{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:37:11Z","timestamp":1788323831629,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.exger.2024.112657","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T20:22:19Z","timestamp":1734466939000},"page":"112657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor"],"prefix":"10.1016","volume":"199","author":[{"given":"Xin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjie","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2024.112657_bb0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40824-018-0134-x","article-title":"Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells","volume":"22","author":"Bae","year":"2018","journal-title":"Biomater. Res."},{"key":"10.1016\/j.exger.2024.112657_bb0010","first-page":"391","volume":"2018","author":"Barnett","year":"1985","journal-title":"Osteoarthritis. Lancet"},{"key":"10.1016\/j.exger.2024.112657_bb0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2016.05.009","article-title":"The joint synovium: a critical determinant of articular cartilage fate in inflammatory joint diseases","volume":"62","author":"Bhattaram","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exger.2024.112657_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.11.003","article-title":"Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations","volume":"184","author":"Boer","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.exger.2024.112657_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.11.003","article-title":"Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations","volume":"184","author":"Boer","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.exger.2024.112657_bb0030","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.exger.2024.112657_bb0035","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.exger.2024.112657_bb0040","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.exger.2024.112657_bb0045","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.exger.2024.112657_bb0050","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/ije\/dyv108","article-title":"Mendelian randomization: where are we now and where are we going?","volume":"44","author":"Burgess","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.exger.2024.112657_bb0055","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022560","article-title":"Causal effect of obstructive sleep apnea on atrial fibrillation: a Mendelian randomization study","volume":"10","author":"Chen","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.exger.2024.112657_bb0060","article-title":"Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis","volume":"375","author":"da Costa","year":"2021","journal-title":"Bmj"},{"key":"10.1016\/j.exger.2024.112657_bb0065","article-title":"Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis. JCI","volume":"6","author":"De Roover","year":"2021","journal-title":"Insight"},{"key":"10.1016\/j.exger.2024.112657_bb0070","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"Emdin","year":"2017","journal-title":"Mendelian Randomization. Jama"},{"key":"10.1016\/j.exger.2024.112657_bb0075","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/art.40928","article-title":"Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK biobank","volume":"71","author":"Funck-Brentano","year":"2019","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exger.2024.112657_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105369","article-title":"Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: an unexpectable link?","volume":"164","author":"Gaspar","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2024.112657_bb0085","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0256-2021","article-title":"Bidirectional relationships of comorbidity with obstructive sleep apnoea","volume":"31","author":"Gleeson","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.exger.2024.112657_bb0090","first-page":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis. Lancet"},{"key":"10.1016\/j.exger.2024.112657_bb0095","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/ije\/dyab251","article-title":"Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index","volume":"51","author":"Hartley","year":"2022","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.exger.2024.112657_bb0100","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet"},{"key":"10.1016\/j.exger.2024.112657_bb0105","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a lancet commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2024.112657_bb0110","first-page":"Cd010842","article-title":"Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review","volume":"4","author":"Hurley","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.exger.2024.112657_bb0115","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1378\/chest.14-0614","article-title":"OSA and pulmonary hypertension: time for a new look","volume":"147","author":"Ismail","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.exger.2024.112657_bb0120","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2024.112657_bb0125","doi-asserted-by":"crossref","first-page":"A553","DOI":"10.1016\/j.chest.2016.02.578","article-title":"Obstructive sleep apnea is risk factor for osteoarthritis","volume":"149","author":"Kanbay","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.exger.2024.112657_bb0130","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5578\/tt.57403","article-title":"Obstructive sleep apnea is a risk factor for osteoarthritis","volume":"66","author":"Kanbay","year":"2018","journal-title":"Tuberk. Toraks"},{"key":"10.1016\/j.exger.2024.112657_bb0135","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.exger.2024.112657_bb0140","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.exger.2024.112657_bb0145","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S2213-2600(15)00051-X","article-title":"On the cutting edge of obstructive sleep apnoea: where next?","volume":"3","author":"Malhotra","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.exger.2024.112657_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.smrv.2012.05.002","article-title":"The reciprocal interaction between obesity and obstructive sleep apnoea","volume":"17","author":"Ong","year":"2013","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.exger.2024.112657_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl. 2","key":"10.1016\/j.exger.2024.112657_bb0160","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.2337\/dc08-s272","article-title":"Abdominal fat and sleep apnea: the chicken or the egg?","volume":"31","author":"Pillar","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2024.112657_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S2213-2600(19)30449-7","article-title":"Time to wake the giant of obstructive sleep apnoea","volume":"8","author":"Respiratory","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.exger.2024.112657_bb0170","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/cdd.2011.111","article-title":"Hypoxia-inducible factor-2\u03b1 regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction","volume":"19","author":"Ryu","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exger.2024.112657_bb0175","doi-asserted-by":"crossref","unstructured":"Safiri, S.; Kolahi, A.-A.; Smith, E.; Hill, C.; Bettampadi, D.; Mansournia, m.a.; Hoy, D.; Ashrafi, A.; Sepidarkish, M.; Almasi-Hashiani, A.; et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the global burden of disease study 2017. Ann. Rheum. Dis. 2020, 79, annrheumdis-2019.","DOI":"10.1136\/bmj.m791"},{"key":"10.1016\/j.exger.2024.112657_bb0180","first-page":"11","article-title":"Multivariable Mendelian randomization and mediation","author":"Sanderson","year":"2021","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.exger.2024.112657_bb0185","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03091-2020","article-title":"Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health","volume":"57","author":"Strausz","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.exger.2024.112657_bb0190","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2337\/dc18-2004","article-title":"Risk of incident obstructive sleep apnea among patients with type 2 diabetes","volume":"42","author":"Subramanian","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2024.112657_bb0195","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41588-018-0327-1","article-title":"Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK biobank data","volume":"51","author":"Tachmazidou","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2024.112657_bb0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12891-018-1993-y","article-title":"Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis","volume":"19","author":"Taylor","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.exger.2024.112657_bb0205","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2024.112657_bb0210","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1183\/13993003.00234-2016","article-title":"Upper airway and systemic inflammation in obstructive sleep apnoea","volume":"48","author":"Vicente","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.exger.2024.112657_bb0215","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.joca.2013.06.027","article-title":"Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus","volume":"21","author":"Wen","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2024.112657_bb0220","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2024.112657_bb0225","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524003036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556524003036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:31:31Z","timestamp":1736217091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556524003036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0531556524003036"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2024.112657","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2024.112657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112657"}}