{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:56:03Z","timestamp":1781772963776,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1448"],"award-info":[{"award-number":["2023NSFSC1448"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2021LZXNYD-J30"],"award-info":[{"award-number":["2021LZXNYD-J30"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024LCYXZX47"],"award-info":[{"award-number":["2024LCYXZX47"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exger.2025.112997","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:44:25Z","timestamp":1765471465000},"page":"112997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dynamic imbalance of autophagy: A molecular link between age-related hearing loss and cognitive dysfunction"],"prefix":"10.1016","volume":"213","author":[{"given":"Haixu","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanmei","family":"Enzha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.exger.2025.112997_bb0005","article-title":"PGC-1\u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response","volume":"12","author":"Abu Shelbayeh","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)."},{"issue":"9","key":"10.1016\/j.exger.2025.112997_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19703","article-title":"Effects of cochlear implantation on cognitive decline in older adults: a systematic review and meta-analysis","volume":"9","author":"An","year":"2023","journal-title":"Heliyon"},{"issue":"10","key":"10.1016\/j.exger.2025.112997_bb0015","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.exger.2025.112997_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.07.084","article-title":"The hippocampus in aging and disease: from plasticity to vulnerability","volume":"309","author":"Bartsch","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.exger.2025.112997_bb0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12929-023-00899-2","article-title":"The role of autophagy in viral infections","volume":"30","author":"Chen","year":"2023","journal-title":"J. Biomed. Sci."},{"issue":"6","key":"10.1016\/j.exger.2025.112997_bb0030","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1080\/15548627.2024.2319901","article-title":"International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis","volume":"20","author":"Chen","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2025.112997_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2019.02.022","article-title":"Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling","volume":"135","author":"Fetoni","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.exger.2025.112997_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"issue":"7095","key":"10.1016\/j.exger.2025.112997_bb0045","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.exger.2025.112997_bb0050","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1080\/15548627.2021.1885183","article-title":"CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.exger.2025.112997_bb0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.exger.2025.112997_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0163-1047(93)90664-4","article-title":"On the role of the hippocampus in learning and memory in the rat","volume":"60","author":"Jarrard","year":"1993","journal-title":"Behav. Neural Biol."},{"issue":"23","key":"10.1016\/j.exger.2025.112997_bb0065","doi-asserted-by":"crossref","first-page":"R1116","DOI":"10.1016\/j.cub.2015.10.049","article-title":"The hippocampus","volume":"25","author":"Knierim","year":"2015","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.exger.2025.112997_bb0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exger.2025.112997_bb0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2010.01.055","article-title":"Time course of neuronal and synaptic plasticity in dorsal cochlear nucleus of guinea pig following chronic kanamycin-induced deafness","volume":"1328","author":"Kong","year":"2010","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.exger.2025.112997_bb0080","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.exger.2025.112997_bb0085","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/gerona\/glr115","article-title":"Hearing loss and cognition among older adults in the United States","volume":"66","author":"Lin","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"9","key":"10.1016\/j.exger.2025.112997_bb0090","doi-asserted-by":"crossref","first-page":"8622","DOI":"10.18632\/aging.103179","article-title":"Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase","volume":"12","author":"Liu","year":"2020","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.exger.2025.112997_bb0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of Age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA otolaryngology-- head & neck surgery"},{"key":"10.1016\/j.exger.2025.112997_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102611","article-title":"Computational methods for ultrastructural analysis of synaptic complexes","volume":"76","author":"Lu\u010di\u0107","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"issue":"6","key":"10.1016\/j.exger.2025.112997_bb0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.exger.2025.112997_bb0110","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2025.112997_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.997619","article-title":"PGC-1\u03b1 activity and mitochondrial dysfunction in preterm infants","volume":"13","author":"Mohammadi","year":"2022","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.exger.2025.112997_bb0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neurobiolaging.2006.12.008","article-title":"Hippocampal hypometabolism predicts cognitive decline from normal aging","volume":"29","author":"Mosconi","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"7","key":"10.1016\/j.exger.2025.112997_bb0125","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awad037","article-title":"Visualizing reactive astrocyte-neuron interaction in Alzheimer\u2019s disease using 11C-acetate and 18F-FDG","volume":"146","author":"Nam","year":"2023","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.exger.2025.112997_bb0130","first-page":"300","article-title":"The regulatory effect and mechanism of PGC-1\u03b1 on mitochondrial function","volume":"77","author":"Nan","year":"2025","journal-title":"Sheng Li Xue Bao"},{"issue":"8","key":"10.1016\/j.exger.2025.112997_bb0135","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2025.112997_bb0140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fgene.2012.00297","article-title":"Mitophagy in neurodegeneration and aging","volume":"3","author":"Palikaras","year":"2012","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.exger.2025.112997_bb0145","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.exger.2025.112997_bb0150","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.exger.2025.112997_bb0155","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1073\/pnas.93.10.4693","article-title":"Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose","volume":"93","author":"Ragozzino","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exger.2025.112997_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2013.00031","article-title":"The ease of language understanding (ELU) model: theoretical, empirical, and clinical advances","volume":"7","author":"R\u00f6nnberg","year":"2013","journal-title":"Front. Syst. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2025.112997_bb0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00238949","article-title":"Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions","volume":"58","author":"Schenk","year":"1985","journal-title":"Exp. Brain Res."},{"issue":"6036","key":"10.1016\/j.exger.2025.112997_bb0170","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.exger.2025.112997_bb0175","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/jn.00156.2021","article-title":"Cortical compensation for hearing loss, but not age, in neural tracking of the fundamental frequency of the voice","volume":"126","author":"Van Canneyt","year":"2021","journal-title":"J. Neurophysiol."},{"issue":"6","key":"10.1016\/j.exger.2025.112997_bb0180","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nri.2017.21","article-title":"Mitochondrial DNA in innate immune responses and inflammatory pathology","volume":"17","author":"West","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"615","key":"10.1016\/j.exger.2025.112997_bb0185","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe5640","article-title":"Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases","volume":"13","author":"Xiang","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1\u20132","key":"10.1016\/j.exger.2025.112997_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and diseases: role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.exger.2025.112997_bb0195","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.200505082","article-title":"Macroautophagy--a novel beta-amyloid peptide-generating pathway activated in Alzheimer\u2019s disease","volume":"171","author":"Yu","year":"2005","journal-title":"J. Cell Biol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525003262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556525003262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:38:33Z","timestamp":1781771913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556525003262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"alternative-id":["S0531556525003262"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2025.112997","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic imbalance of autophagy: A molecular link between age-related hearing loss and cognitive dysfunction","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2025.112997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112997"}}