{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:16:07Z","timestamp":1792552567090,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.exger.2025.112801","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:12:37Z","timestamp":1749035557000},"page":"112801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Systemic oxidative stress associates with delirium in a geriatric population with hip fracture"],"prefix":"10.1016","volume":"207","author":[{"given":"Monika","family":"Trzpis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zernova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin M.","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L.C.","family":"Bulthuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Reinders-Luinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"van Munster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno R.","family":"Bourgonje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2025.112801_bb0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/109454503323028920","article-title":"Reduced level of serum thiols in patients with a diagnosis of active disease","volume":"6","author":"Banne","year":"2003","journal-title":"J. Anti Aging Med."},{"key":"10.1016\/j.exger.2025.112801_bb0010","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/00016470410001123","article-title":"Pathogenesis of and management strategies for postoperative delirium after hip fracture: a review","volume":"75","author":"Bitsch","year":"2004","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.exger.2025.112801_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8090351","article-title":"Serum free thiols are superior to fecal calprotectin in reflecting endoscopic disease activity in inflammatory bowel disease","volume":"8","author":"Bourgonje","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.exger.2025.112801_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.00499","article-title":"Crohn\u2019s disease in clinical remission is marked by systemic oxidative stress","volume":"10","author":"Bourgonje","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exger.2025.112801_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.630543","article-title":"Systemic oxidative stress, aging and the risk of cardiovascular events in the general female population","volume":"8","author":"Bourgonje","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2019.102294","article-title":"Oxidative stress in alzheimer\u2019s disease: a review on emergent natural polyphenolic therapeutics","volume":"49","author":"Cassidy","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9070597","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"Vol. 9","author":"Chang","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.exger.2025.112801_bb0040","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1089\/ars.2017.7083","article-title":"The reactive species Interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine","volume":"27","author":"Cortese-Krott","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.exger.2025.112801_bb0045","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1111\/liv.14562","article-title":"Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population","volume":"40","author":"Damba","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.exger.2025.112801_bb0050","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/CIA.S390906","article-title":"Delirium after surgery for proximal femoral fractures in the frail elderly patient: risk factors and clinical outcomes","volume":"18","author":"de Haan","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exger.2025.112801_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-11-34","article-title":"The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial","volume":"11","author":"De Jonghe","year":"2011","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.exger.2025.112801_bb0060","doi-asserted-by":"crossref","first-page":"E547","DOI":"10.1503\/cmaj.140495","article-title":"Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial","volume":"186","author":"De Jonghe","year":"2014","journal-title":"CMAJ"},{"key":"10.1016\/j.exger.2025.112801_bb0065","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/(SICI)1099-1166(199704)12:4<462::AID-GPS510>3.0.CO;2-Q","article-title":"Differentiating between demented and psychiatric patients with the Dutch version of the IQCODE - pubmed","volume":"12","author":"de Jonghe","year":"1997","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.exger.2025.112801_bb0070","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1055\/s-0038-1634956","article-title":"Risk adjustment in outcome assessment: the Charlson comorbidity index - PubMed","volume":"32","author":"D'Hoore","year":"1993","journal-title":"Methods Inf. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.exger.2025.112801_bb0080","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.exger.2025.112801_bb0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2025.112801_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.729757","article-title":"Oxidative stress and cognitive decline: the neuroprotective role of natural antioxidants","volume":"15","author":"Franzoni","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exger.2025.112801_bb0095","article-title":"Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants","volume":"6","author":"Houldsworth","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.exger.2025.112801_bb0100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/S003329170002691X","article-title":"A short form of the informant questionnaire on cognitive decline in the elderly (IQCODE): development and cross-validation","volume":"24","author":"Jorm","year":"1994","journal-title":"Psychol. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0105","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5542634","article-title":"Patients undergoing surgery for hip fractures suffer from severe oxidative stress as compared to patients with hip osteoarthritis undergoing Total hip arthroplasty","volume":"2021","author":"Karachalios","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.exger.2025.112801_bb0110","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.genhosppsych.2006.06.002","article-title":"The role of oxidative stress in postoperative delirium","volume":"28","author":"Karlidag","year":"2006","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.exger.2025.112801_bb0115","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function","volume":"185","author":"Katz","year":"1963","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.exger.2025.112801_bb0120","first-page":"1","article-title":"Oxidative stress and soluble receptor for advanced glycation end-products play a role in the pathophysiology of delirium after cardiac surgery","volume":"11","author":"Ka\u017amierski","year":"2021","journal-title":"Sci. Rep. 2021"},{"key":"10.1016\/j.exger.2025.112801_bb0125","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-022-00660-9","article-title":"Factors associated with post-operative delirium in hip fracture patients: what should we care","volume":"27","author":"Kong","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.exger.2025.112801_bb0130","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/jnnp-2022-328903","article-title":"Original research: delirium and the risk of developing dementia: a cohort study of 12 949 patients","volume":"93","author":"Leighton","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.exger.2025.112801_bb0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archinternmed.2007.4","article-title":"One-year health care costs associated with delirium in the elderly","volume":"168","author":"Leslie","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/gps.5872","article-title":"Delirium is significantly associated with hospital frailty risk score derived from administrative data","volume":"38","author":"Lim","year":"2023","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.exger.2025.112801_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in oxidative stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.exger.2025.112801_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1021129","article-title":"Reactive oxygen species contribute to delirium-like behavior by activating CypA\/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery","volume":"14","author":"Liu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exger.2025.112801_bb5000","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2016.12.039","article-title":"Intraoperative cerebral oxygenation, oxidative injury, and delirium following cardiac surgery","volume":"103","author":"Lopez","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0155","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.exger.2008.03.011","article-title":"Targeting oxidative stress in surgery: effects of ageing and therapy","volume":"43","author":"Pepe","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112801_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-018-3148-8","article-title":"Patient safety, cost-effectiveness, and quality of life: reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults-study protocol for a stepped-wedge cluster randomized trial (PAWEL study)","volume":"20","author":"S\u00e1nchez","year":"2019","journal-title":"Trials"},{"key":"10.1016\/j.exger.2025.112801_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1891\/rtnp.17.1.31.53169","article-title":"The delirium observation screening scale: a screening instrument for delirium","volume":"17","author":"Schuurmans","year":"2003","journal-title":"Res. Theory Nurs. Pract."},{"key":"10.1016\/j.exger.2025.112801_bb0170","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2025.112801_bb0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4055\/cios.2019.11.3.297","article-title":"Etiology and related factors of postoperative delirium in orthopedic surgery","volume":"11","author":"Song","year":"2019","journal-title":"Clin. Orthop. Surg."},{"key":"10.1016\/j.exger.2025.112801_bb0180","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2013.05.050","article-title":"The thiol pool in human plasma: the central contribution of albumin to redox processes","volume":"65","author":"Turell","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112801_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25112653","article-title":"Targeting oxidative stress for disease prevention and therapy: where do we stand, and where do we go from Here","volume":"25","author":"Vassalle","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.exger.2025.112801_bb0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cca.2017.01.009","article-title":"Postoperative serum thioredoxin concentrations correlate with delirium and cognitive dysfunction after hip fracture surgery in elderly patients","volume":"466","author":"Wu","year":"2017","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.exger.2025.112801_bb5005","doi-asserted-by":"crossref","first-page":"29854","DOI":"10.1038\/s41598-024-80739-x","article-title":"Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests","volume":"14","author":"Yuba","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2025.112801_bb0195","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.18632\/aging.203955","article-title":"The TLR4\/NF-\u03baB\/MAGI-2 signaling pathway mediates postoperative delirium","volume":"14","author":"Zhang","year":"2022","journal-title":"Aging (Albany NY)"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:06:59Z","timestamp":1762308419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525001305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"alternative-id":["S0531556525001305"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112801","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic oxidative stress associates with delirium in a geriatric population with hip fracture","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112801"}}