{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:15:33Z","timestamp":1782926133382,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.exger.2024.112558","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T22:08:55Z","timestamp":1724796535000},"page":"112558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease"],"prefix":"10.1016","volume":"196","author":[{"given":"Yanghong","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.exger.2024.112558_bb0005","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1007\/s12035-016-9906-2","article-title":"Glucose metabolism and AMPK signaling regulate dopaminergic cell death induced by gene (\u03b1-synuclein)-environment (paraquat) interactions [J]","volume":"54","author":"Anandhan","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/17460441.2023.2160440","article-title":"Neuroinflammation, immune response and \u03b1-synuclein pathology: how animal models are helping us to connect dots [J]","volume":"18","author":"Balzano","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.exger.2024.112558_bb0015","article-title":"Anti-\u03b1-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson\u2019s disease [J]","volume":"105969","author":"Brendza","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.exger.2024.112558_bb0020","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease [J]","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/nu8010043","article-title":"Regulation of intestinal glucose absorption by ion channels and transporters [J]","volume":"8","author":"Chen","year":"2016","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2829","article-title":"A true response of the brain network during electroacupuncture stimulation at scalp acupoints: an fMRI with simultaneous EAS study [J]","volume":"13","author":"Chen","year":"2022","journal-title":"Brain and behavior"},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0035","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13075-022-02960-1","article-title":"Augmented PFKFB3-mediated glycolysis by interferon-\u03b3 promotes inflammatory M1 polarization through the JAK2\/STAT1 pathway in local vascular inflammation in Takayasu arteritis [J]","volume":"24","author":"Chen","year":"2022","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.exger.2024.112558_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14110793","article-title":"Zearalenone exposure affects the Keap1-Nrf2 signaling pathway and glucose nutrient absorption related genes of porcine jejunal epithelial cells [J]","volume":"14","author":"Cheng","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.exger.2024.112558_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109191","article-title":"Crosstalk between PI3K\/AKT\/KLF4 signaling and microglia M1\/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson\u2019s disease [J]","volume":"112","author":"El-Deeb","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.exger.2024.112558_bb0050","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41582-019-0155-7","article-title":"Emerging therapies in Parkinson disease - repurposed drugs and new approaches [J]","volume":"15","author":"Elkouzi","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.exger.2024.112558_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1020644","article-title":"NElectroacupuncture of the trigeminal nerve causes -methyl-D-aspartate receptors to mediate blood-brain barrier opening and induces neuronal excitatory changes [J]","volume":"16","author":"Gong","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.exger.2024.112558_bb0060","first-page":"8191","article-title":"Effect of transcutaneous electrical acupoint stimulation on bone loss for patients with foot and ankle fracture: a pragmatic randomized controlled trial [J]","volume":"14","author":"Guo","year":"2022","journal-title":"Am. J. Transl. Res."},{"issue":"9","key":"10.1016\/j.exger.2024.112558_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e30819","article-title":"Electroacupuncture blocked motor dysfunction and gut barrier damage by modulating intestinal NLRP3 inflammasome in MPTP-induced Parkinson\u2019s disease mice [J]","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.exger.2024.112558_bb0070","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00424-020-02433-x","article-title":"Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application [J]","volume":"472","author":"Gyimesi","year":"2020","journal-title":"Arch. Eur. J. Physiol."},{"issue":"11","key":"10.1016\/j.exger.2024.112558_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115887","article-title":"Glucose metabolic dysfunction in neurodegenerative diseases-new mechanistic insights and the potential of hypoxia as a prospective therapy targeting metabolic reprogramming [J]","volume":"22","author":"Han","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0080","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1186\/s12967-023-04638-x","article-title":"miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson\u2019s disease model via regulation of Nox4\/ROS\/Nrf2 signaling [J]","volume":"21","author":"He","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.exger.2024.112558_bb0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijbiomac.2022.12.134","article-title":"The impact of \u03b1-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells [J]","volume":"229","author":"Hourfar","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.exger.2024.112558_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1358525","article-title":"Electroacupuncture at ST25 corrected gut microbial dysbiosis and SNpc lipid peroxidation in Parkinson\u2019s disease rats [J]","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Microbiol."},{"issue":"9","key":"10.1016\/j.exger.2024.112558_bb0095","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","article-title":"Glucose transporters in brain in health and disease [J]","volume":"472","author":"Koepsell","year":"2020","journal-title":"Arch. Eur. J. Physiol."},{"issue":"3","key":"10.1016\/j.exger.2024.112558_bb0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jtcme.2023.01.005","article-title":"Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson\u2019s disease [J]","volume":"13","author":"Lee","year":"2023","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.exger.2024.112558_bb0105","article-title":"Transcutaneous electrical acupoint stimulation combined with electroacupuncture promotes rapid recovery after abdominal surgery: study protocol for a randomized controlled trial [J]","volume":"10","author":"Li","year":"2022","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0110","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41531-022-00352-5","article-title":"Melatonin ameliorates Parkinson\u2019s disease via regulating microglia polarization in a ROR\u03b1-dependent pathway [J]","volume":"8","author":"Li","year":"2022","journal-title":"NPJ Parkinson\u2019s disease"},{"key":"10.1016\/j.exger.2024.112558_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101814","article-title":"Electroacupuncture for motor dysfunction and constipation in patients with Parkinson\u2019s disease: a randomised controlled multi-centre trial [J]","volume":"56","author":"Li","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"9","key":"10.1016\/j.exger.2024.112558_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091846","article-title":"Electroacupuncture promotes recovery of motor function and reduces dopaminergic neuron degeneration in rodent models of Parkinson\u2019s disease [J]","volume":"18","author":"Lin","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2024.112558_bb0125","article-title":"The effect of electroacupuncture versus manual acupuncture through the expression of TrkB\/NF-B in the subgranular zone of the dentate gyrus of telomerase-deficient mice [J]","volume":"2018","author":"Lin","year":"2018","journal-title":"Evidence-based complementary and alternative medicine\u202f: eCAM"},{"issue":"7","key":"10.1016\/j.exger.2024.112558_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3624","article-title":"Sodium-glucose cotransporter 1\/2 inhibition and risk of neurodegenerative disorders: a Mendelian randomization study [J]","volume":"14","author":"Liu","year":"2024","journal-title":"Brain and behavior"},{"key":"10.1016\/j.exger.2024.112558_bb0135","article-title":"Evidence on acupuncture therapies is underused in clinical practice and health policy [J]","volume":"376","author":"Lu","year":"2022","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.exger.2024.112558_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2024.103044","article-title":"Efficacy of acupuncture as adjunct therapy for sleep disorders in Parkinson\u2019s disease: a systematic review and meta-analysis [J]","volume":"82","author":"Mi","year":"2024","journal-title":"Complement. Ther. Med."},{"issue":"34","key":"10.1016\/j.exger.2024.112558_bb0145","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.jafc.1c03541","article-title":"Hydrolyzed chicken meat extract attenuates neuroinflammation and cognitive impairment in middle-aged mouse by regulating M1\/M2 microglial polarization [J]","volume":"69","author":"Ni","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"45","key":"10.1016\/j.exger.2024.112558_bb0150","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1093\/eurheartj\/ehac417","article-title":"Does SGLT1 inhibition add to the benefits of SGLT2 inhibition in the prevention and treatment of heart failure? [J]","volume":"43","author":"Pitt","year":"2022","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.exger.2024.112558_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9120282","article-title":"Glucose-6 phosphate, a central hub for liver carbohydrate metabolism [J]","volume":"9","author":"Rajas","year":"2019","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.exger.2024.112558_bb0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/08941939.2020.1810370","article-title":"Sleeve gastrectomy surgery improves glucose metabolism by downregulating the intestinal expression of sodium-glucose cotransporter-3 [J]","volume":"35","author":"Ren","year":"2022","journal-title":"Journal of investigative surgery\u202f: the official journal of the Academy of Surgical Research"},{"issue":"2","key":"10.1016\/j.exger.2024.112558_bb0165","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jnc.14551","article-title":"RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays brain damage after experimental traumatic brain injury [J]","volume":"147","author":"Sebastiani","year":"2018","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.exger.2024.112558_bb0170","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41401-022-01030-1","article-title":"Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway [J]","volume":"44","author":"Sun","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.exger.2024.112558_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.839796","article-title":"Activation of RAR\u03b1 receptor attenuates neuroinflammation after SAH via promoting M1-to-M2 phenotypic polarization of microglia and regulating Mafb\/Msr1\/PI3K-Akt\/NF-\u03baB pathway [J]","volume":"13","author":"Tian","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2024.112558_bb0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2023.03.001","article-title":"Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration [J]","volume":"200","author":"Tu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"21","key":"10.1016\/j.exger.2024.112558_bb0185","article-title":"L-tryptophan differentially regulated glucose and amino acid transporters in the small intestine of rat challenged with lipopolysaccharide [J]","volume":"12","author":"Wang","year":"2022","journal-title":"Animals\u202f: an open access journal from MDPI"},{"issue":"7","key":"10.1016\/j.exger.2024.112558_bb0190","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1093\/brain\/awab122","article-title":"Reactive microglia enhance the transmission of exosomal \u03b1-synuclein via toll-like receptor 2 [J]","volume":"144","author":"Xia","year":"2021","journal-title":"Brain J. Neurol."},{"issue":"4","key":"10.1016\/j.exger.2024.112558_bb0195","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1159\/000495676","article-title":"TRPC1 deficiency exacerbates cerebral ischemia\/reperfusion-induced neurological injury by potentiating Nox4-derived reactive oxygen species generation [J]","volume":"51","author":"Xu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exger.2024.112558_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.778527","article-title":"Fibroblast growth factor 21 modulates microglial polarization that attenuates neurodegeneration in mice and cellular models of Parkinson\u2019s disease [J]","volume":"13","author":"Yang","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"50","key":"10.1016\/j.exger.2024.112558_bb0205","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013434","article-title":"A study of the effects of 8-week acupuncture treatment on patients with Parkinson\u2019s disease [J]","volume":"97","author":"Yeo","year":"2018","journal-title":"Medicine"},{"issue":"5","key":"10.1016\/j.exger.2024.112558_bb0210","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/cns.12507","article-title":"Effect of acupuncture on the motor and nonmotor symptoms in Parkinson\u2019s disease--a review of clinical studies [J]","volume":"22","author":"Zeng","year":"2016","journal-title":"CNS Neurosci. Ther."},{"issue":"12","key":"10.1016\/j.exger.2024.112558_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278509","article-title":"Efficacy and safety of electric acupuncture in treatment of intractable facial paralysis: a protocol for systematic review and meta-analysis [J]","volume":"17","author":"Zhou","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2024.112558_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102539","article-title":"NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders [J]","volume":"231","author":"Zilberter","year":"2023","journal-title":"Prog. Neurobiol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524002043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524002043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:56:13Z","timestamp":1727301373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556524002043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"alternative-id":["S0531556524002043"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2024.112558","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2024.112558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112558"}}