{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:41:52Z","timestamp":1791387712656,"version":"4.3.3"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.exger.2022.111869","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T01:58:58Z","timestamp":1655085538000},"page":"111869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effects of losartan and exercise on muscle mass and exercise endurance of old mice"],"prefix":"10.1016","volume":"165","author":[{"given":"Chung-Hao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Cheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Hsien","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fang","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao-Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2022.111869_bb0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.exger.2017.06.013","article-title":"Exercise training improves functional status in hypertensive older adults under angiotensin converting enzymes inhibitors medication","volume":"109","author":"Baptista","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2022.111869_bb0010","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.18632\/aging.102114","article-title":"Sex-specific components of frailty in C57BL\/6 mice","volume":"11","author":"Baumann","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.exger.2022.111869_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002227","article-title":"Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia","volume":"3","author":"Burks","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2022.111869_bb0020","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jamda.2020.07.012","article-title":"Effect of angiotensin system inhibitors on physical performance in older people - a systematic review and meta-analysis","volume":"22","author":"Caulfield","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.exger.2022.111869_bb0025","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1589\/jpts.28.547","article-title":"Angiotensin-II blockage, muscle strength, and exercise capacity in physically independent older adults","volume":"28","author":"Coelho","year":"2016","journal-title":"J. Phys. Ther. Sci."},{"key":"10.1016\/j.exger.2022.111869_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.204","article-title":"Diet-induced obesity alters skeletal muscle fiber types of male but not female mice","volume":"2","author":"Denies","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.exger.2022.111869_bb0035","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1139\/y93-128","article-title":"Predicting submaximal oxygen consumption during treadmill running in mice","volume":"71","author":"Fernando","year":"1993","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.exger.2022.111869_bb1000","series-title":"The Mouse in Biomedical Research","author":"Fox","year":"2006"},{"key":"10.1016\/j.exger.2022.111869_bb0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1113\/jphysiol.2004.080564","article-title":"Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats","volume":"567","author":"Gomez-Cabrera","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.freeradbiomed.2007.02.001","article-title":"Moderate exercise is an antioxidant: upregulation of antioxidant genes by training","volume":"44","author":"Gomez-Cabrera","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2022.111869_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.exger.2022.111869_bb0055","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1152\/japplphysiol.00106.2018","article-title":"Losartan has no additive effect on the response to heavy-resistance exercise in human elderly skeletal muscle","volume":"125","author":"Heisterberg","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0060","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2022.111869_bb0065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.phrs.2017.05.008","article-title":"AT1 receptor signaling pathways in the cardiovascular system","volume":"125","author":"Kawai","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2022.111869_bb0070","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1096\/fj.08-128215","article-title":"Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a\/b: linking growth hormone to the androgen receptor","volume":"23","author":"Klover","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2022.111869_bb0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/japplphysiol.00237.2015","article-title":"AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction","volume":"119","author":"Kwon","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0080","first-page":"25","article-title":"Exercise as a remedy for sarcopenia","volume":"17","author":"Landi","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.exger.2022.111869_bb0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0022-510X(88)90132-3","article-title":"What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men","volume":"84","author":"Lexell","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.exger.2022.111869_bb0090","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.exger.2014.07.017","article-title":"Losartan improves measures of activity, inflammation, and oxidative stress in older mice","volume":"58","author":"Lin","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2022.111869_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100980","article-title":"Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis","volume":"56","author":"Livshits","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2022.111869_bb0100","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.biocel.2013.06.024","article-title":"Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials","volume":"45","author":"Marzetti","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exger.2022.111869_bb0105","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.exger.2006.08.011","article-title":"Skeletal muscle apoptosis, sarcopenia and frailty at old age","volume":"41","author":"Marzetti","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2022.111869_bb0110","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1113\/JP270654","article-title":"Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?","volume":"594","author":"Merry","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0115","article-title":"Senescence is associated with elevated intracellular resting [Ca(2 +)] in mice skeletal muscle fibers. An in vivo Study","volume":"11","author":"Mijares","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0120","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.yjmcc.2009.09.006","article-title":"Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin\/nuclear factor of activated T cells pathway","volume":"47","author":"Min","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.exger.2022.111869_bb0125","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1111\/febs.12338","article-title":"Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?","volume":"280","author":"Munoz-Canoves","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.exger.2022.111869_bb0130","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cger.2021.05.008","article-title":"The science of frailty: sex differences","volume":"37","author":"Park","year":"2021","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.exger.2022.111869_bb0135","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2022.111869_bb0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2165\/11594400-000000000-00000","article-title":"Antioxidant supplementation during exercise training: beneficial or detrimental?","volume":"41","author":"Peternelj","year":"2011","journal-title":"Sports Med."},{"key":"10.1016\/j.exger.2022.111869_bb0145","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1748-1716.2011.02344.x","article-title":"Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle","volume":"204","author":"Petersen","year":"2012","journal-title":"Acta Physiol (Oxford)"},{"key":"10.1016\/j.exger.2022.111869_bb0150","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The physical activity guidelines for americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.exger.2022.111869_bb0155","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cger.2011.03.008","article-title":"Current and future pharmacologic treatment of sarcopenia","volume":"27","author":"Rolland","year":"2011","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.exger.2022.111869_bb0160","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1113\/JP271212","article-title":"The ageing neuromuscular system and sarcopenia: a mitochondrial perspective","volume":"594","author":"Rygiel","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2022.111869_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2013.30","article-title":"The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men","volume":"3","author":"Samjoo","year":"2013","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.exger.2022.111869_bb0170","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00395-008-0772-6","article-title":"The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2\/-9 in atrial myocytes","volume":"104","author":"Saygili","year":"2009","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.exger.2022.111869_bb0175","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mad.2017.08.009","article-title":"The physiopathologic role of oxidative stress in skeletal muscle","volume":"170","author":"Scicchitano","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2022.111869_bb0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2007.11.011","article-title":"Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy","volume":"7","author":"Serrano","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2022.111869_bb0185","first-page":"884","article-title":"Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans","volume":"17","author":"Starkie","year":"2003","journal-title":"FEBS J."},{"key":"10.1016\/j.exger.2022.111869_bb0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/MAJ.0b013e318222e620","article-title":"Angiotensin II, oxidative stress and skeletal muscle wasting","volume":"342","author":"Sukhanov","year":"2011","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.exger.2022.111869_bb0195","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1093\/gerona\/glab182","article-title":"Male-female differences in the effects of age on performance measures recorded for 23 hours in mice","volume":"76","author":"Tran","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2022.111869_bb0200","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/01.CIR.98.17.1742","article-title":"Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition","volume":"98","author":"Vescovo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2022.111869_bb0205","doi-asserted-by":"crossref","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the health ABC study","volume":"57","author":"Visser","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2022.111869_bb0210","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/gerona\/63.4.391","article-title":"The physical and biological characterization of a frail mouse model","volume":"63","author":"Walston","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2022.111869_bb0215","doi-asserted-by":"crossref","first-page":"35137","DOI":"10.1074\/jbc.M601320200","article-title":"Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells","volume":"281","author":"Wei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2022.111869_bb0220","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1111\/jcmm.14412","article-title":"Muscle wasting: a review of exercise, classical and non-classical RAS axes","volume":"23","author":"Winslow","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.exger.2022.111869_bb0225","doi-asserted-by":"crossref","first-page":"8224","DOI":"10.1073\/pnas.1121113109","article-title":"Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains","volume":"109","author":"Yuan","year":"2012","journal-title":"PNAS"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556522001772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556522001772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:42:51Z","timestamp":1759981371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556522001772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":46,"alternative-id":["S0531556522001772"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2022.111869","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of losartan and exercise on muscle mass and exercise endurance of old mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2022.111869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111869"}}