{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:13:14Z","timestamp":1777594394703,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.exger.2024.112408","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T10:11:26Z","timestamp":1711188686000},"page":"112408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice"],"prefix":"10.1016","volume":"189","author":[{"given":"Yong-Fang","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Hui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Chao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Hua","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2024.112408_bb0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bone.2006.07.023","article-title":"1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora","volume":"40","author":"Cao","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.exger.2024.112408_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101206","article-title":"Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms","volume":"24","author":"Chaiprasongsuk","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2024.112408_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12951","article-title":"1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16\/p53-senescence signaling","volume":"18","author":"Chen","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2024.112408_bb0020","doi-asserted-by":"crossref","first-page":"11334","DOI":"10.3390\/ijms222111334","article-title":"1,25(OH)2D3 inhibited ferroptosis in zebrafish liver cells (ZFL) by regulating Keap1-Nrf2-GPx4 and NF-\u03baB-hepcidin axis","volume":"22","author":"Cheng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2024.112408_bb0025","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/er.2012-1026","article-title":"The osteocyte: an endocrine cell ... And more","volume":"34","author":"Dallas","year":"2013","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.exger.2024.112408_bb0030","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.exger.2024.112408_bb0035","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of senescent cells in the bone microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2024.112408_bb0040","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/jbmr.3729","article-title":"Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: evidence in young adult mice and older humans","volume":"34","author":"Farr","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2024.112408_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111836","article-title":"Ferroptosis - a new target of osteoporosis","volume":"165","author":"Gao","year":"2022","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2024.112408_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2019.01.021","article-title":"Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation","volume":"163","author":"He","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exger.2024.112408_bb0055","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11914-017-0402-z","article-title":"Aging, osteocytes, and Mechanotransduction","volume":"15","author":"Hemmatian","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.exger.2024.112408_bb0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2024.112408_bb0065","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41419-020-2256-z","article-title":"VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exger.2024.112408_bb0070","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.2147\/DDDT.S269223","article-title":"Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2\/HO-1 signaling pathway","volume":"14","author":"Huang","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.exger.2024.112408_bb0075","doi-asserted-by":"crossref","first-page":"14103","DOI":"10.1038\/s41598-019-50679-y","article-title":"Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model","volume":"9","author":"Jeremy","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2024.112408_bb0080","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1016\/j.csbj.2022.09.018","article-title":"Revealing a novel contributing landscape of ferroptosis-related genes in Parkinson\u2019s disease","volume":"20","author":"Jian","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.exger.2024.112408_bb0085","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/iub.2656","article-title":"Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"key":"10.1016\/j.exger.2024.112408_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1067085","article-title":"Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal","volume":"14","author":"Kou","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2024.112408_bb0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-022-00442-3","article-title":"Eriodictyol ameliorates cognitive dysfunction in APP\/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation","volume":"28","author":"Li","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.exger.2024.112408_bb0095","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2024.112408_bb0105","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101610R","article-title":"Activation of osteoblast ferroptosis via the METTL3\/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss","volume":"36","author":"Lin","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2024.112408_bb0110","doi-asserted-by":"crossref","first-page":"16130","DOI":"10.1038\/s41598-019-52513-x","article-title":"Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence","volume":"9","author":"Lu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2024.112408_bb0115","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s40618-015-0381-9","article-title":"Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK\/SirT1 axis","volume":"39","author":"Marampon","year":"2016","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.exger.2024.112408_bb0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"Ni","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2024.112408_bb0125","first-page":"1313","article-title":"Eldecalcitol for the treatment of osteoporosis","volume":"8","author":"Noguchi","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exger.2024.112408_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104919","article-title":"The application of ferroptosis in diseases","volume":"159","author":"Qiu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2024.112408_bb0135","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bone.2017.06.022","article-title":"Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone","volume":"103","author":"Rolvien","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.exger.2024.112408_bb0140","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s00198-012-2208-2","article-title":"Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation?","volume":"24","author":"Sapir-Koren","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.exger.2024.112408_bb0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jsbmb.2015.09.043","article-title":"Eldecalcitol (ED-71), an analog of 1\u03b1,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas","volume":"164","author":"Shintani","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2024.112408_bb0150","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.exger.2024.112408_bb0155","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3945\/jn.116.239475","article-title":"Activation of Nrf2-antioxidant signaling by 1,25-dihydroxycholecalciferol prevents leptin-induced oxidative stress and inflammation in human endothelial cells","volume":"147","author":"Teixeira","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2024.112408_bb0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2019.01.025","article-title":"Changes in the osteocyte lacunocanalicular network with aging","volume":"122","author":"Tiede-Lewis","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.exger.2024.112408_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2019.151422","article-title":"The osteocyte: a multifunctional cell within the bone","volume":"227","author":"Tresguerres","year":"2020","journal-title":"Ann. Anat."},{"key":"10.1016\/j.exger.2024.112408_bb0170","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S8756-3282(02)00682-8","article-title":"ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis","volume":"30","author":"Uchiyama","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.exger.2024.112408_bb0175","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11914-017-0373-0","article-title":"Osteocyte mechanobiology","volume":"15","author":"Uda","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.exger.2024.112408_bb0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.atherosclerosis.2014.05.911","article-title":"Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals","volume":"235","author":"Valcheva","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.exger.2024.112408_bb0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11914-022-00753-8","article-title":"Pathways controlling formation and maintenance of the osteocyte dendrite network","volume":"20","author":"Wang","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.exger.2024.112408_bb0190","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00441-021-03496-7","article-title":"Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence","volume":"386","author":"Wei","year":"2021","journal-title":"Cell Tissue Res."},{"issue":"Pt 2","key":"10.1016\/j.exger.2024.112408_bb0195","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.freeradbiomed.2022.11.013","article-title":"VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2\/GPX4 pathway in age-related osteoporosis","volume":"193","author":"Xu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2024.112408_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13095","article-title":"1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis","volume":"19","author":"Yang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2024.112408_bb0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41392-020-00253-0","article-title":"Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.exger.2024.112408_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113139","article-title":"Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor","volume":"182","author":"Yashiro","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.exger.2024.112408_bb0215","first-page":"2","article-title":"The relationship between vitamin D and telomere\/telomerase: a comprehensive review","volume":"10","author":"Zarei","year":"2021","journal-title":"J. Frailty Aging"},{"key":"10.1016\/j.exger.2024.112408_bb0220","doi-asserted-by":"crossref","first-page":"F791","DOI":"10.1152\/ajprenal.00247.2009","article-title":"Long-term therapeutic effect of vitamin D analog Doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist","volume":"297","author":"Zhang","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.exger.2024.112408_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801014","article-title":"Vitamin D protects against alcohol-induced liver cell injury within an NRF2-ALDH2 feedback loop","volume":"63","author":"Zhang","year":"2019","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524000500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524000500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T23:20:43Z","timestamp":1712445643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556524000500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":45,"alternative-id":["S0531556524000500"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2024.112408","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2024.112408","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112408"}}