{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:02:10Z","timestamp":1787508130705,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.exger.2024.112415","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T05:26:32Z","timestamp":1712899592000},"page":"112415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease"],"prefix":"10.1016","volume":"190","author":[{"given":"Haoran","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2024.112415_bb0005","doi-asserted-by":"crossref","DOI":"10.1134\/S0006297918090122","article-title":"Immunogenetic factors of neurodegenerative diseases: the role of HLA class II","author":"Aliseychik","year":"2018","journal-title":"Biochemistry Biokhimiia"},{"key":"10.1016\/j.exger.2024.112415_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070680","article-title":"Mitochondria in Health and Disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.exger.2024.112415_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cells11182908","article-title":"Neuroinflammation and Parkinson\u2019s disease-from neurodegeneration to therapeutic opportunities","volume":"11","author":"Ara\u00fajo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exger.2024.112415_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson\u2019s disease: risk factors and prevention","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2024.112415_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102178","article-title":"HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection","author":"Augusto","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.exger.2024.112415_bb0030","doi-asserted-by":"crossref","DOI":"10.1534\/genetics.117.300262","article-title":"Cell biology of the mitochondrion","author":"van der Bliek","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.exger.2024.112415_bb0035","article-title":"Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson\u2019s Disease","author":"Cirstea","year":"2020","journal-title":"Movement disorders\u202f: official journal of the Movement Disorder Society"},{"key":"10.1016\/j.exger.2024.112415_bb0040","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-022-03929-4","article-title":"Matrisome changes in Parkinson\u2019s disease","author":"Downs","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.exger.2024.112415_bb0045","doi-asserted-by":"crossref","DOI":"10.1080\/07391102.2018.1564701","article-title":"Computational approach to suggest a new multi-target-directed ligand as a potential medication for Alzheimer\u2019s disease","author":"Eslami","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.exger.2024.112415_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb6716","article-title":"An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke","volume":"13","author":"Fang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2024.112415_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-020-00191-5","article-title":"Freezing of gait in Parkinson\u2019s disease: pathophysiology, risk factors and treatments","author":"Gao","year":"2020","journal-title":"Translational neurodegeneration"},{"key":"10.1016\/j.exger.2024.112415_bb0060","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","author":"Harrington","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2024.112415_bb0065","doi-asserted-by":"crossref","DOI":"10.3233\/JPD-223153","article-title":"Neuronal presentation of antigen and its possible role in Parkinson\u2019s disease","author":"Hobson","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.exger.2024.112415_bb0070","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s disease: etiopathogenesis and treatment","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.exger.2024.112415_bb0075","doi-asserted-by":"crossref","DOI":"10.3233\/JPD-179006","article-title":"The MPTP story","author":"Langston","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.exger.2024.112415_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2023.07.005","article-title":"The systemic immune response in Parkinson\u2019s disease: focus on the peripheral immune component","author":"Lauritsen","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exger.2024.112415_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.09.033","article-title":"Human MD2 deficiency-an inborn error of immunity with pleiotropic features","author":"Li","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.exger.2024.112415_bb0090","article-title":"Gut microbial metabolite hyodeoxycholic acid targets the TLR4\/MD2 complex to attenuate inflammation and protect against sepsis","author":"Li","year":"2023","journal-title":"Molecular therapy\u202f: the journal of the American Society of Gene Therapy."},{"key":"10.1016\/j.exger.2024.112415_bb0095","article-title":"Recent research progress on metabolic syndrome and risk of Parkinson\u2019s disease","author":"Li","year":"2023","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.exger.2024.112415_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228421","article-title":"Neurodegeneration and inflammation-an interesting interplay in Parkinson\u2019s disease","volume":"21","author":"Marogianni","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2024.112415_bb0105","doi-asserted-by":"crossref","DOI":"10.3233\/JPD-223212","article-title":"New insights and implications of natural killer cells in Parkinson\u2019s disease","author":"Menees","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.exger.2024.112415_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-023-03904-0","article-title":"Mitochondrial dysfunction and Parkinson\u2019s disease: pathogenesis and therapeutic strategies","author":"Moradi Vastegani","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exger.2024.112415_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","author":"Nalls","year":"2019","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.exger.2024.112415_bb0120","doi-asserted-by":"crossref","unstructured":"Pajares M, I Rojo A, Manda G, Bosc\u00e1 L, Cuadrado A. Inflammation in Parkinson's disease: mechanisms and therapeutic implications. Cells (2020). 9. doi:https:\/\/doi.org\/10.3390\/cells9071687.","DOI":"10.3390\/cells9071687"},{"key":"10.1016\/j.exger.2024.112415_bb0125","doi-asserted-by":"crossref","DOI":"10.3233\/NRE-171437","article-title":"Immune biomarkers for the diagnosis of mild traumatic brain injury","author":"Petrone","year":"2017","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.exger.2024.112415_bb0130","doi-asserted-by":"crossref","DOI":"10.2174\/1566523223666230419101023","article-title":"Gene therapy for Alzheimer and Parkinson diseases","author":"Saad","year":"2023","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.exger.2024.112415_bb0135","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-022-11258-w","article-title":"Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson\u2019s disease","author":"Su","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.exger.2024.112415_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2023.10.007","article-title":"Gene signals and SNPs associated with Parkinson\u2019s disease: A nutrigenomics and computational prospective insights","author":"Subramaniyan","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.exger.2024.112415_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/febs.14607","article-title":"Determinants of dopaminergic neuron loss in Parkinson\u2019s disease","author":"Surmeier","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.exger.2024.112415_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1233870","article-title":"The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders","author":"Terrabuio","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2024.112415_bb0155","article-title":"Parkinson\u2019s disease and neuroinflammation - Cellular pathology, mechanisms and therapeutic options","author":"T\u00f6nges","year":"2018","journal-title":"Fortschritte der Neurologie-Psychiatrie"},{"key":"10.1016\/j.exger.2024.112415_bb0160","doi-asserted-by":"crossref","DOI":"10.17116\/jnevro202012010267","article-title":"Neuroendocrine and metabolic impairments in patients with Parkinson\u2019s disease","author":"Verugina","year":"2020","journal-title":"Zhurnal nevrologii i psikhiatrii imeni SS Korsakova"},{"key":"10.1016\/j.exger.2024.112415_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in Parkinson\u2019s disease","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2024.112415_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2020.01.018","article-title":"Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson\u2019s disease","author":"Wijeyekoon","year":"2020","journal-title":"Brain, behavior, and immunity"},{"key":"10.1016\/j.exger.2024.112415_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awab103","article-title":"CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson\u2019s disease","author":"Williams","year":"2021","journal-title":"Brain\u202f: a journal of neurology"},{"key":"10.1016\/j.exger.2024.112415_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0149-0","article-title":"The SH-SY5Y cell line in Parkinson\u2019s disease research: a systematic review","author":"Xicoy","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exger.2024.112415_bb0185","first-page":"1086","article-title":"SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson\u2019s disease","volume":"123","author":"Xie","year":"2010","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.exger.2024.112415_bb0190","doi-asserted-by":"crossref","DOI":"10.5653\/cerm.2022.05610","article-title":"TLR-1, TLR-2, and TLR-6 MYD88-dependent signaling pathway: A potential factor in the interaction of high-DNA fragmentation human sperm with fallopian tube epithelial cells","author":"Zandieh","year":"2023","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.exger.2024.112415_bb0195","article-title":"Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4\/MyD88 and the cGMP-dependent protein kinase pathway","author":"Zhang","year":"2009","journal-title":"Journal of immunology (Baltimore, Md\u202f: 1950)"},{"key":"10.1016\/j.exger.2024.112415_bb0200","doi-asserted-by":"crossref","DOI":"10.1136\/jmedgenet-2017-105047","article-title":"Genetics of Parkinson\u2019s disease and related disorders","author":"Zhang","year":"2018","journal-title":"J. Med. Genet."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524000573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524000573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T08:21:08Z","timestamp":1714206068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556524000573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"alternative-id":["S0531556524000573"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2024.112415","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2024.112415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112415"}}