{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:04Z","timestamp":1791881464274,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.exger.2025.112842","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T06:38:43Z","timestamp":1753339123000},"page":"112842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis"],"prefix":"10.1016","volume":"209","author":[{"given":"Lei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengwen","family":"wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linrong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","article-title":"TSH is a negative regulator of skeletal remodeling","volume":"115","author":"Abe","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.exger.2025.112842_bb0010","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X221083541","article-title":"Osteoporosis in 10 years time: a glimpse into the future of osteoporosis","volume":"14","author":"Adami","year":"2022","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of thyroid hormones in skeletal development and bone maintenance","volume":"37","author":"Bassett","year":"2016","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0020","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ando.2018.09.004","article-title":"Graves\u2019 disease, multinodular goiter and subclinical hyperthyroidism","volume":"80","author":"Bel Lassen","year":"2019","journal-title":"Ann. Endocrinol."},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0025","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1210\/endo.136.5.7720659","article-title":"The molecular response of bone to growth hormone during skeletal unloading: regional differences","volume":"136","author":"Bikle","year":"1995","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ije\/dyv071","article-title":"Mendelian randomization studies: a review of the approaches used and the quality of reporting","volume":"44","author":"Boef","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0035","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"6","key":"10.1016\/j.exger.2025.112842_bb0040","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1093\/ije\/dyy265","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.exger.2025.112842_bb0045","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1530\/EC-20-0167","article-title":"TSH suppressive therapy and bone","volume":"9","author":"Brancatella","year":"2020","journal-title":"Endocr. Connect."},{"issue":"3","key":"10.1016\/j.exger.2025.112842_bb0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res.: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"10","key":"10.1016\/j.exger.2025.112842_bb0055","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/jbmr.120","article-title":"Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk","volume":"25","author":"C\u00e1rcamo-Orive","year":"2010","journal-title":"J. Bone Miner. Res.: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0060","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10654-021-00757-1","article-title":"Mendelian randomisation for mediation analysis: current methods and challenges for implementation","volume":"36","author":"Carter","year":"2021","journal-title":"Eur. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.exger.2025.112842_bb0065","first-page":"S36","article-title":"Insomnia: prevalence, consequences and effective treatment","volume":"199","author":"Cunnington","year":"2013","journal-title":"Med. J. Aust."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?*","volume":"32","author":"Davey Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"issue":"Suppl. 6","key":"10.1016\/j.exger.2025.112842_bb0075","first-page":"S164","article-title":"Osteoporosis and the burden of osteoporosis-related fractures","volume":"17","author":"Dempster","year":"2011","journal-title":"Am. J. Manag. Care"},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0080","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12902-021-00715-8","article-title":"Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation","volume":"21","author":"Deng","year":"2021","journal-title":"BMC Endocr. Disord."},{"issue":"9","key":"10.1016\/j.exger.2025.112842_bb0085","first-page":"3058","article-title":"Profiles of endogenous circulating cortisol and bone mineral density in healthy elderly men","volume":"84","author":"Dennison","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2025.112842_bb0090","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2147\/NSS.S351850","article-title":"Chronic sleep deprivation impaired bone formation in growing rats and down-regulated PI3K\/AKT signaling in bone tissues","volume":"14","author":"Duan","year":"2022","journal-title":"Nat. Sci. Sleep"},{"issue":"8","key":"10.1016\/j.exger.2025.112842_bb0095","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1089\/thy.2014.0589","article-title":"Circadian and circannual rhythms in thyroid hormones: determining the TSH and free T4 reference intervals based upon time of day, age, and sex","volume":"25","author":"Ehrenkranz","year":"2015","journal-title":"Thyroid: Official Journal of the American Thyroid Association"},{"key":"10.1016\/j.exger.2025.112842_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.725829","article-title":"Thyroid dysfunction and sleep disorders","volume":"12","author":"Green","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"issue":"R2","key":"10.1016\/j.exger.2025.112842_bb0110","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","article-title":"Evaluating the potential role of pleiotropy in Mendelian randomization studies","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.exger.2025.112842_bb0115","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/thy.2000.10.1101","article-title":"Diurnal thyrotropin secretion in short-term profound primary hypothyroidism: does it ever persist?","volume":"10","author":"Hirshberg","year":"2000","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0120","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.3390\/ijms24043772","article-title":"Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs","volume":"24","author":"Iantomasi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.exger.2025.112842_bb0125","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporosis Int.: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"issue":"2 Suppl 1","key":"10.1016\/j.exger.2025.112842_bb0130","article-title":"Osteoporosis: a still increasing prevalence","volume":"38","author":"Jy","year":"2006","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12126","article-title":"The aging population: demographics and the biology of aging","volume":"72","author":"Kanasi","year":"2016","journal-title":"Periodontol. 2000"},{"issue":"3","key":"10.1016\/j.exger.2025.112842_bb0140","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem.: International Journal of Laboratory Medicine"},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4248\/BR201302004","article-title":"Role and mechanisms of actions of thyroid hormone on the skeletal development","volume":"1","author":"Kim","year":"2013","journal-title":"Bone Res."},{"key":"10.1016\/j.exger.2025.112842_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1173781","article-title":"Physical activity and reduced risk of fracture in thyroid cancer patients after thyroidectomy \u2014 a nationwide cohort study","volume":"14","author":"Kim","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exger.2025.112842_bb0155","doi-asserted-by":"crossref","first-page":"1539442","DOI":"10.3389\/fendo.2025.1539442","article-title":"Anxiety disorders in patients with thyroid nodules vs. thyroid cancer: a retrospective cohort study","volume":"16","author":"Kornelius","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"2 Suppl","key":"10.1016\/j.exger.2025.112842_bb0160","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2005.08.047","article-title":"Epidemiology, etiology, and diagnosis of osteoporosis","volume":"194","author":"Lane","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.exger.2025.112842_bb0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000262524","article-title":"Role of sleep and sleep loss in hormonal release and metabolism","volume":"17","author":"Leproult","year":"2010","journal-title":"Endocr. Dev."},{"issue":"11","key":"10.1016\/j.exger.2025.112842_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009922","article-title":"Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model","volume":"17","author":"Lin","year":"2021","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0175","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/s41598-025-88412-7","article-title":"The mediating role of thyroid-related hormones between thyroid dysfunction diseases and osteoporosis: a mediation mendelian randomization study","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.exger.2025.112842_bb0180","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/joim.12369","article-title":"Osteoporosis: the evolution of a diagnosis","volume":"277","author":"Lorentzon","year":"2015","journal-title":"J. Intern. Med."},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0185","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"M","year":"2018","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0190","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ecl.2022.10.008","article-title":"Thyroid and aging","volume":"52","author":"Mammen","year":"2023","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.exger.2025.112842_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6757154","article-title":"Thyroid hormones, oxidative stress, and inflammation","volume":"2016","author":"Mancini","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.exger.2025.112842_bb0200","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1210\/endo-125-3-1239","article-title":"Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondroprogenitor cells","volume":"125","author":"Maor","year":"1989","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/bib\/5.4.355","article-title":"Linkage disequilibrium for different scales and applications","volume":"5","author":"Mueller","year":"2004","journal-title":"Brief. Bioinform."},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0210","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jbmr.3879","article-title":"Short sleep is associated with low bone mineral density and osteoporosis in the Women\u2019s Health Initiative","volume":"35","author":"Ochs-Balcom","year":"2020","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0215","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1258\/ebm.2009.009241","article-title":"Dual oxidase, hydrogen peroxide and thyroid diseases","volume":"235","author":"Ohye","year":"2010","journal-title":"Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.exger.2025.112842_bb0220","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ije\/dyq151","article-title":"Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants","volume":"40","author":"Pierce","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0225","doi-asserted-by":"crossref","first-page":"12784","DOI":"10.1038\/s41598-024-62854-x","article-title":"Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis","volume":"14","author":"Qi","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.exger.2025.112842_bb0230","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41574-020-0339-7","article-title":"A broader strategy for osteoporosis interventions","volume":"16","author":"Reid","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0235","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ije\/dyr233","article-title":"Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease","volume":"41","author":"Relton","year":"2012","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0240","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/er.2012-1076","article-title":"Thyrotropin secretion patterns in health and disease","volume":"34","author":"Roelfsema","year":"2013","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0245","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a038984","article-title":"Multivariable Mendelian randomization and mediation","volume":"11","author":"Sanderson","year":"2021","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.exger.2025.112842_bb0250","doi-asserted-by":"crossref","DOI":"10.1093\/ajh\/hpaf034","article-title":"Integrating proteomics and Mendelian randomization to identify new therapeutic targets","author":"Santulli","year":"2025","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.exger.2025.112842_bb0255","doi-asserted-by":"crossref","first-page":"1230932","DOI":"10.3389\/fendo.2023.1230932","article-title":"The relationship of hip fracture and thyroid disorders: a systematic review","volume":"14","author":"SeyedAlinaghi","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0260","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40842-019-0085-8","article-title":"Endocrinology practice patterns of hypothyroidism and osteoporosis management in a U.S. tertiary academic medical center","volume":"5","author":"Shim","year":"2019","journal-title":"Clin. Diab. Endocrinol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0265","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/2047487312460020","article-title":"Insomnia and risk of cardiovascular disease: a meta-analysis","volume":"21","author":"Sofi","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"1","key":"10.1016\/j.exger.2025.112842_bb0270","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11325-021-02445-6","article-title":"Is there any relation between arterial stiffness and insomnia? A challenging question","volume":"26","author":"Sunbul","year":"2022","journal-title":"Sleep Breath. = Schlaf & Atmung"},{"issue":"2","key":"10.1016\/j.exger.2025.112842_bb0275","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jbmr.2446","article-title":"Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep","volume":"30","author":"Swanson","year":"2015","journal-title":"J. Bone Miner. Res.: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"10","key":"10.1016\/j.exger.2025.112842_bb0280","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.4720","article-title":"The economic burden of severe osteoporotic fractures in the French Healthcare Database: the FRACTOS study","volume":"37","author":"Thomas","year":"2022","journal-title":"J. Bone Miner. Res.: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"Suppl. 1","key":"10.1016\/j.exger.2025.112842_bb0285","first-page":"2","article-title":"Impact of sleep and sleep loss on neuroendocrine and metabolic function","volume":"67","author":"Van Cauter","year":"2007","journal-title":"Horm. Res."},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0290","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/EJE-21-1171","article-title":"The interplay of thyroid hormones and the immune system - where we stand and why we need to know about it","volume":"186","author":"Wenzek","year":"2022","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.exger.2025.112842_bb0295","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.smrv.2015.11.004","article-title":"Health economics of insomnia treatments: the return on investment for a good night\u2019s sleep","volume":"30","author":"Wickwire","year":"2016","journal-title":"Sleep Med. Rev."},{"issue":"5","key":"10.1016\/j.exger.2025.112842_bb0300","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041346","article-title":"A review of symptom, pathogenesis and treatment characteristics of the elderly with chronic insomnia","volume":"104","author":"Xia","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.exger.2025.112842_bb0305","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221106884","article-title":"Relationship between sleep pattern and bone mineral density in patients with osteoporotic fracture","volume":"13","author":"Zeng","year":"2022","journal-title":"Ther. Adv. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.exger.2025.112842_bb0310","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.tjnut.2024.02.005","article-title":"Chronic excess iodine intake inhibits bone reconstruction leading to osteoporosis in rats","volume":"154","author":"Zhang","year":"2024","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2025.112842_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117168","article-title":"Associations of sleep behaviors and genetic risk with risk of incident osteoporosis: a prospective cohort study of 293,164 participants","volume":"186","author":"Zhao","year":"2024","journal-title":"Bone"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:24:24Z","timestamp":1791879864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525001718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":63,"alternative-id":["S0531556525001718"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112842","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112842"}}