{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:13:54Z","timestamp":1782828834914,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH030030"],"award-info":[{"award-number":["2024AH030030"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200860"],"award-info":[{"award-number":["82200860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370776"],"award-info":[{"award-number":["82370776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2022-ZQKY-194"],"award-info":[{"award-number":["2022-ZQKY-194"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021-ZQKY-120"],"award-info":[{"award-number":["2021-ZQKY-120"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["X202310366062"],"award-info":[{"award-number":["X202310366062"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.exger.2025.112783","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:09Z","timestamp":1747190109000},"page":"112783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases"],"prefix":"10.1016","volume":"206","author":[{"given":"Feixiang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozhao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7311","key":"10.1016\/j.exger.2025.112783_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature09298","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.exger.2025.112783_bb0010","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1110\/ps.04915904","article-title":"Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function","volume":"13","author":"Arakaki","year":"2004","journal-title":"Protein Science : a Publication of the Protein Society"},{"issue":"11","key":"10.1016\/j.exger.2025.112783_bb0015","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.exger.2025.112783_bb0020","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2019.11.020","article-title":"Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders","volume":"179","author":"Consortium, C.-D.G.o.t.P.G","year":"2019","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.exger.2025.112783_bb0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"4","key":"10.1016\/j.exger.2025.112783_bb0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/0962280206077743","article-title":"Mendelian randomization as an instrumental variable approach to causal inference","volume":"16","author":"Didelez","year":"2007","journal-title":"Stat. Methods Med. Res."},{"issue":"4","key":"10.1016\/j.exger.2025.112783_bb0040","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/ije\/dyz236","article-title":"Comparison with randomized controlled trials as a strategy for evaluating instruments in Mendelian randomization","volume":"49","author":"Gill","year":"2020","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.exger.2025.112783_bb0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41562-019-0566-x","article-title":"Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits","volume":"3","author":"Grotzinger","year":"2019","journal-title":"Nat. Hum. Behav."},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0050","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1038\/s41598-019-42427-z","article-title":"Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network","volume":"9","author":"Hellwege","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2025.112783_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0060","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41467-021-20918-w","article-title":"Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women","volume":"12","author":"Jones","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.exger.2025.112783_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14092336","article-title":"Ephrin B activate Src family kinases in fibroblasts inducing stromal remodeling in prostate cancer","volume":"14","author":"Kakarla","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/gerona\/glr035","article-title":"Prevalence and risk factors of sarcopenia among nursing home older residents","volume":"67","author":"Landi","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"8","key":"10.1016\/j.exger.2025.112783_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002753","article-title":"Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis","volume":"22","author":"Li","year":"2024","journal-title":"PLoS Biol."},{"issue":"11","key":"10.1016\/j.exger.2025.112783_bb0080","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/ecco-jcc\/jjaa086","article-title":"Disturbance of fatty acid desaturation mediated by FADS2 in mesenteric adipocytes contributes to chronic inflammation of Crohn\u2019s disease","volume":"14","author":"Liu","year":"2020","journal-title":"J. Crohns Colitis"},{"issue":"3","key":"10.1016\/j.exger.2025.112783_bb0085","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/jcsm.13463","article-title":"Standardizing trait selection in Mendelian randomization studies concerning sarcopenia","volume":"15","author":"Liu","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"43","key":"10.1016\/j.exger.2025.112783_bb0090","doi-asserted-by":"crossref","first-page":"23893","DOI":"10.1021\/acs.jafc.4c07781","article-title":"Overexpression of ALDOC promotes porcine intramuscular and intermuscular fat deposition by activating the AKT-mTORC1 signaling pathway","volume":"72","author":"Ma","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"7\u20138","key":"10.1016\/j.exger.2025.112783_bb0095","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0899-9007(01)00574-3","article-title":"Anorexia, sarcopenia, and aging","volume":"17","author":"Morley","year":"2001","journal-title":"Nutrition"},{"issue":"19","key":"10.1016\/j.exger.2025.112783_bb0100","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1113\/JP285402","article-title":"Inducible deletion of endothelial cell Efnb2 delays capillary regeneration and attenuates myofibre reinnervation following myotoxin injury in mice","volume":"602","author":"Morton","year":"2024","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.exger.2025.112783_bb0105","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/s41588-024-01933-1","article-title":"Multivariate genomic analysis of 5million people elucidates the genetic architecture of shared components of the metabolic syndrome","volume":"56","author":"Park","year":"2024","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.exger.2025.112783_bb0110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.juro.2007.03.103","article-title":"Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems","volume":"178","author":"Parsons","year":"2007","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0115","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s42003-020-01334-0","article-title":"The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study","volume":"3","author":"Pei","year":"2020","journal-title":"Communications Biology"},{"key":"10.1016\/j.exger.2025.112783_bb0120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.maturitas.2020.01.004","article-title":"Factors associated with sarcopenia: a cross-sectional analysis using UK Biobank","volume":"133","author":"Petermann-Rocha","year":"2020","journal-title":"Maturitas"},{"key":"10.1016\/j.exger.2025.112783_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1290639","article-title":"The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia","volume":"14","author":"Rao","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"15","key":"10.1016\/j.exger.2025.112783_bb0130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.purol.2018.08.005","article-title":"Epidemiology of benign prostatic hyperplasia","volume":"28","author":"Robert","year":"2018","journal-title":"Progres en Urologie : Journal de L'Association Francaise D'urologie Et de La Societe Francaise D'urologie"},{"issue":"5","key":"10.1016\/j.exger.2025.112783_bb0135","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ajhg.2017.09.022","article-title":"Local genetic correlation gives insights into the shared genetic architecture of complex traits","volume":"101","author":"Shi","year":"2017","journal-title":"Am. J. Hum. Genet."},{"issue":"20","key":"10.1016\/j.exger.2025.112783_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11206202","article-title":"Relationship between testosterone and sarcopenia in older-adult men: a narrative review","volume":"11","author":"Shigehara","year":"2022","journal-title":"J. Clin. Med."},{"issue":"20","key":"10.1016\/j.exger.2025.112783_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11206202","article-title":"Relationship between testosterone and sarcopenia in older-adult men: a narrative review","volume":"11","author":"Shigehara","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0150","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s42003-025-07721-9","article-title":"Improving multi-trait genomic prediction by incorporating local genetic correlations","volume":"8","author":"Teng","year":"2025","journal-title":"Communications Biology"},{"issue":"1","key":"10.1016\/j.exger.2025.112783_bb0155","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s12967-022-03722-y","article-title":"Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study","volume":"20","author":"Wang","year":"2022","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.exger.2025.112783_bb0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11926-019-0825-x","article-title":"Ephrins and Eph receptor signaling in tissue repair and fibrosis","volume":"21","author":"Wu","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"issue":"3","key":"10.1016\/j.exger.2025.112783_bb0165","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/pros.23737","article-title":"Prevalence and heritability of benign prostatic hyperplasia and LUTS in men aged 40 years or older in Zhengzhou rural areas","volume":"79","author":"Yue","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.exger.2025.112783_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1475977","article-title":"Advances in sarcopenia and urologic disorders","volume":"11","author":"Zhao","year":"2024","journal-title":"Front. Nutr."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:07:24Z","timestamp":1762308444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525001123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"alternative-id":["S0531556525001123"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112783","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112783"}}