus: the role of oxidative stress","volume":"2019","author":"Luca","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2021.111387_bb0235","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2021.111387_bb0240","first-page":"69","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Manuscript","year":"2016","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0245","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/jhn.12371","article-title":"The human gut microbiota and its interactive connections to diet","volume":"29","author":"Milani","year":"2016","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.exger.2021.111387_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12248","article-title":"mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity","author":"Mizunuma","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2021.111387_bb0255","doi-asserted-by":"crossref","first-page":"9277","DOI":"10.1007\/s00253-019-10165-x","article-title":"Antibiotic effects on gut microbiota, metabolism, and beyond","volume":"103","author":"Mu","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.exger.2021.111387_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)50735-9","article-title":"An array of insulin-activated, proline-directed serine\/threonine protein kinases phosphorylate the p70 S6 kinase","author":"Mukhopadhyay","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2021.111387_bb0265","first-page":"153","article-title":"The effect of succinylsulfathiazole on pteroylglutamic acid deficiency during lactation in the rat","volume":"18","author":"Nelson","year":"1948","journal-title":"Arch. Biochem."},{"key":"10.1016\/j.exger.2021.111387_bb0270","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8486","article-title":"Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment","author":"Nobel","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2021.111387_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2018.03.021","article-title":"Gut microbiota and mTOR signaling: insight on a new pathophysiological interaction","author":"Noureldein","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.exger.2021.111387_bb0280","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.3945\/jn.109.104380","article-title":"Products of the colonic microbiota mediate the effects of diet on colon cancer risk","volume":"139","author":"O\u2019Keefe","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2021.111387_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2017.06.001","article-title":"Oxidative stress plays a key role in butyrate-mediated autophagy via Akt\/mTOR pathway in hepatoma cells","author":"Pant","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.exger.2021.111387_bb0290","series-title":"An Introduction to Medicinal Chemistry","author":"Patrick","year":"2013"},{"key":"10.1016\/j.exger.2021.111387_bb0295","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/postgradmedj-2015-133285","article-title":"Gut microbiota, obesity and diabetes","volume":"92","author":"Patterson","year":"2016","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.exger.2021.111387_bb0300","doi-asserted-by":"crossref","first-page":"15632","DOI":"10.3748\/wjg.v20.i42.15632","article-title":"Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics","volume":"20","author":"Plaza-Diaz","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0305","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/137.12.2742","article-title":"Administration of folate-producing bifidobacteria enhances folate Status in Wistar rats","author":"Pompei","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2021.111387_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting PI3K\/Akt\/mTOR signaling in cancer","author":"Porta","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.exger.2021.111387_bb0315","doi-asserted-by":"crossref","DOI":"10.1001\/archsurg.1942.01210200024002","article-title":"Clinical use of succinylsulfathiazole","author":"Poth","year":"1942","journal-title":"Arch. Surg."},{"key":"10.1016\/j.exger.2021.111387_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052154","article-title":"Regulated in development and DNA damage responses \u22121 (REDD1) protein contributes to insulin signaling pathway in adipocytes","author":"Regazzetti","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111387_bb0325","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1097\/MCG.0000000000001069","article-title":"Antibiotic and modulation of microbiota a new paradigm?","volume":"52","author":"Rizzatti","year":"2018","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0330","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/jn\/121.12.1955","article-title":"Bacterially synthesized folate in rat large intestine is incorporated into host tissue folyl polyglutamates","volume":"121","author":"Rong","year":"1991","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2021.111387_bb0335","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/nu3010118","article-title":"Folate production by probiotic bacteria","volume":"3","author":"Rossi","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2021.111387_bb0340","doi-asserted-by":"crossref","DOI":"10.3109\/10408448509041324","article-title":"The effect of diet on the mammalian gut flora and its metabolic activities","author":"Rowland","year":"1985","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.exger.2021.111387_bb0345","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00319-08","article-title":"Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection","author":"Sekirov","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exger.2021.111387_bb0350","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.exger.2021.111387_bb0355","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/jn\/117.7.1335","article-title":"Sulfonamides and folic acid antagonists: a historical review","volume":"117","author":"Stokstad","year":"1987","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2021.111387_bb0360","doi-asserted-by":"crossref","DOI":"10.4161\/auto.7.2.14277","article-title":"The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer","author":"Tang","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2021.111387_bb0365","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/361590","article-title":"The design of a quantitative Western blot experiment","volume":"2014","author":"Taylor","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.exger.2021.111387_bb0370","doi-asserted-by":"crossref","DOI":"10.1024\/0300-9831.73.6.403","article-title":"Citrus pectin and oligofructose improve folate status and lower serum total homocysteine in rats","author":"Thoma","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.exger.2021.111387_bb0375","first-page":"15163","article-title":"Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World","volume":"20","author":"Tojo","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.exger.2021.111387_bb0380","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5507\/bp.2016.052","article-title":"Nutrition, oxidative stress and intestinal dysbiosis: influence of diet on gut microbiota in inflammatory bowel diseases","volume":"160","author":"Tomasello","year":"2016","journal-title":"Biomed. Pap."},{"key":"10.1016\/j.exger.2021.111387_bb0385","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2010.11.003","article-title":"Folate deficiency regulates expression of DNA polymerase \u03b2 in response to oxidative stress","volume":"50","author":"Unnikrishnan","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2021.111387_bb0390","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7092032","article-title":"Gut microbiota, diet, and chronic diseases: the role played by oxidative stress","volume":"2019","author":"Vasquez","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2021.111387_bb0395","doi-asserted-by":"crossref","first-page":"19246","DOI":"10.1074\/jbc.M109.069807","article-title":"Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice","volume":"285","author":"Ventrella-Lucente","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2021.111387_bb0400","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cbpa.2013.04.011","article-title":"The human microbiome is a source of therapeutic drug targets","volume":"17","author":"Wallace","year":"2013","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.exger.2021.111387_bb0405","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","article-title":"Mechanisms and consequences of intestinal dysbiosis","volume":"74","author":"Weiss","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exger.2021.111387_bb0410","series-title":"Alteration of the Gut Microbiota and Its Effect on AMPK\/NADPH Oxidase Signaling Pathway in 2K1C Rats","author":"Yu","year":"2019"},{"key":"10.1016\/j.exger.2021.111387_bb0415","article-title":"MTORC1 couples immune signals and metabolic programming to establish T reg-cell function","author":"Zeng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exger.2021.111387_bb0420","article-title":"Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice","author":"Zhao","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111387_bb0425","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556521001698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556521001698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:32:15Z","timestamp":1759980735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556521001698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":85,"alternative-id":["S0531556521001698"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2021.111387","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL\/6 mice via a folate independent mechanism","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2021.111387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111387"}}