{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:10:21Z","timestamp":1787497821483,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.exger.2025.112866","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T05:32:26Z","timestamp":1756013546000},"page":"112866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Integrative analysis of inhibition of advanced glycation end-products accumulation and prevention of aging muscle deterioration in animals and human models"],"prefix":"10.1016","volume":"210","author":[{"given":"Moon Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Min","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Yeou","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.exger.2025.112866_bb5015","first-page":"362","article-title":"Pathogenesis of insulin resistance and atherogenic dyslipidemia in nonalcoholic fatty liver disease","volume":"7","author":"Akhtar","year":"2019","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.exger.2025.112866_bb0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.exger.2018.08.006","article-title":"The sit-to-stand muscle power test: an easy, inexpensive and portable procedure to assess muscle power in older people","volume":"112","author":"Alcazar","year":"2018","journal-title":"Exp. Gerontol."},{"issue":"10","key":"10.1016\/j.exger.2025.112866_bb0020","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.exger.2025.112866_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1155175","article-title":"AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration","volume":"16","author":"Bhattacharya","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.exger.2025.112866_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111941","article-title":"Sarcopenia: a dive into metabolism to promote a multimodal, preventive, and regenerative approach","volume":"219","author":"Boccardi","year":"2024","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.exger.2025.112866_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71037-7","article-title":"Skin autofluorescence and cause-specific mortality in a population-based cohort","volume":"14","author":"Boersma","year":"2024","journal-title":"Sci. Rep."},{"issue":"2\u20133","key":"10.1016\/j.exger.2025.112866_bb0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000085276","article-title":"Beta-cell function and insulin resistance evaluated by HOMA in pancreatic cancer subjects with varying degrees of glucose intolerance","volume":"5","author":"Chari","year":"2005","journal-title":"Pancreatology"},{"issue":"8","key":"10.1016\/j.exger.2025.112866_bb0050","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1080\/1028415X.2021.1901047","article-title":"Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-\u03b1\/NF-\u03baB\/caspase-3 signaling in type 2 diabetes rats","volume":"25","author":"Chen","year":"2022","journal-title":"Nutr. Neurosci."},{"issue":"3","key":"10.1016\/j.exger.2025.112866_bb0055","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/path.4674","article-title":"Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway","volume":"238","author":"Chiu","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.exger.2025.112866_bb0060","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3389\/fphys.2017.01045","article-title":"The role of inflammation in age-related sarcopenia","volume":"8","author":"Dalle","year":"2017","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.exger.2025.112866_bb0065","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1089\/ars.2017.7420","article-title":"The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration","volume":"30","author":"De Santa","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.exger.2025.112866_bb5010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029785","article-title":"Effects of exercise and aging on skeletal muscle","volume":"8","author":"Distefano","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"4","key":"10.1016\/j.exger.2025.112866_bb0070","article-title":"Aerobic exercise training activates glyoxalase system to detoxify methylglyoxal and suppress muscle atrophy in aged mice","volume":"21","author":"Egawa","year":"2022","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb0075","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2025.112866_bb0080","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4062\/biomolther.2023.130","article-title":"Aerobic exercise ameliorates muscle atrophy induced by methylglyoxal via increasing gastrocnemius and extensor digitorum longus muscle sensitivity","volume":"31","author":"Hong","year":"2023","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.exger.2025.112866_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112177","article-title":"Age-associated inflammation and implications for skeletal muscle responses to exercise","volume":"177","author":"Kunz","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112866_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111581","article-title":"Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4\/FoxO3a pathway","volume":"127","author":"Liang","year":"2025","journal-title":"Cell. Signal."},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb5005","article-title":"Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation","volume":"1869","author":"Nogueira-Ferreira","year":"2023","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"issue":"11","key":"10.1016\/j.exger.2025.112866_bb0100","first-page":"168","article-title":"Advanced glycation end-products in skeletal muscle aging","volume":"8","author":"Olson","year":"2021","journal-title":"Bioengineering (Basel, Switzerland)"},{"issue":"9","key":"10.1016\/j.exger.2025.112866_bb0105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jdiacomp.2018.06.009","article-title":"Skin autofluorescence is associated with vascular complications in patients with type 2 diabetes","volume":"32","author":"Osawa","year":"2018","journal-title":"J. Diabetes Complications"},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/healthcare13060613","article-title":"Advanced glycation end products and mobility decline: a novel perspective on aging","volume":"13","author":"Park","year":"2025","journal-title":"Healthcare"},{"key":"10.1016\/j.exger.2025.112866_bb5000","series-title":"R: A language and environment for statistical computing","year":"2016"},{"key":"10.1016\/j.exger.2025.112866_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and age-related diseases: role of inflammation triggers and cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.exger.2025.112866_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10091848","article-title":"Advanced glycation end products in health and disease","volume":"10","author":"Reddy","year":"2022","journal-title":"Microorganisms"},{"issue":"10","key":"10.1016\/j.exger.2025.112866_bb0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3126\/ajms.v13i10.46707","article-title":"Pancreatic Beta-cell function and degree of insulin resistance among newly detected type 2 diabetics and their correlation with anthropometric, glucose, and lipid parameters: an observational cross-sectional study","volume":"13","author":"Saha","year":"2022","journal-title":"Asian J. Med. Sci."},{"issue":"4","key":"10.1016\/j.exger.2025.112866_bb0130","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s13410-022-01121-z","article-title":"Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors","volume":"43","author":"Sakly","year":"2023","journal-title":"Int. J. Diabetes Dev. Ctries."},{"key":"10.1016\/j.exger.2025.112866_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced glycation end-products: a review","volume":"44","author":"Singh","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.exger.2025.112866_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ymeth.2020.09.012","article-title":"Advanced glycation end products in musculoskeletal system and disorders","volume":"203","author":"Suzuki","year":"2022","journal-title":"Methods"},{"issue":"10","key":"10.1016\/j.exger.2025.112866_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101383","article-title":"Co-stimulation of AGEs and LPS induces inflammatory mediators through PLC\u03b31\/JNK\/NF-\u03baB pathway in MC3T3-E1 cells","volume":"12","author":"Tanabe","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb0150","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","article-title":"Advanced glycation end products in foods and a practical guide to their reduction in the diet","volume":"110","author":"Uribarri","year":"2010","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.exger.2025.112866_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-013-0453-1","article-title":"Advanced glycation end products (AGE) and diabetes: cause, effect, or both?","volume":"14","author":"Vlassara","year":"2014","journal-title":"Curr. Diab. Rep."},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb0160","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/gtmb.2018.0328","article-title":"Skin autofluorescence is associated with diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: a cross-sectional study","volume":"23","author":"Wan","year":"2019","journal-title":"Genet. Test. Mol. Biomarkers"},{"issue":"10","key":"10.1016\/j.exger.2025.112866_bb0165","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/gerona\/glac025","article-title":"Skin autofluorescence, a noninvasive biomarker of advanced glycation end-products, is associated with frailty: the Rotterdam study","volume":"77","author":"Waqas","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.exger.2025.112866_bb0170","first-page":"109","article-title":"The mediating role of inflammaging between mitochondrial dysfunction and sarcopenia in aging: a review","volume":"12","author":"Xu","year":"2023","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"10.1016\/j.exger.2025.112866_bb5020","doi-asserted-by":"crossref","DOI":"10.1016\/j.medntd.2025.100361","article-title":"Effectiveness, safety and adherence of home-based exercise rehabilitation in patients with coronary heart disease patients: a systematic review","author":"Xue","year":"2025","journal-title":"Med. Nov. Technol. Devices"},{"issue":"3","key":"10.1016\/j.exger.2025.112866_bb0175","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/02713683.2014.918152","article-title":"Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes","volume":"40","author":"Yasuda","year":"2015","journal-title":"Curr. Eye Res."},{"issue":"12","key":"10.1016\/j.exger.2025.112866_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24129881","article-title":"A role for advanced glycation end products in molecular ageing","volume":"24","author":"Zgutka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2025.112866_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107282","article-title":"Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions \u2013 a review","volume":"206","author":"Zhou","year":"2024","journal-title":"Pharmacol. Res."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525001950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T22:51:12Z","timestamp":1758581472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525001950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":38,"alternative-id":["S0531556525001950"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112866","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis of inhibition of advanced glycation end-products accumulation and prevention of aging muscle deterioration in animals and human models","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112866","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112866"}}