{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:58:35Z","timestamp":1791403115094,"version":"4.3.3"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571229"],"award-info":[{"award-number":["31571229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600201"],"award-info":[{"award-number":["2022YFC3600201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.exger.2023.112309","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:19:25Z","timestamp":1697152765000},"page":"112309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"182","author":[{"given":"Huimin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aozhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2023.112309_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101801","article-title":"Presynaptic failure in Alzheimer\u2019s disease","volume":"194","author":"Barthet","year":"2020","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.exger.2023.112309_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12873","article-title":"Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice","volume":"18","author":"Belfiore","year":"2019","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.exger.2023.112309_bb0015","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.exger.2023.112309_bb0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.exger.2023.112309_bb0025","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/brain\/awz060","article-title":"Tau suppresses neuronal activity in vivo, even before tangles form","volume":"142","author":"Busche","year":"2019","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.exger.2023.112309_bb0030","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/bies.201500004","article-title":"Neuronal hyperactivity\u2013a key defect in Alzheimer\u2019s disease?","volume":"37","author":"Busche","year":"2015","journal-title":"Bioessays"},{"issue":"5896","key":"10.1016\/j.exger.2023.112309_bb0035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"issue":"4\u20135","key":"10.1016\/j.exger.2023.112309_bb0040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0028-3908(98)00032-X","article-title":"A re-examination of the role of basal forebrain cholinergic neurons in spatial working memory","volume":"37","author":"Chappell","year":"1998","journal-title":"Neuropharmacology"},{"issue":"16","key":"10.1016\/j.exger.2023.112309_bb0045","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1113\/JP283037","article-title":"Chronic exercise increases excitability of lamina X neurons through enhancement of persistent inward currents and dendritic development in mice","volume":"600","author":"Chen","year":"2022","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.exger.2023.112309_bb0050","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1249\/MSS.0000000000000612","article-title":"Treadmill running reverses cognitive declines due to Alzheimer disease","volume":"47","author":"Cho","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"issue":"6406","key":"10.1016\/j.exger.2023.112309_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8821","article-title":"Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model","volume":"361","author":"Choi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.exger.2023.112309_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113766","article-title":"Effects of altered tau expression on dentate granule cell excitability in mice","volume":"343","author":"Cloyd","year":"2021","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.exger.2023.112309_bb0065","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-012-1038-9","article-title":"Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy","volume":"124","author":"Crimins","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exger.2023.112309_bb0070","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31209","article-title":"Mouse color and wavelength-specific luminance contrast sensitivity are non-uniform across visual space","volume":"7","author":"Denman","year":"2018","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.exger.2023.112309_bb0075","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.jalz.2017.05.003","article-title":"Microvascular changes in Down syndrome with Alzheimer\u2019s-type pathology: insights into a potential vascular mechanism for Down syndrome and Alzheimer\u2019s disease","volume":"13","author":"Drachman","year":"2017","journal-title":"Alzheimers Dement."},{"issue":"7","key":"10.1016\/j.exger.2023.112309_bb0080","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.exger.2023.112309_bb0085","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1532-5415.1991.tb03617.x","article-title":"The effect of planned walking on communication in Alzheimer\u2019s disease","volume":"39","author":"Friedman","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.exger.2023.112309_bb0090","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2013.06.005","article-title":"Hyperexcitability and epileptic seizures in a model of frontotemporal dementia","volume":"58","author":"Garc\u00eda-Cabrero","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exger.2023.112309_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.655245","article-title":"Different modulatory effects of cognitive training and aerobic exercise on resting state functional connectivity of entorhinal cortex in community-dwelling older adults","volume":"13","author":"Gu","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.exger.2023.112309_bb0100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuron.2020.06.005","article-title":"Tipping the scales: peptide-dependent dysregulation of neural circuit dynamics in Alzheimer\u2019s disease","volume":"107","author":"Harris","year":"2020","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.exger.2023.112309_bb0105","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.apmr.2004.03.019","article-title":"The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis","volume":"85","author":"Heyn","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.exger.2023.112309_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-023-00885-4","article-title":"Associations between physical exercise type, fluid intelligence, executive function, and processing speed in the oldest-old (85+)","author":"Ho","year":"2023","journal-title":"Geroscience"},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tins.2022.11.006","article-title":"Entorhinal cortex dysfunction in Alzheimer\u2019s disease","volume":"46","author":"Igarashi","year":"2023","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0120","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer\u2019s disease","volume":"17","author":"Khan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exger.2023.112309_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148429","article-title":"Investigation of the protective effect of long-term exercise on molecular pathways and behaviours in scopolamine induced alzheimer\u2019s disease-like condition","volume":"1814","author":"Kose","year":"2023","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.exger.2023.112309_bb9000","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3758\/s13420-022-00532-6","article-title":"Texas field crickets (Gryllus texensis) use visual cues to place learn but perform poorly when intra- and extra-maze cues conflict","volume":"50","author":"Kozlovsky","year":"2022","journal-title":"Learning & Behavior"},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7326\/0003-4819-144-2-200601170-00004","article-title":"Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older","volume":"144","author":"Larson","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.exger.2023.112309_bb0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.nbd.2015.10.019","article-title":"Soluble A\u03b2 oligomers impair hippocampal LTP by disrupting glutamatergic\/GABAergic balance","volume":"85","author":"Lei","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.exger.2023.112309_bb0140","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1471-4159.2006.04370.x","article-title":"IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro","volume":"101","author":"Lyons","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exger.2023.112309_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2202-9-81","article-title":"Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer\u2019s disease-related pathologies in male triple-transgenic mice","volume":"9","author":"Mastrangelo","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exger.2023.112309_bb0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1196\/annals.1418.005","article-title":"Glutamate and neurotrophic factors in neuronal plasticity and disease","volume":"1144","author":"Mattson","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0155","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuroscience.2003.09.020","article-title":"Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor","volume":"123","author":"Molteni","year":"2004","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0160","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/cells11020244","article-title":"Treadmill exercise prevents decline in spatial learning and memory in 3\u00d7 Tg-AD mice through enhancement of structural synaptic plasticity of the hippocampus and prefrontal cortex","volume":"11","author":"Mu","year":"2022","journal-title":"Cells"},{"issue":"20","key":"10.1016\/j.exger.2023.112309_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012655","article-title":"Treadmill exercise reduces neuroinflammation, glial cell activation and improves synaptic transmission in the prefrontal cortex in 3 x Tg-AD mice","volume":"23","author":"Mu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exger.2023.112309_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","article-title":"Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship","volume":"68","author":"Nelson","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.exger.2023.112309_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2023.152103","article-title":"Moderate-intensity intermittent exercise prevents memory deficit, hippocampal neuron loss, and elevated level of Alzheimer\u2019s dementia markers in the hippocampus of trimethyltin-induced rats","volume":"249","author":"Nurmasitoh","year":"2023","journal-title":"Ann. Anat."},{"issue":"3","key":"10.1016\/j.exger.2023.112309_bb0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2023.112309_bb0185","article-title":"Staging of Alzheimer\u2019s pathology in triple transgenic mice: a light and electron microscopic analysis","volume":"2010","author":"Oh","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.exger.2023.112309_bb0190","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/cercor\/bhz016","article-title":"Aberrant excitatory-inhibitory synaptic mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer\u2019s disease","volume":"29","author":"Petrache","year":"2019","journal-title":"Cereb. Cortex"},{"issue":"5","key":"10.1016\/j.exger.2023.112309_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.01.039","article-title":"Functional imbalance of anterolateral entorhinal cortex and hippocampal dentate\/CA3 underlies age-related object pattern separation deficits","volume":"97","author":"Reagh","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0200","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.07.029","article-title":"Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs","volume":"223","author":"Rocher","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exger.2023.112309_bb0205","article-title":"Effects of three months of aerobic endurance training on motor cortical excitability in schizophrenia patients and healthy subjects","volume":"1-8","author":"Roeh","year":"2018","journal-title":"Neuropsychobiology"},{"issue":"2","key":"10.1016\/j.exger.2023.112309_bb0210","first-page":"109","article-title":"Feasibility [corrected] of regular physical exercise for patients with moderate to severe Alzheimer disease","volume":"4","author":"Rolland","year":"2000","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.exger.2023.112309_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111056","article-title":"Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 beta and pCREB expression","volume":"139","author":"Sabouri","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2023.112309_bb0220","article-title":"Preparation of acute brain slices using an optimized N-methyl-D-glucamine protective recovery method","volume":"132","author":"Ting","year":"2018","journal-title":"J. Vis. Exp."},{"issue":"24","key":"10.1016\/j.exger.2023.112309_bb0225","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1523\/JNEUROSCI.0950-15.2015","article-title":"Amyloid-\u03b2 impairs synaptic inhibition via GABA(a) receptor endocytosis","volume":"35","author":"Ulrich","year":"2015","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2023.112309_bb0230","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2005.11.062","article-title":"Exercise differentially regulates synaptic proteins associated to the function of BDNF","volume":"1070","author":"Vaynman","year":"2006","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.exger.2023.112309_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.11.024","article-title":"A new neuronal target for \u03b2-amyloid peptide in the rat hippocampus","volume":"33","author":"Villette","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.exger.2023.112309_bb0240","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1471-6712.2011.00895.x","article-title":"A community-based exercise programme to improve functional ability in people with Alzheimer\u2019s disease: a randomized controlled trial","volume":"26","author":"Vreugdenhil","year":"2012","journal-title":"Scand. J. Caring Sci."},{"issue":"4","key":"10.1016\/j.exger.2023.112309_bb0245","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.14336\/AD.2022.0110","article-title":"The effects of physical running on dendritic spines and amyloid-beta pathology in 3xTg-AD male mice","volume":"13","author":"Xu","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.exger.2023.112309_bb0250","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcell.2020.00024","article-title":"Parvalbumin interneuron activation-dependent adult hippocampal neurogenesis is required for treadmill running to reverse schizophrenia-like phenotypes","volume":"8","author":"Yi","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"6453","key":"10.1016\/j.exger.2023.112309_bb0255","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"A vicious cycle of \u03b2 amyloid\u2013dependent neuronal hyperactivation","volume":"365","author":"Zott","year":"2019","journal-title":"Science"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556523002309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556523002309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:53:28Z","timestamp":1759982008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556523002309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":52,"alternative-id":["S0531556523002309"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2023.112309","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2023.112309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112309"}}