{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:55:51Z","timestamp":1792176951572,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.exger.2023.112140","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T09:36:42Z","timestamp":1678873002000},"page":"112140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["\u03b2-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN"],"prefix":"10.1016","volume":"175","author":[{"given":"Guang","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.exger.2023.112140_bb0005","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm0756","article-title":"Early SRC activation skews cell fate from apoptosis to senescence","volume":"8","author":"Anerillas","year":"2022","journal-title":"Sci. Adv."},{"issue":"7589","key":"10.1016\/j.exger.2023.112140_bb0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.exger.2023.112140_bb0020","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cmet.2022.04.012","article-title":"Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling","volume":"34","author":"Benjamin","year":"2022","journal-title":"Cell Metab."},{"issue":"7051","key":"10.1016\/j.exger.2023.112140_bb0025","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","article-title":"Crucial role of p53-dependent cellular senescence in suppression of pten-deficient tumorigenesis","volume":"436","author":"Chen","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.exger.2023.112140_bb0030","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cell.2019.07.048","article-title":"Ketone body signaling mediates intestinal stem cell homeostasis and adaptation to diet","volume":"178","author":"Cheng","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.exger.2023.112140_bb0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.exger.2023.112140_bb0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.kint.2021.06.031","article-title":"The ketone body \u03b2-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults","volume":"100","author":"Fang","year":"2021","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.exger.2023.112140_bb0050","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.molcel.2018.07.036","article-title":"\u03b2-hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4","volume":"71","author":"Han","year":"2018","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.exger.2023.112140_bb0055","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s12276-020-0415-z","article-title":"\u03b2-hydroxybutyrate and its metabolic effects on age-associated pathology","volume":"52","author":"Han","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body \u03b2-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med."},{"issue":"5","key":"10.1016\/j.exger.2023.112140_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/17453677008991540","article-title":"Experimental osteoarthritis in rabbits. Preliminary report","volume":"41","author":"Hulth","year":"1970","journal-title":"Acta Orthop. Scand."},{"issue":"10182","key":"10.1016\/j.exger.2023.112140_bb0070","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.exger.2023.112140_bb0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.exger.2023.112140_bb0080","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI95147","article-title":"Senescent cells and osteoarthritis: a painful connection","volume":"128","author":"Jeon","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"6526","key":"10.1016\/j.exger.2023.112140_bb0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","volume":"371","author":"Johmura","year":"2021","journal-title":"Science"},{"issue":"486","key":"10.1016\/j.exger.2023.112140_bb0090","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar6659","article-title":"Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development","volume":"11","author":"Kang","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.exger.2023.112140_bb0095","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00018-022-04186-5","article-title":"ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NF\u03baB activation","volume":"79","author":"Kim","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.exger.2023.112140_bb0100","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41420-022-00896-8","article-title":"SIRT1 restoration enhances chondrocyte autophagy in osteoarthritis through PTEN-mediated EGFR ubiquitination","volume":"8","author":"Lu","year":"2022","journal-title":"Cell Death Discov"},{"issue":"11","key":"10.1016\/j.exger.2023.112140_bb0110","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/jor.22949","article-title":"Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis","volume":"33","author":"Mickiewicz","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1474-9726.2009.00532.x","article-title":"Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice","volume":"9","author":"Mitchell","year":"2010","journal-title":"Aging Cell"},{"issue":"27","key":"10.1016\/j.exger.2023.112140_bb0120","doi-asserted-by":"crossref","first-page":"13533","DOI":"10.1073\/pnas.1820282116","article-title":"Up-regulation of FOXO1 and reduced inflammation by \u03b2-hydroxybutyric acid are essential diet restriction benefits against liver injury","volume":"116","author":"Miyauchi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.exger.2023.112140_bb0125","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2023.112140_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"\u03b2-hydroxybutyrate: a signaling metabolite","volume":"37","author":"Newman","year":"2017","journal-title":"Annu. Rev. Nutr."},{"issue":"3","key":"10.1016\/j.exger.2023.112140_bb0135","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.exger.2023.112140_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1431","article-title":"Emerging roles of hnRNPA1 in modulating malignant transformation","volume":"8","author":"Roy","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"issue":"7","key":"10.1016\/j.exger.2023.112140_bb0150","doi-asserted-by":"crossref","first-page":"509","DOI":"10.7326\/M20-0527","article-title":"Effects of interleukin-1\u03b2 inhibition on incident hip and knee replacement : exploratory analyses from a randomized, double-blind, placebo-controlled trial","volume":"173","author":"Schieker","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"6116","key":"10.1016\/j.exger.2023.112140_bb0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.exger.2023.112140_bb0160","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.tcb.2019.05.002","article-title":"Quiescence: good and bad of stem cell aging","volume":"29","author":"T\u00fcmpel","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"10","key":"10.1016\/j.exger.2023.112140_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103420","article-title":"Xiao W: \u03b2-hydroxybutyrate as an anti-aging metabolite","volume":"13","author":"Wang","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2023.112140_bb0170","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1146\/annurev-biochem-082411-113907","article-title":"PteN","volume":"83","author":"Worby","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.exger.2023.112140_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41413-019-0062-y","article-title":"Sustained akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice","volume":"7","author":"Xie","year":"2019","journal-title":"Bone Res."},{"issue":"8","key":"10.1016\/j.exger.2023.112140_bb0180","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.exger.2023.112140_bb0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.exger.2023.112140_bb0190","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1172\/JCI83676","article-title":"Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis","volume":"126","author":"Zhang","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2023.112140_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103959","article-title":"Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis","volume":"78","author":"Zhang","year":"2022","journal-title":"EBioMedicine"},{"issue":"26","key":"10.1016\/j.exger.2023.112140_bb0200","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1021\/acs.jafc.2c01888","article-title":"circMEF2D negatively regulated by HNRNPA1 inhibits proliferation and differentiation of myoblasts via miR-486-PI3K\/AKT Axis","volume":"70","author":"Zhang","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.exger.2023.112140_bb0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-021-00831-w","article-title":"Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations","volume":"7","author":"Zhu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"13","key":"10.1016\/j.exger.2023.112140_bb0210","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk0011","article-title":"Stem cell-homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model","volume":"8","author":"Zhu","year":"2022","journal-title":"Sci. Adv."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652300061X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652300061X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:45:06Z","timestamp":1759981506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155652300061X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":42,"alternative-id":["S053155652300061X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2023.112140","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2023.112140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112140"}}