{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:36Z","timestamp":1790185296882,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["2022-596"],"award-info":[{"award-number":["2022-596"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["2023-575"],"award-info":[{"award-number":["2023-575"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.exger.2023.112198","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T11:49:49Z","timestamp":1683373789000},"page":"112198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice"],"prefix":"10.1016","volume":"177","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-li","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Shan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2023.112198_bb0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/neup.12373","article-title":"SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions","volume":"37","author":"Akiguchi","year":"2017","journal-title":"Neuropathology"},{"key":"10.1016\/j.exger.2023.112198_bb0010","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/FBP.0b013e32833dcfa5","article-title":"Activators of G-protein signaling 3: a drug addiction molecular gateway","volume":"21","author":"Bowers","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.exger.2023.112198_bb0015","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.exger.2005.05.007","article-title":"The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease","volume":"40","author":"Butterfield","year":"2005","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2023.112198_bb0020","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2019.03.002","article-title":"Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease","volume":"135","author":"Chen","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2023.112198_bb0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.arr.2013.10.002","article-title":"The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model","volume":"13","author":"Cheng","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2023.112198_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114683","article-title":"Identification of potential endocrine disrupting chemicals using gene expression biomarkers","volume":"380","author":"Corton","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.exger.2023.112198_bb0035","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3233\/JAD-143090","article-title":"The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease","volume":"46","author":"Hansen","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2023.112198_bb0040","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/cercor\/bht101","article-title":"Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study","volume":"24","author":"Hokama","year":"2014","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.exger.2023.112198_bb0045","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jalz.2015.11.002","article-title":"Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease","volume":"12","author":"Hondius","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.exger.2023.112198_bb0050","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7627","article-title":"Dendrobium alkaloids decrease A\u03b2 by regulating \u03b1- and \u03b2-secretases in hippocampal neurons of SD rats","volume":"7","author":"Huang","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.exger.2023.112198_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/nu14061197","article-title":"The effects of matcha and decaffeinated matcha on learning, memory and proteomics of hippocampus in senescence-accelerated (SAMP8) mice","volume":"14","author":"Igarashi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2023.112198_bb0060","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1017\/S1461145713001533","article-title":"Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP\/PS1 transgenic mice by stimulation of NO\/cGMP signalling","volume":"17","author":"Jin","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.exger.2023.112198_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21145124","article-title":"Mid-gestation lethality of Atxn2l-ablated mice","volume":"21","author":"Key","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2023.112198_bb0070","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuron.2011.12.020","article-title":"Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment","volume":"73","author":"Kondo","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2023.112198_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/841752","article-title":"Evaluation of chemical constituents and important mechanism of pharmacological biology in dendrobium plants","volume":"2015","author":"Lam","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.exger.2023.112198_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002683","article-title":"Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates a\u03b2 pathology in a drosophila model of Alzheimer's disease","volume":"8","author":"Lang","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exger.2023.112198_bb0085","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1523\/JNEUROSCI.6331-11.2012","article-title":"KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2","volume":"32","author":"Lee","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2023.112198_bb0090","doi-asserted-by":"crossref","first-page":"972","DOI":"10.4103\/1673-5374.324824","article-title":"Potential neuroprotection by Dendrobium nobile lindl alkaloid in Alzheimer's disease models","volume":"17","author":"Li","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.exger.2023.112198_bb0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/cns.12678","article-title":"Dendrobium nobile lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by A\u03b2(25\u201335) in hippocampus neurons in vitro","volume":"23","author":"Li","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.exger.2023.112198_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1060111","article-title":"Identification of candidate genes associated with clinical onset of Alzheimer's disease","volume":"16","author":"Liao","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exger.2023.112198_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146871","article-title":"Dendrobium nobile lindl alkaloid and metformin ameliorate cognitive dysfunction in senescence-accelerated mice via suppression of endoplasmic reticulum stress","volume":"1741","author":"Liu","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.exger.2023.112198_bb0110","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-200063","article-title":"SAMP8 mice as a model of age-related cognition decline with underlying mechanisms in Alzheimer's disease","volume":"75","author":"Liu","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2023.112198_bb0115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3233\/JAD-200308","article-title":"Dendrobium nobile lindl. Alkaloids ameliorate cognitive dysfunction in senescence accelerated SAMP8 mice by decreasing amyloid-\u03b2 aggregation and enhancing autophagy activity","volume":"76","author":"Lv","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.exger.2023.112198_bb0120","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.celrep.2014.12.041","article-title":"A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology","volume":"10","author":"Matarin","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.exger.2023.112198_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40478-021-01219-1","article-title":"Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease","volume":"9","author":"McMillan","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.exger.2023.112198_bb0130","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fphar.2018.01479","article-title":"Dendrobium nobile lindl. Alkaloids decreases the level of intracellular \u03b2-amyloid by improving impaired autolysosomal proteolysis in APP\/PS1 mice","volume":"9","author":"Nie","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2023.112198_bb0135","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2739","article-title":"Dendrobium alkaloids prevent A\u03b2(25\u201335)-induced neuronal and synaptic loss via promoting neurotrophic factors expression in mice","volume":"4","author":"Nie","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.exger.2023.112198_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112839","article-title":"Anti-aging properties of Dendrobium nobile lindl.: from molecular mechanisms to potential treatments","volume":"257","author":"Nie","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exger.2023.112198_bb0145","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/573208","article-title":"Oxidative stress in aging: advances in proteomic approaches","volume":"2014","author":"Ortu\u00f1o-Sahag\u00fan","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2023.112198_bb0150","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbi.2019.05.009","article-title":"Transcriptomic analysis of probable asymptomatic and symptomatic Alzheimer brains","volume":"80","author":"Patel","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exger.2023.112198_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2020.592797","article-title":"HERC1 ubiquitin ligase is required for hippocampal learning and memory","volume":"14","author":"P\u00e9rez-Villegas","year":"2020","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exger.2023.112198_bb0160","doi-asserted-by":"crossref","first-page":"10591","DOI":"10.1038\/s41598-019-47033-7","article-title":"USP10 is a critical factor for tau-positive stress granule formation in neuronal cells","volume":"9","author":"Piatnitskaia","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2023.112198_bb0165","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/humu.23270","article-title":"CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy","volume":"38","author":"Poirier","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.exger.2023.112198_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104069","article-title":"Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation","volume":"25","author":"Quadros","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.exger.2023.112198_bb0175","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.919311","article-title":"Related network and differential expression analyses identify nuclear genes and pathways in the hippocampus of Alzheimer disease","volume":"26","author":"Quan","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.exger.2023.112198_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315097","article-title":"Proteomic signature and mRNA expression in hippocampus of SAMP8 and SAMR1 mice during aging","volume":"23","author":"Reale","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2023.112198_bb0185","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1523\/JNEUROSCI.3129-20.2021","article-title":"Regulation of synapse weakening through interactions of the microtubule associated protein tau with PACSIN1","volume":"41","author":"Regan","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exger.2023.112198_bb0190","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/syn.20933","article-title":"Age-related changes in gene expression are accelerated in Alzheimer's disease","volume":"65","author":"Saetre","year":"2011","journal-title":"Synapse"},{"key":"10.1016\/j.exger.2023.112198_bb0195","article-title":"Use of the open field maze to measure locomotor and anxiety-like behavior in mice","volume":"e52434","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exger.2023.112198_bb0200","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1038\/s41598-017-05504-9","article-title":"RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains","volume":"7","author":"Shi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2023.112198_bb0205","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.neurobiolaging.2011.04.013","article-title":"Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype","volume":"32","author":"Simpson","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exger.2023.112198_bb0210","doi-asserted-by":"crossref","first-page":"14622","DOI":"10.1038\/s41598-018-32948-4","article-title":"Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to wnt signaling in the PFC and hippocampus","volume":"8","author":"Su","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2023.112198_bb0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13073-016-0355-3","article-title":"Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease","volume":"8","author":"Wang","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.exger.2023.112198_bb0220","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41419-022-05170-4","article-title":"USP10 deubiquitinates tau, mediating its aggregation","volume":"13","author":"Wei","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exger.2023.112198_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.023","article-title":"The LMTK-family of kinases: emerging important players in cell physiology and pathogenesis","volume":"1867","author":"Wendler","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.exger.2023.112198_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3268","article-title":"Long non-coding RNA 00507\/miRNA-181c-5p\/TTBK1\/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease","volume":"22","author":"Yan","year":"2020","journal-title":"J. Gene Med."},{"key":"10.1016\/j.exger.2023.112198_bb0235","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.phymed.2013.10.026","article-title":"Alkaloids enriched extract from Dendrobium nobile lindl. Attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain","volume":"21","author":"Yang","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.exger.2023.112198_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154762","article-title":"Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.exger.2023.112198_bb0245","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11064-021-03507-7","article-title":"Icariin ameliorates Alzheimer\u2019s disease pathology by alleviating myelin injury in 3 \u00d7 tg-AD mice","volume":"47","author":"Yu","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exger.2023.112198_bb0250","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12264-016-0021-1","article-title":"Yeast two-hybrid screening for proteins that interact with the extracellular domain of amyloid precursor protein","volume":"32","author":"Yu","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.exger.2023.112198_bb0255","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4103\/1673-5374.211193","article-title":"Protective effects of Dendrobium nobile lindl. Alkaloids on amyloid beta (25\u201335)-induced neuronal injury","volume":"12","author":"Zhang","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.exger.2023.112198_bb0260","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jmb.2011.04.018","article-title":"Structural features and chaperone activity of the NudC protein family","volume":"409","author":"Zheng","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.exger.2023.112198_bb0265","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3233\/JAD-2010-101389","article-title":"Strain- and age-related alteration of proteins in the brain of SAMP8 and SAMR1 mice","volume":"23","author":"Zhu","year":"2011","journal-title":"J. Alzheimers Dis."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556523001195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556523001195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:10:08Z","timestamp":1777882208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556523001195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":53,"alternative-id":["S0531556523001195"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2023.112198","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2023.112198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112198"}}