{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:53:28Z","timestamp":1790880808943,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.exger.2022.111705","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T11:12:13Z","timestamp":1642590733000},"page":"111705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Oxidative stress in multiple organs after sepsis in elderly rats"],"prefix":"10.1016","volume":"160","author":[{"given":"Willian","family":"Margotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Pereira de Souza","family":"Goldim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Simon","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Bagio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Dacoregio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Bernades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everton","family":"Lanzzarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Stork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaina","family":"Cidreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tais Luise","family":"Denicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Joaquim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucineia Gainski","family":"Danielski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiuanne Lino Lobo","family":"Metzker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bonfante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edficher","family":"Margotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricia","family":"Petronilho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2022.111705_bb0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exger.2022.111705_bb0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/01.CCM.0000198527.71819.E1","article-title":"Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis","volume":"34","author":"Alves-Filho","year":"2006","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0015","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2022.111705_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0b013e3181e7e61b","article-title":"Neutrophil paralysis in sepsis","author":"Alves-Filho","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.exger.2022.111705_bb0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00418-011-0787-1","article-title":"Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflammed liver","volume":"135","author":"Amanzada","year":"2011","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.exger.2022.111705_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Andersen","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.exger.2022.111705_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110539.ch5","article-title":"Assays for superoxide dismutase","volume":"32","author":"Bannister","year":"1987","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.exger.2022.111705_bb0045","series-title":"The Biology of Aging","first-page":"2","volume":"I-XII+388","author":"Behnke","year":"1978"},{"key":"10.1016\/j.exger.2022.111705_bb0050","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1378\/chest.100.3.802","article-title":"Gram-negative sepsis. Background, clinical features, and intervention","volume":"100","author":"Bone","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.exger.2022.111705_bb0055","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.2174\/0929867326666190717152739","article-title":"From healthy aging to frailty: in search of the underlying mechanisms","volume":"26","author":"Brivio","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.exger.2022.111705_bb0060","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/PCC.0b013e318198b0e3","article-title":"Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: a case-control study","volume":"10","author":"Cancelier","year":"2009","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0065","first-page":"629","article-title":"Organ dysfunction in sepsis: an ominous trajectory from infection to death","volume":"92","author":"Caraballo","year":"2019","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0070","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1007\/s00134-008-1313-3","article-title":"The nociceptin\/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis","volume":"34","author":"Carvalho","year":"2008","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2016.06.005","article-title":"A synopsis on aging\u2014theories, mechanisms and future prospects","author":"da Costa","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2022.111705_bb0080","first-page":"994","article-title":"Reactive oxygen species and the respiratory tract diseases of large animals","volume":"40","author":"da Silva","year":"2010","journal-title":"Cienc. Rural"},{"key":"10.1016\/j.exger.2022.111705_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3565127","article-title":"ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases","author":"Davalli","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2022.111705_bb0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01967298","article-title":"Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents","volume":"26","author":"De Young","year":"1989","journal-title":"Agents Actions"},{"key":"10.1016\/j.exger.2022.111705_bb0095","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.neuint.2017.06.003","article-title":"Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis","volume":"108","author":"Della Giustina","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.exger.2022.111705_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/nu9070718","article-title":"Protective role for antioxidants in acute kidney disease","author":"Dennis","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2022.111705_bb0105","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","article-title":"Malondialdehyde determination as index of lipid peroxidation","volume":"186","author":"Draper","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exger.2022.111705_bb0110","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0022-4804(90)90260-9","article-title":"Laboratory models of sepsis and septic shock","volume":"49","author":"Fink","year":"1990","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.exger.2022.111705_bb0115","article-title":"Ambient assisted living technologies for older adults with cognitive and physical impairments: a review","author":"Ganesan","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.exger.2022.111705_bb0120","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-017-0689-z","article-title":"Dimethyl fumarate modulates oxidative stress and inflammation in organs after sepsis in rats","volume":"41","author":"Giustina","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2022.111705_bb0125","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765201920190434","article-title":"Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis","volume":"91","author":"Giustina","year":"2019","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.exger.2022.111705_bb0130","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/01.CCM.0000251639.05135.E0","article-title":"Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure","volume":"35","author":"Gomez","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238066","article-title":"Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees","volume":"15","author":"Gonz\u00e1lez","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2022.111705_bb0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jcrc.2019.02.017","article-title":"Lung nitroxidative stress in mechanically-ventilated septic patients: a pilot study","volume":"51","author":"Gorrasi","year":"2019","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.exger.2022.111705_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/geriatrics6020037","article-title":"Nutritional mediators of cellular decline and mitochondrial dysfunction in older adults","author":"Guralnik","year":"2021","journal-title":"Geriatr"},{"key":"10.1016\/j.exger.2022.111705_bb0150","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6639199","article-title":"Reactive oxygen species and their involvement in red blood cell damage in chronic kidney disease","author":"Gwozdzinski","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2022.111705_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/s12858-018-0097-5","article-title":"Simple spectrophotometric assay for measuring catalase activity in biological tissues","volume":"19","author":"Hadwan","year":"2018","journal-title":"BMC Biochem."},{"key":"10.1016\/j.exger.2022.111705_bb0160","doi-asserted-by":"crossref","first-page":"19683","DOI":"10.1074\/jbc.REV119.006217","article-title":"Detection, identification, and quantification of oxidative protein modifications","volume":"294","author":"Hawkins","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2022.111705_bb0165","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0170","doi-asserted-by":"crossref","DOI":"10.12998\/wjcc.v7.i6.691","article-title":"Effects of apoptosis on liver aging","author":"Hu","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.exger.2022.111705_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of aging in the liver","author":"Hunt","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.exger.2022.111705_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/210934","article-title":"New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart","author":"Ikeda","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2022.111705_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2017.03.008","article-title":"Aging and cancer: the role of macrophages and neutrophils","author":"Jackaman","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2022.111705_bb0190","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2017.1309485","article-title":"Autophagy and kidney inflammation","author":"Kimura","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2022.111705_bb0195","doi-asserted-by":"crossref","first-page":"11800","DOI":"10.18632\/oncotarget.2856","article-title":"ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age","volume":"5","author":"Kovalenko","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.exger.2022.111705_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.04.005","article-title":"So! What's aging? Is cardiovascular aging a disease?","volume":"83","author":"Lakatta","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.exger.2022.111705_bb0205","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exger.2022.111705_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.emc.2016.04.005","article-title":"Sepsis and other infectious disease emergencies in the elderly","author":"Liang","year":"2016","journal-title":"Emerg. Med. Clin. North Am."},{"key":"10.1016\/j.exger.2022.111705_bb0215","doi-asserted-by":"crossref","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exger.2022.111705_bb0220","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein meansurement with the folin phenol reagent","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2022.111705_bb0225","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.toxrep.2017.12.017","article-title":"Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury","volume":"5","author":"Luceri","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.exger.2022.111705_bb0230","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4393460","article-title":"Salivary antioxidant barrier, redox status, and oxidative damage to proteins and lipids in healthy children, adults, and the elderly","volume":"2019","author":"Maciejczyk","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2022.111705_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111063","article-title":"Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis","volume":"140","author":"Margotti","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2022.111705_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-016-9933-y","article-title":"Mitochondria and oxidative stress in heart aging","author":"Mart\u00edn-Fern\u00e1ndez","year":"2016","journal-title":"Age (Omaha)"},{"key":"10.1016\/j.exger.2022.111705_bb0245","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bbi.2018.07.016","article-title":"Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats","volume":"73","author":"Netto","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2022.111705_bb0250","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-019-01845-2","article-title":"Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases","author":"Nguyen","year":"2020","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0255","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/cbin.10618","article-title":"Basal neutrophil function in human aging: implications in endothelial cell adhesion","volume":"40","author":"Nogueira-Neto","year":"2016","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.exger.2022.111705_bb0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-4933-5-13","article-title":"The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly","volume":"5","author":"Ogawa","year":"2008","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.exger.2022.111705_bb0265","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3892\/etm.2013.1034","article-title":"Ischemic preconditioning attenuates lipid peroxidation and apoptosis in the cecal ligation and puncture model of sepsis","volume":"5","author":"Olguner","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1323028","article-title":"Cardiolipin, perhydroxyl radicals, and lipid peroxidation in mitochondrial dysfunctions and aging","author":"Panov","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2022.111705_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.jss.2010.11.893","article-title":"Skeletal muscle electron transport chain dysfunction after sepsis in rats","volume":"167","author":"Peruchi","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.exger.2022.111705_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2018.08.1028","article-title":"Diaphragm weakness in the critically ill: basic mechanisms reveal therapeutic opportunities","author":"Petrof","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.exger.2022.111705_bb0285","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-015-0256-4","article-title":"Alpha-lipoic acid attenuates oxidative damage in organs after sepsis","volume":"39","author":"Petronilho","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2022.111705_bb0290","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1007\/s10753-016-0444-x","article-title":"Obesity exacerbates sepsis-induced oxidative damage in organs","volume":"39","author":"Petronilho","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2022.111705_bb0295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5152\/eurasianjmed.2017.17062","article-title":"Sepsis and septic shock: current treatment strategies and new approaches","volume":"49","author":"Polat","year":"2017","journal-title":"Eurasian J. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0300","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201812-2383CP","article-title":"Understanding and enhancing sepsis survivorship priorities for research and practice","author":"Prescott","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2015.02.003","article-title":"Quality control systems in cardiac aging","author":"Quarles","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2022.111705_bb0310","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00134-003-1789-9","article-title":"Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation","volume":"29","author":"Ritter","year":"2003","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0315","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/01.CCM.0000109454.13145.CA","article-title":"Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis","volume":"32","author":"Ritter","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exger.2022.111705_bb0320","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1677\/JOE-07-0260","article-title":"Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice","volume":"194","author":"Rodriguez","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.exger.2022.111705_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.cotox.2017.09.001","article-title":"Oxidative stress in the lung \u2013 the essential paradox","author":"Rogers","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.exger.2022.111705_bb0330","doi-asserted-by":"crossref","DOI":"10.1007\/s10522-018-9762-8","article-title":"Myeloid-derived suppressor cells (MDSC): an important partner in cellular\/tissue senescence","author":"Salminen","year":"2018","journal-title":"Biogerontology"},{"key":"10.1016\/j.exger.2022.111705_bb0335","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002684R","article-title":"Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice","volume":"35","author":"Sch\u00e4del","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2022.111705_bb0340","doi-asserted-by":"crossref","DOI":"10.1007\/s00011-020-01389-z","article-title":"Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality","author":"Shenoy","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.exger.2022.111705_bb0345","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.307474","article-title":"Aging and autophagy in the heart","author":"Shirakabe","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2022.111705_bb0350","first-page":"51066","article-title":"Cecal ligation and puncture-induced sepsis as a model to study autophagy in mice","volume":"84","author":"Siempos","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exger.2022.111705_bb0355","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.exger.2022.111705_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00155","article-title":"Paradoxical roles of the neutrophil in sepsis: protective and deleterious","author":"S\u00f4nego","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2022.111705_bb0365","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-018-1952-x","article-title":"Performance of the quick sequential (sepsis-related) organ failure assessment score as a prognostic tool in infected patients outside the intensive care unit: a systematic review and meta-analysis","volume":"22","author":"Song","year":"2018","journal-title":"Crit. Care"},{"key":"10.1016\/j.exger.2022.111705_bb0370","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.freeradbiomed.2010.11.013","article-title":"The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation","volume":"50","author":"Starr","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2022.111705_bb0375","article-title":"Multi-facets of neutrophil extracellular trap in infectious diseases: moving beyond immunity","volume":"105066","author":"Tabrizi","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.exger.2022.111705_bb0380","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/13510002.2016.1223793","article-title":"The diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis","volume":"22","author":"Talarmin","year":"2017","journal-title":"Redox Rep."},{"key":"10.1016\/j.exger.2022.111705_bb0385","article-title":"The vitals of NETs","author":"Tan","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exger.2022.111705_bb0390","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.rbce.2018.03.016","article-title":"The difference in age is not a key-factor in the modulation of acute exercise-induced muscle oxidative stress","volume":"40","author":"Tromm","year":"2018","journal-title":"Rev. Bras. Cienc.Esporte"},{"key":"10.1016\/j.exger.2022.111705_bb0395","doi-asserted-by":"crossref","DOI":"10.2174\/1567202612666150311111913","article-title":"Obesity promotes oxidative stress and exacerbates sepsis-induced brain damage","volume":"12","author":"Vieira","year":"2015","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.exger.2022.111705_bb0400","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/SHK.0b013e318217025a","article-title":"Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis","volume":"36","author":"Ware","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.exger.2022.111705_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040872","article-title":"Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation","author":"Yang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2022.111705_bb0410","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2017.02.040","article-title":"Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges","volume":"177","year":"2017","journal-title":"Pharmacol. Ther."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556522000134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556522000134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:26:34Z","timestamp":1759980394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556522000134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":81,"alternative-id":["S0531556522000134"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2022.111705","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress in multiple organs after sepsis in elderly rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2022.111705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111705"}}