{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:01:16Z","timestamp":1780308076785,"version":"3.54.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011596","name":"Generalitat of Valencia Ministry of Education Culture Universities and Employment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.exger.2025.112924","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:37:47Z","timestamp":1760197067000},"page":"112924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL\/6 mice"],"prefix":"10.1016","volume":"211","author":[{"given":"Yuichi","family":"Igarashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinko","family":"Sawashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2025.112924_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111521","article-title":"Coenzyme Q10 supplementation - in ageing and disease","volume":"197","author":"Aaseth","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2025.112924_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/neup.12373","article-title":"SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions","volume":"37","author":"Akiguchi","year":"2017","journal-title":"Neuropathology"},{"key":"10.1016\/j.exger.2025.112924_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10010168","article-title":"The effect of coenzyme Q10 on liver injury induced by valproic acid and its antiepileptic activity in rats","volume":"10","author":"Alqarni","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.exger.2025.112924_bb0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0891-5849(94)00233-A","article-title":"Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol","volume":"19","author":"Amimoto","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0025","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/1541-4337.12539","article-title":"Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges","volume":"19","author":"Arenas-Jal","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.exger.2025.112924_bb0030","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exger.2025.112924_bb0035","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/humrep\/dew181","article-title":"Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model","volume":"31","author":"Boots","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.exger.2025.112924_bb0040","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/cells13040353","article-title":"Cellular senescence, mitochondrial dysfunction, and their link to cardiovascular disease","volume":"13","author":"Camacho-Encina","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.exger.2025.112924_bb0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41586-019-1365-2","article-title":"From discoveries in ageing research to therapeutics for healthy ageing","volume":"571","author":"Campisi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exger.2025.112924_bb0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11064-008-9812-8","article-title":"The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model","volume":"34","author":"Chiba","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exger.2025.112924_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1263274","article-title":"Suppression of mouse AApoAII amyloidosis progression by daily supplementation with oxidative stress inhibitors","author":"Dai","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.exger.2025.112924_bb0060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63538","article-title":"Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPAR\u03b1 signaling pathway","volume":"10","author":"Dai","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.exger.2025.112924_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-57906-3","article-title":"Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer","volume":"16","author":"Deng","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2025.112924_bb0070","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3390\/nu11092221","article-title":"The paradox of coenzyme Q10 in aging","volume":"11","author":"D\u00edaz-Casado","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2025.112924_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091811","article-title":"Coenzyme Q10 supplementation and its impact on exercise and sport performance in humans: a recovery or a performance-enhancing molecule?","volume":"14","author":"Drobnic","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2025.112924_bb0080","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32111","article-title":"Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance","author":"Fazakerley","year":"2018","journal-title":"elife"},{"key":"10.1016\/j.exger.2025.112924_bb0085","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41586-024-08026-3","article-title":"Dietary restriction impacts health and lifespan of genetically diverse mice","volume":"634","author":"Francesco","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.exger.2025.112924_bb0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1473-2165.2006.00220.x","article-title":"Anti-inflammatory effects of CoQ10 and colorless carotenoids","volume":"5","author":"Fuller","year":"2006","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.exger.2025.112924_bb0095","article-title":"Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2025.112924_bb0100","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.bbadis.2014.02.008","article-title":"Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency","volume":"1842","author":"Garc\u00eda-Corzo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exger.2025.112924_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12071391","article-title":"New insights on the uptake and trafficking of coenzyme Q","volume":"12","author":"Guile","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.exger.2025.112924_bb0110","first-page":"231","article-title":"Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method","volume":"48","author":"Higuchi","year":"1983","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exger.2025.112924_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yrtph.2006.07.001","article-title":"Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers","volume":"47","author":"Hosoe","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.exger.2025.112924_bb0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0047-6374(84)90168-4","article-title":"Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM)","volume":"26","author":"Hosokawa","year":"1984","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2025.112924_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3181759","article-title":"Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells","volume":"2018","author":"Huo","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.exger.2025.112924_bb0130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02535072","article-title":"Age-related changes in the lipid compositions of rat and human tissues","volume":"24","author":"Kal\u00e9n","year":"1989","journal-title":"Lipids"},{"key":"10.1016\/j.exger.2025.112924_bb0135","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/13506120309041737","article-title":"Polymorphisms of mouse apolipoprotein A-II: seven alleles found among 41 inbred strains of mice","volume":"10","author":"Kitagawa","year":"2003","journal-title":"Amyloid"},{"key":"10.1016\/j.exger.2025.112924_bb0140","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/jn\/115.10.1259","article-title":"Chronic food restriction modulates the advance of senescence in the senescence accelerated mouse (SAM)","volume":"115","author":"Kohno","year":"1985","journal-title":"J. Nutr."},{"key":"10.1016\/j.exger.2025.112924_bb0145","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0891-5849(98)00330-X","article-title":"Effects of coenzyme Q10 and alpha-tocopherol administration on their tissue levels in the mouse: elevation of mitochondrial alpha-tocopherol by coenzyme Q10","volume":"26","author":"Lass","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0150","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.freeradbiomed.2004.01.015","article-title":"The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice","volume":"36","author":"Lee","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0155","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1096\/fasebj.2.12.3044905","article-title":"Aging and glucose homeostasis in C57BL\/6J male mice","volume":"2","author":"Leiter","year":"1988","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2025.112924_bb0160","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0005-2728(98)00028-0","article-title":"Quinone., specificity of complex I","volume":"1364","author":"Lenaz","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exger.2025.112924_bb0165","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1007\/BF00226843","article-title":"The function of coenzyme Q in mitochondria","volume":"71","author":"Lenaz","year":"1993","journal-title":"Clin. Investig."},{"key":"10.1016\/j.exger.2025.112924_bb0170","article-title":"Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis","volume":"12","author":"Li","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.exger.2025.112924_bb0175","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ajpath.2023.03.002","article-title":"Renal function in aged C57BL\/6J mice is impaired by deposition of age-related apolipoprotein A-II amyloid independent of kidney aging","volume":"193","author":"Li","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exger.2025.112924_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu16193305","article-title":"Dietary polyphenols as anti-aging agents: targeting the hallmarks of aging","volume":"16","author":"Liu","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2025.112924_bb6000","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1101\/gad.1352905","article-title":"Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice","volume":"19","author":"Liu","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.exger.2025.112924_bb0185","first-page":"727","article-title":"The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice","volume":"44","author":"L\u00f6nnrot","year":"1998","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.exger.2025.112924_bb0190","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.freeradbiomed.2021.01.024","article-title":"Coenzyme Q homeostasis in aging: response to non-genetic interventions","volume":"164","author":"L\u00f3pez-Lluch","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mad.2010.02.003","article-title":"Is coenzyme Q a key factor in aging?","volume":"131","author":"L\u00f3pez-Lluch","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2025.112924_bb0200","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.exger.2025.112924_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101920","article-title":"High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial","volume":"59","author":"Mitsui","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.exger.2025.112924_bb0210","first-page":"588","article-title":"Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"19","author":"Moradi","year":"2016","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0215","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/biof.156","article-title":"Non-mitochondrial coenzyme Q","volume":"37","author":"Morr\u00e9","year":"2011","journal-title":"Biofactors (Oxford, England)"},{"key":"10.1016\/j.exger.2025.112924_bb0220","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cell.2013.01.013","article-title":"Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis","volume":"152","author":"Mugoni","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.exger.2025.112924_bb0225","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/gerona\/60.8.970","article-title":"Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet","volume":"60","author":"Ochoa","year":"2005","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2025.112924_bb0230","first-page":"196","article-title":"Coenzyme Q10 supplementation modulates NF\u03baB and Nrf2 pathways in exercise training","volume":"15","author":"Pala","year":"2016","journal-title":"J. Sports Sci. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0235","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.exger.2003.10.002","article-title":"Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet","volume":"39","author":"Quiles","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112924_bb0240","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/mnfr.200900155","article-title":"Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice","volume":"54","author":"Schmelzer","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.exger.2025.112924_bb0245","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/iub.388","article-title":"The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice","volume":"62","author":"Schmelzer","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.exger.2025.112924_bb0250","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2021.01.018","article-title":"Coenzyme Q redox signalling and longevity","volume":"164","author":"Scialo","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3164\/jcbn.14-130","article-title":"Coenzyme Q10 and \u03b1-lipoic acid: antioxidant and pro-oxidant effects in plasma and peripheral blood lymphocytes of supplemented subjects","volume":"57","author":"Silvestri","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.exger.2025.112924_bb0260","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00592-015-0767-3","article-title":"Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle","volume":"52","author":"Sin","year":"2015","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.exger.2025.112924_bb0265","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/j.mito.2007.03.006","article-title":"Coenzyme Q, oxidative stress and aging","volume":"7","author":"Sohal","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.exger.2025.112924_bb0270","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.freeradbiomed.2005.08.037","article-title":"Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice","volume":"40","author":"Sohal","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0275","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(81)90084-1","article-title":"A new murine model of accelerated senescence","volume":"17","author":"Takeda","year":"1981","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2025.112924_bb0280","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0531-5565(96)00036-8","article-title":"Senescence-accelerated mouse (SAM): a novel murine model of senescence","volume":"32","author":"Takeda","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112924_bb0285","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.molmet.2013.09.004","article-title":"Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth","volume":"2","author":"Tarry-Adkins","year":"2013","journal-title":"Mol. Metab."},{"key":"10.1016\/j.exger.2025.112924_bb0290","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1089\/ars.2013.5406","article-title":"Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice","volume":"20","author":"Tian","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.exger.2025.112924_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.883251","article-title":"Effectiveness of coenzyme Q10 supplementation for reducing fatigue: a systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Tsai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2025.112924_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21030373","article-title":"Coenzyme Q and its role in the dietary therapy against aging","volume":"21","author":"Varela-L\u00f3pez","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.exger.2025.112924_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112221","article-title":"Dietary antioxidants and lifespan: relevance of environmental conditions, diet, and genotype of experimental models","volume":"178","author":"Varela-L\u00f3pez","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112924_bb0310","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13322","article-title":"The ketogenic diet preserves skeletal muscle with aging in mice","volume":"20","author":"Wallace","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2025.112924_bb0315","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1152\/physrev.00040.2023","article-title":"Understanding coenzyme Q","volume":"104","author":"Wang","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2025.112924_bb0320","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0891-5849(00)00311-7","article-title":"Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice","volume":"29","author":"Witting","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exger.2025.112924_bb0325","doi-asserted-by":"crossref","first-page":"33164","DOI":"10.1074\/jbc.M111570200","article-title":"Induction of protein conformational change in mouse senile amyloidosis","volume":"277","author":"Xing","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2025.112924_bb0330","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1038\/s41598-017-08899-7","article-title":"Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII-mediated PDE4 inhibition","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2025.112924_bb0335","first-page":"273","article-title":"Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension","volume":"11","author":"Yamagami","year":"1975","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.exger.2025.112924_bb0340","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.exger.2005.11.007","article-title":"Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice","volume":"41","author":"Yan","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2025.112924_bb0345","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12031-007-9033-7","article-title":"Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation","volume":"34","author":"Yang","year":"2008","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exger.2025.112924_bb0350","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cca.2015.08.002","article-title":"Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction","volume":"450","author":"Yang","year":"2015","journal-title":"Clin. Chim. Acta"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525002530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525002530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:06:21Z","timestamp":1780304781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525002530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":71,"alternative-id":["S0531556525002530"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112924","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112924"}}