{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:47:23Z","timestamp":1774025243494,"version":"3.50.1"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A2B4012775"],"award-info":[{"award-number":["NRF-2017R1A2B4012775"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.exger.2021.111552","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T01:39:21Z","timestamp":1631497161000},"page":"111552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging"],"prefix":"10.1016","volume":"155","author":[{"given":"Min Kyung","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Geun","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2021.111552_bb0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1874609812666190114144238","article-title":"Changes in body composition of old rats at different time points after dexamethasone administration","volume":"11","author":"Aru","year":"2018","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.exger.2021.111552_bb0010","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neubiorev.2009.12.008","article-title":"Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues","volume":"34","author":"Backman","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.exger.2021.111552_bb0015","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1212\/WNL.48.5.1234","article-title":"Steroid myopathy in cancer patients","volume":"48","author":"Batchelor","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2021.111552_bb0020","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/SCS.0b013e31828014e7","article-title":"Systemic steroid versus combined systemic and intratympanic steroid treatment for sudden sensorineural hearing loss","volume":"24","author":"Baysal","year":"2013","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.exger.2021.111552_bb0025","doi-asserted-by":"crossref","first-page":"15954","DOI":"10.1038\/srep15954","article-title":"Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects","volume":"5","author":"Bordag","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2021.111552_bb0030","first-page":"434","article-title":"Age-related physiological changes and their clinical significance","volume":"135","author":"Boss","year":"1981","journal-title":"West. J. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019194","article-title":"Age related changes in NAD metabolism oxidative stress and Sirt1 activity in wistar rats","volume":"6","author":"Braidy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111552_bb0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.abb.2008.02.034","article-title":"Insulin action and signalling in fat and muscle from dexamethasone-treated rats","volume":"474","author":"Buren","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.exger.2021.111552_bb0045","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1111\/ejn.12732","article-title":"Acoustical enrichment during early postnatal development changes response properties of inferior colliculus neurons in rats","volume":"40","author":"Bures","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0050","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000022113","article-title":"Quality of life determinants and hearing function in an elderly population: Osservatorio Geriatrico Campano Study Group","volume":"45","author":"Cacciatore","year":"1999","journal-title":"Gerontology"},{"key":"10.1016\/j.exger.2021.111552_bb0055","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/meta.2001.25803","article-title":"Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats","volume":"50","author":"Caldefie-Chezet","year":"2001","journal-title":"Metabolism"},{"key":"10.1016\/j.exger.2021.111552_bb0060","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-2005-861302","article-title":"Troglitazone reduces leptinemia during experimental dexamethasone-induced stress","volume":"37","author":"Caldefie-Chezet","year":"2005","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.exger.2021.111552_bb0065","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1532-5415.1993.tb06948.x","article-title":"Sensory impairment and quality of life in a community elderly population","volume":"41","author":"Carabellese","year":"1993","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.exger.2021.111552_bb0070","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1590\/S0100-879X2011007500067","article-title":"Aging alters the production of iNOS, arginase and cytokines in murine macrophages","volume":"44","author":"Cecilio","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.exger.2021.111552_bb0075","doi-asserted-by":"crossref","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2021.111552_bb0080","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.neurobiolaging.2008.09.010","article-title":"Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats","volume":"31","author":"Choi","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.11.004","article-title":"Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity","volume":"63","author":"Cortese","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/07853890701408194","article-title":"Sirtuins: the 'magnificent seven', function, metabolism and longevity","volume":"39","author":"Dali-Youcef","year":"2007","journal-title":"Ann. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnagi.2013.00036","article-title":"Sirtuins: from metabolic regulation to brain aging","volume":"5","author":"Duan","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00008483-200211000-00002","article-title":"Lipids, lipoproteins, and exercise","volume":"22","author":"Durstine","year":"2002","journal-title":"J. Cardpulm. Rehabil."},{"key":"10.1016\/j.exger.2021.111552_bb0105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000346938","article-title":"Effectiveness of systemic high-dose dexamethasone therapy for idiopathic sudden sensorineural hearing loss","volume":"18","author":"Egli Gallo","year":"2013","journal-title":"Audiol Neurootol."},{"key":"10.1016\/j.exger.2021.111552_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/jn.00059.2004","article-title":"Environmental enrichment improves response strength, threshold, selectivity, and latency of auditory cortex neurons","volume":"92","author":"Engineer","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exger.2021.111552_bb0115","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.exger.2010.12.003","article-title":"Pathogenesis of presbycusis in animal models: a review","volume":"46","author":"Fetoni","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2021.111552_bb0120","doi-asserted-by":"crossref","first-page":"15223","DOI":"10.1523\/JNEUROSCI.3252-09.2009","article-title":"One-year brain atrophy evident in healthy aging","volume":"29","author":"Fjell","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0125","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0197-4580(02)00138-0","article-title":"Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice","volume":"24","author":"Frick","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0130","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2021.111552_bb0135","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1046\/j.1460-9568.2003.02917.x","article-title":"Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro","volume":"18","author":"Golde","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fnagi.2016.00241","article-title":"Environmental enrichment modified epigenetic mechanisms in SAMP8 mouse hippocampus by reducing oxidative stress and inflammaging and achieving neuroprotection","volume":"8","author":"Grinan-Ferre","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0145","first-page":"206","article-title":"The effects of early experience on problem-solving at maturity","volume":"2","author":"Hebb","year":"1947","journal-title":"Am Psychol."},{"key":"10.1016\/j.exger.2021.111552_bb0150","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1750-3639.2008.00257.x","article-title":"Reduction of cerebral oxidative stress following environmental enrichment in mice with alzheimer-like pathology","volume":"20","author":"Herring","year":"2010","journal-title":"Brain Pathol."},{"key":"10.1016\/j.exger.2021.111552_bb0155","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00405-010-1270-7","article-title":"Age-related hearing loss or presbycusis","volume":"267","author":"Huang","year":"2010","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.exger.2021.111552_bb0160","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/jcs.001222","article-title":"Dynamic FoxO transcription factors","volume":"120","author":"Huang","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exger.2021.111552_bb0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-12-49","article-title":"Dexamethasone inhibits the nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia","volume":"12","author":"Huo","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0170","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.bbapap.2009.10.024","article-title":"\"Clocks\" in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging","volume":"1804","author":"Imai","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exger.2021.111552_bb0175","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/dom.12171","article-title":"The importance of NAMPT\/NAD\/SIRT1 in the systemic regulation of metabolism and ageing","volume":"15","author":"Imai","year":"2013","journal-title":"Diabetes Obes Metab."},{"key":"10.1016\/j.exger.2021.111552_bb0180","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2007.11.029","article-title":"Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats","volume":"581","author":"Jahng","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exger.2021.111552_bb0185","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1152\/jn.01057.2010","article-title":"Reorganization in processing of spectral and temporal input in the rat posterior auditory field induced by environmental enrichment","volume":"107","author":"Jakkamsetti","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exger.2021.111552_bb0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets","volume":"18","author":"Jiang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/NEN.0b013e3181922348","article-title":"Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease","volume":"68","author":"Julien","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.exger.2021.111552_bb0200","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exger.2021.111552_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.07.093","article-title":"Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro","volume":"1027","author":"Kim","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2021.111552_bb0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.01.027","article-title":"Understanding the odd science of aging","volume":"120","author":"Kirkwood","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.exger.2021.111552_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mad.2009.11.002","article-title":"Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats","volume":"131","author":"Koltai","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2021.111552_bb0220","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.redox.2017.07.008","article-title":"Proteostasis, oxidative stress and aging","volume":"13","author":"Korovila","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2021.111552_bb0225","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.heares.2012.02.009","article-title":"Neuronal connectivity and interactions between the auditory and limbic systems. effects of noise and tinnitus","volume":"288","author":"Kraus","year":"2012","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2021.111552_bb0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","article-title":"Dysregulation of limbic and auditory networks in tinnitus","volume":"69","author":"Leaver","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2021.111552_bb0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.heares.2015.08.005","article-title":"Auditory-limbic interactions in chronic tinnitus: challenges for neuroimaging research","volume":"334","author":"Leaver","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2021.111552_bb0240","doi-asserted-by":"crossref","first-page":"R868","DOI":"10.1016\/j.cub.2007.08.005","article-title":"The amygdala","volume":"17","author":"LeDoux","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.exger.2021.111552_bb0245","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10529-017-2493-0","article-title":"Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE\/RAGE pathway","volume":"40","author":"Lee","year":"2018","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.exger.2021.111552_bb0250","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1590\/S0100-879X2001000400007","article-title":"Influence of dexamethasone and weight loss on the regulation of serum leptin levels in obese individuals","volume":"34","author":"Lerario","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.exger.2021.111552_bb0255","first-page":"3371","article-title":"Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: implications for central presbycusis","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0260","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/path.2102","article-title":"Ageing and hearing loss","volume":"211","author":"Liu","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.exger.2021.111552_bb0265","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.neurobiolaging.2014.03.013","article-title":"Altered arginine metabolism in Alzheimer's disease brains","volume":"35","author":"Liu","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0270","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/138945012799201711","article-title":"NAD metabolism and NAD( )-dependent enzymes: promising therapeutic targets for neurological diseases","volume":"13","author":"Ma","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.exger.2021.111552_bb0275","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000448352","article-title":"Treatment for hearing loss among the elderly: auditory outcomes and impact on quality of life","volume":"21","author":"Manrique-Huarte","year":"2016","journal-title":"Audiol Neurootol."},{"key":"10.1016\/j.exger.2021.111552_bb0280","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1523\/JNEUROSCI.22-23-10449.2002","article-title":"Projection to the inferior colliculus from the basal nucleus of the amygdala","volume":"22","author":"Marsh","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0285","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s10522-010-9279-2","article-title":"Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats","volume":"11","author":"Marton","year":"2010","journal-title":"Biogerontology"},{"key":"10.1016\/j.exger.2021.111552_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042357","article-title":"Age-associated changes in oxidative stress and NAD metabolism in human tissue","volume":"7","author":"Massudi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111552_bb0295","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1044\/jslhr.4001.208","article-title":"Extended high-frequency thresholds in older adults","volume":"40","author":"Matthews","year":"1997","journal-title":"J. Speech Lang. Hear Res."},{"key":"10.1016\/j.exger.2021.111552_bb0300","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.molmed.2015.05.002","article-title":"Molecular aspects of age-related cognitive decline: the role of GABA signaling","volume":"21","author":"McQuail","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0305","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0079-6123(02)38074-9","article-title":"Environmental enrichment and the brain","volume":"138","author":"Mohammed","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.exger.2021.111552_bb0310","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnana.2012.00045","article-title":"Age-related neuronal loss in the rat brain starts at the end of adolescence","volume":"6","author":"Mortera","year":"2012","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exger.2021.111552_bb0315","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fnana.2010.00129","article-title":"Anatomical pathways for auditory memory in primates","volume":"4","author":"Munoz-Lopez","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exger.2021.111552_bb0320","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/B:MCBI.0000049130.58074.73","article-title":"Dexamethasone treatment improves sarcoplasmic reticulum function and contractile performance in aged myocardium","volume":"266","author":"Narayanan","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exger.2021.111552_bb0325","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/archoto.2011.15","article-title":"The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study","volume":"137","author":"Nash","year":"2011","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.exger.2021.111552_bb0330","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1210\/jcem.82.5.3928","article-title":"Dexamethasone increases leptin expression in humans in vivo","volume":"82","author":"Papaspyrou-Rao","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2021.111552_bb0335","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbadis.2015.08.017","article-title":"Sirtuin regulation in aging and injury","volume":"1852","author":"Poulose","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exger.2021.111552_bb0340","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuroscience.2017.11.049","article-title":"The effect of complex acoustic environment during early development on the responses of auditory cortex neurons in rats","volume":"371","author":"Pysanenko","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.exger.2021.111552_bb0345","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.exger.2011.11.010","article-title":"Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction","volume":"47","author":"Quintas","year":"2012","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2021.111552_bb0350","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1474-9726.2007.00355.x","article-title":"Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice","volume":"7","author":"Ramsey","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2021.111552_bb0355","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","article-title":"Tuning out the noise: limbic-auditory interactions in tinnitus","volume":"66","author":"Rauschecker","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2021.111552_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.03.015","article-title":"SIRT1 and NAD as regulators of ageing","volume":"105","author":"Rehan","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2021.111552_bb0365","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","article-title":"Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways","volume":"582","author":"Rodgers","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exger.2021.111552_bb0370","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00002.2003","article-title":"The amygdaloid complex: anatomy and physiology","volume":"83","author":"Sah","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2021.111552_bb0375","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/bies.20799","article-title":"SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?","volume":"30","author":"Salminen","year":"2008","journal-title":"Bioessays."},{"key":"10.1016\/j.exger.2021.111552_bb0380","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nlm.2014.04.002","article-title":"Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats","volume":"114","author":"Sampedro-Piquero","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.exger.2021.111552_bb0385","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cmet.2013.07.013","article-title":"Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH","volume":"18","author":"Satoh","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2021.111552_bb0390","series-title":"Handbook of Clinical Nutrition and Aging","first-page":"211","article-title":"Loss of taste, smell, and other senses with age","author":"Schiffman","year":"2004"},{"key":"10.1016\/j.exger.2021.111552_bb0395","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3389\/fnins.2018.00394","article-title":"Cognitive decline, dementia, Alzheimer's disease and presbycusis: examination of the possible molecular mechanism","volume":"12","author":"Shen","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0400","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0006-8993(02)03575-8","article-title":"Age-related changes of the nitric oxide system in the rat brain","volume":"956","author":"Siles","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2021.111552_bb0405","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neurobiolaging.2012.05.023","article-title":"Environmental enrichment restores neurogenesis and rapid acquisition in aged rats","volume":"34","author":"Speisman","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0410","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1101\/lm.42001","article-title":"Impaired auditory recognition memory in amnesic patients with medial temporal lobe lesions","volume":"8","author":"Squire","year":"2001","journal-title":"Learn. Mem."},{"key":"10.1016\/j.exger.2021.111552_bb0415","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/00016489.2015.1093172","article-title":"Localization of sirtuins (SIRT1-7) in the aged mouse inner ear","volume":"136","author":"Takumida","year":"2016","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.exger.2021.111552_bb0420","doi-asserted-by":"crossref","DOI":"10.3390\/genes9010022","article-title":"The aging mitochondria","volume":"9","author":"Theurey","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.exger.2021.111552_bb0425","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuint.2011.06.014","article-title":"Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice","volume":"59","author":"Tongjaroenbuangam","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.exger.2021.111552_bb0430","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12906-016-1221-y","article-title":"The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats","volume":"16","author":"Tovchiga","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.exger.2021.111552_bb0435","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000106478","article-title":"The complexity of age-related hearing impairment: contributing environmental and genetic factors","volume":"12","author":"Van Eyken","year":"2007","journal-title":"Audiol Neurootol."},{"key":"10.1016\/j.exger.2021.111552_bb0440","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.exger.2021.111552_bb0445","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12944-017-0515-5","article-title":"Effects of aerobic exercise on lipids and lipoproteins","volume":"16","author":"Wang","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.exger.2021.111552_bb0450","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-3701-2-19","article-title":"Regulation of triglyceride metabolism by glucocorticoid receptor","volume":"2","author":"Wang","year":"2012","journal-title":"Cell Biosci."},{"key":"10.1016\/j.exger.2021.111552_bb0455","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.arr.2017.10.002","article-title":"Chronic inflammation - inflammaging - in the ageing cochlea: a novel target for future presbycusis therapy","volume":"40","author":"Watson","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2021.111552_bb0460","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jamaoto.2016.2661","article-title":"Increases in the rate of age-related hearing loss in the older old","volume":"143","author":"Wattamwar","year":"2017","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.exger.2021.111552_bb0465","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exger.2013.12.006","article-title":"SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss","volume":"51","author":"Xiong","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2021.111552_bb0470","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.neurobiolaging.2014.12.034","article-title":"Activation of miR-34a\/SIRT1\/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss","volume":"36","author":"Xiong","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2021.111552_bb0475","article-title":"SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2021.111552_bb0480","doi-asserted-by":"crossref","DOI":"10.4081\/audiores.2012.e2","article-title":"Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss","volume":"2","author":"Yoshida","year":"2012","journal-title":"Audiol Res."},{"key":"10.1016\/j.exger.2021.111552_bb0485","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuro.2013.09.002","article-title":"Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats","volume":"39","author":"Yu","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.exger.2021.111552_bb0490","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1523\/JNEUROSCI.6470-10.2011","article-title":"Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex","volume":"31","author":"Zhou","year":"2011","journal-title":"J. Neurosci."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652100334X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652100334X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:23:31Z","timestamp":1759980211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155652100334X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":98,"alternative-id":["S053155652100334X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2021.111552","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2021.111552","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111552"}}