{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:51:47Z","timestamp":1788501107887,"version":"build-2803163510"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021LZXNYD-J10"],"award-info":[{"award-number":["2021LZXNYD-J10"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0609"],"award-info":[{"award-number":["2022YFS0609"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC0688"],"award-info":[{"award-number":["2022NSFSC0688"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.exger.2023.112181","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T12:29:39Z","timestamp":1682339379000},"page":"112181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["The mechanisms and functions of IL-1\u03b2 in intervertebral disc degeneration"],"prefix":"10.1016","volume":"177","author":[{"given":"Hongtao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhai","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2023.112181_bb0005","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1097\/01.brs.0000231761.73859.2c","article-title":"What is intervertebral disc degeneration, and what causes it?","volume":"31","author":"Adams","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.exger.2023.112181_bb0010","article-title":"Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?","volume":"4","author":"Aoki","year":"2014","journal-title":"J. Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2023.112181_bb0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/13880209.2022.2035773","article-title":"Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2\/STAT3 signal pathway in vitro and in vivo.[J]","volume":"1","author":"Bai","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.exger.2023.112181_bb0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1302\/0301-620X.84B2.0840196","article-title":"Intervertebral discs which cause low back pain secrete high levels of pro-inflammatory mediators","volume":"84","author":"Burke","year":"2002","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.exger.2023.112181_bb0025","article-title":"The role of oxidative stress in intervertebral disc degeneration","author":"Cao","year":"2023","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.exger.2023.112181_bb0030","first-page":"333","article-title":"VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process.J","volume":"1","author":"Capossela","year":"1970","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.exger.2023.112181_bb0035","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1007\/s00586-015-4140-6","article-title":"Duration-dependent influence of dynamic torsion on the intervertebral disc: an intact disc organ culture study.[J]","volume":"11","author":"Chan","year":"2015","journal-title":"Eur. Spine J."},{"issue":"6","key":"10.1016\/j.exger.2023.112181_bb0040","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.joca.2021.02.204","article-title":"Roles of NLRP3 inflammasome in intervertebral disc degeneration","volume":"29","author":"Chao-yang","year":"2021","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.exger.2023.112181_bb0045","first-page":"1","article-title":"Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K\/Akt pathway delaying intervertebral disc degeneration","author":"Chen","year":"1970","journal-title":"J.Connect Tissue Res"},{"key":"10.1016\/j.exger.2023.112181_bb0050","first-page":"21","article-title":"Targeting ferroptosis holds potential for intervertebral disc degeneration therapy","author":"Chen","year":"1970","journal-title":"Cells"},{"key":"10.1016\/j.exger.2023.112181_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biopha.2017.04.093","article-title":"Celastrol reduces IL-1\u03b2 induced matrix catabolism, oxidative stress, and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo","author":"Chen","year":"2017","journal-title":"J. Biomed. Pharmacother."},{"key":"10.1016\/j.exger.2023.112181_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41413-020-0087-2","article-title":"Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1\u03b2\/NF-\u03baB-NLRP3 inflammasome positive feedback loop","author":"Chen","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.exger.2023.112181_bb0065","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/03008207.2022.2063121","article-title":"Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K\/Akt pathway delaying intervertebral disc degeneration.[J]","volume":"6","author":"Chen","year":"2022","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.exger.2023.112181_bb0070","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/art.21639","article-title":"Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis","volume":"54","author":"Dai","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2023.112181_bb0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family.J","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exger.2023.112181_bb0080","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exger.2023.112181_bb0085","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.exger.2023.112181_bb0090","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10495-013-0839-1","article-title":"Cell death in intervertebral disc degeneration","volume":"18","author":"Ding","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.exger.2023.112181_bb0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jcb.1153","article-title":"IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress","volume":"82","author":"Elfervig","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exger.2023.112181_bb0100","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.intimp.2018.10.024","article-title":"Wogonin mitigates intervertebral disc degeneration through the Nrf2\/ARE and MAPK signaling pathways","volume":"65","author":"Fang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exger.2023.112181_bb0105","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1080\/15384101.2016.1152433","article-title":"Disc cell senescence in intervertebral disc degeneration: causes and molecular pathways.[J]","volume":"13","author":"Feng","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exger.2023.112181_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5601593","article-title":"ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration","author":"Feng","year":"2017","journal-title":"J. Oxid. Med. Cell Longev."},{"key":"10.1016\/j.exger.2023.112181_bb0115","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.[J]","volume":"9","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.exger.2023.112181_bb0120","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1001\/jama.279.21.1732","article-title":"Telomerase and the aging cell: implications for human health.[J]","volume":"21","author":"Fossel","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.exger.2023.112181_bb0125","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0140-6736(97)02135-1","article-title":"Nerve ingrowth into diseased intervertebral disc in chronic back pain.J","volume":"9072","author":"Freemont","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2023.112181_bb0130","doi-asserted-by":"crossref","first-page":"9963","DOI":"10.12659\/MSM.918597","article-title":"Naringin protects against interleukin 1\u03b2 (IL-1\u03b2)-induced human nucleus pulposus cells degeneration via downregulation nuclear factor kappa B (NF-\u03baB) pathway and p53 expression","author":"Gao","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.exger.2023.112181_bb0135","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/ar2858","article-title":"Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation","volume":"11","author":"Genevay","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"8","key":"10.1016\/j.exger.2023.112181_bb0140","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/10520295.2012.703692","article-title":"Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells","volume":"87","author":"Gruber","year":"2012","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.exger.2023.112181_bb0145","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/10520295.2013.783235","article-title":"Increased IL-17 expression in degenerated human discs and increased production in cultured annulus cells exposed to IL-1ss and TNF-alpha","volume":"88","author":"Gruber","year":"2013","journal-title":"Biotech. Histochem."},{"issue":"2","key":"10.1016\/j.exger.2023.112181_bb0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexmp.2014.01.002","article-title":"Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-\u03b2 and TNF-\u03b1 in 3D culture","volume":"96","author":"Gruber","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.exger.2023.112181_bb0155","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yexmp.2014.12.002","article-title":"Pro-inflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production","volume":"98","author":"Gruber","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.exger.2023.112181_bb0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fcimb.2014.00083","article-title":"Microbial modulation of host apoptosis and pyroptosis","volume":"4","author":"He","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.exger.2023.112181_bb0165","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbrc.2020.03.161","article-title":"Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway","volume":"526","author":"He","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2023.112181_bb0170","first-page":"1","article-title":"Effects of IL-1\u03b2, IL-20, and BMP-2 on intervertebral disc inflammation under hypoxia. J.J","author":"Hsu","year":"2020","journal-title":"Clin. Med."},{"key":"10.1016\/j.exger.2023.112181_bb0175","first-page":"79","article-title":"BMSC paracrine activity attenuates interleukin-1\u03b2-induced inflammation and apoptosis in rat AF cells via inhibiting relative NF-\u03baB signaling and the mitochondrial pathway","volume":"1","author":"Hu","year":"2017","journal-title":"J. Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.exger.2023.112181_bb0180","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s10753-019-01166-z","article-title":"Nicotinamide phosphoribosyl transferase controls NLRP3 inflammasome activity through MAPK and NF-kappaB signaling in nucleus pulposus cells, as suppressed by melatonin","volume":"43","author":"Huang","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2023.112181_bb0185","first-page":"883","article-title":"Sinapic acid inhibits IL-1\u03b2-induced apoptosis and catabolism in nucleus pulposus cells and ameliorates intervertebral disk degeneration","author":"Huang","year":"2022","journal-title":"J Inflamm Res"},{"issue":"6","key":"10.1016\/j.exger.2023.112181_bb0190","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1021\/acs.biomac.5b00168","article-title":"Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1\u03b2 induced inflammation model of nucleus pulposus cells","volume":"16","author":"Isa","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.exger.2023.112181_bb0195","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.joca.2020.06.009","article-title":"Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain.[J]","volume":"10","author":"Jacobsen","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2023.112181_bb0200","article-title":"Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating miR-483-3p.[J]","volume":"7","author":"Ji","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"issue":"3","key":"10.1016\/j.exger.2023.112181_bb0205","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190043","article-title":"Resveratrol inhibits IL-1\u03b2-mediated nucleus pulposus cell apoptosis through regulating the PI3K\/Akt pathway","volume":"39","author":"Jiang","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exger.2023.112181_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/08916934.2021.1983802","article-title":"MiR-144-3p induced by SP1 promotes IL-1\u03b2-induced pyroptosis in chondrocytes via PTEN\/PINK1\/Parkin axis","volume":"1","author":"Jiang","year":"2022","journal-title":"J.Autoimmunity"},{"key":"10.1016\/j.exger.2023.112181_bb0215","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.freeradbiomed.2019.12.040","article-title":"IL-10 delays the degeneration of intervertebral discs by suppressing the p38 MAPK signaling pathway.[J]","volume":"147","author":"Jun","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.exger.2023.112181_bb0220","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/BRS.0b013e3181b9c986","article-title":"Frequency of lumbar intervertebral disc calcification and angiogenesis, and their correlation with clinical, surgical, and magnetic resonance imaging findings","volume":"35","author":"Karamouzian","year":"2010","journal-title":"Spine"},{"key":"10.1016\/j.exger.2023.112181_bb0225","first-page":"21","article-title":"Lumbar disc disorders and low-back pain: socioeconomic factors and consequences","author":"Katz","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.exger.2023.112181_bb0230","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0b013e3182a211e3","article-title":"Effect of biphasic electrical current stimulation on IL-1beta-stimulated annulus fibrosus cells using in vitro microcurrent generating chamber system","volume":"38","author":"Kim","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.exger.2023.112181_bb0235","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4184\/asj.2015.9.2.155","article-title":"Effect of high glucose on stress-induced senescence of nucleus pulposus cells of adult rats","volume":"9","author":"Kong","year":"2015","journal-title":"Asian Spine J."},{"key":"10.1016\/j.exger.2023.112181_bb0240","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/jor.20814","article-title":"Intervertebral disc cell response to dynamic compression is age and frequency dependent.[J]","volume":"6","author":"Korecki","year":"2009","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.exger.2023.112181_bb0245","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/neuros\/nyx149","article-title":"The role of hypoxia in angiogenesis and extracellular matrix regulation of intervertebral disc cells during inflammatory reactions","volume":"81","author":"Kwon","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.exger.2023.112181_bb0250","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/joa.12817","article-title":"Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue.J","volume":"1","author":"Lama","year":"2018","journal-title":"J. Anat."},{"key":"10.1016\/j.exger.2023.112181_bb0255","article-title":"The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration","volume":"4","author":"Le Maitre","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.exger.2023.112181_bb0260","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar2282","article-title":"Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2023.112181_bb0265","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1042\/BST0350652","article-title":"Matrix synthesis and degradation in human intervertebral disc degeneration","volume":"35","author":"Le Maitre","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.exger.2023.112181_bb0270","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jor.21210","article-title":"Interleukin-1beta induces angiogenesis and innervation in human intervertebral disc degeneration","volume":"29","author":"Lee","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2023.112181_bb0275","article-title":"Oxidative stress and intervertebral disc degeneration: pathophysiology, signaling pathway, and therapy","author":"Li","year":"2023","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.exger.2023.112181_bb0280","first-page":"1679","article-title":"Berberine prevents human nucleus pulposus cells from IL-1\u03b2-induced extracellular matrix degradation and apoptosis by inhibiting the NF-\u03baB pathway","volume":"43","author":"Lu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exger.2023.112181_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108671","article-title":"SIRT1 alleviates IL-1\u03b2 induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration","author":"Ma","year":"2022","journal-title":"J. Int Immunopharmacol"},{"issue":"7051","key":"10.1016\/j.exger.2023.112181_bb0290","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exger.2023.112181_bb0295","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/ar2693","article-title":"Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration","volume":"11","author":"Millward-Sadler","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"17","key":"10.1016\/j.exger.2023.112181_bb0300","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/BRS.0000000000000334","article-title":"ISSLS prize winner: increased innervation and sensory nervous system plasticity in a mouse model of low back pain due to intervertebral disc degeneration","volume":"39","author":"Miyagi","year":"2014","journal-title":"Spine"},{"key":"10.1016\/j.exger.2023.112181_bb0305","doi-asserted-by":"crossref","first-page":"20141191","DOI":"10.1098\/rsif.2014.1191","article-title":"Inflammation in intervertebral disc degeneration and regeneration","volume":"12","author":"Molinos","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.exger.2023.112181_bb0310","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3389\/fimmu.2017.01681","article-title":"Inflammatory processes associated with canine intervertebral disc herniation","author":"Monchaux","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.exger.2023.112181_bb0315","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.joca.2013.12.008","article-title":"Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration","volume":"22","author":"Moon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.exger.2023.112181_bb0320","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3902","article-title":"Extracellular matrix assembly: a multiscale deconstruction.[J]","volume":"12","author":"Mouw","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2023.112181_bb0325","doi-asserted-by":"crossref","first-page":"E710","DOI":"10.1097\/BRS.0000000000001379","article-title":"PGE1 attenuates IL-1\u03b2-induced NGF expression in human intervertebral disc cells","volume":"12","author":"Murata","year":"2016","journal-title":"J. Spine (Phila Pa 1976)"},{"key":"10.1016\/j.exger.2023.112181_bb0330","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jor.22320","article-title":"Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.J","volume":"7","author":"Nasto","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2023.112181_bb0335","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2015.01.137","article-title":"Calcium and mitochondria in the regulation of cell death","volume":"460","author":"Orrenius","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.exger.2023.112181_bb0340","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.joca.2015.02.017","article-title":"Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes","volume":"23","author":"Phillips","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2023.112181_bb0345","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/ar2487","article-title":"Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc","volume":"10","author":"Purmessur","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2023.112181_bb0350","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content.J","volume":"1","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.exger.2023.112181_bb0355","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling.J","volume":"10","author":"Simons","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2023.112181_bb0360","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/s10165-012-0635-8","article-title":"Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes","volume":"23","author":"So","year":"2013","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.exger.2023.112181_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109592","article-title":"1,4-dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1","volume":"121","author":"Song","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exger.2023.112181_bb0370","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.freeradbiomed.2018.04.008","article-title":"Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway","author":"Tang","year":"2018","journal-title":"J. Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2023.112181_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.519172","article-title":"Anisodamine maintains the stability of intervertebral disc tissue by inhibiting the senescence of nucleus pulposus cells and degradation of extracellular matrix via Interleukin-6\/Janus Kinases\/Signal transducer and activator of transcription 3 pathway","author":"Tang","year":"2020","journal-title":"J. Front Pharmacol."},{"issue":"3","key":"10.1016\/j.exger.2023.112181_bb0380","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.spinee.2012.02.027","article-title":"Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration","volume":"13","author":"Vo","year":"2013","journal-title":"Spine J."},{"issue":"13","key":"10.1016\/j.exger.2023.112181_bb0385","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Walle","year":"2016","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.exger.2023.112181_bb0390","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0021-9290(03)00290-2","article-title":"Biological response of the intervertebral disc to dynamic loading.[J]","volume":"3","author":"Walsh","year":"2004","journal-title":"J. Biomech."},{"key":"10.1016\/j.exger.2023.112181_bb0395","article-title":"Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes","author":"Wang","year":"1970","journal-title":"Chem Biol Interact"},{"issue":"23","key":"10.1016\/j.exger.2023.112181_bb0400","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1097\/BRS.0b013e318158cb61","article-title":"Biologic response of the intervertebral disc to static and dynamic compression in vitro","volume":"32","author":"Wang","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.exger.2023.112181_bb0405","first-page":"1448","article-title":"Research progress of cellular senescence and senescent secretory phenotype in intervertebral disc degeneration","volume":"26","author":"Wang","year":"2012","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"10.1016\/j.exger.2023.112181_bb0410","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/ar4353","article-title":"Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2023.112181_bb0415","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/art.37819","article-title":"Tumor necrosis factor \u03b1- and interleukin-1\u03b2-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1.[J]","volume":"3","author":"Wang","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2023.112181_bb0420","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.3892\/mmr.2014.2514","article-title":"Different concentrations of 17\u03b2-estradiol modulates apoptosis induced by interleukin-1\u03b2 in rat annulus fibrosus cells","volume":"5","author":"Wang","year":"2014","journal-title":"J. Mol. Med. Rep."},{"key":"10.1016\/j.exger.2023.112181_bb0425","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0b013e31829a6930","article-title":"Extracellular signal-regulated kinase inhibition modulates rat annulus fibrosus cell response to interleukin-1","volume":"38","author":"Wei","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"issue":"17","key":"10.1016\/j.exger.2023.112181_bb0430","doi-asserted-by":"crossref","first-page":"E1075","DOI":"10.1097\/BRS.0b013e31829a6930","article-title":"Extracellular signal-regulated kinase inhibition modulates rat annulus fibrosus cell response to interleukin-1","volume":"38","author":"Wei","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.exger.2023.112181_bb0435","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0b013e318221e655","article-title":"The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo","volume":"36","author":"Wuertz","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.exger.2023.112181_bb0440","first-page":"2703","article-title":"Cardamonin protects nucleus pulposus cells against IL-1\u03b2-induced inflammation and catabolism via Nrf2\/NF-\u03baB axis","volume":"6","author":"Xie","year":"1970","journal-title":"Food Funct"},{"key":"10.1016\/j.exger.2023.112181_bb0445","article-title":"Leg amputation accelerates senescence of rat lumbar intervertebral discs","volume":"23","author":"Xing","year":"2010","journal-title":"Spine (Phila Pa 1976"},{"key":"10.1016\/j.exger.2023.112181_bb0450","article-title":"Ferroptosis plays a role in human chondrocyte of osteoarthritis induced by IL-1\u03b2 in vitro","author":"Xu","year":"1970","journal-title":"Cartilage"},{"issue":"2","key":"10.1016\/j.exger.2023.112181_bb0455","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s12013-014-0045-y","article-title":"Expression of matrix metalloproteinases is positively related to the severity of disc degeneration and growing age in the east asian lumbar disc herniation patients","volume":"70","author":"Xu","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.exger.2023.112181_bb0460","first-page":"9","article-title":"Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro","author":"Xu","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.exger.2023.112181_bb0465","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/03008207.2018.1442445","article-title":"Interleukin-1\u03b2 induces apoptosis in annulus fibrosus cells through the extracellular signal-regulated kinase pathway.J","volume":"6","author":"Yang","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.exger.2023.112181_bb0470","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/21655979.2021.2016085","article-title":"The protective effects of etomidate against interleukin-1\u03b2 (IL-1\u03b2)-induced oxidative stress, extracellular matrix alteration and cellular senescence in chondrocytes","volume":"1","author":"Yin","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.exger.2023.112181_bb0475","article-title":"circ_0072464 shuttled by bone mesenchymal stem cell-secreted extracellular vesicles inhibits nucleus pulposus cell ferroptosis to relieve intervertebral disc degeneration","author":"Yu","year":"2023","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.exger.2023.112181_bb0480","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1002\/art.23958","article-title":"Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 productions in human osteoarthritic chondrocytes by prostaglandin D2","volume":"58","author":"Zayed","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.exger.2023.112181_bb0485","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13075-019-1986-8","article-title":"Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt\/\u03b2-catenin pathway","volume":"21","author":"Zhan","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exger.2023.112181_bb0490","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3892\/mmr.2012.1238","article-title":"Effects of IGF-1 on IL-1beta-induced apoptosis in rabbit nucleus pulposus cells in vitro","volume":"7","author":"Zhang","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exger.2023.112181_bb0495","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10495-015-1180-7","article-title":"Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1\/2 MAPK pathway","volume":"21","author":"Zhang","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.exger.2023.112181_bb0500","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/jor.24639","article-title":"Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration.[J]","volume":"11","author":"Zhang","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2023.112181_bb0505","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1111\/jcmm.15528","article-title":"Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment.J","volume":"16","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.exger.2023.112181_bb0510","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2023.112181_bb0515","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jor.21285","article-title":"ADAMTS-5 and intervertebral disc degeneration: the results of tissue immunohistochemistry and in vitro cell culture","volume":"29","author":"Zhao","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exger.2023.112181_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108375","article-title":"GSDMD, an executor of pyroptosis, is involved in IL-1\u03b2 secretion in Aspergillus fumigatus keratitis","author":"Zhao","year":"2021","journal-title":"J. Exp. Eye Res."},{"key":"10.1016\/j.exger.2023.112181_bb0525","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s10753-021-01590-0","article-title":"Ganoderic acid a attenuates IL-1\u03b2-induced inflammation in human nucleus pulposus cells through inhibiting the NF-\u03baB pathway.[J]","volume":"2","author":"Zheng","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.exger.2023.112181_bb0530","first-page":"106","article-title":"Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP\/NLRP3\/Caspase-1\/IL-1\u03b2 signaling pathway","author":"Zhou","year":"1970","journal-title":"J. Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2023.112181_bb0535","first-page":"9180","article-title":"SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3\/FOXO3\/SOD2 signaling pathway","volume":"21","author":"Zhou","year":"2019","journal-title":"J.Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.exger.2023.112181_bb0540","article-title":"Ferroptosis: A potential target for the intervention of intervertebral disc degeneration","author":"Zhou","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.exger.2023.112181_bb0545","first-page":"269","article-title":"Dimethyl fumarate protects nucleus pulposus cells from inflammation and oxidative stress and delays intervertebral disc degeneration.J","volume":"6","author":"Zhu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.exger.2023.112181_bb0550","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1007\/s11010-021-04197-z","article-title":"Higenamine mitigates interleukin-1\u03b2-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K\/Akt signaling.J","volume":"11","author":"Zhu","year":"2021","journal-title":"Mol. Cell. Biochem."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652300102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652300102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:11:15Z","timestamp":1777882275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155652300102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":110,"alternative-id":["S053155652300102X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2023.112181","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanisms and functions of IL-1\u03b2 in intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2023.112181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112181"}}